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1. 发明授权

US07153701B1 Method for quantitatively detecting antigen 失效
标题翻译：定量检测抗原的方法
公开(公告)号：US07153701B1
公开(公告)日：2006-12-26
申请号：US09622206
申请日：2000-02-17
申请人： Sunao Hisada , Yukiko Ito , Hiroyuki Matsumoto , Kiyohito Shimura , Kenichi Kasai
发明人： Sunao Hisada , Yukiko Ito , Hiroyuki Matsumoto , Kiyohito Shimura , Kenichi Kasai
IPC分类号： G01N33/561 , G01N33/537 , G01N33/563 , C07K16/00 , C12P21/08
CPC分类号： C07K16/38 , C07K2317/54 , G01N33/561 , G01N33/6857
摘要： A method for quantitatively detecting an antigen which comprises (1) a first step of providing an Fab′ antibody having a uniform isoelectric point, said antibody forming an immune complex with an antigen in an analytical sample and being modified by adding an amino acid sequence comprising a charged amino acid residue and by being labeled with a fluorescent dye, (2) a second step of mixing the Fab′ antibody having a uniform isoelectric point with the analytical sample containing the antigen to obtain a mixture comprising the immune complex, (3) a third step of separating the mixture by performing electrophoresis in a carrier, (4) a fourth step of irradiating an excitation light which excites the fluorescent dye to the mixture separated in the third step to cause fluorescence in the immune complex, and (5) a fifth step of detecting the fluorescence.
摘要翻译：一种用于定量检测抗原的方法，其包括（1）提供具有均匀等电点的Fab'抗体的第一步骤，所述抗体与分析样品中的抗原形成免疫复合物，并通过添加包含带电氨基酸残基并用荧光染料标记;（2）将具有均匀等电点的Fab'抗体与含有抗原的分析样品混合以获得包含免疫复合物的混合物的第二步骤，（3）通过在载体中进行电泳来分离混合物的第三步骤，（4）第四步骤，将激发荧光染料的激发光照射到在第三步骤中分离的混合物中以引发免疫复合物中的荧光;和（5）检测荧光的第五步骤。

2. 发明授权

US08298836B2 Isolated Polynucleotide encoding modified fab' antibody, expression vector, and transformed host cell 失效
标题翻译：编码修饰的fab'抗体，表达载体和转化的宿主细胞的分离的多核苷酸
公开(公告)号：US08298836B2
公开(公告)日：2012-10-30
申请号：US10979640
申请日：2004-11-02
申请人： Sunao Hisada , Yukiko Ito , Hiroyuki Matsumoto , Kiyohito Shimura , Kenichi Kasai
发明人： Sunao Hisada , Yukiko Ito , Hiroyuki Matsumoto , Kiyohito Shimura , Kenichi Kasai
IPC分类号： C07H21/04 , C12N1/20 , C12N15/13 , C12N15/63 , C12N15/70 , C12P21/08 , G01N33/531 , G01N33/577 , G01N33/563 , C12N15/74
CPC分类号： C07K16/38 , C07K2317/54 , G01N33/561 , G01N33/6857
摘要： Disclosed is an isolated polynucleotide encoding a modified Fab' antibody, which includes an Fd chain and an L chain with the Fd chain including a CH1 region and the L chain including a CL region, wherein the modified Fab' antibody further includes a cysteine for binding to a fluorescent dye, and the polynucleotide includes an Fd chain coding region and an L chain coding region linked therebetween in a manner that will allow expression of the modified Fab' antibody. Also disclosed are an expression vector containin the isolated polynucleotide, an isolated transformed host cell containing the expression vector, and a cell culture including the transformed host cell.
摘要翻译：公开了编码修饰的Fab'抗体的分离的多核苷酸，其包含Fd链和具有包含CH1区的Fd链和包含CL区的L链的L链，其中所述修饰的Fab'抗体还包含用于结合的半胱氨酸荧光染料，并且所述多核苷酸包括以允许修饰的Fab'抗体表达的方式连接在其间的Fd链编码区和L链编码区。还公开了在分离的多核苷酸中含有的表达载体，含有表达载体的分离的转化宿主细胞和包含转化的宿主细胞的细胞培养物。

