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1. 发明授权

US07268212B2 Ligand of G protein-coupled receptor protein and DNA thereof 有权
标题翻译： G蛋白偶联受体蛋白及其DNA的配体
公开(公告)号：US07268212B2
公开(公告)日：2007-09-11
申请号：US10480739
申请日：2002-06-13
申请人： Shuji Hinuma , Ryo Fujii , Shoji Fukusumi , Masaaki Mori , Hiromi Yoshida
发明人： Shuji Hinuma , Ryo Fujii , Shoji Fukusumi , Masaaki Mori , Hiromi Yoshida
IPC分类号： C07K14/47
CPC分类号： G01N33/566 , C07K14/47 , C07K14/705 , C07K14/723 , G01N33/92
摘要： A GPR7 ligand containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:1 wherein the N-terminal amino acid residue may optionally be brominated, is useful in developing a receptor-binding assay system with the use of the GPR7 expression system, in screening a candidate compound for a drug such as an antiobestic, etc.
摘要翻译：含有与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的GPR7配体，其中N-末端氨基酸残基可任选被溴化，可用于开发受体结合测定系统，其中使用GPR7表达系统，筛选候选化合物用于药物如抗生物等。

2. 发明申请

US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译：新型G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07H21/04 , C07K14/47 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

3. 发明授权

US06228984B1 Polypeptides their production and use 失效
标题翻译：多肽的生产和使用
公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K1447
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选的药物候选化合物。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

4. 发明授权

US07192723B2 G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译： G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US07192723B2
公开(公告)日：2007-03-20
申请号：US10719587
申请日：2003-11-21
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： C07K7/08 , C07K14/47 , G01N33/566
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

5. 发明授权

US6111076A Human G-protein coupled receptor (HIBCD07) 失效
标题翻译：人G蛋白偶联受体（HIBCD07）
公开(公告)号：US6111076A
公开(公告)日：2000-08-29
申请号：US163669
申请日：1998-09-30
申请人： Shoji Fukusumi , Shuji Hinuma , Ryo Fujii
发明人： Shoji Fukusumi , Shuji Hinuma , Ryo Fujii
IPC分类号： G01N33/566 , A61K38/00 , A61K48/00 , A61P1/04 , A61P3/06 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P19/10 , A61P25/00 , A61P29/00 , C07H21/04 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

6. 发明授权

US5874245A Human G-protein coupled receptor (HIBCD07) 失效
公开(公告)号：US5874245A
公开(公告)日：1999-02-23
申请号：US852806
申请日：1997-05-07
申请人： Shoji Fukusumi , Shuji Hinuma , Ryo Fujii
发明人： Shoji Fukusumi , Shuji Hinuma , Ryo Fujii
IPC分类号： G01N33/566 , A61K38/00 , A61K48/00 , A61P1/04 , A61P3/06 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , A61P19/10 , A61P25/00 , A61P29/00 , C07H21/04 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

7. 发明授权

US07662574B2 Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion 失效
标题翻译： G蛋白偶联受体及其识别配体在鉴定影响催乳素分泌的化合物中的应用
公开(公告)号：US07662574B2
公开(公告)日：2010-02-16
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

8. 发明授权

US06794491B1 Polypeptides, their production and use 失效
标题翻译：多肽，其生产和使用
公开(公告)号：US06794491B1
公开(公告)日：2004-09-21
申请号：US09576290
申请日：2000-05-23
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K14475
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。配体多肽或编码配体多肽的DNA可用于（1）开发诸如垂体的药物功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）使用重组受体蛋白质的表达和药物候选化合物的筛选开发受体结合测定系统。特别地，通过受体结合测定系统利用表达根据本发明的重组G蛋白偶联受体蛋白质，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，并且所获得的激动剂或拮抗剂可用作治疗和预防各种疾病的代理

