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1. 发明授权

US5983777A Method and apparatus for diaphragm pumping with adjustable flow 失效
标题翻译：用于可调节流动的隔膜泵送的方法和装置
公开(公告)号：US5983777A
公开(公告)日：1999-11-16
申请号：US992986
申请日：1997-12-18
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： F04B43/00 , F04B43/067 , F01B19/00 , F16J3/00
CPC分类号： F04B43/067 , F04B43/0063 , F04B2201/0206
摘要： An improved method and apparatus for adjusting the flow of a diaphragm pump. The thickness of the diaphragm itself is capable of being adjusted. Full stroke output is thereby reduced in inverse proportion to the increased volume occupied by the diaphragm. Adjusting the thickness of the diaphragm while the pump is operating provides a means of varying pump output without stopping the pump for adjustments or modifications.
摘要翻译：一种调节隔膜泵流量的改进方法和装置。膜片本身的厚度能够被调整。因此，全行程输出与隔膜占用的增加的体积成反比。在泵运行时调节膜片的厚度提供了改变泵输出的方法，而不会停止泵进行调整或修改。

2. 发明授权

US4853336A Single channel continuous flow system 失效
标题翻译：单通道连续流量系统
公开(公告)号：US4853336A
公开(公告)日：1989-08-01
申请号：US10236
申请日：1987-02-02
申请人： Stephen Saros , John L. Smith , Michael M. Cassaday , Rand E. Herron , Milton H. Pelavin
发明人： Stephen Saros , John L. Smith , Michael M. Cassaday , Rand E. Herron , Milton H. Pelavin
IPC分类号： G01N35/04 , G01N35/08
CPC分类号： G01N35/08 , G01N2035/0415 , G01N2035/0443 , G01N35/025 , Y10T436/117497 , Y10T436/118339
摘要： A continuous flow system is disclosed in which successive liquid segments are established containing different related components of a fluid package, such as an analysis mixture, separated by at least one immiscible segment, passed along a first section of a conduit, combined in a second section of the conduit and mixed while passing along a third section of the conduit, so as to provide a completely mixed segment. This system permits the delayed on-line mixing of different components of an analysis mixture, such as samples with reagents or diluents, as well as mixing and interaction of such components in a single conduit.
摘要翻译：公开了一种连续流动系统，其中建立了连续的液体段，其包含流体包装（例如分析混合物）的不同相关组分，分离混合物由至少一个不混溶段分隔，沿着导管的第一部分通过，在第二部分并在通过导管的第三部分时混合，以便提供完全混合的部分。该系统允许分析混合物的不同组分（例如具有试剂或稀释剂的样品）的延迟在线混合，以及这些组分在单个导管中的混合和相互作用。

3. 发明授权

US5149658A Method for the separation and/or formation of immiscible liquid streams 失效
标题翻译：用于分离和/或形成不混溶液体流的方法
公开(公告)号：US5149658A
公开(公告)日：1992-09-22
申请号：US628804
申请日：1990-12-14
申请人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
发明人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
IPC分类号： B01D17/02 , G01N35/08
CPC分类号： G01N35/08 , B01D17/0214 , Y10T436/118339
摘要： Apparatus and method are provided for the substantial separation on a continuous flow basis of immiscible liquids flowing as a common stream, with one of the liquids substantially encapsulating another of the liquids, in a flow conduit. The conduit comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of another of the liquids; and the liquid separator apparatus are disposed in the conduit and operate to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream as that stream flows into contact with the separator apparatus in the conduit.Apparatus and method for the introduction of a liquid on a continuous flow basis into a flowing stream of another liquid which is immiscible therewith and is flowing in a flow conduit are also provided. The conduit again comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of the other of the liquids; and the liquid introduction apparatus are disposed in the conduit and operate to form a common stream of the liquids for continued flow in the conduit, with one of the liquids being substantially encapsulated by another of the liquids, as the liquids are merged at the liquid introduction apparatus in the conduit.
摘要翻译：提供了设备和方法，用于在流动管道中基于连续流动基本上分离作为流体流动的不混溶液体，其中一种液体基本上封装另一种液体。导管包括内表面，其被液体中的一个选择性地“润湿”，从而基本排除另一种液体; 并且液体分离器装置设置在导管中，并且操作成使该液体或液体的至少一部分与普通液体流分离，因为该流与导管中的分离器装置接触。还提供了用于将液体以连续流动基础引入与其不混溶并在流动管道中流动的另一液体的流动流的装置和方法。导管再次包括内表面，该内表面被其中一种液体选择性地“润湿”，从而基本排除另一种液体; 并且液体引入装置设置在导管中并且操作以形成用于在管道中持续流动的液体的公共流，其中一种液体基本上被另一种液体封装，因为液体在液体引入设备在管道中。

