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1. 发明授权

US08394642B2 Universal sample preparation system and use in an integrated analysis system 有权
公开(公告)号：US08394642B2
公开(公告)日：2013-03-12
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

2. 发明申请

US20110005932A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：US20110005932A1
公开(公告)日：2011-01-13
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N27/447 , H01J5/16 , G01J1/58 , G01N21/64
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。该系统适合不超过10英尺3的外壳。并且可以是封闭的，便携式的和/或电池供电的系统。该系统可用于在不到4小时内从原始样品进行分析。

3. 发明申请

US20100165784A1 INSTRUMENT WITH MICROFLUIDIC CHIP 有权
标题翻译：仪器与微流控芯片
公开(公告)号：US20100165784A1
公开(公告)日：2010-07-01
申请号：US12642665
申请日：2009-12-18
申请人： Stevan B. JOVANOVICH , William D. Nielsen , Michael Recknor , Mary Trounstine
发明人： Stevan B. JOVANOVICH , William D. Nielsen , Michael Recknor , Mary Trounstine
IPC分类号： B01F15/02 , F16L37/56 , F25B21/02 , F16K31/08 , F16K7/00
CPC分类号： B01F5/06 , B01F11/0045 , B01F13/0059 , F16K99/0001 , F16K99/0015 , F16K99/0036 , F16K99/0046 , F16K99/0059 , Y10T137/0318 , Y10T137/87153 , Y10T137/877
摘要： This invention provides microfluidic devices that comprise a fluidics layer having microfluidic channels and one or more regulating layers that regulate the movement of fluid in the channels. The microfluidic devices can be used to mix one or more fluids. At least a portion of the fluidics layer can be isolated from the regulating layer, for example in the form of a shelf. Such isolated portions can be used as areas in which the temperature of liquids is controlled. Also provided are instruments including thermal control devices into which the microfluidic device is engaged so that the thermal control device controls temperature in the isolated portion, and a movable magnetic assembly including magnets with shields so that a focused magnetic field can be applied to or withdrawn from the isolated portion or any other portion of the microfluidic device. Also provided are methods of mixing fluids. The methods include stacking a plurality of alternating boluses of different liquids in a microfluidic channel, and moving the stacked boluses through the channel. In another method, the boluses are moved into a diaphragm valve having a volume able to accommodate several boluses, and then pumping the liquids out of the valve.
摘要翻译：本发明提供了微流体装置，其包括具有微流体通道的流体层和调节通道中的流体运动的一个或多个调节层。微流体装置可用于混合一种或多种流体。流体层的至少一部分可以与调节层隔离，例如以搁板的形式。这种隔离部分可以用作控制液体温度的区域。还提供了包括热控制装置的仪器，其中微流体装置被接合到其中，使得热控制装置控制隔离部分中的温度，以及可移动磁性组件，其包括具有屏蔽的磁体，使得聚焦磁场可以被施加到或从微流体装置的隔离部分或任何其它部分。还提供了混合流体的方法。这些方法包括在微流体通道中堆叠多个不同液体的交替喷射，并且通过通道移动堆叠的推注。在另一种方法中，将大团块移动到具有能够容纳多次喷射的体积的隔膜阀中，然后将液体泵出阀。

4. 发明申请

US20080072663A1 ACCURATE AND TIMELY BODY FLUID ANALYSIS 审中-公开
标题翻译：精确和及时的体液分析
公开(公告)号：US20080072663A1
公开(公告)日：2008-03-27
申请号：US11839487
申请日：2007-08-15
申请人： Richard Keenan , Jeffrey Chiou , Roger Tong , Michael Recknor , Ken Li , James Braig , David Callicoat , Jennifer Gable
发明人： Richard Keenan , Jeffrey Chiou , Roger Tong , Michael Recknor , Ken Li , James Braig , David Callicoat , Jennifer Gable
IPC分类号： G01N33/00 , B01J19/00 , B04B5/10
CPC分类号： G01N35/1095 , A61B5/14532 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150267 , A61B5/150305 , A61B5/150755 , A61B5/150786 , A61B5/150824 , A61B5/153 , A61B5/157 , A61M1/3621 , A61M5/14 , A61M5/1415 , A61M2005/1404 , A61M2005/1726 , A61M2230/201 , B01L3/502 , B01L3/50273 , B01L3/52 , B01L2200/10 , B01L2300/0816 , B01L2400/0478 , B01L2400/0633 , G01N21/35
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. A first component of the bodily fluid is separated from the drawn portion, while the analyte detection system remains in fluid communication with the patient. The analyte detection system analyzes the first component to measure a concentration of an analyte in an accurate and timely manner.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括在患者体内建立分析物检测系统和体液之间的流体连通。体液的一部分从患者身上抽出。分析物检测系统与患者保持流体连通，将体液的第一组分与拉出部分分离。分析物检测系统分析第一个成分，以准确和及时的方式测量分析物的浓度。

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