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1. 发明专利

JP2012158729A Acidic sugar chain sample preparation method 有权
标题翻译：酸性糖链样品制备方法
公开(公告)号：JP2012158729A
公开(公告)日：2012-08-23
申请号：JP2011021313
申请日：2011-02-03
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , FUKUNISHI MASAAKI , ABE HIROKI , AIHARA YAMATO , SHIMAOKA HIDEYUKI
IPC分类号： C08B37/08 , C07D209/40 , C08B37/10
摘要： PROBLEM TO BE SOLVED: To recover and refine an acidic sugar chain, as required, be able to perform labeling with a labeling compound, and simply provide an acidic sugar chain.SOLUTION: The method for preparing an acidic sugar chain from a solution containing the acidic sugar chain includes: a step of bringing a solution containing an acidic sugar chain into contact with a sugar chain solid phase carrier to capture the acidic sugar chain; and a step of cutting out the acidic sugar chain from the sugar chain solid phase carrier to recover the acidic sugar chain. The preparation method can simply recover and refine an acidic sugar chain, and as required, can perform labeling with a labeling compound.
摘要翻译：要解决的问题：根据需要回收和精制酸性糖链，能够用标记化合物进行标记，并简单地提供酸性糖链。解决方案：从含有酸性糖链的溶液制备酸性糖链的方法包括：使含有酸性糖链的溶液与糖链固相载体接触以捕获酸性糖链的步骤; 以及从糖链固相载体上切下酸性糖链以回收酸性糖链的步骤。制备方法可以简单地回收和精制酸性糖链，并且根据需要，可以用标记化合物进行标记。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011089941A Particle complex, particle complex preservation method, and inspection method of biochemical sample 审中-公开
标题翻译：颗粒复合物，颗粒复合保存方法和生物化学样品检测方法
公开(公告)号：JP2011089941A
公开(公告)日：2011-05-06
申请号：JP2009245000
申请日：2009-10-26
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , SHIMAOKA HIDEYUKI , AKAMINE AKINORI
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To provide a particle preservation container and a particle preservation method capable of reducing loss of particles and reducing the deactivation of active radicals in a surface.
SOLUTION: A particle complex comprises a plurality of particles for fixing biological materials and a covering body made of a resin material for covering the plurality of particles. The particle preservation container is constituted of a container body comprising a protrusion part having a tapered shape having an open tip and a base-end open part having an open base end. The particle preservation method comprises the process for inserting a grid-like receiving implement inside and the filling process for inserting the particle complex in the container body and placing it to the upper surface of the grid-like receiving implement.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供能够减少颗粒损失并减少表面活性自由基失活的颗粒保存容器和颗粒保存方法。解决方案：颗粒复合体包括多个用于固定生物材料的颗粒和由用于覆盖多个颗粒的树脂材料制成的覆盖体。颗粒保存容器由容器主体构成，容器主体包括具有开口尖端的锥形形状的突出部分和具有开口基端的基部开口部分。颗粒保存方法包括将格栅状接收器具插入内部的过程和用于将颗粒复合体插入容器主体中并将其放置在格栅状接纳器具的上表面的填充过程。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011072970A Tablet containing sugar chain trapping material and use thereof 审中-公开
标题翻译：包含糖链条的材料及其使用的片剂
公开(公告)号：JP2011072970A
公开(公告)日：2011-04-14
申请号：JP2009229879
申请日：2009-10-01
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SHIMAOKA HIDEYUKI , ABE MIDORI
IPC分类号： B01J20/26 , B01J20/34 , C08F8/32 , C08F220/20 , C08F220/58 , G01N1/34 , G01N21/78 , G01N30/88
摘要： PROBLEM TO BE SOLVED: To provide a tablet which does not require a complicated operation in the introduction of a sugar chain trapping material even in a high throughput assay by facilitating the introduction of a prescribed quantity of the sugar chain trapping material with a simple operation and use thereof.
