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1. 发明申请

US20090142565A1 Mesoporous Silica And Production Method Thereof 审中-公开
标题翻译：介孔二氧化硅及其制备方法
公开(公告)号：US20090142565A1
公开(公告)日：2009-06-04
申请号：US12063502
申请日：2006-08-11
申请人： Shun Takahashi , Kazutami Sakamoto , Kouzou Hiwatari
发明人： Shun Takahashi , Kazutami Sakamoto , Kouzou Hiwatari
IPC分类号： B32B7/00 , C01B33/12
CPC分类号： C01B37/02 , B01J20/103 , B01J20/28083 , C01B33/1435 , C01B33/158
摘要： The object of the present invention is to provide a production method of mesoporous silica under electrolyte-free conditions by using a surfactant aggregate structure as a template and to provide mesoporous silica with a new shape, which could not be obtained in the past. It is possible to prepare mesoporous silica under electrolyte-free conditions by reacting a nonionic surfactant and a water-soluble silicate monomer with a specific structure under neutral conditions. In addition, a sheet-like mesoporous silica can be prepared in the use of a nonionic surfactant that can form a ribbon phase or a nematic phase in suitable temperature and concentration ranges in a water solution.
摘要翻译：本发明的目的是通过使用表面活性剂聚集体结构作为模板，在无电解质条件下提供介孔二氧化硅的制造方法，并提供过去无法获得的新型的介孔二氧化硅。通过在中性条件下使非离子表面活性剂和具有特定结构的水溶性硅酸盐单体反应，可以在无电解质条件下制备介孔二氧化硅。此外，可以使用可以在适当的温度和浓度范围内在水溶液中形成带状或向列相的非离子表面活性剂制备片状介孔二氧化硅。

2. 发明申请

US20100016200A1 Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition 失效
标题翻译：通过混合水溶性硅烷衍生物获得的二氧化硅复合胶囊，含有它的组合物和透明的凝胶形式组合物
公开(公告)号：US20100016200A1
公开(公告)日：2010-01-21
申请号：US12440614
申请日：2007-09-11
申请人： Yuko Nagare , Kei Watanabe , Kazutami Sakamoto , Shun Takahashi , Teruhiko Hineno
发明人： Yuko Nagare , Kei Watanabe , Kazutami Sakamoto , Shun Takahashi , Teruhiko Hineno
IPC分类号： A61K8/06
CPC分类号： A61Q19/10 , A61K8/0291 , A61K8/0295 , A61K8/042 , A61K8/11 , A61K8/25 , A61K8/585 , A61K2800/262 , A61K2800/412 , A61Q1/02
摘要： The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
摘要翻译：本发明提供了可以容易地制备的新的二氧化硅复合胶囊，含有二氧化硅复合胶囊的组合物，以及外观透明性和使用质地优异的透明凝胶状组合物，特别是具有改进的透明凝胶状组合物用作清洁剂时的清洁性能。通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合，可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。此外，通过混合表面活性剂，水，油和具有特定结构的水溶性硅烷衍生物，可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。此外，通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂，油和水的配方中，可以获得表现出优异的外观透明度，使用质地和清洁性能的透明凝胶状组合物，以及能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。