3. 发明申请

US20050239215A1 Method for quantitatively detecting antigen 失效
标题翻译：定量检测抗原的方法
公开(公告)号：US20050239215A1
公开(公告)日：2005-10-27
申请号：US10979640
申请日：2004-11-02
申请人： Sunao Hisada , Yukiko Ito , Hiroyuki Matsumoto , Kiyohito Shimura , Kenichi Kasai
发明人： Sunao Hisada , Yukiko Ito , Hiroyuki Matsumoto , Kiyohito Shimura , Kenichi Kasai
IPC分类号： C07K16/38 , G01N33/557 , G01N33/561 , G01N33/68
CPC分类号： C07K16/38 , C07K2317/54 , G01N33/561 , G01N33/6857
摘要： A method for quantitatively detecting an antigen which comprises (1) a first step of providing an Fab′ antibody having a uniform isoelectric point, said antibody forming an immune complex with an antigen in an analytical sample and being modified by adding an amino acid sequence comprising a charged amino acid residue and by being labeled with a fluorescent dye, (2) a second step of mixing the Fab′ antibody having a uniform isoelectric point with the analytical sample containing the antigen to obtain a mixture comprising the immune complex, (3) a third step of separating the mixture by performing electrophoresis in a carrier, (4) a fourth step of irradiating an excitation light which excites the fluorescent dye to the mixture separated in the third step to cause fluorescence in the immune complex, and (5) a fifth step of detecting the fluorescence.
摘要翻译：一种用于定量检测抗原的方法，其包括（1）提供具有均匀等电点的Fab'抗体的第一步骤，所述抗体与分析样品中的抗原形成免疫复合物，并通过添加包含带电氨基酸残基并用荧光染料标记;（2）将具有均匀等电点的Fab'抗体与含有抗原的分析样品混合以获得包含免疫复合物的混合物的第二步骤，（3）通过在载体中进行电泳来分离混合物的第三步骤，（4）第四步骤，将激发荧光染料的激发光照射到在第三步骤中分离的混合物中以引发免疫复合物中的荧光;和（5）检测荧光的第五步骤。

4. 发明授权

US5866683A Isoelectric point markers for isoelectric focusing with fluorescence detection 失效
标题翻译：用于具有荧光检测的等电聚焦的等电点标记
公开(公告)号：US5866683A
公开(公告)日：1999-02-02
申请号：US623833
申请日：1996-03-29
申请人： Kiyohito Shimura , Kenichi Kasai , Hiroyuki Matsumoto , Hisayoshi Takamoto
发明人： Kiyohito Shimura , Kenichi Kasai , Hiroyuki Matsumoto , Hisayoshi Takamoto
IPC分类号： G01N21/64 , G01N27/447 , C07K7/00
CPC分类号： C07K1/28 , G01N21/6428 , G01N27/44726 , G01N27/44795 , G01N2410/02 , Y10S930/28
摘要： Provided are isoelectric point(pI) markers for isoelectric focusing with fluorescence detection. The markers are fluorescence-labeled oligopeptides which comprise a fluorescence dye bonded chemically to the amino group of N-terminal amino acid of oligopeptide. The marker shows its unique and narrow pI band(peak) in electrophoresis or isoelectric focusing. The markers can be designed to have appropriate pI value, and cover wide range of pI (3
摘要翻译：提供了用于具有荧光检测的等电聚焦的等电点（pI）标记。标记是荧光标记的寡肽，其包含与寡肽的N-末端氨基酸的氨基化学键合的荧光染料。该标记显示其在电泳或等电聚焦中的独特且窄的pI带（峰）。标记可以被设计成具有适当的pI值，并且覆盖pI（3

5. 发明授权

US06890799B2 Device for sealing and cooling multi-chip modules 失效
标题翻译：密封和冷却多芯片模块的装置
公开(公告)号：US06890799B2
公开(公告)日：2005-05-10
申请号：US10338485
申请日：2003-01-07
申请人： Takahiro Daikoku , Kenichi Kasai , Toshitada Netsu , Koichi Koyano , Takayuki Uda
发明人： Takahiro Daikoku , Kenichi Kasai , Toshitada Netsu , Koichi Koyano , Takayuki Uda
IPC分类号： H01L23/10 , H01L23/473 , H01L21/48 , H01L23/34 , H05K7/20
CPC分类号： H01L23/10 , H01L23/473 , H01L2224/16 , H01L2224/73253 , H01L2924/01322 , H01L2924/09701 , H01L2924/15311 , H01L2924/15312 , H01L2924/16152 , H01L2924/16195 , H01L2924/1626
摘要： According to the invention, a sealing top plate in a multi-chip module is formed from a ceramic with high thermal conductivity having a thermal expansion coefficient consistent with that of a multi-layer circuit substrate. A cooling flow path cover covering the entirety of cooling flow path grooves is formed as a separate metallic member. The back surface of the sealing top plate, on which are formed the cooling flow path grooves, is bonded directly to the back surface of a semiconductor device using solder. A thermal-conductive jacket with low thermal resistance is provided. A multi-chip module sealing frame is soldered to the edge of the sealing top plate. Furthermore, a sealing material such as an O-ring is simply interposed between the edge of the sealing top plate and the cooling water path cover, and tightening means is used to tighten the metallic cooling flow path cover and the multi-chip module sealing frame to each other.
摘要翻译：根据本发明，多芯片模块中的密封顶板由具有与多层电路基板的热膨胀系数一致的高导热性的陶瓷形成。覆盖整个冷却流路槽的冷却流路盖形成为单独的金属部件。密封顶板的形成冷却流路槽的背面使用焊料直接接合在半导体装置的背面。提供具有低热阻的导热护套。多芯片模块密封框架焊接到密封顶板的边缘。此外，诸如O形圈的密封材料简单地介于密封顶板的边缘和冷却水通道盖之间，并且紧固装置用于紧固金属冷却流路盖和多芯片模块密封框架对彼此。

