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1. 发明授权

US07700701B2 Water-soluble polymer compound having sugar chains 失效
标题翻译：具有糖链的水溶性高分子化合物
公开(公告)号：US07700701B2
公开(公告)日：2010-04-20
申请号：US10556231
申请日：2004-05-07
申请人： Susumu Nishiguchi , Atsushi Toda , Shin-Ichiro Nishimura , Kuriko Yamada
发明人： Susumu Nishiguchi , Atsushi Toda , Shin-Ichiro Nishimura , Kuriko Yamada
IPC分类号： C08F222/38
CPC分类号： C08F251/00 , C08F220/06
摘要： A polymer compound having a monosaccharide or an oligosaccharide residue, or an amino acid or peptide residue bound to a monosaccharide or an oligosaccharide residue bound to a side chain of a water-soluble polymer through a linker containing a selectively cleavable bond, the water-soluble polymer containing 20 to 80 mol % of (meth)acrylic acid residue.
摘要翻译：具有单糖或寡糖残基的高分子化合物或与通过含有选择性可切割键的接头与水溶性聚合物的侧链结合的单糖或寡糖残基结合的氨基酸或肽残基，水溶性含有20〜80摩尔％的（甲基）丙烯酸残基的聚合物。

2. 发明申请

US20060287457A1 Sugar chain-containing water-soluble polymer compound 失效
标题翻译：含糖链的水溶性高分子化合物
公开(公告)号：US20060287457A1
公开(公告)日：2006-12-21
申请号：US10556231
申请日：2004-05-07
申请人： Susumu Nishiguchi , Atsushi Toda , Shin-Ichiro Nishimura , Kuriko Yamada
发明人： Susumu Nishiguchi , Atsushi Toda , Shin-Ichiro Nishimura , Kuriko Yamada
IPC分类号： C08F120/00
CPC分类号： C08F251/00 , C08F220/06
摘要： A polymer compound having a monosaccharide or an oligosaccharide residue, or an amino acid or peptide residue bound to a monosaccharide or an oligosaccharide residue bound to a side chain of a water-soluble polymer through a linker containing a selectively cleavable bond, the water-soluble polymer containing 20 to 80 mol % of (meth)acrylic acid residue.
摘要翻译：具有单糖或寡糖残基的高分子化合物或与通过含有选择性可切割键的接头与水溶性聚合物的侧链结合的单糖或寡糖残基结合的氨基酸或肽残基，水溶性含有20〜80摩尔％的（甲基）丙烯酸残基的聚合物。

3. 发明授权

US06962809B1 Sugar chain synthesizer 失效
标题翻译：糖链合成器
公开(公告)号：US06962809B1
公开(公告)日：2005-11-08
申请号：US10482626
申请日：2002-07-01
申请人： Kisaburo Deguchi , Genzo Hirata , Junkichi Miura , Masahito Ito , Shinichiro Nishimura , Susumu Nishiguchi , Atsushi Toda , Hiroaki Nakagawa , Kuriko Yamada
发明人： Kisaburo Deguchi , Genzo Hirata , Junkichi Miura , Masahito Ito , Shinichiro Nishimura , Susumu Nishiguchi , Atsushi Toda , Hiroaki Nakagawa , Kuriko Yamada
IPC分类号： C12P19/14 , C12P19/18 , C12M1/34
CPC分类号： C12P19/18 , C12P19/14
摘要： A sugar chain synthesizer comprising one or more reaction columns packed with immobilized glycosyltransferase and/or glycosidase; one or more separation means, arranged downstream from the reaction columns, for separating reaction products, unreaction products and byproducts contained in the solution eluted from the reaction columns; a first pump for feeding a primer of water soluble polymer and buffer solution to the reaction columns through a first selector valve; a second pump for feeding a buffer solution and sugar nucleotide solution to any one of the reaction columns through a second selector valve; one or more circulation flow paths connecting between a flow path downstream from the separation means and a flow path upstream from each of the reaction columns; and a third selector valve, arranged between the separation means and one or more circulation flow paths, for selective connection between the separation means and a desired circulation flow path. This synthesizer ensures continuous and automatic synthesis of sugar chains even if complicated.
摘要翻译：一种糖链合成仪，其包含一个或多个填充有固定的糖基转移酶和/或糖苷酶的反应柱; 一个或多个分离装置，布置在反应塔的下游，用于分离从反应塔洗脱的溶液中所含的反应产物，未反应产物和副产物; 第一泵，用于通过第一选择阀向反应塔供给水溶性聚合物和缓冲溶液的底漆; 第二泵，其通过第二选择阀将缓冲溶液和糖核苷酸溶液供给到任一反应塔; 连接在分离装置下游的流动路径和每个反应塔上游的流动路径之间的一个或多个循环流动路径; 以及第三选择阀，布置在所述分离装置和一个或多个循环流动路径之间，用于分离装置和期望的循环流动路径之间的选择性连接。这种合成器即使复杂，也能确保糖链的连续和自动合成。

