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1. 发明申请

US20100008873A1 Use of benzotriazole derivatives for photostabilisation 有权
标题翻译：苯并三唑衍生物用于光稳定化
公开(公告)号：US20100008873A1
公开(公告)日：2010-01-14
申请号：US11919104
申请日：2006-04-20
申请人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
发明人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
IPC分类号： A61K8/49 , A61P17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

2. 发明授权

US08361446B2 Use of benzotriazole derivatives for photostabilisation 有权
标题翻译：苯并三唑衍生物用于光稳定化
公开(公告)号：US08361446B2
公开(公告)日：2013-01-29
申请号：US11919104
申请日：2006-04-20
申请人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
发明人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
IPC分类号： A61K8/49 , A61P17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

3. 发明授权

US09656103B2 Light protecting-effective cosmetic or dermatological preparations 有权
公开(公告)号：US09656103B2
公开(公告)日：2017-05-23
申请号：US11632686
申请日：2005-07-11
申请人： Stefan Müller , Thomas Ehlis , Jochen Giesinger , Gilbert Kreyer
发明人： Stefan Müller , Thomas Ehlis , Jochen Giesinger , Gilbert Kreyer
IPC分类号： A61Q17/04 , A61K8/02 , A61K9/107 , A61K8/06
CPC分类号： A61Q17/04 , A61K8/02 , A61K9/107 , A61K2800/412
摘要： Disclosed is the use of an insoluble or sparingly soluble micronized substance class which is not a cosmetic UV absorber and which is dispersed in the oil- or water-phase of a cosmetic or dermatological composition for the enhancement of light protecting action of this cosmetic or dermatological composition comprising at least one cosmetic UV filter which is soluble in the water- or oil-phase. The cosmetic preparation according to the invention shows a remarkable increase in SPF.

4. 发明申请

US20090214453A1 Use of Transmission Dyes for Protecting Human Skin From Browning and Ageing 有权
标题翻译：使用透射染料保护人体皮肤免于褐变和老化
公开(公告)号：US20090214453A1
公开(公告)日：2009-08-27
申请号：US12086648
申请日：2006-12-11
申请人： Stefan Müller , Jurg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
发明人： Stefan Müller , Jurg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
IPC分类号： A61Q17/04 , C07D241/04
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

5. 发明授权

US08097240B2 Use of transmission dyes for protecting human skin from browning and ageing 有权
标题翻译：使用透射染料保护人体皮肤免受褐变和老化
公开(公告)号：US08097240B2
公开(公告)日：2012-01-17
申请号：US12086648
申请日：2006-12-11
申请人： Stefan Müller , Jürg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
发明人： Stefan Müller , Jürg Haase , Thomas Ehlis , Gilbert Kreyer , Jochen Giesinger , Martin Vogt
IPC分类号： A61Q17/04 , C07D241/04
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

6. 发明申请

US20080075746A1 Light Protecting-Effective Cosmetic or Dermatological Preparations 有权
标题翻译：光保护有效的化妆品或皮肤病学制剂
公开(公告)号：US20080075746A1
公开(公告)日：2008-03-27
申请号：US11632686
申请日：2005-07-11
申请人： Stefan Muller , Thomas Ehlis , Jochen Giesinger , Gilbert Kreyer
发明人： Stefan Muller , Thomas Ehlis , Jochen Giesinger , Gilbert Kreyer
IPC分类号： A61K8/02 , A61K8/00 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/02 , A61K9/107 , A61K2800/412
摘要： Disclosed is the use of an insoluble or sparingly soluble micronized substance class which is not a cosmetic UV absorber and which is dispersed in the oil- or water-phase of a cosmetic or dermatological composition for the enhancement of light protecting action of this cosmetic or dermatological composition comprising at least one cosmetic UV filter which is soluble in the water- or oil-phase. The cosmetic preparation according to the invention shows a remarkable increase in SPF.
摘要翻译：公开了使用不是化妆品UV吸收剂并且分散在化妆品或皮肤病学组合物的油相或水相中的不溶性或微溶的微粉化物质类，以增强该化妆品或皮肤病学的光保护作用组合物，其包含至少一种可溶于水相或油相的化妆品UV过滤器。根据本发明的化妆品显示出SPF的显着增加。

