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1. 发明授权

US4853336A Single channel continuous flow system 失效
标题翻译：单通道连续流量系统
公开(公告)号：US4853336A
公开(公告)日：1989-08-01
申请号：US10236
申请日：1987-02-02
申请人： Stephen Saros , John L. Smith , Michael M. Cassaday , Rand E. Herron , Milton H. Pelavin
发明人： Stephen Saros , John L. Smith , Michael M. Cassaday , Rand E. Herron , Milton H. Pelavin
IPC分类号： G01N35/04 , G01N35/08
CPC分类号： G01N35/08 , G01N2035/0415 , G01N2035/0443 , G01N35/025 , Y10T436/117497 , Y10T436/118339
摘要： A continuous flow system is disclosed in which successive liquid segments are established containing different related components of a fluid package, such as an analysis mixture, separated by at least one immiscible segment, passed along a first section of a conduit, combined in a second section of the conduit and mixed while passing along a third section of the conduit, so as to provide a completely mixed segment. This system permits the delayed on-line mixing of different components of an analysis mixture, such as samples with reagents or diluents, as well as mixing and interaction of such components in a single conduit.
摘要翻译：公开了一种连续流动系统，其中建立了连续的液体段，其包含流体包装（例如分析混合物）的不同相关组分，分离混合物由至少一个不混溶段分隔，沿着导管的第一部分通过，在第二部分并在通过导管的第三部分时混合，以便提供完全混合的部分。该系统允许分析混合物的不同组分（例如具有试剂或稀释剂的样品）的延迟在线混合，以及这些组分在单个导管中的混合和相互作用。

2. 发明授权

US4669756A Zero dead volume connector 失效
标题翻译：零死体连接器
公开(公告)号：US4669756A
公开(公告)日：1987-06-02
申请号：US735528
申请日：1985-05-20
申请人： Michael M. Cassaday , Leon Castellani , Stephen Saros
发明人： Michael M. Cassaday , Leon Castellani , Stephen Saros
IPC分类号： G01N30/38 , B01D15/08 , F16B7/18 , F16L19/00 , F16L47/00 , G01N30/26 , F16L27/12
CPC分类号： F16L47/00
摘要： New and improved connector is provided for the zero dead volume connection of separate, like diameter flexible tubing lengths by direct tubing length end abutment and connection under controlled conditions. The connector is particularly adapted for use with tubing lengths of fluorocarbon or like materials in contemporary biomedical sample liquid analysis systems which utilize an immiscible isolation liquid or "oil" to minimize sample liquid carryover and maximize the accuracy of sample liquid analysis results.
摘要翻译：提供了新的和改进的连接器，用于在受控条件下通过直接管道长度端邻接和连接的单独的类似直径的柔性管段的零死体积连接。连接器特别适用于当代生物医学样品液体分析系统中的氟化碳或类似材料的管道长度，其利用不混溶的隔离液体或“油”以最小化样品液体携带并最大化样品液体分析结果的准确性。

3. 发明授权

US4602995A Liquid level adjusting and filtering device 失效
标题翻译：液位调节和过滤装置
公开(公告)号：US4602995A
公开(公告)日：1986-07-29
申请号：US735847
申请日：1985-05-20
申请人： Michael M. Cassaday , Rand Herron , Kenneth F. Uffenheimer , John L. Smith
发明人： Michael M. Cassaday , Rand Herron , Kenneth F. Uffenheimer , John L. Smith
IPC分类号： G01N33/48 , G01N1/00 , G01N33/49 , G01N35/10 , B01D33/00
CPC分类号： G01N33/491
摘要： New and improved, liquid level adjusting and filtering device is provided, and is operable upon insertion into a container to automatically adjust the level of a liquid as contained in the container to a predetermined, precisely repeatable location, and to filter the thusly level-adjusted liquid. The device is particularly adapted for use in conjunction with test tube-like devices, in the nature of those marketed under the Trademark "Vacutainer" by the Becton-Dickinson Company of East Rutherford, NJ, containing whole blood samples which have been separated as by centrifugation into respective blood cell, buffy and blood serum layers; and is operable in that context to present blood serum samples to automated sample analysis systems at the same predetermined and precisely repeatable location relative to the aspirating probe means of such systems.
摘要翻译：提供了新的和改进的液位调节和过滤装置，并且在插入到容器中以便将包含在容器中的液体的水平自动调节到预定的，精确可重复的位置时可操作，并且将因此被调节的水平液体。该装置特别适合与试管类装置一起使用，其性质是由新泽西州东卢瑟福的Becton-Dickinson公司在“Vacutainer”商标范围内销售的，其中包含已经被分离的全血样本离心分离到各自的血细胞，血沉棕质和血清层; 并且在该上下文中可操作地将相对于这种系统的抽吸探针装置的血清样品呈现在相同的预定和精确可重复的位置处的自动化样品分析系统。

