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1. 发明申请

US20100105045A1 DNP63A Gene and Screening Methods of Anticancer Agent by Using it 有权
标题翻译： DNP63A基因和抗癌剂的筛选方法
公开(公告)号：US20100105045A1
公开(公告)日：2010-04-29
申请号：US12532267
申请日：2007-03-30
申请人： Hyun Sook Lee , Jung Hwa Lee
发明人： Hyun Sook Lee , Jung Hwa Lee
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2333/4748
摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.
摘要翻译：本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。

2. 发明授权

US08232070B2 DNP63A gene and screening methods of anticancer agent by using it 有权
标题翻译： DNP63A基因和抗癌剂的筛选方法
公开(公告)号：US08232070B2
公开(公告)日：2012-07-31
申请号：US12532267
申请日：2007-03-30
申请人： Hyun Sook Lee , Jung Hwa Lee
发明人： Hyun Sook Lee , Jung Hwa Lee
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2333/4748
摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.
摘要翻译：本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。

3. 发明授权

US09435771B2 Multi-functional option valve, multifunctional fully automatic liquid chromatography system including the same, and method for analyzing sample using the same 有权
标题翻译：多功能选择阀，包括其的多功能全自动液相色谱系统和使用其的样品分析方法
公开(公告)号：US09435771B2
公开(公告)日：2016-09-06
申请号：US13397409
申请日：2012-02-15
申请人： Sang-Won Lee , Seok-Won Hyung , Jung Hwa Lee , Kyong-Chul Kim , Dong-Gi Mun
发明人： Sang-Won Lee , Seok-Won Hyung , Jung Hwa Lee , Kyong-Chul Kim , Dong-Gi Mun
IPC分类号： G01N30/08 , G01N30/20 , B01D15/14 , B01D15/16
CPC分类号： G01N30/08 , B01D15/14 , B01D15/16 , G01N30/20 , G01N2030/085 , G01N2030/201 , G01N2030/202
摘要： Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump.
摘要翻译：提供一种用于液相色谱系统的多功能选择阀。所述多功能选择阀包括多个端口，所述第一尺寸分离柱的两端可以在其一端连接到所述多个端口，所述多功能选择阀包括：流体通过模式，其中导入的流体不通过所述第一尺寸分离柱但已经出院了引入其中的流体通过第一维分离柱然后排出的柱通过模式; 以及防止流体被引入的流体阻塞模式。当使用多功能选择阀时，它会修改色谱溶剂的流路，从而使得多功能液相色谱系统能够通过单个二元泵进行一维分离，二维分离，在线消化和在线磷酸肽浓缩。

4. 发明申请

US20090036679A1 METHOD FOR RESOLVING ENANTIOMERS FROM RACEMIC MIXTURE HAVING CHIRAL CARBON IN ALPHA POSITION OF NITROGEN 审中-公开
标题翻译：用于在具有硝酸盐的氨基位置处具有正二氧化碳的混合物的方法
公开(公告)号：US20090036679A1
公开(公告)日：2009-02-05
申请号：US12278073
申请日：2006-07-31
申请人： Soon Kil Ahn , Hong Woo Lee , In Taek Lim , Dai Sig Im , Joong Bok Ahn , Jung Hwa Lee
发明人： Soon Kil Ahn , Hong Woo Lee , In Taek Lim , Dai Sig Im , Joong Bok Ahn , Jung Hwa Lee
IPC分类号： C07D411/04 , C07D217/00
CPC分类号： C07D411/04 , C07D217/14 , C07D217/16
摘要： Disclosed relates to a simplified method for resolving enantiomers by dissolving a racemic mixture having chiral carbon in α-position of nitrogen and an amino acid to prepare a diastereomeric salt, not using catalyses or enzymes, with enhancing the optical purity remarkably. Moreover, the present invention can prepare the enantiomers in large quantities without using expensive catalysts or without controlling the reaction conditions for the activity of enzymes applied.
摘要翻译：本发明涉及通过将具有手性碳的外消旋混合物溶解在氮的一个位置和氨基酸来制备非对映异构体盐，而不是使用催化剂或酶，从而显着提高光学纯度来解决对映异构体的简化方法。此外，本发明可以大量制备对映异构体，而不需要使用昂贵的催化剂，或者不控制反应条件对所用酶的活性。

