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1. 发明申请

US20100165784A1 INSTRUMENT WITH MICROFLUIDIC CHIP 有权
标题翻译：仪器与微流控芯片
公开(公告)号：US20100165784A1
公开(公告)日：2010-07-01
申请号：US12642665
申请日：2009-12-18
申请人： Stevan B. JOVANOVICH , William D. Nielsen , Michael Recknor , Mary Trounstine
发明人： Stevan B. JOVANOVICH , William D. Nielsen , Michael Recknor , Mary Trounstine
IPC分类号： B01F15/02 , F16L37/56 , F25B21/02 , F16K31/08 , F16K7/00
CPC分类号： B01F5/06 , B01F11/0045 , B01F13/0059 , F16K99/0001 , F16K99/0015 , F16K99/0036 , F16K99/0046 , F16K99/0059 , Y10T137/0318 , Y10T137/87153 , Y10T137/877
摘要： This invention provides microfluidic devices that comprise a fluidics layer having microfluidic channels and one or more regulating layers that regulate the movement of fluid in the channels. The microfluidic devices can be used to mix one or more fluids. At least a portion of the fluidics layer can be isolated from the regulating layer, for example in the form of a shelf. Such isolated portions can be used as areas in which the temperature of liquids is controlled. Also provided are instruments including thermal control devices into which the microfluidic device is engaged so that the thermal control device controls temperature in the isolated portion, and a movable magnetic assembly including magnets with shields so that a focused magnetic field can be applied to or withdrawn from the isolated portion or any other portion of the microfluidic device. Also provided are methods of mixing fluids. The methods include stacking a plurality of alternating boluses of different liquids in a microfluidic channel, and moving the stacked boluses through the channel. In another method, the boluses are moved into a diaphragm valve having a volume able to accommodate several boluses, and then pumping the liquids out of the valve.
摘要翻译：本发明提供了微流体装置，其包括具有微流体通道的流体层和调节通道中的流体运动的一个或多个调节层。微流体装置可用于混合一种或多种流体。流体层的至少一部分可以与调节层隔离，例如以搁板的形式。这种隔离部分可以用作控制液体温度的区域。还提供了包括热控制装置的仪器，其中微流体装置被接合到其中，使得热控制装置控制隔离部分中的温度，以及可移动磁性组件，其包括具有屏蔽的磁体，使得聚焦磁场可以被施加到或从微流体装置的隔离部分或任何其它部分。还提供了混合流体的方法。这些方法包括在微流体通道中堆叠多个不同液体的交替喷射，并且通过通道移动堆叠的推注。在另一种方法中，将大团块移动到具有能够容纳多次喷射的体积的隔膜阀中，然后将液体泵出阀。

2. 发明授权

US5760130A Aminosilane/carbodiimide coupling of DNA to glass substrate 失效
标题翻译： DNA与玻璃基质的氨基硅烷/碳二亚胺偶联
公开(公告)号：US5760130A
公开(公告)日：1998-06-02
申请号：US854989
申请日：1997-05-13
申请人： Richard F. Johnston , Mary Trounstine
发明人： Richard F. Johnston , Mary Trounstine
IPC分类号： C07H21/00 , C12Q1/68 , C08G63/48 , C08G63/91
CPC分类号： C07H21/00 , C12Q1/6834 , B01J2219/00497
摘要： A method for coupling DNA to a glass substrate by aminating the glass substrate with an aminosilane, reacting DNA with a carbodiimide/imidazole solution to create a 5'-phosphorimidazolide, and reacting the aminated glass substrate and phosphorimidazolide to couple the DNA to the substrate.
摘要翻译：一种通过用氨基硅烷胺化玻璃底物来将DNA偶联到玻璃基底上的方法，使DNA与碳二亚胺/咪唑溶液反应以产生5'-磷杂咪唑化物，并使胺化的玻璃底物和磷光咪唑化物反应以将DNA偶联到底物上。

3. 发明申请

US20050227252A1 Diffraction grating-based encoded articles for multiplexed experiments 审中-公开
$Diffraction grating-based encoded articles for multiplexed experiments$
标题翻译：用于多重实验的基于衍射光栅的编码文章
公开(公告)号：US20050227252A1
公开(公告)日：2005-10-13
申请号：US10990057
申请日：2004-11-15
申请人： John Moon , Martin Putnam , Michel Perbost , John Quinn , Mary Trounstine
发明人： John Moon , Martin Putnam , Michel Perbost , John Quinn , Mary Trounstine
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6845 , B01L3/508 , G01N33/54313 , G01N33/54353
摘要： The present invention provides methods and compositions directed toward assays of a broad range of analytes using specific targeting chemicals that bind to the analytes. The assays are founded on the use of coded assay articles to which the targeting chemicals are attached. Additionally the codes are such that they are interrogated and determined in real time. The target is analyzed as to identity, presence and quantity in real time. The methods and compositions of the invention are highly suitable for use in high-complexity multiplexed assay systems. All the methods and compositions are based on assay article that includes an optical substrate to which the chemical is bound, and in which is disposed at least one diffraction grating. The grating provides an output optical signal when illuminated by an incident light signal which is indicative of the code in the substrate. In general, coded assay article or sets thereof are employed in assay methods, including multiplexed assay methods, according to which a sample is contacted with an article or a set, and any analytes that bind to the attached chemical are identified according to the code, detected and/or quantitated.
摘要翻译：本发明提供了使用与分析物结合的特定靶向化学物质来测定广泛范围的分析物的方法和组合物。测定建立在使用靶向化学品所连接的编码测定制品的基础上。此外，这些代码使得它们被实时询问并确定。对目标进行身份，存在和数量的实时分析。本发明的方法和组合物非常适用于高复杂度复合测定系统。所有方法和组合物都基于包含化学结合的光学基底的测定制品，并且其中设置有至少一个衍射光栅。当由入射光信号照亮时，光栅提供输出光信号，该入射光信号指示衬底中的代码。通常，编码的测定法或其组合用于测定方法，包括多重测定方法，根据该测定方法，将样品与制品或组合物接触，并且根据代码鉴定与附着的化学物质结合的任何分析物，检测和/或定量。

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