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1. 发明申请

US20190038574A1 NANOPARTICLE TARGETED DRUG DELIVERY TO THE LUNGS USING EXTRA-TESTICULAR SERTOLI CELLS 审中-公开
公开(公告)号：US20190038574A1
公开(公告)日：2019-02-07
申请号：US16154922
申请日：2018-10-09
申请人： ARUN KUMAR , SHYAM S. MOHAPATRA , DON F. CAMERON
发明人： ARUN KUMAR , SHYAM S. MOHAPATRA , DON F. CAMERON
IPC分类号： A61K31/12 , A61K47/61 , A61K47/36 , C12N5/071 , A61K47/69 , A61K9/00 , A61K49/00 , A61K9/51 , A61B5/00 , B82Y5/00 , A61K9/50 , A61K47/46
摘要： A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of interest is provided. Testis-derived rat Sertoli cells were pre-loaded with chitosan nanoparticles coupled with or without the drug curcumin, pre-labeled with a fluorescent cell marker and then injected intravenously into the control or asthmatic mouse model host. Intact pre-loaded, pre-labeled Sertoli cells were present in the lungs at 15 minutes post-injection, appeared entrapped in the pulmonary pre-capillary vascular bed around alveolar sacs but were not present one hour post-injection although Sertoli cell label and cellular debris was. Most of the injected nanoparticle load (70%) and curcumin load (80%) was present in the lungs 15 minutes post-injection, and remained at 70% and 80%, respectively, one hour post-injection.

2. 发明申请

US20180195037A1 Three-Dimensional Fibrous Scaffolds for Cell Culture 审中-公开
公开(公告)号：US20180195037A1
公开(公告)日：2018-07-12
申请号：US15490100
申请日：2017-04-18
申请人： Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
发明人： Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
IPC分类号： C12N5/00 , C12N5/09
CPC分类号： C12N5/0062 , C12N5/0068 , C12N5/0693 , C12N2533/40 , C12N2533/72
摘要： Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.

3. 发明申请

US20180045681A1 SYSTEM AND METHOD OF MEASURING CELL VIABILITY AND GROWTH 审中-公开
公开(公告)号：US20180045681A1
公开(公告)日：2018-02-15
申请号：US15682070
申请日：2017-08-21
申请人： Shyam S. Mohapatra , Subhra Mohapatra , Rasim Oytun Guldiken , Rajesh R. Nair
发明人： Shyam S. Mohapatra , Subhra Mohapatra , Rasim Oytun Guldiken , Rajesh R. Nair
IPC分类号： G01N29/02 , G01N29/036
摘要： A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.

4. 发明申请

US20170137812A1 COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS 审中-公开
公开(公告)号：US20170137812A1
公开(公告)日：2017-05-18
申请号：US15350622
申请日：2016-11-14
申请人： Shyam S. Mohapatra , Srinivas Nagaraj Bharadwaj , Subhra Mohapatra
发明人： Shyam S. Mohapatra , Srinivas Nagaraj Bharadwaj , Subhra Mohapatra
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K47/6807 , A61K47/6849 , A61K47/6929 , C12N5/0639 , C12N5/0645 , C12N5/0647 , C12N15/111 , C12N2310/141 , C12N2310/17 , C12N2320/30 , C12N2501/65 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Provided are methods of treating an inflammatory disease in a subject in need thereof by administering an amount of microRNA 142, an amount of microRNA 223 or an amount of microRNA 142 and an amount of micro RNA 223 to the subject in need thereof.

5. 发明授权

US09624473B2 Three-dimensional fibrous scaffolds for cell culture 有权
公开(公告)号：US09624473B2
公开(公告)日：2017-04-18
申请号：US13775536
申请日：2013-02-25
申请人： Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
发明人： Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
IPC分类号： C12N5/00 , C12N5/09
CPC分类号： C12N5/0062 , C12N5/0068 , C12N5/0693 , C12N2533/40 , C12N2533/72
摘要： Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.

