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1. 发明申请

WO2007092418A3 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 审中-公开
标题翻译：聚合，可降解药水和涂层
公开(公告)号：WO2007092418A3
公开(公告)日：2008-08-14
申请号：PCT/US2007003101
申请日：2007-02-06
申请人： TEPHA INC , SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
发明人： SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
IPC分类号： A61L31/04 , A61L31/14
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可以用于制造可提供有利的径向强度，抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以快速部署

2. 发明申请

WO2010017014A2 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 审中-公开
标题翻译：聚合物，可降解药物洗脱支架和涂层
公开(公告)号：WO2010017014A2
公开(公告)日：2010-02-11
申请号：PCT/US2009051024
申请日：2009-07-17
申请人： TEPHA INC , SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
发明人： SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
IPC分类号： A61L31/10 , A61F2/82 , A61L31/16
CPC分类号： A61L31/18 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L- lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
摘要翻译：已经开发出具有改进性能的可吸收支架和可吸收支架涂层。这些装置优选包含4-羟基丁酸酯的生物相容性共聚物或均聚物，以及任选的聚-L-乳酸和其他可吸收聚合物和添加剂。这些材料的组合物可用于制造可吸收的支架，其提供有利的径向强度，抵抗反冲和蠕变，可在球囊导管上塑性扩张，并且可在体内快速部署。来源于这些材料的支架涂层提供了生物相容的，均匀的涂层，这些涂层是可延展的，并且可以在没有涂层裂化和/或脱敏的情况下扩张并且可以用作药物掺入的涂层基质。

3. 发明申请

WO2008145765A2 ELECTRODE AND MEASURING DEVICE FOR MEASURING THE ELECTRIC ACTIVITY IN AN ELECTRICALLY ACTIVE TISSUE 审中-公开
标题翻译：铅和测量器具，用于测量电活动在电活性的组织
公开(公告)号：WO2008145765A2
公开(公告)日：2008-12-04
申请号：PCT/EP2008056801
申请日：2008-06-02
申请人： UNIV ROSTOCK , BEHREND DETLEF , SCHMITZ KLAUS-PETER , PAU HANS WILHELM , STERNBERG KATRIN , SCHMIDT WOLFRAM
发明人： BEHREND DETLEF , SCHMITZ KLAUS-PETER , PAU HANS WILHELM , STERNBERG KATRIN , SCHMIDT WOLFRAM
IPC分类号： A61B5/0488
CPC分类号： A61B5/0492 , A61B5/6882 , A61N1/05
摘要： The present invention relates to an electrode and a measuring device for measuring the action current and/or the action potential of an electrically active tissue. The aim of the present invention is to provide an electrode for measuring action currents and/or action potentials in electrically active tissues that can be produced in a simple and cost-effective manner that, on the one hand, guarantees a safe but reversible fixation of the electrode in the muscle tissue and, on the other hand, traumatizes the muscle tissue as little as possible. According to the invention, an electrode with an elongated electrode base body (1) having a first end (3) and a second end (4) is proposed, wherein the electrode is designed in a way, such that it can only be guided through a tissue (2) in a forward motion (6) along the longitudinal axis of the electrode basic body (1).
摘要翻译：本发明涉及一种电极和用于测量所述反应物流和/或电活性组织的动作电位的测量装置。它是本发明的一个目的是在电活性组织提供一种简单和廉价的制造的电极对动作电流和/或动作电位的测量中，一方面确保了在肌肉组织中的安全，而且是可逆的固定，而另一个尽可能少受创伤的肌肉组织。根据本发明的具有细长电极体的电极（1）设置有一个第一端（3）和第二端（4），其中，所述电极是它通过织物形成，（2）仅在向前方向（6）沿电极基体（1）的纵轴线能够被引导。

