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1. 发明申请

US20160016140A1 Integrated Analysis System 有权
标题翻译：综合分析系统
公开(公告)号：US20160016140A1
公开(公告)日：2016-01-21
申请号：US14804675
申请日：2015-07-21
申请人： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
发明人： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
IPC分类号： B01J19/00 , C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译：本发明提供用于执行综合分析的系统，设备，方法和套件。综合分析可以包括样品处理，库构建，扩增和测序。集成分析可以在一个或多个流体连接的模块中进行。一个或多个模块可以由计算机控制和/或自动化。可以对组织样品，临床样品或环境样品进行综合分析。集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。

2. 发明授权

US08512538B2 Capillary electrophoresis device 有权
标题翻译：毛细管电泳装置
公开(公告)号：US08512538B2
公开(公告)日：2013-08-20
申请号：US13113968
申请日：2011-05-23
申请人： Lars Majlof , Ezra Van Gelder
发明人： Lars Majlof , Ezra Van Gelder
IPC分类号： G05D23/00 , G01N27/447 , G01N27/453
CPC分类号： G01N27/44708
摘要： This invention provides a capillary electrophoresis device in which capillaries are thermally regulated on a thermally responsive electrical path attached to an electrically insulating circuit board. This invention also provides an optical scanner useful for scanning an array of capillaries. A laser, optical detector and optical selector are in an arrangement that allows the optical detector to selectively detect an optical signal from any one or more of the plurality of electrophoresis capillaries.
摘要翻译：本发明提供一种毛细管电泳装置，其中毛细管在附着于电绝缘电路板的热响应电路上进行热调节。本发明还提供了一种用于扫描毛细管阵列的光学扫描仪。激光器，光学检测器和光学选择器处于允许光学检测器选择性地检测来自多个电泳毛细管中的一个或多个的光学信号的布置。

3. 发明申请

US20110290648A1 Capillary Electrophoresis Device 有权
标题翻译：毛细管电泳装置
公开(公告)号：US20110290648A1
公开(公告)日：2011-12-01
申请号：US13113968
申请日：2011-05-23
申请人： Lars Majlof , Ezra Van Gelder
发明人： Lars Majlof , Ezra Van Gelder
IPC分类号： G01N27/447
CPC分类号： G01N27/44708
摘要： This invention provides a capillary electrophoresis device in which capillaries are thermally regulated on a thermally responsive electrical path attached to an electrically insulating circuit board. This invention also provides an optical scanner useful for scanning an array of capillaries. A laser, optical detector and optical selector are in an arrangement that allows the optical detector to selectively detect an optical signal from any one or more of the plurality of electrophoresis capillaries.
摘要翻译：本发明提供一种毛细管电泳装置，其中毛细管在附着于电绝缘电路板的热响应电路上进行热调节。本发明还提供了一种用于扫描毛细管阵列的光学扫描仪。激光器，光学检测器和光学选择器处于允许光学检测器选择性地检测来自多个电泳毛细管中的一个或多个的光学信号的布置。

4. 发明申请

US20100303687A1 FLUIDIC DEVICES WITH DIAPHRAGM VALVES 有权
标题翻译：带透气阀的流体装置
公开(公告)号：US20100303687A1
公开(公告)日：2010-12-02
申请号：US12789186
申请日：2010-05-27
申请人： Iuliu I. BLAGA , Stevan B. Jovanovich , Boris Kobrin , Ezra Van Gelder
发明人： Iuliu I. BLAGA , Stevan B. Jovanovich , Boris Kobrin , Ezra Van Gelder
IPC分类号： B01J8/00 , B81B3/00 , F15C3/04 , G05D7/00 , B32B37/02 , B32B38/10 , B32B38/00
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , F16K99/0001 , F16K2099/0073 , Y10T137/0318 , Y10T137/2224 , Y10T137/87716 , Y10T156/10 , Y10T436/11 , Y10T436/2575
摘要： This invention provides fluidic devices, in particular microfluidic devices, with diaphragm valves having low failure rates. Low failure rates are achieved by inhibiting sticking of the diaphragm to functional surfaces such as valve seats, valve chamber and fluidic channels and conduits. One way to implement this is to provide exposed surfaces facing the diaphragm, particularly valve seats, with a low energy material, such as a noble metal, a perfluorinated polymer, a self-assembled monolayer, hard diamond, diamond-like carbon or a metal oxide. In other embodiments, the valves are provided with ridges and the diaphragm is adhered to the fluidic or actuation layer with an adhesive material.
摘要翻译：本发明提供具有低故障率的隔膜阀的流体装置，特别是微流体装置。通过抑制膜片到诸如阀座，阀室和流体通道和管道的功能表面的粘附来实现低故障率。实现这一点的一种方法是提供面向隔膜，特别是阀座的暴露表面，其具有低能材料，例如贵金属，全氟化聚合物，自组装单层，硬金刚石，类金刚石碳或金属氧化物。在其他实施例中，阀设置有脊，并且隔膜用粘合剂材料粘附到流体或致动层。