4. 发明授权

US4357301A Reaction cuvette 失效
标题翻译：反应试管
公开(公告)号：US4357301A
公开(公告)日：1982-11-02
申请号：US284845
申请日：1981-07-20
申请人： Michael M. Cassaday , Herman G. Diebler , Dario Svenjak , Kenneth F. Uffenheimer
发明人： Michael M. Cassaday , Herman G. Diebler , Dario Svenjak , Kenneth F. Uffenheimer
IPC分类号： G01N33/48 , G01N21/03 , G01N21/25 , G01N35/02 , G01N21/13
CPC分类号： G01N21/253
摘要： The reaction cuvette adapted to receive a liquid dispensing probe and having at least one surface of hydrophilic material which is treated or formed to have inwardly extending projections against which the liquid is dispensed.
摘要翻译：反应试管适于接收液体分配探针并具有至少一个亲水材料表面，其被处理或形成为具有向内延伸的突起，液体被分配到其上。

5. 发明授权

US6150182A Method for separation of components in a biochemical reaction utilizing a combination of magnetic and centrifugal processes 失效
标题翻译：使用磁力和离心过程的组合分离生化反应中的组分的方法
公开(公告)号：US6150182A
公开(公告)日：2000-11-21
申请号：US201010
申请日：1998-11-30
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： B03C1/28 , G01N35/00 , G01N33/553 , C12Q1/66 , G01N15/06 , G01N35/08
CPC分类号： B03C1/288 , G01N35/0098 , Y10S435/971 , Y10S436/806 , Y10S436/807 , Y10S436/824 , Y10T436/111666 , Y10T436/117497
摘要： A method for combining magnetic and centrifugal extraction techniques in a manner that improves wash efficiency and reduces the relative disadvantages of stand alone magnetic or centrifugal systems is provided. Centrifugation occurs about the rotational axis of a generally circular container with generally vertical sides featuring an inward protruding physical feature designed to retain material that exceeds the density of supernatent liquid and that is bound to magnetic particles during the centrifugation. During centrifugation, an external magnetic field is applied about the rotational axis of the container such that magnetic lines of force penetrate the container in any desired location. The magnetic and centrifugal forces may be independently modulated or modulated in relative unison to suit the hydrodynamic characteristics of a given complex.
摘要翻译：提供了一种以提高洗涤效率和降低独立磁力或离心系统的相对缺点的方式组合磁力和离心萃取技术的方法。围绕大致圆形容器的旋转轴线进行离心，其大致垂直侧面具有向内突出的物理特征，其设计成保留超过上清液密度并且在离心过程中与磁性颗粒结合的材料。在离心期间，围绕容器的旋转轴线施加外部磁场，使得磁力线在任何期望的位置穿过容器。磁力和离心力可以相对一致地独立地调节或调节以适应给定络合物的流体动力特性。

6. 发明授权

US5045473A Apparatus and method for the separation and/or formation of immicible liquid streams 失效
公开(公告)号：US5045473A
公开(公告)日：1991-09-03
申请号：US73049
申请日：1987-07-14
申请人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
发明人： Michael M. Cassaday , Vito F. Christiano , Bachalli Vasudeva
IPC分类号： B01D17/02 , G01N35/08
CPC分类号： G01N35/08 , B01D17/0214 , Y10T436/118339
摘要： Apparatus and method are provided for the substantial separation on a continuous flow basis of immisicible liquids flowing as a common stream, with one of said liquids substantially encapsulating another of said liquids, in a flow conduit. The conduit comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of another of the liquids; and the liquid separator apparatus are disposed in the conduit and operate to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream as that stream flows into contact with the separator apparatus in the conduit.Apparatus and method for the introduction of a liquid on a continuous flow basis into a flowing stream of another liquid which is immisicible therewith and is flowing in a flow conduit are also provided. The conduit again comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of the other of the liquids; and the liquid introduction apparatus are disposed in the conduit and operate to form a common stream of the liquids for continued flow in the conduit, with one of the liquids being substantially encapsulated by another of the liquids, as the liquids are merged at the liquid introduction apparatus in the conduit.A liquid processing system including the conduit is provided wherein the liquid introduction apparatus are utilized to form the common liquids stream with one of the liquids being substantially encapsulated within the other of the liquids at a first location in the system; and the liquid separator apparatus are utilized to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream at a second location in the system which is downstream of the first location.As representatively configured in the herein disclosed preferred embodiments, the apparatus and method are applied to automated continuous flow sample liquid analysis systems wherein one of the liquids is an aqueous sample liquid, and the other of the liquids is an isolation liquid which selectively "wets" the hydrophobic inner surface of the flow conduit to the substantial exclusion of the aqueous sample liquids, and which functions to substantially encapsulate the aqueous sample liquids in the common liquids stream; and, for such application, the apparatus and method provide for significant increase in the accuracy of the sample liquid analysis results.