4. 发明申请

WO2007090373A3 NOVEL ADHESIVES FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：新胶粘剂用于医疗应用
公开(公告)号：WO2007090373A3
公开(公告)日：2008-08-07
申请号：PCT/DE2007000192
申请日：2007-02-02
申请人： UNIV ROSTOCK , BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMOHL KATHLEEN , KRAMER SVEN , NIES BERTHOLD
发明人： BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMOHL KATHLEEN , KRAMER SVEN , NIES BERTHOLD
IPC分类号： A61L24/10 , C09J189/00
CPC分类号： C09J175/04 , A61L24/043 , C08G18/10 , C08G18/428 , C08G18/6446 , C08L89/00 , C09J189/00 , Y10T428/2982 , C08L67/04 , C08G18/64
摘要： The invention relates to adhesives, particularly medical adhesives, suited for gluing hard and soft tissue. A combinatory preparation consisting of peptides, terminally functionalized oligolactones and, optionally, catalysts of a cross-linking reaction between these components is disclosed.
摘要翻译：本发明涉及粘合剂，尤其适用于硬和软组织的接合医用粘合剂。本发明公开的肽末端官能oligolactones和任选的催化剂，交联这些组分之间的反应的组合制剂。

5. 发明申请

WO2009121634A3 DEVICE FOR OSTEOSYNTHESIS 审中-公开
标题翻译： DEVICE骨接合术
公开(公告)号：WO2009121634A3
公开(公告)日：2010-08-05
申请号：PCT/EP2009002770
申请日：2009-04-03
申请人： UNIV ROSTOCK , BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMIDT WOLFRAM
发明人： BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMIDT WOLFRAM
IPC分类号： A61L27/16 , A61L27/50 , A61L27/54 , A61L27/58
CPC分类号： A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/406 , A61L2300/41 , A61L2300/412 , C08L67/04
摘要： The aim of the invention is to provide an osteosynthesis plate (100) or a kit for osteosynthesis that clearly reduces the risks associated with the treatment of a bone fracture using the osteosynthesis of a bone plate, in particular the danger of infections and pressure necrosis compared to those of prior art. Said osteosynthesis plate (100) comprises at least one deformation area that is adequate for the load and at least two through openings (10) for introducing securing means, one side of said osteosynthesis plate having a structured surface that is at least partially provided with an adhesive.
摘要翻译：在（100）以提供接骨板或用于骨接合术的试剂盒，通过该骨折与钢板固定，尤其是感染和相比于现有技术的压力坏死的风险的治疗的风险显著减少，接骨板（100）与处理过的建议至少一个负载足够变形区，并与用于引入的紧固装置，其特征在于，结构化表面被放置在其一侧上的至少部分地设置有粘合剂的至少两个通道开口（10）。

6. 发明申请

WO2008046405A2 TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译：治疗骨质疏松症
公开(公告)号：WO2008046405A2
公开(公告)日：2008-04-24
申请号：PCT/DE2007001853
申请日：2007-10-16
申请人： UNIV ROSTOCK , GRADL GEORG , BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMOHL KATHLEEN , KRAMER SVEN
发明人： GRADL GEORG , BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMOHL KATHLEEN , KRAMER SVEN
IPC分类号： A61L27/12 , A61L27/22 , A61L27/24 , A61L27/54
CPC分类号： A61K38/44 , A61K33/06 , A61K38/39 , A61K45/06 , A61L24/0084 , A61L27/46 , A61L2430/02 , C12Y110/03002 , C08L89/06 , A61K2300/00
摘要： The present invention relates to a combination for the treatment of osteoporosis and/or the prophylaxis and treatment of bone fractures, said combination comprising collagen, an additional peptide, a calcium-containing substance and a wetting agent with a terminally functionalized oligolactone. The invention also relates to artificial bones and implants produced by the combination and to the use of said combination for fixing implants and treating osteoporosis and/or the prophylaxis and treatment of bone fractures. The invention further relates to a method for producing artificial bones and implants.
摘要翻译：本发明涉及一种用于治疗骨质疏松症的组合和/或用于预防和治疗骨骨折其中胶原，其它肽，含钙物质和交联剂与末端官能oligolactone包括。本发明还人造骨制成的组合和植入物和植入物的固定和骨质疏松症和/或用于预防和治疗骨骨折的治疗中使用该组合的。此外，本发明涉及一种用于制造人造骨和植入物的方法。

7. 发明专利

DE19917032C2 未知
公开(公告)号：DE19917032C2
公开(公告)日：2002-10-02
申请号：DE19917032
申请日：1999-04-15
申请人： BEHREND DETLEF , FRIESE KLAUS , SCHMITZ KLAUS-PETER
发明人： BEHREND DETLEF , FRIESE KLAUS , SCHMITZ KLAUS-PETER
IPC分类号： A61F2/12

