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1. 发明申请

US20130053913A1 Method and System to Adjust Pacing Parameters Based on Systolic Interval Heart Sounds 审中-公开
标题翻译：基于收缩期间心脏声音调整起搏参数的方法和系统
公开(公告)号：US20130053913A1
公开(公告)日：2013-02-28
申请号：US13223117
申请日：2011-08-31
申请人： Steve Koh , Gene A. Bornzin , Jeffery D. Snell
发明人： Steve Koh , Gene A. Bornzin , Jeffery D. Snell
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B7/00 , A61B7/04 , A61N1/36585
摘要： A method is provided to determine pacing parameters for an implantable medical device (IMD) and collects heart sounds during the cardiac cycles. The method comprises changing a value for a pacing parameter between the cardiac cycles and analyzing a characteristic of interest from the heart sounds. The method comprises setting a desired value for the pacing parameter based on the characteristic of interest from the heart sounds. The system comprises inputs configured to be coupled to at least one lead having electrodes to sense intrinsic events and to deliver pacing pulses over cardiac cycles. The system has a sensor for collecting heart sounds during cardiac cycles and controller to control delivery of pacing pulses based on pacing parameters. The controller changes a value for at least one of the pacing parameters between the cardiac cycles and provides an analysis module to analyze a characteristic of interest from the heart sounds.
摘要翻译：提供了一种用于确定可植入医疗装置（IMD）的起搏参数并在心脏周期期间收集心脏声音的方法。该方法包括在心脏周期之间改变起搏参数的值并且从心脏声音分析感兴趣的特征。该方法包括基于来自心音的感兴趣的特征来设置起搏参数的期望值。该系统包括被配置为耦合到具有电极以感测固有事件并且在心动周期上传送起搏脉冲的至少一个引线的输入。该系统具有用于在心动周期期间收集心脏声音的传感器和控制器，以根据起搏参数控制起搏脉冲的传递。控制器改变心脏周期之间的至少一个起搏参数的值，并提供分析模块来分析来自心脏声音的兴趣特征。

2. 发明授权

US08321020B1 System and method for detecting and correcting atrial undersensing 有权
标题翻译：用于检测和纠正心房不足的系统和方法
公开(公告)号：US08321020B1
公开(公告)日：2012-11-27
申请号：US11549494
申请日：2006-10-13
申请人： Gene A. Bornzin , Peter Boileau , Jeffery D. Snell
发明人： Gene A. Bornzin , Peter Boileau , Jeffery D. Snell
IPC分类号： A61N1/362
CPC分类号： A61N1/3624 , A61N1/3704 , A61N1/371
摘要： A method for operating an implantable medical device includes delivering a plurality of pacing pulses to an atria of a patient's heart and monitoring intrinsic atrial activity to detect intrinsic atrial contractions between one or more of the plurality of pacing pulses. The method further includes detecting atrial undersensing as a function of the detection of intrinsic atrial contractions.
摘要翻译：一种用于操作可植入医疗装置的方法包括将多个起搏脉冲输送到患者心脏的心房并监测内在心房活动以检测多个起搏脉冲中的一个或多个之间的固有心房收缩。该方法还包括检测心房不足，作为内在心房收缩的检测的函数。

3. 发明授权

US08126550B2 Methods and devices involving automatic atrial blanking 有权
标题翻译：涉及自动心房消隐的方法和装置
公开(公告)号：US08126550B2
公开(公告)日：2012-02-28
申请号：US12177405
申请日：2008-07-22
申请人： George E. Eisinger , Jeffery D. Snell , Gene A. Bornzin
发明人： George E. Eisinger , Jeffery D. Snell , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3704 , A61N1/3622
摘要： During a period of time comprising a plurality of cardiac cycles, a time relationship between ventricular events and atrial detections is established. Based on the relationship, a post-ventricular atrial refractory period is defined. The period includes an absolute atrial refractory period and a segmented relative atrial refractory period, wherein the segmented relative atrial refractory period includes at least one blanking window during which atrial detections of ventricular events have or are likely to occur.
摘要翻译：在包括多个心动周期的时间段期间，建立了心室事件与心房检测之间的时间关系。根据关系，定义了心室后不应期。该期间包括绝对心房不应期和分段的相对心房不应期，其中所述分段的相对心房不应期包括至少一个消融窗口，在此期间心房事件已经或可能发生。