4. 发明授权

US08648436B2 Solid-state imaging device, method for manufacturing solid-state imaging device, and electronic apparatus 有权
标题翻译：固态成像装置，固态成像装置的制造方法以及电子装置
公开(公告)号：US08648436B2
公开(公告)日：2014-02-11
申请号：US13039702
申请日：2011-03-03
申请人： Atsushi Toda
发明人： Atsushi Toda
IPC分类号： H01L31/00
CPC分类号： H01L27/1463 , H01L27/14625 , H01L27/1464 , H01L27/14687 , H01L31/0322 , Y02E10/541 , Y02P70/521
摘要： A solid-state imaging device is provided with a pixel region in which a plurality of pixels including photoelectric conversion films are arrayed and pixel isolation portions are interposed between the plurality of pixels, wherein the photoelectric conversion film is a chalcopyrite-structure compound semiconductor composed of a copper-aluminum-gallium-indium-sulfur-selenium based mixed crystal or a copper-aluminum-gallium-indium-zinc-sulfur-selenium based mixed crystal and is disposed on a silicon substrate in such a way as to lattice-match the silicon substrate concerned, and the pixel isolation portion is formed from a compound semiconductor subjected to doping concentration control or composition control in such a way as to become a potential barrier between the photoelectric conversion films disposed in accordance with the plurality of pixels.
摘要翻译：固体摄像装置具备像素区域，其中排列有包括光电转换膜的多个像素，并且在多个像素之间插入像素隔离部分，其中光电转换膜是由...组成的黄铜矿结构化合物半导体铜 - 镓 - 镓 - 铟 - 硫 - 硒基混合晶体或铜 - 铝 - 镓 - 铟 - 锌 - 硫 - 硒基混合晶体，并且以这样的方式设置在硅衬底上，以使晶格匹配硅衬底，并且像素隔离部分由经过掺杂浓度控制或成分控制的化合物半导体形成，以便成为根据多个像素设置的光电转换膜之间的势垒。