6. 发明授权

US06213786B1 Electronic device and multi-pin connector therefor 失效
标题翻译：电子设备和多针连接器
公开(公告)号：US06213786B1
公开(公告)日：2001-04-10
申请号：US09632242
申请日：2000-08-03
申请人： Kiyoshi Matsui , Takayuki Ono , Kenichi Kasai , Tsutomu Imai , Morio Suzuki , Hideyuki Fukasawa , Mitugu Shirai , Toshitaka Murakawa , Takeji Siokawa , Takeshi Kuroda
发明人： Kiyoshi Matsui , Takayuki Ono , Kenichi Kasai , Tsutomu Imai , Morio Suzuki , Hideyuki Fukasawa , Mitugu Shirai , Toshitaka Murakawa , Takeji Siokawa , Takeshi Kuroda
IPC分类号： H01R1200
CPC分类号： H05K3/303 , H01R43/0256 , H05K7/1084 , H05K2201/09472 , H05K2201/10704 , H05K2203/0195 , H05K2203/167 , Y02P70/613 , Y10T29/49126 , Y10T29/49149
摘要： A multi-pin connector has contact pins fixedly soldered into bottomed connection holes which are in desired positions on a printed board, so that the contact pins are arrayed in a desired form without a housing. The multi-pin connector can be manufactured in a short period of time and can have any pitch, any number of pins and any shape.
摘要翻译：多针连接器具有固定焊接到印制板上所需位置的有底连接孔中的接触针，使得接触针以期望的形式排列而没有外壳。多针连接器可以在短时间内制造，并且可以具有任何间距，任意数量的销和任何形状。

7. 发明授权

US5774334A Low thermal resistant, fluid-cooled semiconductor module 失效
标题翻译：低耐热，流体冷却的半导体模块
公开(公告)号：US5774334A
公开(公告)日：1998-06-30
申请号：US520338
申请日：1995-08-28
申请人： Keizo Kawamura , Noriyuki Ashiwake , Takahiro Daikoku , Akio Idei , Kenichi Kasai , Hideyuki Kimura , Atsuo Nishihara , Toshio Hatada , Shigeyuki Sasaki
发明人： Keizo Kawamura , Noriyuki Ashiwake , Takahiro Daikoku , Akio Idei , Kenichi Kasai , Hideyuki Kimura , Atsuo Nishihara , Toshio Hatada , Shigeyuki Sasaki
IPC分类号： H01L23/433 , H05K7/20
CPC分类号： H01L23/4338 , H01L2224/16 , H01L2224/73253
摘要： Semiconductor devices are fixed on a substrate by solder and a semiconductor module having an enclosed structure is formed by the substrate, flanges and a housing. Two groups of heat conducting members, each having fins respectively in contract with the semiconductor devices and an inner wall of the housing are attached to the semiconductors. A fin thickness of each fin of the two groups of heat conducting members is comparatively thick, a fin height is low and the respective fins of the respective opposed heat conducting members have with very small clearances therebetween. A liquid as a heat conducting medium is enclosed in the semiconductor module. The liquid level of the semiconductor module is controlled such that it contacts a uppermost semiconductor device in the semiconductor module in a vertical arrangement. Further, valve mechanisms for introducing and removing a cooling fluid are provided at a top face and a bottom face of a space formed in the semiconductor module. The mass production capability of the heat conducting members is improved by providing such highly rigid fins, and improved cooling function is provided by firmly introducing the cooling medium to the respective fins while permitting the module to be reduced in size.
摘要翻译：半导体器件通过焊料固定在衬底上，并且具有封闭结构的半导体模块由衬底，凸缘和壳体形成。两组导热构件分别与半导体装置收缩的翅片和壳体的内壁连接到半导体。两组导热构件的每个翅片的翅片厚度相对较厚，翅片高度低，并且相应的相对的导热构件的各个翅片之间的间隙非常小。作为导热介质的液体封装在半导体模块中。半导体模块的液面被控制成使得其以垂直方式接触半导体模块中的最上面的半导体器件。此外，在半导体模块中形成的空间的顶面和底面设置有用于引入和移除冷却流体的阀机构。通过提供这种高度刚性的翅片来提高导热构件的批量生产能力，并且通过将冷却介质牢固地引入各个翅片来提供改进的冷却功能，同时允许模块减小尺寸。