5. 发明授权

US5635728A Rotating scanner system for reading multiple storage layer radiation screens 失效
标题翻译：用于读取多个存储层辐射屏幕的旋转扫描仪系统
公开(公告)号：US5635728A
公开(公告)日：1997-06-03
申请号：US493109
申请日：1995-06-19
申请人： Gary R. Cantu , Joseph R. Rimsa , Ezra Van Gelder , Daniel B. Steinberg , Iain H. Hueton
发明人： Gary R. Cantu , Joseph R. Rimsa , Ezra Van Gelder , Daniel B. Steinberg , Iain H. Hueton
IPC分类号： G01N23/04
CPC分类号： G03B42/08 , G01N23/04
摘要： A system is provided for reading an image stored on a storage layer radiation screen. The system includes a carousel for holding a storage layer radiation screen and a screen scanning system. The screen scanning system includes a carousel mount on which the carousel may be mounted and a rotation mechanism for rotating the carousel mount, rotation of the carousel mount serving to rotate the carousel about a rotational axis which, in turn, causes the screens held on the carousel to move in a circular path about the rotational axis. The carousel is preferably removable from the carousel mount. The screen scanning system also includes an image acquisition optical system positioned adjacent the circular path of the screen, the image acquisition optical system including an excitation system for focusing an excitation beam on a portion of the screen to cause a light emission, and an emission collecting system for collecting the light emitted from the screen. The screen scanning system may further include an optics driver for moving the image acquisition optical system in a direction parallel to the rotational axis of the carousel. A method is provided for reading images stored on multiple storage layer radiation screens. The method includes attaching multiple storage layer radiation screens to a carousel, rotating the carousel about a rotational axis such that the screens move in a circular path about the rotational axis, focusing an excitation beam at a point on the circular path such that the portions of the screens passing the point on the circular path emit light, collecting the light emitted, and moving the point on the circular path on which the excitation beam is focused in a direction parallel to the rotational axis.
摘要翻译：提供一种用于读取存储在存储层辐射屏幕上的图像的系统。该系统包括用于保持存储层辐射屏幕和屏幕扫描系统的转盘。屏幕扫描系统包括可以安装圆盘传送带的旋转架安装件和用于旋转传送带安装件的旋转机构，用于旋转传送带安装件的转盘安装架的旋转，其用于使转盘绕旋转轴线旋转，这又使得保持在屏幕上的屏幕圆盘传送带围绕旋转轴线以圆形路径移动。圆盘传送带优选地可从圆盘传送带安装件移除。屏幕扫描系统还包括邻近屏幕的圆形路径定位的图像采集光学系统，图像采集光学系统包括用于将激发光束聚焦在屏幕的一部分上以引起发光的激发系统，以及发射采集用于收集从屏幕发出的光的系统。屏幕扫描系统还可以包括光学驱动器，用于沿平行于圆盘传送带的旋转轴线的方向移动图像采集光学系统。提供一种用于读取存储在多个存储层辐射屏幕上的图像的方法。该方法包括将多个存储层辐射屏幕附接到转盘上，使转盘围绕旋转轴线旋转，使得屏幕围绕旋转轴线以圆形路径移动，将激励光束聚焦在圆形路径上的点处，通过圆形路径上的点的屏幕发光，收集发射的光，并使激发光束聚焦的圆形路径上的点沿平行于旋转轴线的方向移动。

6. 发明授权

US5459325A High-speed fluorescence scanner 失效
标题翻译：高速荧光扫描仪
公开(公告)号：US5459325A
公开(公告)日：1995-10-17
申请号：US277900
申请日：1994-07-19
申请人： Iain Hueton , Ezra Van Gelder
发明人： Iain Hueton , Ezra Van Gelder
IPC分类号： G01N21/64 , G01N27/447
CPC分类号： G01N21/6452 , G01N27/44721 , G01N2021/6417 , G01N2201/101
摘要： A high-speed fluorescence scanner for scanning a sample at equal angles is disclosed. The scanner has most of its optical components, including a light beam source, a detector, and various filters, lenses, and reflectors, in a fixed position, removed from the scan head. The lightweight scan head contains a single reflector and lens combination which is reciprocated rapidly along one axis to lengthen and shorten a region of the path of a collimated excitation beam and to form a scan line on a sample. The fluorescence emission may be gathered by the lens of the scan head and directed back, generally along the optical path of the excitation beam, to a detector. Another embodiment of the scanner places the light source, in miniature form, directly on the scan head. The sample may be translated in an axis orthogonal to the scan line in order to stimulate fluorescent emission from a two-dimensional portion of the sample. The design of the optical assembly currently permits scan speeds of up to approximately 100 inches per second.
摘要翻译：公开了一种以相等的角度扫描样品的高速荧光扫描仪。扫描仪具有大部分光学部件，包括光束源，检测器以及处于固定位置的各种过滤器，透镜和反射器，从扫描头移除。轻型扫描头包含单个反射器和透镜组合，其沿着一个轴线快速往复运动，以延长和缩短准直激励光束的路径的区域并在样本上形成扫描线。荧光发射可以由扫描头的透镜聚集，并且通常沿着激发光束的光路向后指向检测器。扫描仪的另一个实施例将光源以微型形式放置在扫描头上。样品可以在与扫描线正交的轴上平移，以刺激来自样品的二维部分的荧光发射。光学组件的设计目前允许每秒高达约100英寸的扫描速度。

