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1. 发明授权

US08293717B2 Materials and methods for prevention and treatment of RNA viral diseases 有权
标题翻译：用于预防和治疗RNA病毒疾病的材料和方法
公开(公告)号：US08293717B2
公开(公告)日：2012-10-23
申请号：US12638800
申请日：2009-12-15
申请人： Shyam S. Mohapatra , Aruna K. Behera
发明人： Shyam S. Mohapatra , Aruna K. Behera
IPC分类号： A01N43/04 , C12N15/63 , C12Q1/68 , C07H21/02 , C07K14/00
CPC分类号： A61K38/45 , A61K38/217 , A61K38/51 , A61K48/00 , A61K48/005 , C12N9/1241 , C12N2710/10343 , C12N2799/022
摘要： The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of the septa in the lungs. Levels of chemokines, such as MIP1-α, are also reduced upon overexpression of 2-5AS. The subject invention also pertains to pharmaceutical compositions containing a nucleotide sequence encoding 2-5 AS and a pharmaceutically acceptable carrier, as well as vectors for delivery of the 2-5 AS nucleotide sequence.
摘要翻译：本发明涉及通过增加患者体内2-5寡聚腺苷酸合成酶（2-5AS）活性的量来抑制患者内RNA病毒感染的方法。优选地，本发明的预防和治疗方法包括向有需要的患者施用编码2-5AS或其至少一种催化活性片段（例如p40，p69，p100亚基）的核苷酸。本发明人已经确定2-5AS的过度表达导致上皮细胞损伤减少，在全脑周围和血管周围区域中单核细胞的浸润减少以及肺中隔膜增厚的减少。趋化因子水平，如MIP1-α，在2-5AS过度表达时也降低。本发明还涉及含有编码2-5AS的核苷酸序列和药学上可接受的载体的药物组合物，以及用于递送2-5AS核苷酸序列的载体。

2. 发明申请

US20110052558A1 MATERIALS AND METHODS FOR PREVENTION AND TREATMENT OF RNA VIRAL DISEASES 有权
标题翻译：用于预防和治疗RNA病毒的材料和方法
公开(公告)号：US20110052558A1
公开(公告)日：2011-03-03
申请号：US12638800
申请日：2009-12-15
申请人： Shyam S. Mohapatra , Aruna K. Behera
发明人： Shyam S. Mohapatra , Aruna K. Behera
IPC分类号： A61K38/53 , A61P31/14 , A61K31/7088 , C12N15/63 , C12N5/10
CPC分类号： A61K38/45 , A61K38/217 , A61K38/51 , A61K48/00 , A61K48/005 , C12N9/1241 , C12N2710/10343 , C12N2799/022
摘要： The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of the septa in the lungs. Levels of chemokines, such as MIP1-α, are also reduced upon overexpression of 2-5AS. The subject invention also pertains to pharmaceutical compositions containing a nucleotide sequence encoding 2-5 AS and a pharmaceutically acceptable carrier, as well as vectors for delivery of the 2-5 AS nucleotide sequence.
摘要翻译：本发明涉及通过增加患者体内2-5寡聚腺苷酸合成酶（2-5AS）活性的量来抑制患者内RNA病毒感染的方法。优选地，本发明的预防和治疗方法包括向有需要的患者施用编码2-5AS或其至少一种催化活性片段（例如p40，p69，p100亚基）的核苷酸。本发明人已经确定2-5AS的过度表达导致上皮细胞损伤减少，在全脑周围和血管周围区域中单核细胞的浸润减少，以及肺中隔膜增厚的减少。趋化因子水平，如MIP1-α，在2-5AS过度表达时也降低。本发明还涉及含有编码2-5AS的核苷酸序列和药学上可接受的载体的药物组合物，以及用于递送2-5AS核苷酸序列的载体。

