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1. 发明专利

JP2014089148A Sugar chain array and method for producing the same 有权
标题翻译：糖链阵列及其生产方法
公开(公告)号：JP2014089148A
公开(公告)日：2014-05-15
申请号：JP2012240246
申请日：2012-10-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI
IPC分类号： G01N33/53 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a sugar chain array using substance, in which signal intensity is high and which hardly contaminate the sugar chain on a substrate, as a grid marker.SOLUTION: It is found that fluorescence intensity of N-ethyl-N'- [5- (N"-succinimidyl oxycarbonyl) pentyl] indocarbocyanine iodide is high, and its fluorochrome does not stick to a sugar chain on a substrate.
摘要翻译：要解决的问题：提供使用信号强度高且几乎不污染基底上的糖链的物质作为栅格标记的糖链阵列。解决方案：发现N-乙基-N的荧光强度 ' - [5-（N“ - 琥珀酰亚氨基氧羰基）戊基]吲哚羰花青碘化物高，其荧光染料不粘在基底上的糖链上。

2. 发明专利

JP2011214997A Base material for measuring sugar chain and detection method for the same 审中-公开
标题翻译：用于测量糖链的基材和相同的检测方法
公开(公告)号：JP2011214997A
公开(公告)日：2011-10-27
申请号：JP2010083316
申请日：2010-03-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI , IGARASHI KOTA
IPC分类号： G01N31/00 , G01N1/30 , G01N21/78 , G01N33/52 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting simply sugar chain molecules fixed to a base material and a base material for detecting sugar chain based on the same.SOLUTION: The base material for measuring sugar chain molecules fixed to a base material is a base material for measuring sugar chain characterized by measuring the fixed sugar chain with a sugar chain dyeing method and a measuring method which is the sugar chain dyeing method where the periodic acid Schiff's reaction is suitable. Thereby, the sugar chain molecules fixed on a chip and the like can be simply measured. The measurement enables provision of sugar chain measuring chip, and is also used for quality control of sugar chain fixed base material and the like.
摘要翻译：要解决的问题：提供简单地检测固定在基材上的糖链分子和用于检测糖链的基材的方法。解决方案：用于测量固定在基材上的糖链分子的基材是用于测定糖链的基质，其特征在于用糖链染色法测定固定糖链，其测定方法是高碘酸希夫反应适合的糖链染色方法。因此，可以简单地测量固定在芯片等上的糖链分子。该测量能够提供糖链测量芯片，并且还用于糖链固定基材等的质量控制。

3. 发明专利

JP2014209084A 糖鎖試料の調製方法审中-公开
标题翻译：糖链样品的制备方法
公开(公告)号：JP2014209084A
公开(公告)日：2014-11-06
申请号：JP2013237120
申请日：2013-11-15
申请人：住友ベークライト株式会社 , Sumitomo Bakelite Co Ltd
发明人： TOYODA MASATETSU , FUKUSHIMA MASAO , FUKUNISHI YOSHIAKI , SAKAGUCHI MIDORI , ABE HIROKI
IPC分类号： G01N27/62 , G01N30/88
CPC分类号： G01N27/62 , G01N30/88
摘要：【課題】ヒト細胞の高マンノース型糖鎖以外の糖鎖の検出や分析が簡便に行える糖鎖試料の調製方法及びその利用を提供する。【解決手段】一態様において、ヒト生体由来材料から得られうる糖鎖原料から、高マンノース型糖鎖を除去することを含む、糖鎖試料の調製方法に関する。その他の態様において、糖鎖試料中の糖鎖を検出又は分析する方法であって、前記糖鎖試料を本開示にかかる糖鎖試料の調製方法により調製することを含む、ヒトの糖鎖の検出又は分析方法に関する。さらにその他の態様において、ヒト生体由来材料から本開示にかかる糖鎖試料の調製方法により調製された糖鎖試料について糖鎖の検出を行うこと、及び、異なる2以上のヒト生体由来材料から得られた前記検出結果を比較することを含む、糖鎖バイオマーカーのスクリーニング方法に関する。【選択図】図1
摘要翻译：要解决的问题：提供能够容易地进行来自人细胞的高甘露糖糖链的糖链的检测分析的糖链样品的制备方法及其用途。解决方案：一种方法包括：制备糖来自从人类生物体的材料获得的糖链材料的链样品，包括去除高甘露糖糖链; 检测或分析与人糖链的检测或分析方法相关的糖链样品中的糖链，包括制备糖链样品的制备方法; 筛选糖链生物标志物，包括检测根据来自人类生物体的糖链样品的制备方法制备的糖链样品中的糖链，并比较从人类生物体获得的两种或更多种材料的检测结果。