8. 发明专利

DE19917032A1 Modelable breast prosthesis, with flexible, limp outer sheath is filled with open-cell flexible foam formed in situ and sheath with microporous surface coated with resorbable biomaterial with protein coating containing drugs 未知
公开(公告)号：DE19917032A1
公开(公告)日：2000-11-23
申请号：DE19917032
申请日：1999-04-15
申请人： BEHREND DETLEF , FRIESE KLAUS , SCHMITZ KLAUS PETER
发明人： BEHREND DETLEF , FRIESE KLAUS , SCHMITZ KLAUS-PETER
IPC分类号： A61F2/12
摘要： In a modelable breast prosthesis, which has a flexible, limp outer sheath with an opening, open-cell flexible foam is introduced in situ through the opening in the sheath, which has a microporous surface and a layer of resorbable biomaterial with adhered extracellular matrix proteins on the surface, in which the tumor-suppressive and anti-inflammatory drugs are incorporated. An Independent claim is also included for the production of this prosthesis.

9. 发明申请

WO2008101922A2 STAPEDIUS MUSCLE ELECTRODE 审中-公开
标题翻译： STAPEDIUSMUSKELELEKTRODE
公开(公告)号：WO2008101922A2
公开(公告)日：2008-08-28
申请号：PCT/EP2008051995
申请日：2008-02-19
申请人： UNIV ROSTOCK , PAU HANS WILHELM , BEHREND DETLEF , SCHMIDT WOLFRAM , SCHMITZ KLAUS-PETER
发明人： PAU HANS WILHELM , BEHREND DETLEF , SCHMIDT WOLFRAM , SCHMITZ KLAUS-PETER
CPC分类号： A61B5/0492 , A61B5/6817 , A61N1/0541
摘要： The invention relates to a stapedius muscle electrode array for detecting the action currents generated when a human stapedius muscle is contracted. Said array comprises an electrode (2, 2', 2'') that is adapted for bipolar discharge and is to be attached to a human stapedius muscle. The electrode has two flexible, elastic, electrically conducting elongate elements (2a, 2b), each of which has a distal (4a, 4b) and a proximal end (17a, 17b) and is helically preshaped along at least some of the length thereof to the distal end (4a, 4b) thereof in such a way that the distal end (4a, 4b) and a section of the respective elongate element (2a, 2b) which adjoins the distal end (4a, 4b) can be placed at least in part around the tendon (7) extending between the stapedius muscle and the stapes while the helical part can be guided along the tendon (7), can be moved in the direction of the stapedius muscle, and can be at least partly twisted into and/or slid onto the region of the muscle belly (6) adjoining the tendon (7). The two elongate elements (2a, 2b) are electrically insulated from one another, and the helical parts (3) thereof are intertwined in such a way as to run around a common centerline (11), allowing the helical parts (3) to be jointly placed around the tendon (7), be guided along the tendon (7), and be brought in contact with the stapedius muscle.
摘要翻译：本发明涉及用于检测人sta骨肌收缩中产生的动作电流的sta裂肌电极组件。它包括用于连接到人类sta骨肌的双极引线适配电极（2,2'，2“）。该电极包括两个柔性的，弹性的导电伸长部件（2A，2B）上的每一个的远端（4A，4B）和近端（17A，17B）并且沿着其长度向上的至少一部分至其远端端部（4A，4B）是预先形成的以这样的方式螺旋地使得远端（4A，4B），并在相应的细长元件的该相邻部分（2a，2b）的至少部分（到镫骨肌和镫骨腱之间延伸可以拧下来7）和沿弦螺旋部件7被引导在镫骨肌移动方向（）和至少部分地邻近（在肌腱7）肌腹的区域（6）和/或推到这个区域。在这种情况下，两个细长元件（2A，2B）彼此和它们的螺旋部分（3），以便嵌套布置成旋转公共中心线（11）绝缘并围绕肌腱放置在一起（7），（沿弦7 ）并且可以与sta骨肌接触。

10. 发明专利

CA2640750C POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS COMPRISING COPOLYMERS OR HOMOPOLYMERS OF 4-HYDROXYBUTYRATE 未知
公开(公告)号：CA2640750C
公开(公告)日：2013-12-17
申请号：CA2640750
申请日：2007-02-06
申请人： TEPHA INC
发明人： SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
IPC分类号： A61L31/04 , A61L31/14
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

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