5. 发明授权

US08470574B2 L-succinylaminoacylase and process for producing L-amino acid using it 有权
标题翻译： L-琥珀酰氨基酰化酶及其制备L-氨基酸的方法
公开(公告)号：US08470574B2
公开(公告)日：2013-06-25
申请号：US12989728
申请日：2009-05-07
申请人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Takeshi Miyata , Aya Oosato , Shinya Kumagai , Toshihide Yamada
发明人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Takeshi Miyata , Aya Oosato , Shinya Kumagai , Toshihide Yamada
IPC分类号： C12N9/14 , C07K1/00
CPC分类号： C12N9/80 , A23L33/175 , C12P13/04 , C12P13/06 , C12P41/007
摘要： The present invention provides an L-aminoacylase which is able to produce L-tert-leucine being useful as an intermediate for pharmaceuticals.A protein which is characterized in being represented by any of the following (a) to (d): (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; and (d) a protein which consists of an amino acid sequence where one or several amino acid (s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity.
摘要翻译：本发明提供能够产生L-叔亮氨酸的L-氨基酸酰基酶，其可用作药物的中间体。特征在于以下（a）〜（d）中任一项所示的蛋白质：（a）由由SEQ ID No：1所示的核酸序列组成的基因编码的蛋白质; （b）由SEQ ID No：2所示的氨基酸序列组成的蛋白质; （c）由严格条件下与SEQ ID No：1所示核酸序列互补且具有L-琥珀酰氨基酰化酶活性的核酸序列杂交的多核苷酸编码的蛋白质; 和（d）由氨基酸序列组成的蛋白质，其中一个或几个氨基酸被取代，缺失，插入和/或添加在由SEQ ID No：2所示的氨基酸序列组成的蛋白质中并具有L-琥珀酰氨基酰化酶活性。

6. 发明授权

US08395686B2 Solid-state imaging device, method of manufacturing the same, and camera 失效
公开(公告)号：US08395686B2
公开(公告)日：2013-03-12
申请号：US12292338
申请日：2008-11-17
申请人： Keiji Tatani , John Rennie , Susumu Inoue , Atsushi Toda
发明人： Keiji Tatani , John Rennie , Susumu Inoue , Atsushi Toda
IPC分类号： H04N3/14 , H04N5/335
CPC分类号： H04N9/045 , H01L27/14621 , H01L27/14627
摘要： A solid-state imaging device is provided. The solid-state imaging device includes a plurality of arrayed pixels, an optical inner filter layer, and an inner-layer lens. Each of the plurality of arrayed pixels includes a photoelectric conversion portion and a pixel transistor. The optical inner filter layer is configured to block infrared light and faces a light-receiving surface of the photoelectric conversion portion of a desired pixel among the arrayed pixels. The inner-layer lens is formed below the optical inner filter layer.

7. 发明申请

US20130009263A1 SOLID-STATE IMAGING DEVICE AND ELECTRONIC APPARATUS 有权
标题翻译：固态成像装置和电子装置
公开(公告)号：US20130009263A1
公开(公告)日：2013-01-10
申请号：US13534309
申请日：2012-06-27
申请人： Keisuke Hatano , Atsushi Toda
发明人： Keisuke Hatano , Atsushi Toda
IPC分类号： H01L27/146
CPC分类号： H01L27/14647 , H01L27/14621 , H01L27/1464
摘要： A solid-state imaging device includes a plurality of photoelectric conversion regions stacked at different depths within a semiconductor substrate of each pixel to photoelectrically convert light of different wavelength bands, and a discharge region formed between the photoelectric conversion regions adjacent to each other in a depth direction of the semiconductor substrate to discharge charges generated by photoelectric conversion in regions between the photoelectric conversion regions.
摘要翻译：固态成像装置包括多个光电转换区域，该多个光电转换区域堆叠在每个像素的半导体衬底内的不同深度处，以对不同波长带的光进行光电转换，并且形成在彼此相邻的光电转换区域之间的放电区域方向来放电在光电转换区域之间的区域中通过光电转换产生的电荷。

8. 发明授权

US08168938B2 Method of manufacturing an optical member having stacked high and low refractive index layers 有权
$Method of manufacturing an optical member having stacked high and low refractive index layers$
标题翻译：具有堆叠的高折射率层和低折射率层的光学构件的制造方法
公开(公告)号：US08168938B2
公开(公告)日：2012-05-01
申请号：US13093525
申请日：2011-04-25
申请人： Atsushi Toda
发明人： Atsushi Toda
IPC分类号： H01J3/14 , H01L21/00
CPC分类号： H01L31/18 , G02B5/188 , H01L27/14625 , H01L27/14627 , H01L27/14632 , H01L27/14685
摘要： A method of making an optical member including high refractive index layers and low refractive index layers, which are each relatively thin as compared with an optical length, and disposed alternately in the lateral direction with respect to an optical axis. Each width of the high refractive index layers and the low refractive index layers is equal to or smaller than the wavelength order of incident light.
摘要翻译：一种制造包括高折射率层和低折射率层的光学构件的方法，其与光学长度相比相对较薄，并且相对于光轴在横向上交替设置。高折射率层和低折射率层的每个宽度等于或小于入射光的波长顺序。