8. 发明申请

US20150276517A1 Mechanical Quantity Measuring Device 审中-公开
标题翻译：机械量测量装置
公开(公告)号：US20150276517A1
公开(公告)日：2015-10-01
申请号：US14403385
申请日：2012-05-25
申请人： Kisho Ashida , Hiroyuki Ohta , Hiromi Shimazu , Kenichi Kasai
发明人： Kisho Ashida , Hiroyuki Ohta , Hiromi Shimazu , Kenichi Kasai
IPC分类号： G01L1/22
CPC分类号： G01L1/2293 , G01L1/18 , G01L1/2243
摘要： A load cell including sensor chip (1) on which plural resistive elements rectangular in a plan view are formed, and a member (2) is provided on a front surface side of a semiconductor substrate made of silicon single crystal. The member (2) includes a load portion (3), a fixed pedestal portion (4), and a strain generation portion (5) that is spaced apart from the load portion (3) and the fixed pedestal portion (4), and arranged between the load portion (3) and the fixed pedestal portion (4). The sensor chip (1) is attached onto a front side surface (2a) of the strain generation portion (5) of the member (2) so that a direction of the silicon single crystal in the semiconductor substrate is parallel to a load direction, and a longitudinal direction of the plural resistive elements has an angle of 45° with respect to a load direction.
摘要翻译：一种传感器芯片（1）的测力传感器，其上形成有平面图中矩形的多个电阻元件，并且在由硅单晶制成的半导体衬底的正面侧设置有构件（2）。构件（2）包括负载部分（3），固定基座部分（4）和与负载部分（3）和固定基座部分（4）间隔开的应变产生部分（5），以及布置在负载部分（3）和固定基座部分（4）之间。传感器芯片（1）安装在构件（2）的应变产生部分（5）的前侧表面（2a）上，使得半导体衬底中的单晶硅的<100>方向平行于多个电阻元件的纵向方向相对于负载方向具有45°的角度。

9. 发明授权

US08424092B2 Electronic apparatus for authenticating a battery pack 有权
标题翻译：用于认证电池组的电子设备
公开(公告)号：US08424092B2
公开(公告)日：2013-04-16
申请号：US13227549
申请日：2011-09-08
申请人： Akira Ikeuchi , Itsuki Nakano , Kenichi Kasai , Katsuya Suzuki , Kuniharu Suzuki
发明人： Akira Ikeuchi , Itsuki Nakano , Kenichi Kasai , Katsuya Suzuki , Kuniharu Suzuki
IPC分类号： G06F11/30 , G06F12/14 , G06F12/16 , G06F1/26 , G08B23/00 , G08B13/00 , G08B21/00 , G08B29/00
CPC分类号： H04L9/3271 , H01M10/4221 , H01M10/4257 , H01M10/48 , H01M2220/30 , H04L2209/805
摘要： A battery pack includes at least one rechargeable battery configured to output power; a remaining battery capacity detection unit configured to detect a remaining battery capacity of the at least one rechargeable battery; and a cryptographic unit configured to output a response word in response to an external request word by encrypting the external request word based on a cryptographic algorithm with a common code key.
摘要翻译：电池组包括配置成输出电力的至少一个可再充电电池; 剩余电池容量检测单元，被配置为检测所述至少一个可再充电电池的剩余电池容量; 以及密码单元，被配置为通过基于具有公共密钥的密码算法加密外部请求字来响应于外部请求字输出响应字。

10. 发明申请

US20120030480A1 BATTERY PACK AND ELECTRONIC APPARATUS 有权
标题翻译：电池组和电子设备
公开(公告)号：US20120030480A1
公开(公告)日：2012-02-02
申请号：US13227549
申请日：2011-09-08
申请人： Akira IKEUCHI , Itsuki Nakano , Kenichi Kasai , Katsuya Suzuki , Kuniharu Suzuki
发明人： Akira IKEUCHI , Itsuki Nakano , Kenichi Kasai , Katsuya Suzuki , Kuniharu Suzuki
IPC分类号： G06F21/00
CPC分类号： H04L9/3271 , H01M10/4221 , H01M10/4257 , H01M10/48 , H01M2220/30 , H04L2209/805
摘要： A battery pack includes at least one rechargeable battery configured to output power; a remaining battery capacity detection unit configured to detect a remaining battery capacity of the at least one rechargeable battery; and a cryptographic unit configured to output a response word in response to an external request word by encrypting the external request word based on a cryptographic algorithm with a common code key.
摘要翻译：电池组包括配置成输出电力的至少一个可再充电电池; 剩余电池容量检测单元，被配置为检测所述至少一个可再充电电池的剩余电池容量; 以及密码单元，被配置为通过基于具有公共密钥的密码算法加密外部请求字来响应于外部请求字输出响应字。

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