5. 发明申请

US20090136461A1 Neuronal differentiation method of adult stem cells using small molecules 审中-公开
标题翻译：使用小分子的成体干细胞的神经元分化方法
公开(公告)号：US20090136461A1
公开(公告)日：2009-05-28
申请号：US12284117
申请日：2008-09-18
申请人： Moon Suk Kim , Hyun Hee Ahn , Jung Hwa Lee , Hee Jung Jung , Hai Bang Lee , Kyung Sook Kim , Ju Young Lee
发明人： Moon Suk Kim , Hyun Hee Ahn , Jung Hwa Lee , Hee Jung Jung , Hai Bang Lee , Kyung Sook Kim , Ju Young Lee
IPC分类号： A61K35/30 , C12N5/08 , A61P25/00
CPC分类号： C12N5/0618 , C12N2501/065 , C12N2506/1353 , C12N2506/1384
摘要： The present invention relates to a neuronal differentiation method of adult stem cells using small molecules, more particularly to a method for inducing differentiation of adult stem cells into nerve cells using small molecules, which enables effective differentiation into nerve cells and, thus, is useful in treating intractable CNS disorders such as Parkinson's disease, dementia, Alzheimer's disease and spinal cord injury.
摘要翻译：本发明涉及使用小分子的成体干细胞的神经元分化方法，更具体地涉及使用小分子诱导成体干细胞分化为神经细胞的方法，其能够有效分化成神经细胞，因此可用于治疗顽固性CNS疾病如帕金森病，痴呆，阿尔茨海默病和脊髓损伤。

6. 发明申请

US20100040660A1 DEVELOPMENT OF A TISSUE - ENGINEERED SCAFFOLD FOR NERVE REGENERATION USING A BIOCOMPATIBLE AND INJECTABLE HYDROGEL 审中-公开
标题翻译：组织开发 - 使用生物化学和可注射水凝胶进行神经再生的工程化SCAFF
公开(公告)号：US20100040660A1
公开(公告)日：2010-02-18
申请号：US12189951
申请日：2008-08-12
申请人： Moon Suk Kim , Hai Bang Lee , Ju Young Lee , Hyun Hee Ahn , Jung Hwa Lee , Kyung Sook Kim
发明人： Moon Suk Kim , Hai Bang Lee , Ju Young Lee , Hyun Hee Ahn , Jung Hwa Lee , Kyung Sook Kim
IPC分类号： A61K9/00 , C12N5/00 , A61K35/12 , A61P25/00
CPC分类号： C12N5/0622 , A61K35/12 , A61L27/3629 , A61L27/3834 , A61L27/3878 , A61L2400/06 , A61L2430/32 , C12N2533/40 , C12N2533/92
摘要： The present invention relates to a tissue-engineered scaffold prepared by using a biocompatible and injectable hydrogel, and particularly to a tissue-engineered scaffold capable of regenerating or recovering an injured spinal nerve for central nervous system after being implanted to connect neurons, prepared by combining an adult stem cell or a nerve cell with a physiologically active material on tissue-engineered carriers comprising biocompatible and temperature-sensitive polyethylene glycol/polyester block copolymer or biocompatible and injectable hydrogel made of small intestinal submucosa tissue powder with sol-gel phase transition behavior.
摘要翻译：本发明涉及通过使用生物相容性和可注射的水凝胶制备的组织工程化支架，特别涉及能够在被植入以连接神经元之后再生或恢复用于中枢神经系统的受损脊髓神经的组织工程化支架，其通过组合成体干细胞或在组织工程载体上具有生理活性物质的神经细胞，其包含由溶胶 - 凝胶相变行为的小肠粘膜下层组织粉末制成的生物相容性和温度敏感性聚乙二醇/聚酯嵌段共聚物或生物相容性和可注射的水凝胶。