3. 发明授权

US08030267B2 Silica composite capsules obtained by blending water-soluble silane derivative, composition containing the same, and transparent gel-form composition 失效
标题翻译：通过混合水溶性硅烷衍生物，含有它们的组合物和透明凝胶状组合物获得的二氧化硅复合胶囊
公开(公告)号：US08030267B2
公开(公告)日：2011-10-04
申请号：US12440614
申请日：2007-09-11
申请人： Yuko Nagare , Kei Watanabe , Kazutami Sakamoto , Shun Takahashi , Teruhiko Hineno
发明人： Yuko Nagare , Kei Watanabe , Kazutami Sakamoto , Shun Takahashi , Teruhiko Hineno
IPC分类号： C11D9/36 , C11D3/44
CPC分类号： A61Q19/10 , A61K8/0291 , A61K8/0295 , A61K8/042 , A61K8/11 , A61K8/25 , A61K8/585 , A61K2800/262 , A61K2800/412 , A61Q1/02
摘要： The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
摘要翻译：本发明提供了可以容易地制备的新的二氧化硅复合胶囊，含有二氧化硅复合胶囊的组合物，以及外观透明性和使用质地优异的透明凝胶状组合物，特别是具有改进的透明凝胶状组合物用作清洁剂时的清洁性能。通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合，可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。此外，通过混合表面活性剂，水，油和具有特定结构的水溶性硅烷衍生物，可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。此外，通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂，油和水的配方中，可以获得表现出优异的外观透明度，使用质地和清洁性能的透明凝胶状组合物，以及能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。

4. 发明授权

US07405315B2 Mesoporous silica and process for producing the same 失效
标题翻译：介孔二氧化硅及其制备方法
公开(公告)号：US07405315B2
公开(公告)日：2008-07-29
申请号：US10716427
申请日：2003-11-20
申请人： Takashi Tatsumi , Hideaki Yoshitake , Toshiyuki Yokoi , Shunai Che , Kazutami Sakamoto
发明人： Takashi Tatsumi , Hideaki Yoshitake , Toshiyuki Yokoi , Shunai Che , Kazutami Sakamoto
IPC分类号： C07F7/04
CPC分类号： C01B37/02 , C07B2200/11 , C07F7/1804
摘要： (A) An anionic surfactant, (B) a silicate monomer and (C) a basic silane are mixed in water or a mixed solvent of a water-miscible organic solvent and water to obtain a mesoporous silica complex having mesopores with a uniform size, the anionic surfactant Component (A) is removed by washing the resultant mesoporous silica complex with an acidic aqueous solution, a water-miscible organic solvent or an aqueous solution thereof to obtain a mesoporous silica outer shell utilizing the structure of the mesoporous silica complex as a template, and the mesoporous silica complex or the mesoporous silica outer shell is calcined to obtain a mesoporous silica. The mesoporous silica can be synthesized in this manner utilizing the anionic surfactant micelle with a remarkably low affinity to the silicate monomer.
摘要翻译：（A）阴离子表面活性剂，（B）硅酸盐单体和（C）碱性硅烷在水或水混溶性有机溶剂与水的混合溶剂中混合，得到具有均匀尺寸的介孔的介孔二氧化硅配合物，通过用酸性水溶液，水溶性有机溶剂或其水溶液洗涤所得介孔二氧化硅配合物来除去阴离子表面活性剂组分（A），以获得使用介孔二氧化硅络合物的结构的介孔二氧化硅外壳作为模板和介孔二氧化硅配合物或介孔二氧化硅外壳进行煅烧，得到介孔二氧化硅。可以以这种方式利用对硅酸盐单体的亲和力非常低的阴离子表面活性剂胶束来合成介孔二氧化硅。

5. 发明申请

US20050118204A1 Methods for controlling membrane permeability of a membrane permeable substance and screening methods for a membrane permeable substance 审中-公开
标题翻译：用于控制膜渗透性的膜渗透性的方法和膜可渗透物质的筛选方法
公开(公告)号：US20050118204A1
公开(公告)日：2005-06-02
申请号：US10948755
申请日：2004-09-24
申请人： Kazutami Sakamoto , Yoshinobu Takino , Kazuko Ogasahara
发明人： Kazutami Sakamoto , Yoshinobu Takino , Kazuko Ogasahara
IPC分类号： A61K9/00 , A61K38/00 , C12N5/074 , C12N5/078 , C12Q1/00 , G01N33/50
CPC分类号： G01N33/5008 , C12N5/0641 , C12N5/0672
摘要： The present invention relates to a method for controlling membrane permeability of a membrane permeable substance, and more particularly it relates to a method for controlling membrane permeability of a membrane permeable substance by changing the curvature of the membrane. The invention also relates to a screening method for a membrane permeable substance, and more particularly, it relates to a screening method for a membrane permeable substance, in which the change of curvature of the membrane and/or the phase change of the membrane, which occurs upon adding a test substance, is detected to evaluate the membrane permeability of the test substance.
摘要翻译：本发明涉及一种用于控制膜渗透性的膜渗透性的方法，更具体地，涉及通过改变膜的曲率来控制膜渗透性的膜渗透性的方法。本发明还涉及膜可渗透物质的筛选方法，更具体地说，涉及膜渗透性物质的筛选方法，其中膜的曲率变化和/或膜的相变，其中在检测物质的添加时发生检测，以评价检测物质的膜渗透性。

