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1. 发明授权

US07403891B2 Apparatus and method for recognizing biological named entity from biological literature based on UMLS 失效
标题翻译：基于UMLS的生物文献识别生物命名实体的装置和方法
公开(公告)号：US07403891B2
公开(公告)日：2008-07-22
申请号：US10777072
申请日：2004-02-13
申请人： Soo Jun Park , Tae Hyun Kim , Hyun Sook Lee , Hyun Chul Jang , Seon Hee Park
发明人： Soo Jun Park , Tae Hyun Kim , Hyun Sook Lee , Hyun Chul Jang , Seon Hee Park
IPC分类号： G06F17/27 , G06F17/21 , G06F7/00 , G06F17/30 , G10L15/00
CPC分类号： G06Q50/22 , G06F19/00 , Y10S707/99933 , Y10S707/99943
摘要： The present invention relates to an apparatus and method for recognizing biological named entity from biological literature based on united medical language system (UMLS). The apparatus and the method receives metathesaurus from the UMLS, constructs a concept name database, a single name database and a category keyterm database, which are language resources to be used recognize a named entity, receives each concept name stored in the concept name database, extracts features of each of the concept names by using data stored in the single name database and the category keyterm database, constructs a rule database by creating rules used to recognize the named entity and filtering the rules by using the extracted features, receives a biological literature, extracts nouns and noun phrases that are candidate named entities, applies the rules stored in the rule database to the nouns and the noun phrases, and recognizes the named entities. In the present invention, the biological named entities can be effectively extracted which can be used as important information individual in input literature.
摘要翻译：本发明涉及一种基于联合医学语言系统（UMLS）从生物文献识别生物命名实体的装置和方法。该装置和方法从UMLS接收metathesaurus，构建一个概念名称数据库，一个单一名称数据库和一个类别keyterm数据库，它们是用于识别命名实体的语言资源，接收存储在概念名称数据库中的每个概念名称，通过使用存储在单个名称数据库和类别keyterm数据库中的数据来提取每个概念名称的特征，通过创建用于识别命名实体的规则并通过使用提取的特征来过滤规则来构建规则数据库，接收生物文献提取作为候选名称实体的名词和名词短语，将存储在规则数据库中的规则应用于名词和名词短语，并识别命名实体。在本发明中，可以有效地提取生物名称的实体，其可以用作输入文献中个体的重要信息。

2. 发明申请

US20050091081A1 Apparatus and method for recognizing biological named entity from biological literature based on UMLS 失效
标题翻译：基于UMLS的生物文献识别生物命名实体的装置和方法
公开(公告)号：US20050091081A1
公开(公告)日：2005-04-28
申请号：US10777072
申请日：2004-02-13
申请人： Soo Jun Park , Tae Hyun Kim , Hyun Sook Lee , Hyun Chul Jang , Seon Hee Park
发明人： Soo Jun Park , Tae Hyun Kim , Hyun Sook Lee , Hyun Chul Jang , Seon Hee Park
IPC分类号： G06F17/20 , G06Q50/00 , G06F17/60
CPC分类号： G06Q50/22 , G06F19/00 , Y10S707/99933 , Y10S707/99943
摘要： The present invention relates to an apparatus and method for recognizing biological named entity from biological literature based on united medical language system (UMLS). The apparatus and the method receives metathesaurus from the UMLS, constructs a concept name database, a single name database and a category keyterm database, which are language resources to be used recognize a named entity, receives each concept name stored in the concept name database, extracts features of each of the concept names by using data stored in the single name database and the category keyterm database, constructs a rule database by creating rules used to recognize the named entity and filtering the rules by using the extracted features, receives a biological literature, extracts nouns and noun phrases that are candidate named entities, applies the rules stored in the rule database to the nouns and the noun phrases, and recognizes the named entities. In the present invention, the biological named entities can be effectively extracted which can be used as important information individual in input literature.
摘要翻译：本发明涉及一种基于联合医学语言系统（UMLS）从生物文献识别生物命名实体的装置和方法。该装置和方法从UMLS接收metathesaurus，构建一个概念名称数据库，一个单一名称数据库和一个类别keyterm数据库，它们是用于识别命名实体的语言资源，接收存储在概念名称数据库中的每个概念名称，通过使用存储在单个名称数据库和类别keyterm数据库中的数据来提取每个概念名称的特征，通过创建用于识别命名实体的规则并通过使用提取的特征来过滤规则来构建规则数据库，接收生物文献提取作为候选名称实体的名词和名词短语，将存储在规则数据库中的规则应用于名词和名词短语，并识别命名实体。在本发明中，可以有效地提取生物名称的实体，其可以用作输入文献中个体的重要信息。

