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1. 发明专利

JP2013083490A Marker for diagnosing gastrointestinal cancer, and method for inspecting gastrointestinal cancer 审中-公开
标题翻译：用于诊断胃肠癌的标记和检查胃肠癌的方法
公开(公告)号：JP2013083490A
公开(公告)日：2013-05-09
申请号：JP2011222353
申请日：2011-10-06
申请人： Kagoshima Univ , 国立大学法人鹿児島大学 , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , Mitsubishi Chemical Medience Corp , 三菱化学メディエンス株式会社
发明人： NATSUGOE SHOJI , UCHIKADO YASUTO , HASHIGUCHI TERUTO , SHINCHI HIROYUKI , MAEMURA KIMINARI , MATAKI TAKEHIRO , MORIWAKI NORICHIKA , SEKIJIMA MASARU , SHIMAOKA HIDEYUKI , ABE MIDORI , FUKUSHIMA MASAO , IGARASHI KOTA , ABE HIROKI , AIHAA DAICHI
IPC分类号： G01N27/62
CPC分类号： G01N33/6893 , G01N33/57446 , G01N33/57469
摘要： PROBLEM TO BE SOLVED: To provide a marker for diagnosing gastrointestinal cancer which can be used for an inspection method for simply inspecting gastrointestinal cancer at an early stage, and a method for inspecting gastrointestinal cancer for simply inspecting gastrointestinal cancer at an early stage.SOLUTION: A marker for diagnosing gastrointestinal cancer is used for identifying presence/absence of affection with gastrointestinal cancer, is an N-coupling type sugar chain to be separated from glycoprotein contained in blood and has characteristics in sugar chain arrangement. In the marker, the mass-to-charge ratio of the peak by mass analysis by using a MALDI-TOF-MAS type analyzer is any of 2521/mz, 2216 m/z, 2054 m/z, 2681 m/z, and 3108 m/z.
摘要翻译：待解决的问题：提供可用于早期简单检查胃肠癌的检查方法的胃肠癌诊断标记，以及早期检查胃肠癌的方法。解决方案：用于诊断胃肠癌的标志物用于鉴定与胃肠癌有关的存在/不存在，是从血液中包含的糖蛋白分离的N-偶联型糖链，并且具有糖链排列的特征。在标记中，通过使用MALDI-TOF-MAS型分析仪进行质量分析的质荷比是2521 / mz，2216m / z，2054m / z，2681m / z和 3108米/秒。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012122073A Polymer particle 审中-公开
标题翻译：聚合物颗粒
公开(公告)号：JP2012122073A
公开(公告)日：2012-06-28
申请号：JP2012006298
申请日：2012-01-16
申请人： Shinichiro Nishimura , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 紳一郎西村
发明人： NISHIMURA SHINICHIRO , SHIMAOKA HIDEYUKI
IPC分类号： C08F20/60 , C12Q1/04 , G01N33/53 , G01N33/543 , G01N33/547 , G01N37/00
CPC分类号： G01N33/543 , G01N2400/00
摘要： PROBLEM TO BE SOLVED: To provide a means for forming a support useful for research on the participation of sugar chain in biological reaction, and a polymer particle for the separation and purification of merely sugar chains and sugar containing material from a sample that contains inclusions such as living tissue with a simple operation; and to provide a means to fabricate a sugar chain chip that is a device in which sugar chains are fixed on a substrate by a simple and efficient method.SOLUTION: The support supports a functional group that specifically reacts with the aldehyde group of sugar chains, wherein the functional group is at least one selected from an oxylamino group, hydrazide group, and semithiocarbazide group. The polymer particle and the sugar chip are also provide to which the support is applied.