9. 发明授权

US6114139A G-protein coupled receptor protein and a DNA encoding the receptor 失效
标题翻译： G蛋白偶联受体蛋白和编码受体的DNA
公开(公告)号：US6114139A
公开(公告)日：2000-09-05
申请号：US513974
申请日：1995-09-14
申请人： Shuji Hinuma , Masaki Hosoya , Ryo Fujii , Tetsuya Ohtaki , Shoji Fukusumi , Kazuhiro Ohgi
发明人： Shuji Hinuma , Masaki Hosoya , Ryo Fujii , Tetsuya Ohtaki , Shoji Fukusumi , Kazuhiro Ohgi
IPC分类号： C07K14/705 , C07K14/72 , C12N15/12 , C12Q1/68 , C12N5/10 , C12N15/63
CPC分类号： C12Q1/6876 , C07K14/705 , C07K14/70571 , C07K14/723 , C12Q2600/158
摘要： DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or near the first membrane-spanning domain or the sixth membrane-spanning domain each of known various G protein coupled receptor proteins were designed and synthesized. Methods of amplifying G protein coupled receptor protein-encoding DNAs using the above DNA primers, and novel target G protein coupled receptor protein-encoding DNAs are also provided. Screening of DNA libraries can be efficiently carried out. Human pituitary gland or amygdala-derived and mouse pancreas-derived G protein coupled receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above G protein coupled receptor proteins, processes for producing the above G protein coupled receptor proteins, methods of determining ligands for the above G protein coupled receptor proteins, methods of screening compounds that inhibit the binding between the ligand and the G protein coupled receptor proteins or screening kits therefor, compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compounds or salts thereof, and antibodies against the above protein coupled receptor proteins or partial peptides thereof are provided.
摘要翻译： PCT No.PCT / JP95 / 01599 Sec。 371 1995年9月14日第 102（e）1995年9月14日PCT PCT 1995年8月10日PCT公布。出版物WO96 / 05302 日期1996年2月22日提供了有效筛选编码G蛋白偶联受体蛋白的DNA片段的DNA引物。与与编码对应于或接近第一跨膜结构域或第六跨膜结构域的氨基酸序列的核苷酸序列（同源的）的核苷酸序列互补的引物，每个已知的各种G蛋白偶联受体蛋白被设计和合成。还提供了使用上述DNA引物扩增G蛋白偶联受体蛋白质编码DNA的方法，以及新的靶向G蛋白偶联受体蛋白质编码DNA。可以有效地进行DNA文库的筛选。人类垂体腺或来自扁桃体的小鼠胰腺衍生的G蛋白偶联受体蛋白等，或其盐，其部分肽，编码上述G蛋白偶联受体蛋白质的DNA，用于产生上述G蛋白偶联受体蛋白质的方法，确定上述G蛋白偶联受体蛋白质的配体的方法，筛选抑制配体和G蛋白偶联受体蛋白质或其筛选试剂盒之间的结合的化合物的方法，通过上述筛选方法获得的化合物或其盐或筛选试剂盒提供含有上述化合物或其盐的药物组合物和针对上述蛋白质偶联受体蛋白质或其部分肽的抗体。

10. 发明申请

US20080160033A1 Novel Screening Method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20080160033A1
公开(公告)日：2008-07-03
申请号：US10542408
申请日：2004-01-15
申请人： Yasuaki Ito , Ryo Fujii , Shuji Hinuma , Shoji Fukusumi , Minoru Maruyama
发明人： Yasuaki Ito , Ryo Fujii , Shuji Hinuma , Shoji Fukusumi , Minoru Maruyama
IPC分类号： A61K39/395 , G01N33/68 , C07H21/04 , C07K14/705 , C12N5/06 , A61P5/00 , A61P35/00 , A61P31/12 , A61P3/00 , C12P21/02 , C12N15/63 , A61K31/711 , G01N33/566
CPC分类号： C07K14/723 , A61K31/711 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein comprising the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 8, or a salt thereof, and a fatty acid, a compound or its salt that changes the binding property of the receptor protein or a salt thereof to the fatty acid can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1，SEQ ID NO：3或SEQ ID NO：8表示的氨基酸序列相同或基本相同的G蛋白偶联受体蛋白或其盐，和脂肪酸可以有效地筛选改变受体蛋白质或其盐与脂肪酸的结合性的化合物或其盐。

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