3. 发明授权

US08257953B2 Hyperthermophilic DNA polymerase and methods of preparation thereof 有权
标题翻译：超嗜热DNA聚合酶及其制备方法
公开(公告)号：US08257953B2
公开(公告)日：2012-09-04
申请号：US12089587
申请日：2006-10-02
申请人： Jung Hyun Lee , Suk Tae Kwon , Sung Gyun Kang , Sang Jin Kim , Jung Ho Hyun , Kae Kyoung Kwon , Yun Jae Kim , Hyun Sook Lee , Seung Seob Bae , Ki Hoon Nam , Jae Kyu Lim , Jung Ho Jeon , Sung Hyun Yang
发明人： Jung Hyun Lee , Suk Tae Kwon , Sung Gyun Kang , Sang Jin Kim , Jung Ho Hyun , Kae Kyoung Kwon , Yun Jae Kim , Hyun Sook Lee , Seung Seob Bae , Ki Hoon Nam , Jae Kyu Lim , Jung Ho Jeon , Sung Hyun Yang
IPC分类号： C12N9/12 , C12N15/11
CPC分类号： C12N9/1252
摘要： The present invention relates to a hyperthermophilic DNA polymerase and a preparation method thereof. The invention provides a novel hyperthermophilic DNA polymerase isolated from a Thermococcus sp. strain, a functional equivalent thereof, a protein having the amino acid sequence thereof, and a preparation method thereof. The DNA polymerase according to the invention is a DNA polymerase, which is hyperthermophilic and has an elongation ability and fidelity higher than those of prior commercial DNA polymerases. Thus, the DNA polymerase according to the invention will be useful in precision analysis, precision diagnosis, identification and the like, which require accurate PCR.
摘要翻译：本发明涉及一种超嗜热DNA聚合酶及其制备方法。本发明提供了从Thermococcus sp。分离的新型超嗜热DNA聚合酶。菌株，其功能等同物，具有其氨基酸序列的蛋白质及其制备方法。根据本发明的DNA聚合酶是DNA聚合酶，其是超嗜热的，并且具有比以前的商业DNA聚合酶更高的伸长能力和保真度。因此，根据本发明的DNA聚合酶可用于需要精确PCR的精密分析，精确诊断，鉴定等。

4. 发明授权

US08632471B2 Pulsimeter sensor using hall device 有权
标题翻译：脉冲传感器使用霍尔器
公开(公告)号：US08632471B2
公开(公告)日：2014-01-21
申请号：US12310640
申请日：2007-02-20
申请人： Sang Suk Lee , Sang Dae Choi , Myoung Chone An , Young Kuen Choi , Ki Wang Kim , Dal Ho Park , Do Gwun Hwang , Soo Yong Ahn , Mi Sun Kim , Hyun Sook Lee , Hyeon Ho Kim
发明人： Sang Suk Lee , Sang Dae Choi , Myoung Chone An , Young Kuen Choi , Ki Wang Kim , Dal Ho Park , Do Gwun Hwang , Soo Yong Ahn , Mi Sun Kim , Hyun Sook Lee , Hyeon Ho Kim
IPC分类号： A61B5/02
CPC分类号： A61B5/02438 , A61B5/02444 , A61B2562/02 , A61B2562/046
摘要： The present invention relates to a noninvasive medical pulsimeter sensor using a hall device. By forming a pulse-sensing part array with a hall device as a magnetic sensor, over the skin-contacting part which consists of a magnetic material, the present invention increases the integrity of sensors, enables to understand the spatial characteristics of the pulse which cannot be determined by the conventional pressure sensors, minimize the time for searching the pulse, and is applicable widely to portable pulsimeters and the likes.
摘要翻译：本发明涉及使用霍尔装置的无创医疗脉搏传感器。通过形成具有作为磁传感器的霍尔器件的脉冲感测部件阵列，在由磁性材料构成的皮肤接触部分之上，本发明增加了传感器的完整性，使得能够理解不能由传统的压力传感器确定，从而最小化搜索脉冲的时间，并广泛应用于便携式脉搏计等。