9. 发明申请

US20120001072A1 PHYSICAL INFORMATION ACQUISITION METHOD, PHYSICAL INFORMATION ACQUISITION DEVICE, AND SEMICONDUCTOR DEVICE 有权
标题翻译：物理信息获取方法，物理信息获取装置和半导体装置
公开(公告)号：US20120001072A1
公开(公告)日：2012-01-05
申请号：US13232597
申请日：2011-09-14
申请人： Atsushi Toda , Genta Sato
发明人： Atsushi Toda , Genta Sato
IPC分类号： G01J5/02
CPC分类号： H04N5/33 , H04N9/045 , H04N9/64 , H04N9/735
摘要： A physical information acquisition method in which a corresponding wavelength region of visible light with at least one visible light detection unit coupled to an image signal processing unit is detected, each said visible light detection unit comprising a color filter adapted to transmit the corresponding wavelength region of visible light; a wavelength region of infrared light with at least one infrared light detection unit coupled to the image signal processing unit is detected; and, with the signal processing unit, a first signal received from the at least one visible light detection unit by subtracting a product from said first signal is corrected, said product resulting from multiplication of a second signal received from the at least one infrared light detection unit and a predetermined coefficient factor.
摘要翻译：一种物理信息获取方法，其中检测到具有耦合到图像信号处理单元的至少一个可见光检测单元的可见光的相应波长区域，每个所述可见光检测单元包括滤色器，所述滤色器适于透射相应的波长区域可见光; 检测与图像信号处理单元耦合的至少一个红外光检测单元的红外光的波长区域; 并且通过所述信号处理单元，从所述至少一个可见光检测单元接收的通过从所述第一信号中减去乘积的第一信号被校正，所述乘积是从所述至少一个红外光检测单位和预定系数因子。

10. 发明申请

US20110250653A1 L-SUCCINYLAMINOACYLASE AND PROCESS FOR PRODUCING L-AMINO ACID USING IT 有权
标题翻译： L-磺酰氨基酸和使用其生产L-氨基酸的方法
公开(公告)号：US20110250653A1
公开(公告)日：2011-10-13
申请号：US13139205
申请日：2009-12-10
申请人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Shinya Kumagai
发明人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Shinya Kumagai
IPC分类号： C12P13/04 , C12N15/55 , C12N9/78
CPC分类号： C12N9/80 , C12P13/04 , C12P13/06 , C12P13/222 , C12P41/007
摘要： The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; or (d) a protein which consists of an amino acid sequence where one or several amino acid(s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity. This enzyme is able to produce a sterically bulky unnatural amino acid such as L-tert-leucine etc. which is useful as an intermediate for pharmaceuticals.
摘要翻译：本发明提供了一种L-琥珀酰基酰化酶，其由以下组成：（a）由由SEQ ID No：1所示的核酸序列组成的基因编码的蛋白质; （b）由SEQ ID No：2所示的氨基酸序列组成的蛋白质; （c）由严格条件下与SEQ ID No：1所示核酸序列互补且具有L-琥珀酰氨基酰化酶活性的核酸序列杂交的多核苷酸编码的蛋白质; 或（d）由氨基酸序列组成的蛋白质，其中一个或多个氨基酸被取代，缺失，插入和/或添加在由SEQ ID No：2所示的氨基酸序列组成的蛋白质中并具有L-琥珀酰氨基酰化酶活性。该酶能够产生空间庞大的非天然氨基酸如L-叔亮氨酸等，其可用作药物的中间体。

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