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1. 发明申请

WO2009085823A8 MEDICAL DEVICES CONTAINING MELT-BLOWN NON-WOVENS OF POLY-R-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含有聚-R-羟基丁酸酯和共聚物的熔喷无纺布的医疗器械
公开(公告)号：WO2009085823A8
公开(公告)日：2009-08-27
申请号：PCT/US2008087159
申请日：2008-12-17
申请人： TEPHA INC , HO KICHERL , WILLIAMS SIMON F , RIZK SAID , MARTIN DAVID P
发明人： HO KICHERL , WILLIAMS SIMON F , RIZK SAID , MARTIN DAVID P
IPC分类号： D04H1/56 , A61L17/10
CPC分类号： A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric non- wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 µm to 50 µm, and thickness from 10 µm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4- hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly- 4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non- woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高爆裂强度，平均直径为1μm至50μm的细纤维和10μm至50mm的厚度。通过允许无纺织物的纤维在网收集期间最初保持熔化而使得改进的纤维内聚成为可能。在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方式是聚-4-羟基丁酸酯或其共聚物的非织造物，其中所述非织造物具有大于0.1Kgf的破裂强度，其中所述非织物通过连续熔喷法得到。非织造物可以用于各种目的，包括制造医疗器械。

2. 发明申请

WO2008070428A3 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：WO2008070428A3
公开(公告)日：2009-08-13
申请号：PCT/US2007084991
申请日：2007-11-16
申请人： TEPHA INC , RIZK SAID , MARTIN DAVID P , HO KICHERL , WILLIAMS SIMON F
发明人： RIZK SAID , MARTIN DAVID P , HO KICHERL , WILLIAMS SIMON F
IPC分类号： A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , B29C55/04 , B29C55/12 , C08J5/22
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 µm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。这些可以用于各种目的，包括制造医疗器械。

3. 发明申请

WO2007092464A3 METHODS AND DEVICES FOR ROTATOR CUFF REPAIR 审中-公开
标题翻译： ROTATOR CUFF维修的方法和设备
公开(公告)号：WO2007092464A3
公开(公告)日：2008-07-03
申请号：PCT/US2007003185
申请日：2007-02-05
申请人： TEPHA INC , COLEMAN STRUAN , MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
发明人： COLEMAN STRUAN , MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
IPC分类号： A61L27/18
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0642 , A61B2017/00893 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti- adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
摘要翻译：已经开发了用于腱和韧带修复的包括肩袖修复的插入和增强装置以及使用关节镜方法进行输送的方法。该装置优选衍生自生物相容性聚羟基链烷酸酯，优选衍生自4-羟基丁酸酯的共聚物或均聚物。这些装置可以关节镜地传送，并且提供额外的益处，例如支持手术修复，高初始强度，体内延长的强度保持力，柔韧性，抗粘连性，改善的生物相容性，体内重塑健康组织的能力，最小疾病传播的风险或增强感染的选择，包括足够高的强度的选项，以防止缝合线拉出或植入装置的其他脱离，最终吸收消除异物反应的未来风险或干扰后续程序，有竞争力的成本，长期的机械稳定性。这些装置还特别适用于儿科人群，其最终吸收不应阻碍生长。

4. 发明申请

WO2004101002A3 POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS 审中-公开
标题翻译：聚羟基烷基酯医用纺织品和纤维
公开(公告)号：WO2004101002A3
公开(公告)日：2006-10-26
申请号：PCT/US2004013475
申请日：2004-04-30
申请人： TEPHA INC , MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
发明人： MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
IPC分类号： D01F6/62 , A61F2/00 , A61L20060101 , A61L17/10 , A61L27/18 , A61L31/06 , B32B5/02 , D01F6/84
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are formed from fibers of biocompatible copolymers or homopolymers of 4-hydroxybutyrate having a tensile strength of greater than 126 MPa. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和外科网。这些装置由具有拉伸强度大于126MPa的生物相容性共聚物或4-羟基丁酸酯的均聚物的纤维形成。这些装置提供比目前可获得的更广泛的体内强度保留性能，并且可以提供额外的益处，例如抗粘附性能，降低的感染风险或由吸收和最终消除装置而产生的其他手术后问题，以及有竞争力的成本。这些装置还可以特别适用于儿科人群，其吸收不应阻碍生长，并在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合，以提供具有改善的机械，生物和处理性质的植入物。