5. 发明申请

US20100297706A1 MUTANT DNA POLYMERASES AND THEIR GENES FROM THERMOCOCCUS 审中-公开
标题翻译：突变DNA聚合酶及其基因
公开(公告)号：US20100297706A1
公开(公告)日：2010-11-25
申请号：US12525347
申请日：2007-10-02
申请人： Jung Hyun Lee , Sung Gyun Kang , Sang Jin Kim , Kae Kyoung Kwon , Hyun Sook Lee , Yun Jae Kim , Yong Gu Ryu , Seung Seob Bae , Jae Kyu Lim , Jung Ho Jeon , Yo Na Cho
发明人： Jung Hyun Lee , Sung Gyun Kang , Sang Jin Kim , Kae Kyoung Kwon , Hyun Sook Lee , Yun Jae Kim , Yong Gu Ryu , Seung Seob Bae , Jae Kyu Lim , Jung Ho Jeon , Yo Na Cho
IPC分类号： C12P19/34 , C12N9/10 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C12N9/1252
摘要： The present invention relates to mutant DNA polymerases and their genes isolated from Thermococcus sp. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids sequences, recombinant vectors containing said nucleic acids sequences, host cells transformed with thereof and methods for producing mutant DNA polymerase protein by using thereof. As mutant DNA polymerases according to the present invention have increased processivity by site-specific mutagenesis on exonuclease active site compared to wild type DNA polymerase, the present invention is broadly applicable for PCR in various molecular genetic technologies.
摘要翻译：本发明涉及从Thermococcus sp。分离的突变型DNA聚合酶及其基因。更具体地，本发明涉及最初从Thermococcus sp NA1分离的突变型DNA聚合酶。菌株并通过位点特异性诱变产生，其氨基酸序列，编码所述突变型DNA聚合酶的基因，其核酸序列，含有所述核酸序列的重组载体，用其转化的宿主细胞和通过使用其产生突变型DNA聚合酶蛋白的方法。由于本发明的突变型DNA聚合酶与野生型DNA聚合酶相比，通过对外切核酸酶活性位点的位点特异性诱变具有增加的进行性，因此本发明广泛适用于各种分子遗传技术中的PCR。

6. 发明申请

US20110020896A1 MUTANT DNA POLYMERASES AND THEIR GENES 审中-公开
标题翻译：突变DNA聚合酶及其基因
公开(公告)号：US20110020896A1
公开(公告)日：2011-01-27
申请号：US12444015
申请日：2007-10-02
申请人： Jung Hyun Lee , Sung Gyun Kang , Sang Jin Kim , Kae Kyoung Kwon , Hyun Sook Lee , Yun Jae Kim , Seung Seob Bae , Jae Kyu Lim , Jung Ho Jeon , Yo Na Cho , Suk Tae Kwon
发明人： Jung Hyun Lee , Sung Gyun Kang , Sang Jin Kim , Kae Kyoung Kwon , Hyun Sook Lee , Yun Jae Kim , Seung Seob Bae , Jae Kyu Lim , Jung Ho Jeon , Yo Na Cho , Suk Tae Kwon
IPC分类号： C12N9/12 , C07H21/00 , C12N15/63 , C12N5/10
CPC分类号： C12N9/1252
摘要： The present invention relates to mutant DNA polymerases, their genes and their uses. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids and PCR methods by using thereof. As mutant DNA polymerases according to the present invention have decreased proofreading activity and changed function of inosine sensing effectively compared to wild type DNA polymerase, PCR using primers with specific nucleic acids has made rapid progress. Therefore, the present invention is broadly applicable for PCR in various molecular genetic technologies.
摘要翻译：本发明涉及突变型DNA聚合酶，其基因及其用途。更具体地，本发明涉及最初从Thermococcus sp NA1分离的突变型DNA聚合酶。菌株并通过位点特异性诱变产生，其氨基酸序列，编码所述突变型DNA聚合酶的基因，其核酸和通过其使用的PCR方法。由于与野生型DNA聚合酶相比，根据本发明的突变型DNA聚合酶与野生型DNA聚合酶相比，具有降低的校正活性和肌苷感应功能的改变，所以使用具有特异性核酸的引物的PCR已经取得了快速进展。因此，本发明广泛适用于各种分子遗传技术中的PCR。

