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1. 发明申请

US20050158327A1 Interrupting the interaction of intercellular adhesion molecule-1 and respiratory syncytial virus for prevention and treatment of infection 审中-公开
标题翻译：中断细胞间粘附分子-1和呼吸道合胞病毒的相互作用，用于预防和治疗感染
公开(公告)号：US20050158327A1
公开(公告)日：2005-07-21
申请号：US11079834
申请日：2005-03-14
申请人： Shyam Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
发明人： Shyam Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
IPC分类号： A61K39/42 , A61K48/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2320/32
摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. Also provided is a method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.
摘要翻译：提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。还提供了通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

2. 发明授权

US06900299B1 Interrupting the interaction of intercellular adhesion molecule-1 and respiratory syncytial virus for prevention and treatment of infection 失效
标题翻译：中断细胞间粘附分子-1和呼吸道合胞病毒的相互作用，用于预防和治疗感染
公开(公告)号：US06900299B1
公开(公告)日：2005-05-31
申请号：US10440000
申请日：2003-05-16
申请人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
发明人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
IPC分类号： A61K39/42 , A61K48/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2320/32
摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.
摘要翻译：提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

3. 发明申请

US20110052601A1 COMPOSITIONS COMPRISING ANTI-ICAM-1 ANTIBODIES 审中-公开
标题翻译：包含抗ICAM-1抗体的组合物
公开(公告)号：US20110052601A1
公开(公告)日：2011-03-03
申请号：US12390246
申请日：2009-02-20
申请人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
发明人： Shyam S. Mohapatra , Aruna Behera , Hiroto Matsuse , Mukesh Kumar
IPC分类号： A61K39/42 , A61P11/00 , A61P31/12
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2320/32
摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.
摘要翻译：提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

4. 发明授权

US06489306B2 Method of intranasal gene transfer for protection against respiratory infection 有权
标题翻译：用于防止呼吸道感染的鼻内基因转移方法
公开(公告)号：US06489306B2
公开(公告)日：2002-12-03
申请号：US09259411
申请日：1999-02-23
申请人： Shyam S. Mohapatra , Hiroto Matsuse , Aruna K. Behera , Mukesh Kumar
发明人： Shyam S. Mohapatra , Hiroto Matsuse , Aruna K. Behera , Mukesh Kumar
IPC分类号： A61K4800
CPC分类号： A61K38/217 , A61K48/00 , Y10S977/924
摘要： A method of preventing a respiratory infection by administering DNA which encodes IFN is provided. Also provided is a therapy for the prevention of a respiratory infection containing DNA which encodes IFN.
摘要翻译：提供了通过施用编码IFN的DNA来预防呼吸道感染的方法。还提供了用于预防含有编码IFN的DNA的呼吸道感染的治疗方法。

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