5. 发明申请

WO2011119742A2 COATINGS FOR THE MANUFACTURE AND APPLICATION OF POLYHYDROXYALKANOATE MEDICAL DEVICES 审中-公开
标题翻译：聚羟基烷酸酯医疗器械的制造和应用涂料
公开(公告)号：WO2011119742A2
公开(公告)日：2011-09-29
申请号：PCT/US2011029638
申请日：2011-03-23
申请人： TEPHA INC , MARTIN DAVID P , RIZK SAID , MONTCRIEFF JON I , CONNELLY DENNIS W
发明人： MARTIN DAVID P , RIZK SAID , MONTCRIEFF JON I , CONNELLY DENNIS W
IPC分类号： A61L17/10 , A61L27/18 , D01F6/62
CPC分类号： A61F2/0063 , A61B17/04 , A61F2/12 , A61L17/105 , A61L17/145 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , D01D5/096 , D01F6/625 , D01G99/005 , D04C1/06 , D04C1/12 , D06L1/12 , D06L1/14 , D06M10/025 , D06M15/15 , D06M15/333 , D06M15/53 , D06M2200/40 , D10B2509/04 , Y10T428/2967 , Y10T428/298 , C08L67/04
摘要： Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures.
摘要翻译：已经开发了可应用于聚羟基链烷酸酯（PHA）聚合物的生物相容性涂层和旋涂，以及由PHA聚合物制成的医疗装置。涂层赋予PHA聚合物更好的润滑性，特别是由这些材料制成的纤维和辫子，使得该涂料非常适用于医疗设备，如PHA编织缝合线。旋涂可用于PHA纤维，以促进其制造，也可用于将其转化为其他产品，包括医用纺织品。纺丝整理剂用于保护复丝纤维束，并且在挤出后保持它们完整，并且还赋予纤维束和单丝纤维润滑性，使得它们在随后的加工步骤中特别是在纺织加工中不被损坏。涂层减少例如编织缝线的组织阻力。

6. 发明申请

WO2006015276A3 NON-CURLING POLYHYDROXYALKANOATE SUTURES 审中-公开
标题翻译：非固化聚羟基烷酸酯
公开(公告)号：WO2006015276A3
公开(公告)日：2006-03-23
申请号：PCT/US2005027120
申请日：2005-07-29
申请人： TEPHA INC , RIZK SAID
发明人： RIZK SAID
IPC分类号： A61L17/10
CPC分类号： D01F6/625 , A61L17/105 , C08G63/06 , Y10T428/2913 , Y10T442/10
摘要： Absorbable polyester fibers, braids, and surgical meshes with improved handling properties have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available and have a decreased tendency to curl, in the preferred embodiement, due to the inclusion of relaxation and annealing steps following extrusion and orientation of the fiber. Filaments prepared according to these methods are characterized by the following physical properties: (i) elongation to break from about 17% to about 85% (ii) Young's modulus of less than 350,000 psi, (iii) knot to straight ratio (knot strength/tensile strength) of 55-80% or (iv) load at break from 1100 to 4200 grams.
摘要翻译：已经开发了具有改进的操作性能的可吸收的聚酯纤维，辫子和外科手术网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。由于在纤维的挤出和取向之后包含松弛和退火步骤，这些装置提供了比目前可获得的更广泛的体内强度保持性能，并且在优选的实施方式中具有降低的卷曲倾向。根据这些方法制备的丝线的特征在于以下物理性能：（i）约17％至约85％的断裂伸长率（ii）小于350,000psi的杨氏模量，（iii）结直直率（结强度/ 拉伸强度）为55-80％，或（iv）断裂载荷为1100至4200克。