7. 发明授权

US4865993A Minimum carryover container, and analysis system incorporating the same 失效
标题翻译：最小残留容器及其结合的分析系统
公开(公告)号：US4865993A
公开(公告)日：1989-09-12
申请号：US161930
申请日：1988-02-29
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： B01L3/00 , G01N1/00 , G01N35/08
CPC分类号： G01N35/08 , B01L3/508 , B01L2300/0858 , G01N35/1095 , Y10T436/117497 , Y10T436/118339
摘要： Minimum carryover container for the successive containment of discrete liquids as are successively introduced thereinto, and minimum carryover discrete liquid analysis system utilizing the container, are disclosed and operate through use of container materials which are selectively wettable by an immiscible isolation liquid which is introduced to the container independently of the discrete liquids to form an independently flowing isolation liquid stream which covers the walls of the container from the container inlet to the container outlet thereby preventing contact by the discrete liquids with the container walls. The container can include wall portions enabling the transmission of light energy therethrough from the outside of the container. The analysis system makes use of the container for the successive containment and processing for analysis of the discrete liquids; and for the generation and supply of an isolation liquid based discrete liquid stream containing the processed discrete liquids in series to analysis apparatus, the successive supply of the processed discrete liquids in series to analysis apparatus by the successive withdrawal thereof from the container, or the successive analyses of the processed discrete liquids in situ in the container, respectively.
摘要翻译：公开了用于连续引入其中的分离液体的连续容纳物的最小携带容器，以及利用该容器的最小携带离散液体分析系统，并通过使用容器材料进行操作，所述容器材料可选择性地被不混溶的隔离液体润湿，容器独立于分立的液体以形成独立流动的隔离液体流，其从容器入口到容器出口覆盖容器的壁，从而防止离散的液体与容器壁的接触。容器可以包括能够从容器的外部透过光能的壁部分。分析系统利用容器进行分离液体的连续封闭和加工; 并且为了分离装置将含有经加工的离散液体的基于隔离液体的离散液体流的产生和供应连续地通过连续地从容器中提取分离装置而连续地供应到分析装置中，在容器中原位处理的离散液体的分析。

8. 发明授权

US4526754A Sample transport system 失效
标题翻译：样品运输系统
公开(公告)号：US4526754A
公开(公告)日：1985-07-02
申请号：US403886
申请日：1982-07-30
申请人： Donald A. Burns , Marvin Margoshes , Michael M. Cassaday
发明人： Donald A. Burns , Marvin Margoshes , Michael M. Cassaday
IPC分类号： B65G53/00 , B01J4/00 , G01N1/00 , G01N35/08
CPC分类号： G01N35/08 , Y10T436/118339
摘要： A transport system is provided in which a plurality of samples are introduced into a carrier stream flowing through a conduit, whose inner surface is coated with an immiscible liquid film. The carrier stream can be a sequence of alternating gas and liquid segments which are in direct contact with each other and, thus, not encompassed by the immiscible liquid. Samples are introduced at various points along the conduit and, thus, the system allows for the collection and transport of samples from a plurality of remote locations to at least one central receiving station where they can, for example, be analyzed. Carryover between successive samples to be transported is effectively eliminated.
摘要翻译：提供了一种输送系统，其中将多个样品引入流过导管的载体流中，其内表面涂覆有不混溶的液膜。载体流可以是交替的气体和液体段的序列，其彼此直接接触，并且因此不被不混溶液体包围。样品被引入沿着导管的各个点，因此，系统允许将样品从多个远程位置收集和传输到至少一个中央接收站，在这些中心接收站中，例如可以对其进行分析。有效地消除了要运输的连续样品之间的残留。