7. 发明申请

US20120128745A1 BENZYLIDENE MALONATES 审中-公开
标题翻译：苯并噻唑啉酮
公开(公告)号：US20120128745A1
公开(公告)日：2012-05-24
申请号：US13322628
申请日：2010-05-19
申请人： Markus Hansch , Thomas Ehlis , Olof Wallquist , Barbara Wagner , Bernd Herzog , Jochen Giesinger
发明人： Markus Hansch , Thomas Ehlis , Olof Wallquist , Barbara Wagner , Bernd Herzog , Jochen Giesinger
IPC分类号： A61K8/02 , C07C69/734 , A61K8/41 , A61K8/49 , A61K8/37 , A61Q17/04
CPC分类号： A61K8/37 , A61Q17/04 , C07C69/73
摘要： Disclosed is the use of benzylidene malonates of formula (1) wherein R1 is methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; a radical of formula (1a) or a radical of formula (1b) wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; for the protection of human and animal hair and skin against UV radiation.
摘要翻译：公开了使用式（1）的亚苄基丙二酸酯，其中R 1是甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基，那么R是叔丁基。丁基; 式（1a）的基团或式（1b）的基团，其中R2和R3彼此独立地为氢; 或甲基; R4是甲基; 乙基; 或正丙基; R5和R6彼此独立地是氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基，那么R是异丙基; 用于保护人和动物的头发和皮肤免受紫外线辐射。

8. 发明授权

US08535648B2 Stabilization of UV-sensitive active ingredients 有权
标题翻译：紫外线敏感活性成分的稳定化
公开(公告)号：US08535648B2
公开(公告)日：2013-09-17
申请号：US12520880
申请日：2008-01-16
申请人： Barbara Wagner , Bernd Herzog , Stefan Müller , Thomas Ehlis
发明人： Barbara Wagner , Bernd Herzog , Stefan Müller , Thomas Ehlis
IPC分类号： A61K8/00
CPC分类号： A61K8/41 , A61K8/35 , A61K8/44 , A61K2800/52 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/004 , A61Q19/04
摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.
摘要翻译：公开了式（1）的部花青衍生物用于稳定紫外线敏感活性成分如二苯甲酰甲烷衍生物的用途。