4. 发明专利

JP2012158729A Acidic sugar chain sample preparation method 有权
标题翻译：酸性糖链样品制备方法
公开(公告)号：JP2012158729A
公开(公告)日：2012-08-23
申请号：JP2011021313
申请日：2011-02-03
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , FUKUNISHI MASAAKI , ABE HIROKI , AIHARA YAMATO , SHIMAOKA HIDEYUKI
IPC分类号： C08B37/08 , C07D209/40 , C08B37/10
摘要： PROBLEM TO BE SOLVED: To recover and refine an acidic sugar chain, as required, be able to perform labeling with a labeling compound, and simply provide an acidic sugar chain.SOLUTION: The method for preparing an acidic sugar chain from a solution containing the acidic sugar chain includes: a step of bringing a solution containing an acidic sugar chain into contact with a sugar chain solid phase carrier to capture the acidic sugar chain; and a step of cutting out the acidic sugar chain from the sugar chain solid phase carrier to recover the acidic sugar chain. The preparation method can simply recover and refine an acidic sugar chain, and as required, can perform labeling with a labeling compound.
摘要翻译：要解决的问题：根据需要回收和精制酸性糖链，能够用标记化合物进行标记，并简单地提供酸性糖链。解决方案：从含有酸性糖链的溶液制备酸性糖链的方法包括：使含有酸性糖链的溶液与糖链固相载体接触以捕获酸性糖链的步骤; 以及从糖链固相载体上切下酸性糖链以回收酸性糖链的步骤。制备方法可以简单地回收和精制酸性糖链，并且根据需要，可以用标记化合物进行标记。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2014066532A Sugar chain fixing carrier, manufacturing method thereof and compound carrier in which sugar chain fixing carrier is fixed with sugar chain or sugar chain containing material 审中-公开
标题翻译：糖链固定载体，其制造方法和糖链固定载体与糖链或糖链包含材料固定的化合物载体
公开(公告)号：JP2014066532A
公开(公告)日：2014-04-17
申请号：JP2012210343
申请日：2012-09-25
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI , MATSUMOTO TAKAYUKI
IPC分类号： G01N33/543 , C08F20/28 , C08F290/06 , G01N33/545 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a sugar chain fixing carrier and a manufacturing method thereof, and a compound carrier in which the sugar chain fixing carrier is fixed with a sugar chain or a sugar chain containing material superior in fixing capability of the sugar chain or the sugar chain containing material with little non-specific absorption of protein or the like.SOLUTION: The sugar chain fixing carrier for fixing a sugar chain or a sugar chain containing material is obtained by fixing a polymer material, on the carrier surface, by copolymerizing ethylenically unsaturated polymerizable monomer (a) having alkylene glycol residue, ethylenically unsaturated polymerizable monomer (b) having a functional group fixing the sugar chain or the sugar chain containing material and ethylenically unsaturated polymerizable monomer (c) having a crosslinkable functional group.
摘要翻译：要解决的问题：提供一种糖链固定载体及其制造方法，以及其中糖链固定载体用糖链或含糖链的材料固定的化合物载体，其具有优于糖链的定影能力或含糖链的材料几乎不具有非特异性吸收蛋白质等。解决方案：用于固定糖链或含糖链材料的糖链固定载体是通过将聚合物材料固定在载体表面上，通过共聚合具有亚烷基二醇残基的烯键式不饱和可聚合单体（a），具有固定糖链的官能团的烯属不饱和可聚合单体（b）或含糖链的材料和具有交联性官能团的烯属不饱和可聚合单体（c）。