9. 发明授权

US5192504A Flushable low carryover container 失效
标题翻译：可冲洗的低残留容器
公开(公告)号：US5192504A
公开(公告)日：1993-03-09
申请号：US387267
申请日：1989-07-28
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： B01L3/00 , G01N1/00 , G01N35/08
CPC分类号： G01N35/08 , B01L3/508 , B01L2300/0858 , G01N35/1095 , Y10T436/117497 , Y10T436/118339
摘要： Minimum carryover container for the successive containment of discrete liquids as are successively introduced thereinto, and minimum carryover discrete liquid analysis system utilizing the container, are disclosed; and operate through use of container materials which are selectively wettable by an immiscible isolation liquid which is introduced to the container independently of the discrete liquids to form an independently flowing isolation liquid stream which covers the walls of the container from the container inlet to the container outlet thereby preventing contact by the discrete liquids with the container walls. The container can include wall portions enabling the transmission of light energy therethrough from the outside of the container. The analysis system makes use of the container for the successive containment and processing for analysis of the discrete liquids; and for the generation and supply of an isolation liquid based discrete liquid stream containing the processed discrete liquids in series to analysis apparatus, the successive supply of the processed discrete liquids in series to anlysis apparatus by the successive withdrawal thereof from the container, or the successive analyses of the processed discrete liquids in situ in the container, respectively.
摘要翻译：公开了连续引入其中的连续容纳分立液体的最小排放容器，以及利用该容器的最小携带离散液体分析系统。并通过使用容器材料进行操作，所述容器材料可选择性地被不混溶的隔离液体润湿，所述隔离液体被独立于离散的液体引入到容器中，以形成独立流动的隔离液体流，其从容器入口到容器出口从而防止离散液体与容器壁接触。容器可以包括能够从容器的外部透过光能的壁部分。分析系统利用容器进行分离液体的连续封闭和加工; 并且为了分离装置将含有经处理的离散液体的基于隔离液体的离散液体流的产生和供应连续地通过连续地从容器中提取分离液体而连续地供给分解装置，在容器中原位处理的离散液体的分析。

10. 发明授权

US4678641A Isolation liquid layer retention device 失效
标题翻译：隔离液层保留装置
公开(公告)号：US4678641A
公开(公告)日：1987-07-07
申请号：US879918
申请日：1986-06-30
申请人： Michael M. Cassaday
发明人： Michael M. Cassaday
IPC分类号： G01N35/02 , B01J19/16 , B01L99/00 , G01N1/00 , G01N35/00 , G01N35/10 , B01L11/00
CPC分类号： B01J19/16 , B01L99/00 , G01N2035/00277 , G01N35/1095
摘要： A new and improved isolation liquid layer retention device is provided, and comprises a porous member operatively associated with the interior of a container which contains a quantity of an aqueous liquid having a layer of a generally immiscible isolation liquid which is generally of greater density disposed thereon. The porous member is operable to cause the aqueous liquid to form a generally convex meniscus to strongly support the generally denser isolation liquid layer thereon to prevent the sinking of the isolation liquid into the aqueous liquid; and is operable to act as a moderating control by virtue of a "source and sink" action vis-a-vis the isolation liquid to maintain a uniform and readily reproducible configuration for the isolation liquid layer on a container-to-container basis with regard to each of a plurality of the containers. The device is particularly adapted for use with a plurality of containers of aqueous sample and reagent liquids in contemporary automated sample liquid analysis systems.
摘要翻译：提供了一种新的和改进的隔离液层保持装置，并且包括可操作地与容器内部相关联的多孔构件，该多孔构件包含一定量的水性液体，该水性液体具有通常具有较大密度的层，通常不混溶的隔离液体通常具有较大密度。多孔构件可操作以使水性液体形成大致凸起的弯液面，以强力地支撑其上通常更密的隔离液层，以防止隔离液体沉入水性液体中; 并且可操作地作为相对于隔离液体的“源和汇”动作的调节控制，以便在容器到容器的基础上保持用于隔离液层的均匀且容易重现的构造到多个容器中的每一个。该装置特别适用于当代自动化样品液体分析系统中的多个水性样品和试剂液体的容器。

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