摘要翻译：要解决的问题：提供一种用于形成用于研究糖链参与生物反应的载体的方法，以及用于从样品中仅分离和纯化糖链和含糖材料的聚合物颗粒，含有简单操作的活组织等夹杂物; 并且提供一种制造糖链芯片的方法，该糖链芯片是通过简单有效的方法将糖链固定在基材上的装置。解决方案：载体支持与糖链的醛基特异性反应的官能团，其中官能团为选自氧基氨基，酰肼基和半硫代卡巴肼基中的至少一种。还提供了聚合物颗粒和糖片，其中施加了载体。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2009244147A Efficacy prediction method of carcinostatic 有权
标题翻译：有效预测方法
公开(公告)号：JP2009244147A
公开(公告)日：2009-10-22
申请号：JP2008092061
申请日：2008-03-31
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： NISHIO KAZUTO , MATSUMOTO KAZUKO , FUJIWARA KAZUHIKO , YOKOYAMA KANEHISA , FUKUSHIMA MASAO , SHIMAOKA HIDEYUKI , ABE MIDORI
IPC分类号： G01N27/62 , G01N33/15 , G01N33/48 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide method or the like for previously predicting efficacy of trastuzumab in breast cancer treatment before administering the trastuzumab. SOLUTION: In this method, mass analysis is conducted for N-linked sugar chain in blood plasma collected from breast cancer patient before trastuzumab dosing, and then 31 mass spectrum peaks are detected. As a result of review on correlation between these 31 sugar chains and clinical information, it is verified that detected intensity of 2,534 m/z sugar chain in effective case of trastuzumab treatment (non-PD group) is significantly higher than that of ineffective case of trastuzumab treatment (PD group), and that significant extension of time to progression was found on the group with higher 2,534 m/z sugar chain. From the above analysis result, these inventors came to a conclusion that efficacy of trastuzumab in breast cancer treatment could be predicted with the detected intensity of 2,534 m/z sugar chain defined as an indicator. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供方法等，以便在施用曲妥珠单抗之前预测曲妥珠单抗在乳腺癌治疗中的功效。解决方案：在曲妥珠单抗给药前，从乳腺癌患者收集的血浆中的N-连接糖链进行质量分析，然后检测到31个质谱峰。通过对31种糖链与临床信息的相关性进行综述，证实曲妥珠单抗治疗（非PD组）有效情况下2,534 m / z糖链的检出强度明显高于无效组曲妥珠单抗治疗（PD组），并且在具有较高2,534m / z糖链的组中发现显着延长进展时间。从上述分析结果可以看出，曲妥珠单抗在乳腺癌治疗中的疗效可以用检测到的2,534m / z糖链强度作为指标来预测。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009192337A Oxyl amino group-containing compound and labeled target compound 有权
标题翻译：含有氨基的氨基化合物和标记的目标化合物
公开(公告)号：JP2009192337A
公开(公告)日：2009-08-27
申请号：JP2008032538
申请日：2008-02-14
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , SHIMAOKA HIDEYUKI
IPC分类号： G01N30/88 , G01N21/33 , G01N21/64 , G01N27/62 , G01N30/04 , G01N30/72 , G01N30/74 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a compound capable of readily labeling a target compound included in a biological sample, and analyzable by both high-performance liquid chromatographic and mass spectrometric analytical instruments. SOLUTION: An oxyl amino group-including compound having a structure shown by formula (1), and the target compound labeled by the oxyl amino group-including compound are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够容易地标记生物样品中包含的目标化合物并可由高效液相色谱和质谱分析仪器分析的化合物。解决方案：提供具有式（1）所示结构的含氧基氨基的化合物和由含氧基氨基的化合物标记的目标化合物。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009156587A Analyzing method of sugar chain of glycoprotein 有权
标题翻译：糖蛋白糖链分析方法
公开(公告)号：JP2009156587A
公开(公告)日：2009-07-16
申请号：JP2007331663
申请日：2007-12-25
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SHIMAOKA HIDEYUKI , ABE MIDORI
IPC分类号： G01N1/10 , C12Q1/34 , C12Q1/37 , G01N27/447 , G01N33/53 , G01N33/545
摘要： PROBLEM TO BE SOLVED: To provide a method of analyzing trace amounts of sugar chains of a glycoprotein, particularly sugar chains of a glycoprotein existed in a gel after an electrophoresis operation or on a blotting membrane after a blotting operation. SOLUTION: The method for analyzing sugar chains of a glycoprotein in a sample comprises the steps of: (a) obtaining a solid phase in which a glycoprotein is held; (b) treating the solid phase with a means for disengaging sugar chains; (c) eluting the disengaged sugar chains from the solid phase to obtain a solution containing the sugar chains; (d) contacting the solution containing the sugar chains with a capturing carrier specifically connecting with sugar chains to capture the sugar chains onto the capturing carrier; (e) removing materials other than sugar chains that are not connected with the capturing carrier; (f) disengaging the sugar chains connected with the capturing carrier to obtain a purified sugar chain sample; and (g) analyzing the sugar chains. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种分析糖蛋白的痕量糖链，特别是在电泳操作之后凝胶中存在的糖蛋白的糖链，或者在印迹操作之后的印迹膜上分析痕量糖链的方法。解决方案：用于分析样品中糖蛋白糖链的方法包括以下步骤：（a）获得其中保持糖蛋白的固相; （b）用脱链糖链的方法处理固相; （c）从固相中分离出脱离的糖链以获得含有糖链的溶液; （d）将含有糖链的溶液与特异性连接糖链的捕获载体接触以将糖链捕获到捕获载体上; （e）去除不与捕获载体相连的糖链以外的物质; （f）脱离与捕获载体连接的糖链，以获得纯化的糖链样品; 和（g）分析糖链。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2009142238A Method for isolating and detecting cell surface sugar chain 审中-公开
标题翻译：用于分离和检测细胞表面糖链的方法
公开(公告)号：JP2009142238A
公开(公告)日：2009-07-02
申请号：JP2007325345
申请日：2007-12-18
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： ABE MIDORI , SHIMAOKA HIDEYUKI
IPC分类号： C12N5/07 , C12N5/071 , C12S3/00 , G01N27/62 , G01N30/88 , G01N33/483 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide methods for easily and exhaustively isolating and detecting cell surface sugar chains without using a special device. SOLUTION: The method for isolating the cell surface sugar chains includes a step for bringing cells into contact with a solution containing an enzyme having ability for cleaving the sugar chains bonded to a protein and/or a lipid. Preferably, the cell is a cultured cell or a cell collected from a tissue, and the enzyme is an endo-type glycosidase. The method for detecting the cell surface sugar chain includes a step for capturing the isolated sugar chain by a carrier or a compound for specifically capturing the sugar chain. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供在不使用特殊装置的情况下容易且彻底地分离和检测细胞表面糖链的方法。解决方案：分离细胞表面糖链的方法包括使细胞与含有切割与蛋白质和/或脂质结合的糖链的能力的酶的溶液接触的步骤。优选地，细胞是从组织收集的培养细胞或细胞，并且该酶是内切型糖苷酶。用于检测细胞表面糖链的方法包括通过用于特异性捕获糖链的载体或化合物捕获分离的糖链的步骤。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2004170351A Usage of plastic substrate for microarray 有权
标题翻译：用于微晶的塑料基材的使用
公开(公告)号：JP2004170351A
公开(公告)日：2004-06-17
申请号：JP2002339171
申请日：2002-11-22
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SHIMAOKA HIDEYUKI , YOKOYAMA KANEHISA
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microarray with high detection accuracy by reducing a background fluorescence amount of the substrate thereof and suppressing non-specific absorbance and chemical bond of a detection target material.
SOLUTION: In an usage of plastic substrate for the microarray with a surface to which an aldehyde group is introduced, the background fluorescence amount is further reduced by including the step of, after a physiologically active substance is fixed to a part of the surface of the substrate, converting the aldehyde group into a functional group other than the aldehyde group. The mechanism for converting the aldehyde group is preferably a reduction by a reaction with a metal hydrogen compound or an alcohol addition reaction.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：通过降低其底物的背景荧光量并抑制检测目标材料的非特异性吸光度和化学键，提供具有高检测精度的微阵列。解决方案：在使用具有引入醛基的表面的微阵列的塑料基材中，通过包括以下步骤进一步降低背景荧光量：将生理活性物质固定在一部分将醛基转化为醛基以外的官能团。用于转化醛基的机理优选是通过与金属氢化合物的反应或醇加成反应的还原。版权所有（C）2004，JPO

8. 发明专利

JP2003286358A Substrate for microchip and method for manufacturing the same 审中-公开
标题翻译：微型基板及其制造方法
公开(公告)号：JP2003286358A
公开(公告)日：2003-10-10
申请号：JP2002090244
申请日：2002-03-28
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SAWAI HIROSHI , YOKOYAMA KANEHISA , SHIMAOKA HIDEYUKI
IPC分类号： G01N33/53 , C08J7/06 , C12M1/00 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a substrate for a microchip which can hold in a high density a functional group fixating a biochemically active substance and which can be manufactured by a simplified cheap method, as well as to provide a manufacturing method thereof.