6. 发明授权

US09161901B2 Nanoparticle targeted drug delivery to the lungs using extra-testicular Sertoli cells 有权
标题翻译：使用睾丸内Sertoli细胞将纳米颗粒靶向药物递送至肺
公开(公告)号：US09161901B2
公开(公告)日：2015-10-20
申请号：US12918265
申请日：2009-02-23
申请人： Arun Kumar , Shyam S. Mohapatra , Don F. Cameron
发明人： Arun Kumar , Shyam S. Mohapatra , Don F. Cameron
IPC分类号： A61K35/48 , A61K9/00 , A61B5/00 , A61K9/50 , A61K9/51 , A61K31/12 , A61K47/36 , A61K47/46 , A61K47/48 , A61K49/00 , B82Y5/00
CPC分类号： A61K31/12 , A61B5/0071 , A61B5/4848 , A61K9/0019 , A61K9/5068 , A61K9/5161 , A61K47/36 , A61K47/46 , A61K47/61 , A61K47/6901 , A61K47/6939 , A61K49/0043 , A61K49/0093 , A61K49/0097 , B82Y5/00 , C12N5/0683
摘要： A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of interest is provided. Testis-derived rat Sertoli cells were pre-loaded with chitosan nanoparticles coupled with or without the drug curcumin, pre-labeled with a fluorescent cell marker and then injected intravenously into the control or asthmatic mouse model host. Intact pre-loaded, pre-labeled Sertoli cells were present in the lungs at 15 minutes post-injection, appeared entrapped in the pulmonary pre-capillary vascular bed around alveolar sacs but were not present one hour post-injection although Sertoli cell label and cellular debris was. Most of the injected nanoparticle load (70%) and curcumin load (80%) was present in the lungs 15 minutes post-injection, and remained at 70% and 80%, respectively, one hour post-injection.
摘要翻译：提供了通过静脉内注射负载有与感兴趣的化合物结合的多个壳聚糖纳米颗粒的Sertoli细胞将感兴趣的化合物递送到受试者的肺的方法。睾丸衍生的大鼠支持细胞预先装载有或不含药物姜黄素的壳聚糖纳米颗粒，用荧光细胞标记物预先标记，然后静脉内注射到对照或哮喘小鼠模型宿主中。完整的预加载，预先标记的Sertoli细胞在注射后15分钟存在于肺中，似乎被夹带在肺泡囊周围的肺前毛细血管血管床中，但注射后1小时不存在，尽管Sertoli细胞标记和细胞碎片是。在注射后15分钟，大部分注射的纳米粒子负载（70％）和姜黄色素负荷（80％）分别存在于肺中，并且在注射后1小时分别保持在70％和80％。

7. 发明授权

US09091640B1 Chitosan-graphene biosensors and methods for their use 有权
标题翻译：壳聚糖 - 石墨烯生物传感器及其使用方法
公开(公告)号：US09091640B1
公开(公告)日：2015-07-28
申请号：US14028920
申请日：2013-09-17
申请人： Shyam S. Mohapatra , Kyle A. Cissell , Subbiah Alwarappan
发明人： Shyam S. Mohapatra , Kyle A. Cissell , Subbiah Alwarappan
IPC分类号： G01N27/30
CPC分类号： G01N27/307 , B82Y30/00 , G01N27/48
摘要： Provided herein is a method for detecting mutations in polynucleotide sequences through the use of a glassy carbon electrode (GCE) coated with a chitosan-graphene nanosheet material (also referred to herein as a “CMG electrode.”) It is a surprising finding of the present invention that the CMG electrodes can be used to detect non-hybridization of capture and target polynucleotides using voltammetry, wherein non-hybridization indicates a mutation or difference in the target polynucleotide as compared to a control.
摘要翻译：本文提供了通过使用涂覆有壳聚糖 - 石墨烯纳米片材料（本文也称为“CMG电极”）的玻璃碳电极（GCE）来检测多核苷酸序列中的突变的方法。这是令人惊奇的发现本发明可以使用CMG电极来检测使用伏安法的捕获和靶多核苷酸的非杂交，其中非杂交指示与对照相比靶靶多核苷酸的突变或差异。