6. 发明申请

US20090043003A1 INORGANIC MESOPOROUS MATERIAL HAVING CHIRAL TWISTED STRUCTURE AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译：无纺织物材料，具有双向结构及其制造方法
公开(公告)号：US20090043003A1
公开(公告)日：2009-02-12
申请号：US11579203
申请日：2005-04-28
申请人： Takashi Tatsumi , Shunai Che , Kazutami Sakamoto
发明人： Takashi Tatsumi , Shunai Che , Kazutami Sakamoto
IPC分类号： C08L79/00 , C08J9/00 , C23C16/44
CPC分类号： C01B37/02 , B01D15/3833 , B01J20/103 , B01J20/28007 , B01J20/28083 , B01J20/283 , B01J20/29 , B01J20/3057 , B22F1/0025 , B82Y30/00 , C30B29/16 , C30B29/605
摘要： A chiral inorganic mesoporous material characterized by having a chiral twisted structure and being mesoporous; a process for producing the material; and a method of using the material. The process for inorganic mesoporous material production is a method in which one or more polymerizable inorganic monomers selected from the group consisting of polymerizable inorganic monomers and polymerizable inorganic monomers having a functional group capable of having a charge are polymerized in the presence of a solvent using as a template a self-assembly of a chiral surfactant such as an N-(higher alkanoyl)amino acid salt. Examples of the use of the inorganic mesoporous material include the separation of racemates and reaction fields for asymmetric syntheses.
摘要翻译：一种手性无机介孔材料，其特征在于具有手性扭曲结构并且具有介孔性; 一种生产该材料的方法; 以及使用该材料的方法。无机介孔材料生产方法是一种或多种选自可聚合无机单体和具有可带电荷的官能团的可聚合无机单体的可聚合无机单体在溶剂存在下使用如下方法聚合的方法：模板是手性表面活性剂如N-（高级烷酰基）氨基酸盐的自组装。使用无机介孔材料的实例包括外消旋体的分离和不对称合成的反应场。