7. 发明公开

EP3285684A1 ABSORBABLE IMPLANTS FOR PLASTIC SURGERY 审中-实审
公开(公告)号：EP3285684A1
公开(公告)日：2018-02-28
申请号：EP16720265
申请日：2016-04-19
申请人： TEPHA INC
发明人： LIMEM SKANDER , STIRES EMILY , HOLMES REBECCA , RIZK SAID , MOSES ARIKHA , FELIX FABIO , VAN NATTA BRUCE
IPC分类号： A61F2/00 , A61F2/12
CPC分类号： A61F2/12 , A61F2/0059 , A61F2/0063 , A61F2210/0004 , A61F2230/0076 , A61F2240/001 , A61L27/18 , A61L2430/04 , C08L67/04
摘要： Absorbable implants (200) for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/ breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.

8. 发明专利

BR112022003620A2 Dispositivos médicos contendo poli(succinato de butileno) e copolímeros do mesmo 未知
公开(公告)号：BR112022003620A2
公开(公告)日：2022-05-24
申请号：BR112022003620
申请日：2020-08-31
申请人： TEPHA INC
发明人： GANATRA AMIT , DAVID P MARTIN , GERMAN OSWALDO HOHL LOPEZ , GUO KAI , RIZK SAID , SIMON F WILLIAMS , LIMEM SKANDER
IPC分类号： A61L17/00 , A61L17/06 , A61L17/10 , A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58
摘要： dispositivos médicos contendo poli(succinato de butileno) e copolímeros do mesmo. implantes, coberturas e receptáculos reabsorvíveis compreendendo poli(succinato de butileno) e copolímeros do mesmo foram desenvolvidos. os implantes são preferivelmente esterilizados, e contêm menos do que 20 unidades de endotoxina por dispositivo como determinado pelo ensaio de lisado de amebócito de limulus (lal), e são particularmente adequados para uso em procedimentos onde a retenção de resistência prolongada é necessária, e podem incluir um ou mais agentes bioativos. os implantes podem ser fabricados de fibras e malhas de poli(succinato de butileno) e copolímeros do mesmo, ou por moldagem por impressão 3d, pultrusão ou outro método de processamento por fusão ou solvente. os implantes, ou as fibras predefinidas nestes, podem ser orientados. estas coberturas e receptáculos podem ser usadas para segurar, ou parcial/completamente cobrir, dispositivos tais como marca-passos e neuroestimuladores. as coberturas, receptáculos e implantes descritos na presente invenção, podem ser fabricados de malhas, tramas, treliças, não-tecidos, películas, fibras, espumas, formas moldadas, pultrudadas, usinadas e impressas em 3d.

9. 发明专利

CA2969429C METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 未知
公开(公告)号：CA2969429C
公开(公告)日：2020-10-27
申请号：CA2969429
申请日：2015-12-10
申请人： TEPHA INC
发明人： GANATRA AMIT , FELIX FABIO , SHAH BHAVIN , BERNASCONI MATTHEW , RIZK SAID , MARTIN DAVID P , WILLIAMS SIMON F
IPC分类号： D01F6/62 , A61L2/08 , A61L2/16 , A61L15/12 , A61L15/14 , A61L17/10 , A61L27/18 , A61L31/06 , C12P1/04 , C12P7/40 , D01D5/00 , D01F8/14
摘要： Resorbable multifilament yams and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yams and fibers are produced by cold drawing the multifilament yams and monofilament fibers before hot drawing the yams and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yams and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yams have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yams and fibers may be used to make various medical devices for various applications.

10. 发明专利

CA3091812A1 MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 未知
公开(公告)号：CA3091812A1
公开(公告)日：2019-09-06
申请号：CA3091812
申请日：2019-03-01
申请人： TEPHA INC
发明人： WILLIAMS SIMON F , RIZK SAID , MARTIN DAVID P
IPC分类号： A61L27/18 , A61L17/00 , A61L17/06 , A61L17/10 , A61L27/54 , A61L27/56 , A61L27/58
摘要： Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

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