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    • 4. 发明申请
    • Safety container
    • 安全容器
    • US20060219651A1
    • 2006-10-05
    • US10555388
    • 2004-04-27
    • Shun Takahashi
    • Shun Takahashi
    • B65D41/04B65D55/02
    • B65D50/041
    • A safety container includes a container main body, an internal cap configured to be fit to an opening part of the container main body, and an external cap configured to be fit to the internal cap rotatably and moveably in upper and lower directions. The external cap is not rotated with the internal cap in a case where only the external cap is rotated in an opening direction. The external cap is rotated in a state where the external cap is pressed toward an internal cap side so that the external cap and the internal cap are engaged and the internal cap is opened and separated from the container main body. The safety container further comprises an inner ring having an end part where an engaging part engaged at a top part of the opening part of the container main body is provided and another end part where a slide contact part is provided. The internal cap is rotated with the external cap while the internal cap slides and contacts the slide contact part, by rotating the external cap in the opening direction in a state where the external cap is pressed toward the internal cap side until a rotation angle reaches a designated angle.
    • 安全容器包括容器主体,构造成与容器主体的开口部配合的内盖,以及外壳,其被构造成可以上下方向可旋转地并且可移动地嵌合在内盖上。 在只有外盖在打开方向旋转的情况下,外盖不会与内盖一起旋转。 外盖在外盖被向内侧盖侧挤压的状态下旋转,使得外盖和内盖接合,内盖与容器主体分离。 安全容器还包括内环,其具有端部,其中设置有与容器主体的开口部的顶部接合的接合部,以及设置有滑动接触部的另一端部。 内盖在外罩被旋转的同时,内盖滑动并与滑动接触部接触,通过在将外盖向内盖侧按压的状态下使打开方向旋转,直到旋转角达到 指定角度
    • 5. 发明申请
    • Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition
    • 通过混合水溶性硅烷衍生物获得的二氧化硅复合胶囊,含有它的组合物和透明的凝胶形式组合物
    • US20100016200A1
    • 2010-01-21
    • US12440614
    • 2007-09-11
    • Yuko NagareKei WatanabeKazutami SakamotoShun TakahashiTeruhiko Hineno
    • Yuko NagareKei WatanabeKazutami SakamotoShun TakahashiTeruhiko Hineno
    • A61K8/06
    • A61Q19/10A61K8/0291A61K8/0295A61K8/042A61K8/11A61K8/25A61K8/585A61K2800/262A61K2800/412A61Q1/02
    • The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
    • 本发明提供了可以容易地制备的新的二氧化硅复合胶囊,含有二氧化硅复合胶囊的组合物,以及外观透明性和使用质地优异的透明凝胶状组合物,特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合,可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外,通过混合表面活性剂,水,油和具有特定结构的水溶性硅烷衍生物,可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外,通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂,油和水的配方中,可以获得表现出优异的外观透明度,使用质地和清洁性能的透明凝胶状组合物,以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。
    • 6. 发明申请
    • WATER-SOLUBLE METAL ALCOHOLATE DERIVATIVES, PRODUCTION METHODS THEREOF, AND SOLID GELATINOUS EXTERNAL PREPARATIONS CONTAINING THE SAME
    • 水溶性金属醇盐衍生物,其生产方法和含有其的固体外消旋制剂
    • US20090149554A1
    • 2009-06-11
    • US12063275
    • 2006-08-11
    • Yuko IshikawaKatzutami SakamotoToshikhiko SekiIsao YajimaShun TakahashiKei Watanabe
    • Yuko IshikawaKatzutami SakamotoToshikhiko SekiIsao YajimaShun TakahashiKei Watanabe
    • A61K47/24C07F7/28C07F7/02
    • C07F7/045A61K9/0014A61K47/10C07C31/20
    • The object of the present invention is to provide a production method of water-soluble silane derivatives, the separation and purification of which are easy, and the reaction for which can be conducted under an industrially practicable temperature condition (under the temperature condition of 90° C. or lower) and to provide compounds with which solid gelatinous external preparations, with excellent stability against a temperature change and against an effect of additives and with excellent usability, can be prepared. The water-soluble silane derivative could be formed by the substitution reaction of a metal alkoxide with a polyhydric alcohol under the presence of a solid catalyst. According to this production method, the separation of the catalyst from the product is very easy, and the reaction can be carried out under the temperature condition of 90° C. or lower. The obtained water-soluble metal alcoholate derivative can satisfactory solidify an aqueous formulation of an external preparation by its blending thereinto. The obtained solid gelatinous external preparation has excellent stability against a temperature change and against the effect of additives. In addition, the external preparation is easily disintegrated during use; thus the usability such as easiness to be scooped up with fingers and spreadability during application is excellent.
    • 本发明的目的是提供一种水溶性硅烷衍生物的制造方法,其分离纯化容易,其反应可以在工业上可行的温度条件下(在90℃的温度条件下进行) C.或更低),并且可以制备具有优异的耐温度变化稳定性和抗添加剂效果以及优异可用性的固体胶状外用制剂的化合物。 水溶性硅烷衍生物可以通过金属醇盐与多元醇在固体催化剂存在下的取代反应形成。 根据该制造方法,催化剂与产物的分离非常容易,反应可以在90℃以下的温度条件下进行。 所得到的水溶性金属醇化物衍生物可以通过其混合来使外用制剂的水性制剂充分固化。 所得固体凝胶状外用制剂对温度变化和添加剂的效果具有优异的稳定性。 此外,外用制剂在使用过程中容易分解; 因此在使用时易于用手指舀起的可用性和铺展性优异。
    • 8. 发明授权
    • Silica composite capsules obtained by blending water-soluble silane derivative, composition containing the same, and transparent gel-form composition
    • 通过混合水溶性硅烷衍生物,含有它们的组合物和透明凝胶状组合物获得的二氧化硅复合胶囊
    • US08030267B2
    • 2011-10-04
    • US12440614
    • 2007-09-11
    • Yuko NagareKei WatanabeKazutami SakamotoShun TakahashiTeruhiko Hineno
    • Yuko NagareKei WatanabeKazutami SakamotoShun TakahashiTeruhiko Hineno
    • C11D9/36C11D3/44
    • A61Q19/10A61K8/0291A61K8/0295A61K8/042A61K8/11A61K8/25A61K8/585A61K2800/262A61K2800/412A61Q1/02
    • The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
    • 本发明提供了可以容易地制备的新的二氧化硅复合胶囊,含有二氧化硅复合胶囊的组合物,以及外观透明性和使用质地优异的透明凝胶状组合物,特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合,可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外,通过混合表面活性剂,水,油和具有特定结构的水溶性硅烷衍生物,可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外,通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂,油和水的配方中,可以获得表现出优异的外观透明度,使用质地和清洁性能的透明凝胶状组合物,以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。