4. 发明授权

US07643872B2 System and method for detecting cardiac ischemia based on T-Waves using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07643872B2
公开(公告)日：2010-01-05
申请号：US11686784
申请日：2007-03-15
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452 , A61N1/36
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

5. 发明申请

US20090264950A1 MEDICAL DEVICES AND SYSTEMS HAVING SEPARATE POWER SOURCES FOR ENABLING DIFFERENT TELEMETRY SYSTEMS 有权
标题翻译：具有独立电源的医疗设备和系统用于启用不同的远程系统
公开(公告)号：US20090264950A1
公开(公告)日：2009-10-22
申请号：US12104301
申请日：2008-04-16
申请人： Jeffery D. Snell , Gene A. Bornzin
发明人： Jeffery D. Snell , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/378 , A61N1/025 , A61N1/37217 , Y10S128/904
摘要： An implantable medical device includes a first, short-range telemetry circuit; a second, long-range telemetry circuit; a first power system that powers the first telemetry circuit; and a second power system that powers the second telemetry circuit. The second power system includes an internal charging system and a rechargeable battery coupled to the internal charging system. The internal charging system may be configured for electromagnetic-inductive or RF-transmission coupling with an external charging system. A controller monitors the energy level of the rechargeable battery and provides an signal indicative of the level.
摘要翻译：可植入医疗装置包括第一短距离遥测电路; 第二个远程遥测电路; 为第一遥测电路供电的第一电力系统; 以及为第二遥测电路供电的第二电力系统。第二电力系统包括内部充电系统和连接到内部充电系统的可再充电电池。内部充电系统可以被配置为与外部充电系统进行电磁感应或RF传输耦合。控制器监视可再充电电池的能量级并提供指示电平的信号。

6. 发明申请

US20090018595A1 SYSTEMS AND METHODS FOR EMPLOYING MULTIPLE FILTERS TO DETECT T-WAVE OVERSENSING AND TO IMPROVE TACHYARRHYTHMIA DETECTION WITHIN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用多个过滤器检测T波波纹的系统和方法以及改进在可植入医疗设备中的TACHYARRHYTHMIA检测
公开(公告)号：US20090018595A1
公开(公告)日：2009-01-15
申请号：US11776266
申请日：2007-07-11
申请人： Rupinder Bharmi , Jeffery D. Snell , Gene A. Bornzin , Joseph J. Florio , Peter Boileau
发明人： Rupinder Bharmi , Jeffery D. Snell , Gene A. Bornzin , Joseph J. Florio , Peter Boileau
IPC分类号： A61N1/365
CPC分类号： A61B5/0464 , A61B5/04014 , A61B5/0456 , A61N1/3622 , A61N1/3925 , A61N1/3962
摘要： Techniques are described for detecting tachyarrhythmia and also for preventing T-wave oversensing using a narrowband bradycardia filter in combination with a narrowband tachycardia filter. In some embodiments, a separate wideband filter is also exploited. In one illustrative example, ventricular tachycardia (VT) is detected by: detecting a preliminary indication of VT using signals filtered by the bradycardia filter and, in response, confirming the detection of VT using signals filtered by the tachycardia filter. That is, the bradycardia filter, traditionally used only to detect bradycardia, is additionally used to provide a preliminary indication of VT. The tachycardia filter is then activated to confirm the detection of VT before therapy is delivered. In this manner, the tachycardia filter need not run continuously, but is instead activated only when there is some indication of possible VT, and hence power is saved. Numerous other exemplary techniques are set forth herein for arrhythmia detection and for T-wave oversensing detection.
摘要翻译：描述了用于检测快速性心律失常的技术，并且还使用窄带心动过缓过滤器与窄带心动过速过滤器结合来预防T波过度感觉的技术。在一些实施例中，还利用单独的宽带滤波器。在一个说明性示例中，通过以下方式来检测室性心动过速（VT）：使用由心动过缓过滤器过滤的信号检测VT的初步指示，并且作为响应，使用由心动过速过滤器过滤的信号确认VT的检测。也就是说，传统上仅用于检测心动过缓的心动过缓过滤器另外用于提供VT的初步指示。然后激活心动过速过滤器以确认在治疗之前VT的检测。以这种方式，心动过速过滤器不需要连续运行，而是仅当存在可能的VT的一些指示时激活，因此节省功率。本文中阐述了许多其它示例性技术用于心律失常检测和T波超检测。