6. 发明专利

JP2013200239A Quality evaluation method and preservation method for sugar chain array 审中-公开
标题翻译：糖链的质量评估方法和保存方法
公开(公告)号：JP2013200239A
公开(公告)日：2013-10-03
申请号：JP2012069259
申请日：2012-03-26
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI
IPC分类号： G01N33/53 , G01N33/531 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method to evaluate quality of a sugar chain array comprising sialo-sugar chains and a method to preserve the sugar chain array without degradation.SOLUTION: Quality of a sugar chain array comprising sialo-sugar chains is evaluated by using hydrolysis of sialic acid as an indicator, and the degradation of the sugar chain array comprising sialo-sugar chains is prevented by preserving under dry condition.
摘要翻译：要解决的问题：提供一种评估包含唾液糖链的糖链阵列质量的方法以及保持糖链阵列而不降解的方法。解决方案：包含唾液糖链的糖链阵列的质量通过使用唾液酸的水解作为指示剂，并且通过在干燥条件下保存来防止包含唾液糖链的糖链阵列的降解。

7. 发明专利

JP2013019707A Biochip 审中-公开
标题翻译： BIOCHIP
公开(公告)号：JP2013019707A
公开(公告)日：2013-01-31
申请号：JP2011151392
申请日：2011-07-08
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , ABE HIROKI
IPC分类号： G01N35/02 , C07K17/00 , C12N9/96 , C12N15/09 , G01N33/545 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide efficient immobilization of a bioactive substance in a well on a base material without drying even when the amount of a used solution is suppressed, with respect to a biochip which immobilizes the bioactive substance in the well on the base material.SOLUTION: A microchip which has one or more wells for measurement of the bioactive substance sectioned by partitions is characterized in having removable coating bodies above bottom surfaces of the wells in the wells. The coating bodies allow suppressing the amount of the used solution and drying and thereby make the biochip efficient.
摘要翻译：要解决的问题：即使当使用的溶液的量被抑制时，为了提供生物活性物质在基材上的井中的有效固定，而不干燥，相对于将生物活性物质固定在井中的生物芯片基材。解决方案：具有一个或多个用于测量由隔板分隔的生物活性物质的孔的微芯片的特征在于在孔中的孔的底表面上方具有可移除的涂层体。涂层体允许抑制使用的溶液的量并干燥，从而使生物芯片有效。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2012211817A Method for measuring sugar chain and base material for immobilizing sugar chains 有权
标题翻译：用于测量糖链和碱性物质以确定糖链的方法
公开(公告)号：JP2012211817A
公开(公告)日：2012-11-01
申请号：JP2011077506
申请日：2011-03-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI , SHIMAOKA HIDEYUKI , ABE MIDORI , AIHAA DAICHI
IPC分类号： G01N33/53 , G01N21/78 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a method for quantifying sugar chains which are immobilized on a base material without destroying them by quantifying the sugar chains which are not immobilized on the base material, and to provide a base material for immobilizing sugar chains based on the method.SOLUTION: In a base material where sugar chains are immobilized, a method for measuring a sugar chain quantifies immobilized sugar chains by quantifying sugar chains that are not immobilized on the base material. The method for measuring a sugar chain makes it possible to obtain the base material for immobilizing sugar chains having a precise quantity of immobilized sugar chains. As a result, a total inspection can be achieved without performing a destructive test of the sugar chains on the base material for immobilizing sugar chains, so that the base material for immobilizing sugar chains of stable quality can be obtained.
摘要翻译：待解决的问题：提供一种定量固定在基材上的糖链的方法，而不会通过定量未固定在基材上的糖链而破坏它们，并提供用于固定糖链的基材基于该方法。解决方案：在糖链固定的基质中，测定糖链的方法通过定量未固定在基材上的糖链来定量固定的糖链。糖链的测定方法可以获得固定糖固定糖链的固定化糖链的基材。结果，可以在不进行糖链固定的基材上的糖链的破坏性试验的情况下实现全面检查，从而可以获得用于固定质量稳定的糖链的基材。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2012201653A Sugar chain library, method for forming the same, and sugar chain array immobilizing the same 审中-公开
标题翻译：糖链库，其形成方法和固定相同的糖链
公开(公告)号：JP2012201653A
公开(公告)日：2012-10-22
申请号：JP2011069578
申请日：2011-03-28
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： IGARASHI KOTA , SHIMAOKA HIDEYUKI , ABE MIDORI , ABE HIROKI
IPC分类号： C07H1/06 , C40B40/12 , C40B50/08 , G01N30/88 , G01N33/545 , G01N33/547 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a polymer compound for bioassay, which immobilizes a sugar chain array using a conveniently formed sugar chain library without coating an adsorption inhibitor, and to provide various sugar chain array substrates using the polymer compound for bioassay.SOLUTION: The sugar chain array is formed by building a sugar chain library with a sugar chain which is obtained by: capturing a sugar chain or a sugar derivative with a primary amino group of a substrate for sugar chain purification, having the primary amino group to purify the sugar chain; recovering the sugar chain or the sugar derivative; and purifying the sugar chain or the sugar derivative, and immobilizing the sugar chain of the sugar chain library in a shape of an array by coating a substrate surface with the polymer compound for capturing sugar.
摘要翻译：要解决的问题：提供用于生物测定的聚合物化合物，其使用方便形成的糖链文库固定糖链阵列而不涂覆吸附抑制剂，并且使用该聚合物化合物提供用于生物测定的各种糖链阵列底物。解决方案：通过构建具有糖链的糖链文库形成糖链阵列，该糖链文库通过以下步骤获得：通过以下步骤获得糖链或糖衍生物：用于糖链纯化的底物的伯氨基，其具有主链氨基来净化糖链; 回收糖链或糖衍生物; 并纯化糖链或糖衍生物，并通过用捕获糖的高分子化合物涂覆基底表面，将糖链文库的糖链固定成阵列形状。版权所有（C）2013，JPO＆INPIT