SOLUTION: The tablet contains the sugar chain trapping material expressed by (formula 1) and salt. In (formula 1), a support expresses a polymer matrix and R expresses a 1-20C hydrocarbon chain which can be interrupted by -O-, -S-, -NH-, -CO- and -CONH.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：为了提供即使在高产量测定中也不需要引入糖链捕获材料的复杂操作的片剂，通过促进规定量的糖链捕获材料的引入，简单的操作和使用。解决方案：片剂含有由（式1）和盐表示的糖链捕获材料。在（式1）中，载体表示聚合物基质，R表示可以被-O - ， - S-，-NH-，-CO-和-CONH间隔的1-20C烃链。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2009244147A Efficacy prediction method of carcinostatic 有权
标题翻译：有效预测方法
公开(公告)号：JP2009244147A
公开(公告)日：2009-10-22
申请号：JP2008092061
申请日：2008-03-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： NISHIO KAZUTO , MATSUMOTO KAZUKO , FUJIWARA KAZUHIKO , YOKOYAMA KANEHISA , FUKUSHIMA MASAO , SHIMAOKA HIDEYUKI , ABE MIDORI
IPC分类号： G01N27/62 , G01N33/15 , G01N33/48 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide method or the like for previously predicting efficacy of trastuzumab in breast cancer treatment before administering the trastuzumab. SOLUTION: In this method, mass analysis is conducted for N-linked sugar chain in blood plasma collected from breast cancer patient before trastuzumab dosing, and then 31 mass spectrum peaks are detected. As a result of review on correlation between these 31 sugar chains and clinical information, it is verified that detected intensity of 2,534 m/z sugar chain in effective case of trastuzumab treatment (non-PD group) is significantly higher than that of ineffective case of trastuzumab treatment (PD group), and that significant extension of time to progression was found on the group with higher 2,534 m/z sugar chain. From the above analysis result, these inventors came to a conclusion that efficacy of trastuzumab in breast cancer treatment could be predicted with the detected intensity of 2,534 m/z sugar chain defined as an indicator. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供方法等，以便在施用曲妥珠单抗之前预测曲妥珠单抗在乳腺癌治疗中的功效。解决方案：在曲妥珠单抗给药前，从乳腺癌患者收集的血浆中的N-连接糖链进行质量分析，然后检测到31个质谱峰。通过对31种糖链与临床信息的相关性进行综述，证实曲妥珠单抗治疗（非PD组）有效情况下2,534 m / z糖链的检出强度明显高于无效组曲妥珠单抗治疗（PD组），并且在具有较高2,534m / z糖链的组中发现显着延长进展时间。从上述分析结果可以看出，曲妥珠单抗在乳腺癌治疗中的疗效可以用检测到的2,534m / z糖链强度作为指标来预测。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2009192337A Oxyl amino group-containing compound and labeled target compound 有权
标题翻译：含有氨基的氨基化合物和标记的目标化合物
公开(公告)号：JP2009192337A
公开(公告)日：2009-08-27
申请号：JP2008032538
申请日：2008-02-14
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , SHIMAOKA HIDEYUKI
IPC分类号： G01N30/88 , G01N21/33 , G01N21/64 , G01N27/62 , G01N30/04 , G01N30/72 , G01N30/74 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a compound capable of readily labeling a target compound included in a biological sample, and analyzable by both high-performance liquid chromatographic and mass spectrometric analytical instruments. SOLUTION: An oxyl amino group-including compound having a structure shown by formula (1), and the target compound labeled by the oxyl amino group-including compound are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够容易地标记生物样品中包含的目标化合物并可由高效液相色谱和质谱分析仪器分析的化合物。解决方案：提供具有式（1）所示结构的含氧基氨基的化合物和由含氧基氨基的化合物标记的目标化合物。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2009156587A Analyzing method of sugar chain of glycoprotein 有权
标题翻译：糖蛋白糖链分析方法
公开(公告)号：JP2009156587A
公开(公告)日：2009-07-16
申请号：JP2007331663
申请日：2007-12-25
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SHIMAOKA HIDEYUKI , ABE MIDORI
IPC分类号： G01N1/10 , C12Q1/34 , C12Q1/37 , G01N27/447 , G01N33/53 , G01N33/545