7. 发明授权

US07155282B1 Automatic sensitivity control and method for use in an implantable cardiac stimulation device 有权
标题翻译：自动灵敏度控制和用于可植入心脏刺激装置的方法
公开(公告)号：US07155282B1
公开(公告)日：2006-12-26
申请号：US10719307
申请日：2003-11-21
申请人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
发明人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
IPC分类号： A61N1/362
CPC分类号： A61N1/3704 , A61B5/0452 , A61B5/0456
摘要： A threshold sensing control for use in an implantable cardiac stimulation device controls the sensing of cardiac activity during a current cardiac cycle of a heart while avoiding sensing a T wave. The system includes a sensing circuit that senses cardiac activity of the heart during a cardiac cycle preceding the current cardiac cycle, a detector that measures selected T wave and R wave characteristics of the cardiac activity and a control circuit that varies the sensing threshold based upon the measured selected R wave and T wave characteristics. The sensing threshold control may be implemented for both intrinsic and paced beats.
摘要翻译：用于可植入心脏刺激装置的阈值感测控制器控制在心脏的当前心动周期期间对心脏活动的感测，同时避免感测T波。该系统包括感测电路，该感测电路在当前心动周期之前的心动周期期间感测心脏的心脏活动，测量心脏活动的所选T波和R波特征的检测器以及基于测量选定的R波和T波特性。感测阈值控制可以针对内部节奏和节奏节拍实现。

8. 发明授权

US07225015B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
公开(公告)号：US07225015B1
公开(公告)日：2007-05-29
申请号：US10603398
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0468
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

9. 发明授权

US09415226B1 Method and apparatus with anodal capture monitoring 有权
标题翻译：具有阳极捕获监测的方法和装置
公开(公告)号：US09415226B1
公开(公告)日：2016-08-16
申请号：US11961720
申请日：2007-12-20
申请人： Jeffery D. Snell , Gene A. Bornzin , Laurence S. Sloman , Jong Gill
发明人： Jeffery D. Snell , Gene A. Bornzin , Laurence S. Sloman , Jong Gill
IPC分类号： A61N1/00 , A61N1/362
CPC分类号： A61N1/3622 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： During cross-chamber pacing, where anodal capture may not be desirable, pulses are applied between a cathode electrode in a first chamber and an anode electrode in a second chamber. A capture detector detects for capture of the second chamber by the pacing pulses. If capture of the second chamber persists, another electrode is selected as the anodal electrode. During single-chamber pacing, where anodal capture may be desirable, pulses are applied between a cathode electrode and an anode electrode associated with the same chamber. A capture detector detects for capture at both electrodes. If anodal capture is not detected, the energy of the pacing pulse is increased, until anodal capture is detected.
摘要翻译：在跨室起搏期间，可能不需要阳极捕获，脉冲施加在第一室中的阴极和第二室中的阳极之间。捕获检测器通过起搏脉冲检测第二腔室的捕获。如果第二室的捕获持续，则选择另一电极作为阳极电极。在可以期望阳极捕获的单室起搏期间，在与相同的室相关联的阴极和阳极之间施加脉冲。捕获检测器检测两个电极的捕获。如果没有检测到阳极捕获，则起搏脉冲的能量增加，直到检测到阳极捕获。

10. 发明授权

US08260404B1 Systems and methods for employing multiple filters to detect T-wave oversensing and to improve tachyarrhythmia detection within an implantable medical device 有权
标题翻译：使用多个滤波器来检测T波过度感知并改善可植入医疗装置内的快速性心律失常检测的系统和方法
公开(公告)号：US08260404B1
公开(公告)日：2012-09-04
申请号：US11776275
申请日：2007-07-11
申请人： Rupinder Bharmi , Jeffery D. Snell , Gene A. Bornzin , Joseph J. Florio , Peter Boileau
发明人： Rupinder Bharmi , Jeffery D. Snell , Gene A. Bornzin , Joseph J. Florio , Peter Boileau
IPC分类号： A61B5/0452 , A61B5/0456
CPC分类号： A61B5/0456 , A61B5/0464 , A61B5/725 , A61N1/3702 , A61N1/395
摘要： Techniques for detecting tachyarrhythmia and also for preventing T-wave oversensing use signals filtered by a narrowband bradycardia filter in combination with signals filtered by a narrowband tachycardia filter. A separate wideband filter may also be used.
摘要翻译：用于检测快速性心律失常并且还用于预防T波超检的技术使用由窄带心动过缓过滤器滤波的信号与由窄带心动过速过滤器过滤的信号组合。也可以使用单独的宽带滤波器。

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