10. 发明专利

JP2014102194A High polymer and carrier having surface covered with high polymer 审中-公开
标题翻译：高聚合物和载体具有覆盖高分子聚合物的表面
公开(公告)号：JP2014102194A
公开(公告)日：2014-06-05
申请号：JP2012255308
申请日：2012-11-21
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE HIROKI , MATSUMOTO TAKAYUKI
IPC分类号： G01N33/545
摘要： PROBLEM TO BE SOLVED: To provide a high polymer having excellent ability immobilizing a sugar chain, etc., high adhesion to a carrier, small non-specific absorption of protein, etc., and physical and chemical stability, and to provide a carrier having the high polymer immobilized on the surface and a composite carrier having a sugar chain, etc., immobilized with the high polymer.SOLUTION: A high polymer obtained by co-polymerizing an ethylene unsaturated polymeric monomer having a hydrophobic group and an ethylene unsaturated polymeric monomer having a functional group immobilizing a sugar chain, etc., or a high polymer obtained by co-polymerizing the monomers and an ethylene unsaturated polymeric monomer having a hydrophilic group has excellent ability immobilizing the sugar chain, etc., high adhesion to a carrier, small non-specific absorption of an object to be detected and physical and chemical stability such as hard dissolution in a cleaning process and the like. A carrier covered with the high polymer can be used for a biochip, etc..
摘要翻译：要解决的问题：提供一种具有优异的固定糖链等的能力的高分子，对载体的高粘合性，蛋白质的非特异性吸收性等，以及物理和化学稳定性，以及提供具有固定在表面上的高聚合物和具有固定有高聚物的糖链等的复合载体。溶液：通过将具有疏水基团的乙烯不饱和聚合单体和乙烯不饱和聚合单体共聚而获得的高分子具有固定糖链等的官能团或通过共聚单体和具有亲水基团的乙烯不饱和聚合单体获得的高分子聚合物具有优异的固定糖链等的能力，对载体的高附着力，要检测的物体的小的非特异性吸收以及诸如清洁过程中的硬溶解的物理和化学稳定性等。用聚合物覆盖的载体可用于生物芯片等。

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