7. 发明授权

US06967521B2 Temperature detecting circuit 失效
标题翻译：温度检测电路
公开(公告)号：US06967521B2
公开(公告)日：2005-11-22
申请号：US10732430
申请日：2003-12-10
申请人： Jung Hwa Lee
发明人： Jung Hwa Lee
IPC分类号： G01K7/42 , G01K3/10 , H03K3/42
CPC分类号： G01K3/10
摘要： A temperature detecting circuit includes a first delay unit for outputting a reference signal, a second delay unit for outputting a plurality of delay signals, a detecting unit for outputting a plurality of detecting signals according to the reference signal and delay signals, an encoder for encoding the plurality of the detecting signals, a buffer for outputting the output signal of the encoder to the outside and a fuse information from the outside to a select means, and the select unit that can be programmed according to the fuse information, for outputting a plurality of output signals to the detecting means according to a program state.
摘要翻译：温度检测电路包括用于输出参考信号的第一延迟单元，用于输出多个延迟信号的第二延迟单元，用于根据参考信号和延迟信号输出多个检测信号的检测单元，用于编码的编码器多个检测信号，用于将编码器的输出信号输出到外部的缓冲器和从外部到选择装置的熔丝信息，以及可以根据熔丝信息编程的选择单元，用于输出多个根据程序状态向检测装置输出输出信号。

8. 发明授权

US06498763B2 Semiconductor memory device having a memory block with a decreased capacitance 有权
标题翻译：具有具有减小的电容的存储块的半导体存储器件
公开(公告)号：US06498763B2
公开(公告)日：2002-12-24
申请号：US09835812
申请日：2001-04-17
申请人： Jung Hwa Lee
发明人： Jung Hwa Lee
IPC分类号： G11C800
CPC分类号： G11C5/025
摘要： A semiconductor memory device includes a plurality of memory cell arrays. Each of the memory cell arrys includes a plurality of memory blocks. A row decoder is located adjacent to the memory cell array. Capacitance of the memory block becomes smaller as the memory block location becomes farther from the row decoder.
摘要翻译：半导体存储器件包括多个存储单元阵列。每个存储器单元包括多个存储块。行解码器位于存储单元阵列附近。存储器块的电容随着存储器块位置变得越来越小于行解码器而变小。

9. 发明申请

US20120145617A1 MULTI-FUNCTIONAL OPTION VALVE, MULTIFUNCTIONAL FULLY AUTOMATIC LIQUID CHROMATOGRAPHY SYSTEM INCLUDING THE SAME, AND METHOD FOR ANALYZING SAMPLE USING THE SAME 有权
标题翻译：多功能选择阀，包括其的多功能全自动液相色谱系统和使用其分析样品的方法
公开(公告)号：US20120145617A1
公开(公告)日：2012-06-14
申请号：US13397409
申请日：2012-02-15
申请人： Sang-Won Lee , Seok-Won Hyung , Jung Hwa Lee , Kyong-Chul Kim , Dong-Gi Mun
发明人： Sang-Won Lee , Seok-Won Hyung , Jung Hwa Lee , Kyong-Chul Kim , Dong-Gi Mun
IPC分类号： B01D15/10 , G01N30/84 , B22D41/16
CPC分类号： G01N30/08 , B01D15/14 , B01D15/16 , G01N30/20 , G01N2030/085 , G01N2030/201 , G01N2030/202
摘要： Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump.
摘要翻译：提供一种用于液相色谱系统的多功能选择阀。所述多功能选择阀包括多个端口，所述第一尺寸分离柱的两端可以在其一端连接到所述多个端口，所述多功能选择阀包括：流体通过模式，其中导入的流体不通过所述第一尺寸分离柱但已经出院了引入其中的流体通过第一维分离柱然后排出的柱通过模式; 以及防止流体被引入的流体阻塞模式。当使用多功能选择阀时，它会修改色谱溶剂的流路，从而使得多功能液相色谱系统能够通过单个二元泵进行一维分离，二维分离，在线消化和在线磷酸肽浓缩。

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