4. 发明授权

US4422773A Apparatus and method for the non-invasive mixing of a flowing fluid stream 失效
标题翻译：用于非流体混合流动流体的装置和方法
公开(公告)号：US4422773A
公开(公告)日：1983-12-27
申请号：US175222
申请日：1980-08-04
申请人： Michael M. Cassaday , John L. Smith
发明人： Michael M. Cassaday , John L. Smith
IPC分类号： B01F5/00 , B01F5/06 , G01N35/08
CPC分类号： B01F5/0646 , B01F5/0647 , G01N35/08
摘要： New and improved apparatus and method for thorough, non-invasive mixing of a flowing fluid stream, either continuous or segmented, are provided and, as disclosed, are embodied in a mixing conduit which comprises a plurality of interconnected bends, which may be in the form of arcuate coils or sections, successive arcuate sections being operable to establish secondary flow patterns in differing orientations within the flowing fluid stream, or individual segments thereof. Such arcuate sections may be disposed in a same plane, if formed in serpentine fashion, or in non-parallel, preferably orthogonal planes, if formed in a tortuous fashion. Also, the arcuate sections, or a series thereof may be formed in stacked fashion and located in essentially parallel planes.
摘要翻译：提供了用于彻底，非侵入式混合连续或分段的流体流的新的和改进的装置和方法，并且如所公开的那样，它们被实施在混合管道中，混合管道包括多个互连的弯头，其可以在弧形线圈或部分的形式，连续的弓形部分可操作以在流动流体流或其各个部分内以不同取向建立二次流动模式。如果以蛇形方式形成，或者如果以曲折方式形成，则这些弧形部分可以设置在相同的平面中，或者在非平行的，优选正交的平面中。此外，弓形部分或其一系列可以以堆叠方式形成并且位于基本上平行的平面中。

5. 发明授权

US5983777A Method and apparatus for diaphragm pumping with adjustable flow 失效
标题翻译：用于可调节流动的隔膜泵送的方法和装置
公开(公告)号：US5983777A
公开(公告)日：1999-11-16
申请号：US992986
申请日：1997-12-18
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： F04B43/00 , F04B43/067 , F01B19/00 , F16J3/00
CPC分类号： F04B43/067 , F04B43/0063 , F04B2201/0206
摘要： An improved method and apparatus for adjusting the flow of a diaphragm pump. The thickness of the diaphragm itself is capable of being adjusted. Full stroke output is thereby reduced in inverse proportion to the increased volume occupied by the diaphragm. Adjusting the thickness of the diaphragm while the pump is operating provides a means of varying pump output without stopping the pump for adjustments or modifications.
摘要翻译：一种调节隔膜泵流量的改进方法和装置。膜片本身的厚度能够被调整。因此，全行程输出与隔膜占用的增加的体积成反比。在泵运行时调节膜片的厚度提供了改变泵输出的方法，而不会停止泵进行调整或修改。