3. 发明申请

US20080175832A1 Materials and Methods for Prevention and Treatment of RNA Viral Diseases 审中-公开
标题翻译： RNA病毒疾病预防和治疗的材料与方法
公开(公告)号：US20080175832A1
公开(公告)日：2008-07-24
申请号：US12016041
申请日：2008-01-17
申请人： Shyam S. Mohapatra , Aruna K. Behera
发明人： Shyam S. Mohapatra , Aruna K. Behera
IPC分类号： A61K38/53 , A61K31/711 , C12N15/63 , C12N5/06 , C12N1/00 , C12N5/10
CPC分类号： A61K38/45 , A61K38/217 , A61K38/51 , A61K48/00 , A61K48/005 , C12N9/1241 , C12N2710/10343 , C12N2799/022
摘要： The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of the septa in the lungs. Levels of chemokines, such as MIP1-α, are also reduced upon overexpression of 2-5AS. The subject invention also pertains to pharmaceutical compositions containing a nucleotide sequence encoding 2-5 AS and a pharmaceutically acceptable carrier, as well as vectors for delivery of the 2-5 AS nucleotide sequence.
摘要翻译：本发明涉及通过增加患者体内2-5寡聚腺苷酸合成酶（2-5AS）活性的量来抑制患者内RNA病毒感染的方法。优选地，本发明的预防和治疗方法包括向有需要的患者施用编码2-5AS或其至少一种催化活性片段（例如p40，p69，p100亚基）的核苷酸。本发明人已经确定2-5AS的过度表达导致上皮细胞损伤减少，在全脑周围和血管周围区域中单核细胞的浸润减少以及肺中隔膜增厚的减少。趋化因子水平，如MIP1-α，在2-5AS过度表达时也降低。本发明还涉及含有编码2-5AS的核苷酸序列和药学上可接受的载体的药物组合物，以及用于递送2-5AS核苷酸序列的载体。

4. 发明授权

US07354908B2 Materials and methods for prevention and treatment of RNA viral diseases 有权
标题翻译：用于预防和治疗RNA病毒疾病的材料和方法
公开(公告)号：US07354908B2
公开(公告)日：2008-04-08
申请号：US10426436
申请日：2003-04-30
申请人： Shyam S. Mohapatra , Aruna K. Behera
发明人： Shyam S. Mohapatra , Aruna K. Behera
IPC分类号： A01N43/04 , A01N61/00 , C12Q1/68 , C12N15/63 , C07H21/04
CPC分类号： A61K38/45 , A61K38/217 , A61K38/51 , A61K48/00 , A61K48/005 , C12N9/1241 , C12N2710/10343 , C12N2799/022
摘要： The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of the septa in the lungs. Levels of chemokines, such as MIP1-α, are also reduced upon overexpression of 2-5AS. The subject invention also pertains to pharmaceutical compositions containing a nucleotide sequence encoding 2-5 AS and a pharmaceutically acceptable carrier, as well as vectors for delivery of the 2-5 AS nucleotide sequence.
摘要翻译：本发明涉及通过增加患者体内2-5寡聚腺苷酸合成酶（2-5AS）活性的量来抑制患者内RNA病毒感染的方法。优选地，本发明的预防和治疗方法包括向有需要的患者施用编码2-5AS或其至少一种催化活性片段（例如p40，p69，p100亚基）的核苷酸。本发明人已经确定2-5AS的过度表达导致上皮细胞损伤减少，在全脑周围和血管周围区域中单核细胞的浸润减少以及肺中隔膜增厚的减少。趋化因子水平，如MIP1-α，在2-5AS过度表达时也降低。本发明还涉及含有编码2-5AS的核苷酸序列和药学上可接受的载体的药物组合物，以及用于递送2-5AS核苷酸序列的载体。

5. 发明授权

US06489306B2 Method of intranasal gene transfer for protection against respiratory infection 有权
标题翻译：用于防止呼吸道感染的鼻内基因转移方法
公开(公告)号：US06489306B2
公开(公告)日：2002-12-03
申请号：US09259411
申请日：1999-02-23
申请人： Shyam S. Mohapatra , Hiroto Matsuse , Aruna K. Behera , Mukesh Kumar
发明人： Shyam S. Mohapatra , Hiroto Matsuse , Aruna K. Behera , Mukesh Kumar
IPC分类号： A61K4800
CPC分类号： A61K38/217 , A61K48/00 , Y10S977/924
摘要： A method of preventing a respiratory infection by administering DNA which encodes IFN is provided. Also provided is a therapy for the prevention of a respiratory infection containing DNA which encodes IFN.
摘要翻译：提供了通过施用编码IFN的DNA来预防呼吸道感染的方法。还提供了用于预防含有编码IFN的DNA的呼吸道感染的治疗方法。

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