摘要： PROBLEM TO BE SOLVED: To provide a method of analyzing trace amounts of sugar chains of a glycoprotein, particularly sugar chains of a glycoprotein existed in a gel after an electrophoresis operation or on a blotting membrane after a blotting operation. SOLUTION: The method for analyzing sugar chains of a glycoprotein in a sample comprises the steps of: (a) obtaining a solid phase in which a glycoprotein is held; (b) treating the solid phase with a means for disengaging sugar chains; (c) eluting the disengaged sugar chains from the solid phase to obtain a solution containing the sugar chains; (d) contacting the solution containing the sugar chains with a capturing carrier specifically connecting with sugar chains to capture the sugar chains onto the capturing carrier; (e) removing materials other than sugar chains that are not connected with the capturing carrier; (f) disengaging the sugar chains connected with the capturing carrier to obtain a purified sugar chain sample; and (g) analyzing the sugar chains. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种分析糖蛋白的痕量糖链，特别是在电泳操作之后凝胶中存在的糖蛋白的糖链，或者在印迹操作之后的印迹膜上分析痕量糖链的方法。解决方案：用于分析样品中糖蛋白糖链的方法包括以下步骤：（a）获得其中保持糖蛋白的固相; （b）用脱链糖链的方法处理固相; （c）从固相中分离出脱离的糖链以获得含有糖链的溶液; （d）将含有糖链的溶液与特异性连接糖链的捕获载体接触以将糖链捕获到捕获载体上; （e）去除不与捕获载体相连的糖链以外的物质; （f）脱离与捕获载体连接的糖链，以获得纯化的糖链样品; 和（g）分析糖链。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2009142238A Method for isolating and detecting cell surface sugar chain 审中-公开
标题翻译：用于分离和检测细胞表面糖链的方法
公开(公告)号：JP2009142238A
公开(公告)日：2009-07-02
申请号：JP2007325345
申请日：2007-12-18
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , SHIMAOKA HIDEYUKI
IPC分类号： C12N5/07 , C12N5/071 , C12S3/00 , G01N27/62 , G01N30/88 , G01N33/483 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide methods for easily and exhaustively isolating and detecting cell surface sugar chains without using a special device. SOLUTION: The method for isolating the cell surface sugar chains includes a step for bringing cells into contact with a solution containing an enzyme having ability for cleaving the sugar chains bonded to a protein and/or a lipid. Preferably, the cell is a cultured cell or a cell collected from a tissue, and the enzyme is an endo-type glycosidase. The method for detecting the cell surface sugar chain includes a step for capturing the isolated sugar chain by a carrier or a compound for specifically capturing the sugar chain. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供在不使用特殊装置的情况下容易且彻底地分离和检测细胞表面糖链的方法。解决方案：分离细胞表面糖链的方法包括使细胞与含有切割与蛋白质和/或脂质结合的糖链的能力的酶的溶液接触的步骤。优选地，细胞是从组织收集的培养细胞或细胞，并且该酶是内切型糖苷酶。用于检测细胞表面糖链的方法包括通过用于特异性捕获糖链的载体或化合物捕获分离的糖链的步骤。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2009118774A Method for detecting rna sequence 有权
标题翻译：检测RNA序列的方法
公开(公告)号：JP2009118774A
公开(公告)日：2009-06-04
申请号：JP2007296113
申请日：2007-11-14
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SAITO SUSUMU , ABE MIDORI
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/53 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting RNA sequence by which a plurality of target genes can be detected simply and quickly. SOLUTION: The method for detecting the RNA sequences includes (a) a step for using a carrier having continuous identical reaction spaces, a first region to which an oligonucleotide for catching RNA is immobilized, and a second region to which two or more oligonucleotides for detecting the RNA sequences are immobilized, supplying a solution containing the RNA of a detection target to the reaction spaces, and hybridizing the RNA with the immobilized oligonucleotide for catching the RNA to catch the RNA; (b) a step for elongating the oligonucleotide for catching the RNA with the caught RNA as a template to synthesize a cDNA chain; (c) a step for amplifying the DNA chain with the cDNA chain as a template; and (d) a step for detecting the state of the hybridization of the amplified DNA chain with the immobilized oligonucleotide for detecting the RNA sequence. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供用于检测简单快速地检测多个靶基因的RNA序列的方法。解决方案：用于检测RNA序列的方法包括（a）使用具有连续相同反应空间的载体的步骤，固定用于捕获RNA的寡核苷酸的第一区域和两个或更多个第二区域固定用于检测RNA序列的寡核苷酸，将含有检测靶的RNA的溶液供应到反应空间，并将RNA与固定的寡核苷酸杂交以捕获RNA以捕获RNA; （b）用捕获的RNA作为模板延长用于捕获RNA的寡核苷酸以合成cDNA链的步骤; （c）以cDNA链为模板扩增DNA链的步骤; 和（d）检测扩增的DNA链与用于检测RNA序列的固定化寡核苷酸的杂交状态的步骤。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2013083490A Marker for diagnosing gastrointestinal cancer, and method for inspecting gastrointestinal cancer 审中-公开
标题翻译：用于诊断胃肠癌的标记和检查胃肠癌的方法
公开(公告)号：JP2013083490A
公开(公告)日：2013-05-09
申请号：JP2011222353
申请日：2011-10-06
申请人： Kagoshima Univ , 国立大学法人鹿児島大学 , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Mitsubishi Chemical Medience Corp , 三菱化学メディエンス株式会社
发明人： NATSUGOE SHOJI , UCHIKADO YASUTO , HASHIGUCHI TERUTO , SHINCHI HIROYUKI , MAEMURA KIMINARI , MATAKI TAKEHIRO , MORIWAKI NORICHIKA , SEKIJIMA MASARU , SHIMAOKA HIDEYUKI , ABE MIDORI , FUKUSHIMA MASAO , IGARASHI KOTA , ABE HIROKI , AIHAA DAICHI
IPC分类号： G01N27/62
CPC分类号： G01N33/6893 , G01N33/57446 , G01N33/57469
摘要： PROBLEM TO BE SOLVED: To provide a marker for diagnosing gastrointestinal cancer which can be used for an inspection method for simply inspecting gastrointestinal cancer at an early stage, and a method for inspecting gastrointestinal cancer for simply inspecting gastrointestinal cancer at an early stage.SOLUTION: A marker for diagnosing gastrointestinal cancer is used for identifying presence/absence of affection with gastrointestinal cancer, is an N-coupling type sugar chain to be separated from glycoprotein contained in blood and has characteristics in sugar chain arrangement. In the marker, the mass-to-charge ratio of the peak by mass analysis by using a MALDI-TOF-MAS type analyzer is any of 2521/mz, 2216 m/z, 2054 m/z, 2681 m/z, and 3108 m/z.
摘要翻译：待解决的问题：提供可用于早期简单检查胃肠癌的检查方法的胃肠癌诊断标记，以及早期检查胃肠癌的方法。解决方案：用于诊断胃肠癌的标志物用于鉴定与胃肠癌有关的存在/不存在，是从血液中包含的糖蛋白分离的N-偶联型糖链，并且具有糖链排列的特征。在标记中，通过使用MALDI-TOF-MAS型分析仪进行质量分析的质荷比是2521 / mz，2216m / z，2054m / z，2681m / z和 3108米/秒。版权所有（C）2013，JPO＆INPIT

10. 发明专利

JP2012189439A Method for manufacturing sugar chain sample 审中-公开
标题翻译：制造糖链样品的方法
公开(公告)号：JP2012189439A
公开(公告)日：2012-10-04
申请号：JP2011052987
申请日：2011-03-10
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , SHIMAOKA HIDEYUKI
IPC分类号： G01N33/53 , C12P19/14 , C12Q1/34 , G01N33/545
摘要： PROBLEM TO BE SOLVED: To provide means for isolating N-linked sugar chains and O-linked sugar chains from complex carbohydrate and respectively refining and manufacturing these sugar chains.SOLUTION: By a manufacturing method including a first isolation step for isolating either one of O-linked sugar chains and N-linked sugar chains from complex carbohydrate, a first collection step for collecting the sugar chains isolated by the first isolation step, a second isolation step for isolating the other sugar chains from the complex carbohydrate treated by the first isolation step and a second collection step for collecting the sugar chains isolated by the second isolation step, the O-linked sugar chains and the N-linked sugar chains can be separately purified.
摘要翻译：要解决的问题：提供从复合碳水化合物中分离N-连接的糖链和O-连接的糖链并分别提炼和制造这些糖链的方法。解决方案：通过包括用于从复合碳水化合物分离O-连接的糖链和N-连接的糖链中的任一种的第一分离步骤的制备方法，用于收集通过第一分离步骤分离的糖链的第一收集步骤，用于从由第一分离步骤处理的复合碳水化合物中分离其它糖链的第二分离步骤和用于收集通过第二分离步骤分离的糖链的第二收集步骤，O-连接的糖链和N-连接的糖链可以单独纯化。版权所有（C）2013，JPO＆INPIT

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