SOLUTION: The substrate for a microchip, which is used for fixating the biochemically active substance, is characterized in that on the surface of a saturated cyclic polyolefin resin using as the raw material various monomers including norbornene or a norbornene derivative there is formed a layer 500 Åthick or thinner consisting of a silicon compound. This substrate can be manufactured by the dry coating of silicon oxide by vacuum deposition method, sputtering method, CVD method, and the like.
COPYRIGHT: (C)2004,JPO
摘要翻译：解决问题的方案为了提供一种能够高密度地保持固定生物化学活性物质并可通过简便的方法制造的功能组的微芯片基板，并提供其制造方法。解决方案：用于固定生物化学活性物质的微芯片用基材的特征在于，在作为原料的饱和环状聚烯烃树脂的表面，形成了包括降冰片烯或降冰片烯衍生物的各种单体，由硅化合物组成的500厚度的薄膜。该基板可以通过真空蒸镀法，溅射法，CVD法等的氧化硅的干式涂布来制造。版权所有（C）2004，JPO

9. 发明专利

JP2003279572A Board for microchip and manufacturing method thereof 有权
标题翻译：小型微波炉及其制造方法
公开(公告)号：JP2003279572A
公开(公告)日：2003-10-02
申请号：JP2002081837
申请日：2002-03-22
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： YOKOYAMA KANEHISA , SAWAI HIROSHI , SHIMAOKA HIDEYUKI
IPC分类号： G01N33/53 , C12N15/09 , C40B40/02 , C40B50/06 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To obtain a board for microchips which enables hybridization that does not cause a variation in the amount of immobilized DNA fragment chains and further has high efficiency and reproducibility in the immobilization of the fragment chains.
SOLUTION: In the board for microchips, aminoalkylsilane where an aldehyde group originating from glutaraldehyde is introduced into an amino acid, and alkylsilane coexist on the surface. A manufacturing method of the board for microchips includes surface oxidation treatment (1), contact with a solution containing aminoalkylsilane and alkylsilane (2), and contact with a solution containing glutaraldehyde (3).
COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2014070188A Processing apparatus 审中-公开
标题翻译：加工设备
公开(公告)号：JP2014070188A
公开(公告)日：2014-04-21
申请号：JP2012218522
申请日：2012-09-28
申请人： Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社
发明人： SAKAGUCHI MIDORI , SHIMAOKA HIDEYUKI
IPC分类号： C08B37/00
摘要： PROBLEM TO BE SOLVED: To provide processing apparatus that can process fluid to be processed without waste, with excellent accuracy.SOLUTION: There is provided a processing apparatus 1 that includes: a multiwell filter plate 100 which includes a well formation part 108 including a plurality of wells 101, and a frame part 109 which is arranged to enclose a surrounding of a back surface of the well formation part 108, and in which a recessed portion 110 is formed at a back surface side in a position corresponding to the well formation part 108; and a multiwell plate 200 which is arranged below the multiwell filter plate 100 and includes a well formation part 202 having a plurality of wells 201 and is sized to be able to be inserted in the recessed portion 110. In the multiwell plate 200, when being arranged below the multiwell filter plate 100, the well formation part 202 is inserted in the recessed portion 110, thereby, a top edge of the well formation part 202 is positioned upper than a bottom edge of a frame part 109 in a vertical direction.
摘要翻译：要解决的问题：提供能够以高精度处理无废物的处理流体的处理装置。解决方案：提供一种处理装置1，其包括：多孔过滤板100，其包括具有多个的井101，以及框部109，其被布置成包围井形成部108的后表面的周围，并且其中凹部110形成在对应于井形成部的位置的后表面侧 108; 以及多孔板200，其布置在多孔过滤板100下方，并且包括具有多个孔201的孔形成部分202，并且其尺寸被设计成能够插入到凹部110中。在多孔板200中布置在多孔过滤板100的下方，将井形成部202插入到凹部110内，从而使成井部202的上边缘位于框架部109的上下方向上方。

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