7. 发明授权

US5985922A Amino acid derivatives and active oxygen-resisting agent 失效
标题翻译：氨基酸衍生物和活性氧化剂
公开(公告)号：US5985922A
公开(公告)日：1999-11-16
申请号：US54508
申请日：1998-04-03
申请人： Manabu Kitazawa , Kazutami Sakamoto , Keiji Iwasaki
发明人： Manabu Kitazawa , Kazutami Sakamoto , Keiji Iwasaki
IPC分类号： A61K8/30 , A61K8/00 , A61K8/40 , A61K8/42 , A61K8/44 , A61K8/49 , A61K31/195 , A61K31/198 , A61K31/24 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q5/02 , A61Q11/00 , A61Q19/00 , C07C229/14 , C07C229/34 , C07C229/36 , C07C237/06 , C09K15/20 , C09K15/22 , A01N37/12 , A01N37/18 , C07C229/28
CPC分类号： C07C237/06 , C07C229/14 , C07C229/36
摘要： Provided is a novel active oxygen-resisting agent which has an excellent active oxygen resistance and which exhibits a good solubility in an oil solvent. An active oxygen-resisting agent containing as an active ingredient an amino acid derivative represented by the following formula (I) ##STR1## wherein Ar represents a substituted or substituted 2-hydroxyphenyl group or a pyridyl group, said substitution being selected from the group consisting of a halogen atom, a C.sub.1-6 alkyl group, a hydroxyl group, a hydroxy C.sub.1-6 alkyl group, a nitro group, a C.sub.1-6 alkoxyl group or a carboxyl group, R.sup.1 represents a side chain of an amino acid, X represents --O-- or --NH--, R.sup.2 represents a C.sub.8-22 alkyl group, and n represents 0 or 1, or its salt.
摘要翻译：本发明提供一种具有优异的活性氧阻力并且在油溶剂中表现出良好溶解性的新型活性氧化物。作为活性成分含有由下式（I）表示的氨基酸衍生物的活性耐氧化剂，其中Ar表示取代或取代的2-羟基苯基或吡啶基，所述取代选自卤素原子，C 1-6烷基，羟基，羟基C 1-6烷基，硝基，C 1-6烷氧基或羧基，R 1表示氨基酸的侧链，X表示-O-或 - NH-，R 2表示C 8-22烷基，n表示0或1，或其盐。

8. 发明授权

US08063114B2 Inorganic mesoporous material having chiral twisted structure and process for producing the same 失效
标题翻译：具有手性扭转结构的无机介孔材料及其制造方法
公开(公告)号：US08063114B2
公开(公告)日：2011-11-22
申请号：US11579203
申请日：2005-04-28
申请人： Takashi Tatsumi , Shunai Che , Kazutami Sakamoto
发明人： Takashi Tatsumi , Shunai Che , Kazutami Sakamoto
IPC分类号： C08G77/00 , C08G63/44
CPC分类号： C01B37/02 , B01D15/3833 , B01J20/103 , B01J20/28007 , B01J20/28083 , B01J20/283 , B01J20/29 , B01J20/3057 , B22F1/0025 , B82Y30/00 , C30B29/16 , C30B29/605
摘要： A chiral inorganic mesoporous material characterized by having a chiral twisted structure and being mesoporous; a process for producing the material; and a method of using the material. The process for inorganic mesoporous material production is a method in which one or more polymerizable inorganic monomers selected from the group consisting of polymerizable inorganic monomers and polymerizable inorganic monomers having a functional group capable of having a charge are polymerized in the presence of a solvent using as a template a self-assembly of a chiral surfactant such as an N-(higher alkanoyl)amino acid salt. Examples of the use of the inorganic mesoporous material include the separation of racemates and reaction fields for asymmetric syntheses.
摘要翻译：一种手性无机介孔材料，其特征在于具有手性扭曲结构并且具有介孔性; 一种生产该材料的方法; 以及使用该材料的方法。无机介孔材料生产方法是一种或多种选自可聚合无机单体和具有可带电荷的官能团的可聚合无机单体的可聚合无机单体在溶剂存在下使用如下方法聚合的方法：模板是手性表面活性剂如N-（高级烷酰基）氨基酸盐的自组装。使用无机介孔材料的实例包括外消旋体的分离和不对称合成的反应场。

9. 发明授权

US07375085B1 Melanocyte-stimulating hormone inhibitors 有权
标题翻译：促黑细胞激素抑制剂
公开(公告)号：US07375085B1
公开(公告)日：2008-05-20
申请号：US09926391
申请日：2000-04-25
申请人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
发明人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
IPC分类号： C07K5/08 , A61K38/00
CPC分类号： C07K5/0812 , A61K38/00
摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.
摘要翻译：在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂并且另外可以容易地制造，并且在保存期间的稳定性优异。

10. 发明授权

US07105570B2 Cysteine derivatives 有权
公开(公告)号：US07105570B2
公开(公告)日：2006-09-12
申请号：US10323930
申请日：2002-12-20
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K31/195 , A61K31/22
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

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