6. 发明授权

US5149658A Method for the separation and/or formation of immiscible liquid streams 失效
标题翻译：用于分离和/或形成不混溶液体流的方法
公开(公告)号：US5149658A
公开(公告)日：1992-09-22
申请号：US628804
申请日：1990-12-14
申请人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
发明人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
IPC分类号： B01D17/02 , G01N35/08
CPC分类号： G01N35/08 , B01D17/0214 , Y10T436/118339
摘要： Apparatus and method are provided for the substantial separation on a continuous flow basis of immiscible liquids flowing as a common stream, with one of the liquids substantially encapsulating another of the liquids, in a flow conduit. The conduit comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of another of the liquids; and the liquid separator apparatus are disposed in the conduit and operate to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream as that stream flows into contact with the separator apparatus in the conduit.Apparatus and method for the introduction of a liquid on a continuous flow basis into a flowing stream of another liquid which is immiscible therewith and is flowing in a flow conduit are also provided. The conduit again comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of the other of the liquids; and the liquid introduction apparatus are disposed in the conduit and operate to form a common stream of the liquids for continued flow in the conduit, with one of the liquids being substantially encapsulated by another of the liquids, as the liquids are merged at the liquid introduction apparatus in the conduit.
摘要翻译：提供了设备和方法，用于在流动管道中基于连续流动基本上分离作为流体流动的不混溶液体，其中一种液体基本上封装另一种液体。导管包括内表面，其被液体中的一个选择性地“润湿”，从而基本排除另一种液体; 并且液体分离器装置设置在导管中，并且操作成使该液体或液体的至少一部分与普通液体流分离，因为该流与导管中的分离器装置接触。还提供了用于将液体以连续流动基础引入与其不混溶并在流动管道中流动的另一液体的流动流的装置和方法。导管再次包括内表面，该内表面被其中一种液体选择性地“润湿”，从而基本排除另一种液体; 并且液体引入装置设置在导管中并且操作以形成用于在管道中持续流动的液体的公共流，其中一种液体基本上被另一种液体封装，因为液体在液体引入设备在管道中。

7. 发明授权

US4357301A Reaction cuvette 失效
标题翻译：反应试管
公开(公告)号：US4357301A
公开(公告)日：1982-11-02
申请号：US284845
申请日：1981-07-20
申请人： Michael M. Cassaday , Herman G. Diebler , Dario Svenjak , Kenneth F. Uffenheimer
发明人： Michael M. Cassaday , Herman G. Diebler , Dario Svenjak , Kenneth F. Uffenheimer
IPC分类号： G01N33/48 , G01N21/03 , G01N21/25 , G01N35/02 , G01N21/13
CPC分类号： G01N21/253
摘要： The reaction cuvette adapted to receive a liquid dispensing probe and having at least one surface of hydrophilic material which is treated or formed to have inwardly extending projections against which the liquid is dispensed.
摘要翻译：反应试管适于接收液体分配探针并具有至少一个亲水材料表面，其被处理或形成为具有向内延伸的突起，液体被分配到其上。

8. 发明授权

US6150182A Method for separation of components in a biochemical reaction utilizing a combination of magnetic and centrifugal processes 失效
标题翻译：使用磁力和离心过程的组合分离生化反应中的组分的方法
公开(公告)号：US6150182A
公开(公告)日：2000-11-21
申请号：US201010
申请日：1998-11-30
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： B03C1/28 , G01N35/00 , G01N33/553 , C12Q1/66 , G01N15/06 , G01N35/08
CPC分类号： B03C1/288 , G01N35/0098 , Y10S435/971 , Y10S436/806 , Y10S436/807 , Y10S436/824 , Y10T436/111666 , Y10T436/117497
摘要： A method for combining magnetic and centrifugal extraction techniques in a manner that improves wash efficiency and reduces the relative disadvantages of stand alone magnetic or centrifugal systems is provided. Centrifugation occurs about the rotational axis of a generally circular container with generally vertical sides featuring an inward protruding physical feature designed to retain material that exceeds the density of supernatent liquid and that is bound to magnetic particles during the centrifugation. During centrifugation, an external magnetic field is applied about the rotational axis of the container such that magnetic lines of force penetrate the container in any desired location. The magnetic and centrifugal forces may be independently modulated or modulated in relative unison to suit the hydrodynamic characteristics of a given complex.
摘要翻译：提供了一种以提高洗涤效率和降低独立磁力或离心系统的相对缺点的方式组合磁力和离心萃取技术的方法。围绕大致圆形容器的旋转轴线进行离心，其大致垂直侧面具有向内突出的物理特征，其设计成保留超过上清液密度并且在离心过程中与磁性颗粒结合的材料。在离心期间，围绕容器的旋转轴线施加外部磁场，使得磁力线在任何期望的位置穿过容器。磁力和离心力可以相对一致地独立地调节或调节以适应给定络合物的流体动力特性。