7. 发明申请

US20100105045A1 DNP63A Gene and Screening Methods of Anticancer Agent by Using it 有权
标题翻译： DNP63A基因和抗癌剂的筛选方法
公开(公告)号：US20100105045A1
公开(公告)日：2010-04-29
申请号：US12532267
申请日：2007-03-30
申请人： Hyun Sook Lee , Jung Hwa Lee
发明人： Hyun Sook Lee , Jung Hwa Lee
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2333/4748
摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.
摘要翻译：本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。

8. 发明授权

US08232070B2 DNP63A gene and screening methods of anticancer agent by using it 有权
标题翻译： DNP63A基因和抗癌剂的筛选方法
公开(公告)号：US08232070B2
公开(公告)日：2012-07-31
申请号：US12532267
申请日：2007-03-30
申请人： Hyun Sook Lee , Jung Hwa Lee
发明人： Hyun Sook Lee , Jung Hwa Lee
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2333/4748
摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.
摘要翻译：本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。

9. 发明申请

US20100311142A1 Novel Hydrogenases Isolated from Thermococcus SPP., Genes Encoding the Same, and Methods for Producing Hydrogen Using Microorganisms Having the Genes 有权
标题翻译：从热球菌SPP分离的新型氢化酶，其编码基因以及使用具有基因的微生物产生氢的方法
公开(公告)号：US20100311142A1
公开(公告)日：2010-12-09
申请号：US12746090
申请日：2009-09-07
申请人： Jung Hyun Lee , Sung Gyun Kang , Hyun Sook Lee , Sang Jin Kim , Kae Kyoung Kwon , Sun Shin Cha , Jung Ho Jeon , Yona Cho , Yun Jae Kim , Seung Seop Bae , Jae Kyu Lim , In Soon Jeong
发明人： Jung Hyun Lee , Sung Gyun Kang , Hyun Sook Lee , Sang Jin Kim , Kae Kyoung Kwon , Sun Shin Cha , Jung Ho Jeon , Yona Cho , Yun Jae Kim , Seung Seop Bae , Jae Kyu Lim , In Soon Jeong
IPC分类号： C12P3/00 , C12N9/02 , C12N15/53 , C12N15/63 , C12N1/00
CPC分类号： C12N9/0006 , C12N9/0067 , C12P3/00 , C12R1/01 , Y02P20/132 , Y02P20/52
摘要： The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.
摘要翻译：本发明涉及从属于Thermococcus spp的新型超嗜热菌株分离的新型氢化酶，编码氢化酶的基因，以及使用具有该基因的菌株产生氢的方法。根据本发明的氢生产方法，仅通过在特定培养条件下培养菌株可以产生大量的氢。因此，本发明的方法的优点在于它们比现有的氢气生产方法更经济和有效，并且即使在高温下也可以产生氢。

10. 发明申请

US20100179440A1 Pulsimeter sensor using hall device 有权
标题翻译：脉冲传感器使用霍尔器
公开(公告)号：US20100179440A1
公开(公告)日：2010-07-15
申请号：US12310640
申请日：2007-02-20
申请人： Sang Suk Lee , Sang Dae Choi , Myoung Chone An , Young Kuen Choi , Ki Wang Kim , Dal Ho Park , Do Gwun Hwang , Soo Yong Ahn , Mi Sun Kim , Hyun Sook Lee , Hyeon Ho Kim
发明人： Sang Suk Lee , Sang Dae Choi , Myoung Chone An , Young Kuen Choi , Ki Wang Kim , Dal Ho Park , Do Gwun Hwang , Soo Yong Ahn , Mi Sun Kim , Hyun Sook Lee , Hyeon Ho Kim
IPC分类号： A61B5/0245
CPC分类号： A61B5/02438 , A61B5/02444 , A61B2562/02 , A61B2562/046
摘要： The present invention relates to a noninvasive medical pulsimeter sensor using a hall device. By forming a pulse-sensing part array with a hall device as a magnetic sensor, over the skin-contacting part which consists of a magnetic material, the present invention increases the integrity of sensors, enables to understand the spatial characteristics of the pulse which cannot be determined by the conventional pressure sensors, minimize the time for searching the pulse, and is applicable widely to portable pulsimeters and the likes.
摘要翻译：本发明涉及使用霍尔装置的无创医疗脉搏传感器。通过形成具有作为磁传感器的霍尔器件的脉冲感测部件阵列，在由磁性材料构成的皮肤接触部分之上，本发明增加了传感器的完整性，使得能够理解不能由传统的压力传感器确定，从而最小化搜索脉冲的时间，并广泛应用于便携式脉搏计等。

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