9. 发明授权

US07772242B2 Merocyanine derivatives 有权
公开(公告)号：US07772242B2
公开(公告)日：2010-08-10
申请号：US11630489
申请日：2005-06-20
申请人： Barbara Wagner , Frank Bienewald , Heinz Wolleb , Olof Wallquist , Bernd Herzog , Thomas Ehlis , Jürg Haase
发明人： Barbara Wagner , Frank Bienewald , Heinz Wolleb , Olof Wallquist , Bernd Herzog , Thomas Ehlis , Jürg Haase
IPC分类号： A61K31/519 , A61K31/445 , A61K31/16 , A61K31/165
CPC分类号： A61K8/498 , A61K8/4913 , A61K8/494 , A61Q17/04
摘要： Disclosed is the use of the compounds of formula wherein Q is —OH; —OR7; —NH2; —NHR7; —NR7R8; or —N═R9; T is —COR5; —CN; or —SO2—(C6-C12)aryl; R1 is hydrogen; —OR7, —SR7; —NHR7; —NR7R8; C1-C22alkyl; C2-C12Alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl, C2-C11heteroaralkyl; C6-C10aryl; or C1-C9heteroaryl; R2 and R3 independently from each other are C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl, C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C3-C12cycloheteroalkyl; C2-C11heteroaralkyl, C6-C10aryl; or C1-C9heteroaryl; R4 is cyano; COR7, COOR7; CONH2; CONHR7; CONR7R8; SO2(C6-C12)aryl, C2-C12alk-1 -enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl, C3-C5heterocycloalkyl, C6-C10aryl; or C1-C9heteroaryl; R5 is —COR7; —COOR7; —OR7; —SR7, —NHR7, —NR7R8; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12alkylphenyl; C1-C12alkoxy-C6-C10aryl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C3-C12cycloheteroalkyl; C6-C10aryl; C1-C12alkoxy-C6-C10aryl or C1-C9heteroaryl; R6, R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; o-C6-C10aryl; or C1-C9heteroaryl; R9 is a (C1-C6)alkylidene radical; or R1 and R2, R1 and Q, R1 and R4, R1 and R6, R2 and R3, R3 and Q, R6 and Q, T and Q, each independently, are linked together, so that 1, 2, 3 or 4 carbocyclic or N, O and/or S-heterocyclic rings are formed, wherein each of them, independently from each other, may be condensed with an aromatic or heteroaromatic ring, and/or more N-, O- and/or S-heterocycic rings, and each N atom in a N-heterocyclic ring may be substituted by C1-C22alkyl; and n is a number from 1 to 4; for protecting of human hair and skin against the damaging effect of UV radiation.

10. 发明授权

US6111103A Diresorcinyl-alkoxy- and -aryloxy-s-triazines 失效
标题翻译：二氧化物 - 烷氧基 - 和 - 芳氧基-s-三嗪
公开(公告)号：US6111103A
公开(公告)日：2000-08-29
申请号：US287029
申请日：1999-04-06
申请人： Thomas Ehlis , Elek Borsos , Helmut Luther , Bernd Herzog
发明人： Thomas Ehlis , Elek Borsos , Helmut Luther , Bernd Herzog
IPC分类号： A61K8/00 , A61K8/49 , A61Q17/04 , C07D251/22 , C07D251/26 , C07D405/12 , C08K5/3492 , C09K3/00 , C09K15/30
CPC分类号： C07D405/12 , A61K8/4966 , A61Q17/04 , C07D251/22
摘要： The invention relates to diresorcinyl-alkoxy- and -aryloxy-triazines of the formula ##STR1## in which R.sub.1 is C.sub.2 -C.sub.30 alkyl; C.sub.2 -C.sub.30 alkenyl; unsubstituted or C.sub.1 -C.sub.5 alkyl-mono- or polysubstituted C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.5 alkoxy-C.sub.1 -C.sub.12 alkyl; amino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 monoalkylamino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 dialkylamino-C.sub.1 -C.sub.12 alkyl; a radical of the formula ##STR2## R.sub.2, R.sub.3 and R.sub.4, independently of one another, are hydrogen, hydroxyl, C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.30 alkenyl,R.sub.5 is hydrogen; or C.sub.1 -C.sub.5 alkyl;m.sub.1 is 0 or 1; andn.sub.1 is 1 to 5.The novel compounds are suitable as cosmetic UV-A absorbers.
摘要翻译：本发明涉及下式的二缩水甘油基 - 烷氧基 - 和 - 芳氧基 - 三嗪，其中R 1是C 2 -C 30烷基; C2-C30烯基; 未取代的或C 1 -C 5烷基 - 单取代或多取代的C 5 -C 12环烷基，C 1 -C 5烷氧基-C 1 -C 12烷基; 氨基-C 1 -C 12烷基; C 1 -C 5单烷基氨基-C 1 -C 12烷基; C 1 -C 5二烷基氨基-C 1 -C 12烷基; 式R2，R3和R4彼此独立的基团是氢，羟基，C 1 -C 30烷基，C 1 -C 30烯基，R 5是氢; 或C 1 -C 5烷基; m1为0或1; n1为1〜5。新化合物适合作为化妆品UV-A吸收剂。

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