9. 发明授权

US5045473A Apparatus and method for the separation and/or formation of immicible liquid streams 失效
公开(公告)号：US5045473A
公开(公告)日：1991-09-03
申请号：US73049
申请日：1987-07-14
申请人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
发明人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
IPC分类号： B01D17/02 , G01N35/08
CPC分类号： G01N35/08 , B01D17/0214 , Y10T436/118339
摘要： Apparatus and method are provided for the substantial separation on a continuous flow basis of immisicible liquids flowing as a common stream, with one of said liquids substantially encapsulating another of said liquids, in a flow conduit. The conduit comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of another of the liquids; and the liquid separator apparatus are disposed in the conduit and operate to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream as that stream flows into contact with the separator apparatus in the conduit.Apparatus and method for the introduction of a liquid on a continuous flow basis into a flowing stream of another liquid which is immisicible therewith and is flowing in a flow conduit are also provided. The conduit again comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of the other of the liquids; and the liquid introduction apparatus are disposed in the conduit and operate to form a common stream of the liquids for continued flow in the conduit, with one of the liquids being substantially encapsulated by another of the liquids, as the liquids are merged at the liquid introduction apparatus in the conduit.A liquid processing system including the conduit is provided wherein the liquid introduction apparatus are utilized to form the common liquids stream with one of the liquids being substantially encapsulated within the other of the liquids at a first location in the system; and the liquid separator apparatus are utilized to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream at a second location in the system which is downstream of the first location.As representatively configured in the herein disclosed preferred embodiments, the apparatus and method are applied to automated continuous flow sample liquid analysis systems wherein one of the liquids is an aqueous sample liquid, and the other of the liquids is an isolation liquid which selectively "wets" the hydrophobic inner surface of the flow conduit to the substantial exclusion of the aqueous sample liquids, and which functions to substantially encapsulate the aqueous sample liquids in the common liquids stream; and, for such application, the apparatus and method provide for significant increase in the accuracy of the sample liquid analysis results.

10. 发明授权

US4865993A Minimum carryover container, and analysis system incorporating the same 失效
标题翻译：最小残留容器及其结合的分析系统
公开(公告)号：US4865993A
公开(公告)日：1989-09-12
申请号：US161930
申请日：1988-02-29
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： B01L3/00 , G01N1/00 , G01N35/08
CPC分类号： G01N35/08 , B01L3/508 , B01L2300/0858 , G01N35/1095 , Y10T436/117497 , Y10T436/118339
摘要： Minimum carryover container for the successive containment of discrete liquids as are successively introduced thereinto, and minimum carryover discrete liquid analysis system utilizing the container, are disclosed and operate through use of container materials which are selectively wettable by an immiscible isolation liquid which is introduced to the container independently of the discrete liquids to form an independently flowing isolation liquid stream which covers the walls of the container from the container inlet to the container outlet thereby preventing contact by the discrete liquids with the container walls. The container can include wall portions enabling the transmission of light energy therethrough from the outside of the container. The analysis system makes use of the container for the successive containment and processing for analysis of the discrete liquids; and for the generation and supply of an isolation liquid based discrete liquid stream containing the processed discrete liquids in series to analysis apparatus, the successive supply of the processed discrete liquids in series to analysis apparatus by the successive withdrawal thereof from the container, or the successive analyses of the processed discrete liquids in situ in the container, respectively.
摘要翻译：公开了用于连续引入其中的分离液体的连续容纳物的最小携带容器，以及利用该容器的最小携带离散液体分析系统，并通过使用容器材料进行操作，所述容器材料可选择性地被不混溶的隔离液体润湿，容器独立于分立的液体以形成独立流动的隔离液体流，其从容器入口到容器出口覆盖容器的壁，从而防止离散的液体与容器壁的接触。容器可以包括能够从容器的外部透过光能的壁部分。分析系统利用容器进行分离液体的连续封闭和加工; 并且为了分离装置将含有经加工的离散液体的基于隔离液体的离散液体流的产生和供应连续地通过连续地从容器中提取分离装置而连续地供应到分析装置中，在容器中原位处理的离散液体的分析。

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