7. 发明授权

US5424841A Apparatus for measuring spatial distribution of fluorescence on a substrate 失效
标题翻译：用于测量衬底上荧光的空间分布的装置
公开(公告)号：US5424841A
公开(公告)日：1995-06-13
申请号：US069150
申请日：1993-05-28
申请人： Ezra Van Gelder , Bee C. Liang , Richard F. Johnston , Robert T. Loder, Jr.
发明人： Ezra Van Gelder , Bee C. Liang , Richard F. Johnston , Robert T. Loder, Jr.
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6441
摘要： A fluorescence detection scanner and method employing a fiberoptic collector, positioned adjacent to the scanning plane of the excitation beam, with a light collecting surface which is oriented to reject back-scattered excitation light from the incident surface of the sample support. The scanning plane of the excitation beam is off normal relative to the incident surface of the sample support and the light collecting surface is located within the area defined by the resulting acute angle of incidence. The light collecting surface is angled away from the location at which the incident excitation beam intersects the surface of the sample support so that back-scattered excitation light does not enter the optical fibers. The orientation of the light collector results in a four to five-fold decrease in excitation-light background without attenuation of the fluorescence emitted by the sample. Long-pass interference filters, selected to reject the excitation wavelength, are located at the input and output surfaces of the fiberoptic light collector to further reduce background excitation light. Multiple fluorophores are discriminated by sequentially scanning the sample with a different interchangeable narrow bandpass filter for each fluorophore. Internal fluorescence standards in the sample are used to determine filter efficiencies for each label in each filter image and the quantity of each fluorophore is computed by linear analysis. Increased detector sensitivity allows linear quantitation of multiple fluorophores in the femto-mole range.
摘要翻译：一种荧光检测扫描器和采用与激发光束的扫描平面相邻的光纤收集器的方法，该光收集表面被定向成阻止来自样品支架的入射表面的反向散射的激发光。激发光束的扫描平面相对于样品支架的入射表面正常，并且光收集表面位于由所产生的锐角入射限定的区域内。光收集表面远离入射激发光束与样品支架表面相交的位置成角度，使得后向散射的激发光不进入光纤。光收集器的取向导致激发光背景下降4-5倍，而不会使样品发射的荧光发生衰减。被选择以抑制激发波长的长通干涉滤光器位于光纤集光器的输入和输出表面，以进一步减少背景激发光。通过用每个荧光团的不同可互换的窄带通滤光器顺序扫描样品来区分多个荧光团。使用样品中的内部荧光标准来确定每个过滤图像中每个标记的过滤效率，并且通过线性分析计算每个荧光团的量。增加的检测器灵敏度允许在毫微微摩尔范围内的多个荧光团的线性定量。

8. 发明申请

US20130203634A1 INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：综合分析系统
公开(公告)号：US20130203634A1
公开(公告)日：2013-08-08
申请号：US13202884
申请日：2011-08-20
申请人： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
发明人： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译：本发明提供用于执行综合分析的系统，设备，方法和套件。综合分析可以包括样品处理，库构建，扩增和测序。集成分析可以在一个或多个流体连接的模块中进行。一个或多个模块可以由计算机控制和/或自动化。可以对组织样品，临床样品或环境样品进行综合分析。集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。

9. 发明申请

US20110240127A1 Fluidic Article Fabricated In One Piece 审中-公开
标题翻译：流体制品在一件
公开(公告)号：US20110240127A1
公开(公告)日：2011-10-06
申请号：US13075165
申请日：2011-03-29
申请人： David Eberhart , Ezra Van Gelder
发明人： David Eberhart , Ezra Van Gelder
IPC分类号： F15D1/00 , B32B1/00 , B32B3/30
CPC分类号： F16K99/0015 , B01J2219/00353 , B01J2219/00389 , B01J2219/00398 , B01J2219/00722 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2300/165 , B01L2400/0655 , C40B50/08 , C40B60/14 , F16K99/0059 , Y10T137/0318 , Y10T137/8593 , Y10T428/13 , Y10T428/1397
摘要： In one aspect this invention provides an article fabricated in one piece comprising at least one aperture through the piece, wherein the aperture defines a non-microfluidic volume, and a microfluidic channel formed in a surface of the piece onto which the aperture opens, wherein the channel is in fluidic communication with the aperture, wherein the aperture and the microfluidic channel define a fluidic circuit.
摘要翻译：在一个方面，本发明提供了一件制造的制品，其包括穿过该片的至少一个孔，其中孔限定非微流体体积，以及形成在该孔的开口的孔的表面中的微流体通道，其中，通道与孔流体连通，其中孔径和微流体通道限定流体回路。

10. 发明申请

US20110005932A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：US20110005932A1
公开(公告)日：2011-01-13
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N27/447 , H01J5/16 , G01J1/58 , G01N21/64
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。该系统适合不超过10英尺3的外壳。并且可以是封闭的，便携式的和/或电池供电的系统。该系统可用于在不到4小时内从原始样品进行分析。

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