8. 发明申请

US20140004520A1 MATERIALS AND METHODS FOR PROFILING MICRORNAS 有权
标题翻译：材料和方法简介微阵列
公开(公告)号：US20140004520A1
公开(公告)日：2014-01-02
申请号：US14000517
申请日：2012-03-16
申请人： Shyam S. Mohapatra , Jia-Wang Wang
发明人： Shyam S. Mohapatra , Jia-Wang Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6876 , C12Q2525/161 , C12Q2525/173 , C12Q2525/207
摘要： The present invention provides materials and methods for detecting, quantifying, and/or high-throughput-profiling microRNAs. Advantageously, the present invention is more sensitive and specific than other currently-available miRNA qPCR assays. In addition, the present invention is convenient, easy-to-perform, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of all miRNAs, a universal reverse primer for PCR amplification reaction, and universal probes. In another embodiment, the present invention provides assays that allow simultaneous detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction.
摘要翻译：本发明提供用于检测，定量和/或高通量分析微小RNA的材料和方法。有利地，本发明比其他目前可用的miRNA qPCR测定更灵敏和特异。此外，本发明方便，易于使用，性价比高。在一个实施方案中，本发明提供了用于所有miRNA逆转录的通用引物，用于PCR扩增反应的通用反向引物和通用探针。在另一个实施方案中，本发明提供允许使用单次逆转录反应同时检测和/或定量多个靶miRNA的测定。

9. 发明申请

US20130144163A1 DRUG DELIVERY DEVICE FOR OVARIAN CANCER 有权
标题翻译：用于OVARIAN癌症的药物递送装置
公开(公告)号：US20130144163A1
公开(公告)日：2013-06-06
申请号：US13486540
申请日：2012-06-01
申请人： Arun Kumar , Susana K. Lai-Yuen , Shyam S. Mohapatra
发明人： Arun Kumar , Susana K. Lai-Yuen , Shyam S. Mohapatra
IPC分类号： A61M31/00
CPC分类号： A61M31/00 , A61B17/42 , A61B17/43 , A61M2210/1408 , A61M2210/1425
摘要： A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, a cylindrical chamber and a plunger. The device is a single-use applicator designed in a shape similar to a tampon to facilitate its insertion through the vagina and into the uterus. Positioning of the device centrally in the uterus is accomplished through the use of ultrasound. The chamber is inserted into the tubular inserter. Adjusting the length of the chamber inserted into the tubular inserter controls the amount of tubing released from the apertures in the tubular inserter. Ultrasound is used to ensure the proper placement of each tube at the entrance of each fallopian tube. The plunger is inserted into the chamber and adjustment of the plunger controls the amount of the agent released into the tubes.
摘要翻译：药物输送装置被设计成通过与输卵管直接接触直接将药剂递送至卵巢。该装置由三个主要部件组成：管状插入器，圆柱形腔和柱塞。该装置是一种单一使用的涂抹器，其设计成类似于棉塞的形状，以便于其插入通过阴道并进入子宫。通过使用超声波将器械定位在子宫中央。将腔室插入管状插入器中。调整插入到管状插入器中的腔室的长度控制从管状插入器中的孔释放的管道的量。超声波用于确保每个管道在每个输卵管入口处的正确放置。柱塞被插入到腔室中，并且柱塞的调节控制释放到管中的药剂的量。

10. 发明申请

US20120289420A1 MICRORNA BIOMARKERS FOR AIRWAY DISEASES 审中-公开
标题翻译： MICRORNA气象病毒生物标志物
公开(公告)号：US20120289420A1
公开(公告)日：2012-11-15
申请号：US13424253
申请日：2012-03-19
申请人： SHYAM S. MOHAPATRA , JIA-WANG WANG
发明人： SHYAM S. MOHAPATRA , JIA-WANG WANG
IPC分类号： C40B30/04 , C07H21/02 , C40B40/06
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides miRNA biomarkers useful for diagnosis, prognosis, and/or treatment of airway diseases such as asthma, asthma exacerbation and nasal polyps.
摘要翻译：本发明提供了可用于诊断，预后和/或治疗气道疾病如哮喘，哮喘加重和鼻息肉的miRNA生物标志物。

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