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    • 1. 发明申请
    • Method of controlling cell functions
    • 控制细胞功能的方法
    • US20090232771A1
    • 2009-09-17
    • US11632459
    • 2005-07-12
    • Shuji HinumaMasaki HosoyaRie Kunisada
    • Shuji HinumaMasaki HosoyaRie Kunisada
    • A61K35/12C12Q1/68C12N5/10A01N1/02C07K14/47C07H21/04C12N5/06C12N5/08
    • G01N33/5073A61K38/00C07K14/4702G01N33/5023
    • The present invention provides methods of screening genes associated with cell regeneration, growth and differentiation and regulators for cell regeneration, growth or differentiation; regulators for cell regeneration, growth or differentiation; and so on. More specifically, the present invention provides methods of screening genes associated with cell regeneration, growth and differentiation, which comprises the step of quantitatively analyzing expression levels of multiple genes collectively in a cell having a regeneration, differentiation or growth capability to thereby identify the genes associated with the regeneration, growth or differentiation of the cell; methods of screening genes associated with cell regeneration, growth and differentiation, which comprises the step of quantitatively analyzing expression levels of multiple genes collectively in a cell having a regeneration, differentiation or growth capability to thereby identify one or more genes that show higher expression levels in the cell or are specific in expression as compared to the other cells; and, the step of contacting at least one candidate substance capable of regulating the functions of the identified genes or their gene products with the cell and comparing changes before and after the contact; and so on.
    • 本发明提供筛选与细胞再生,生长和分化相关的基因以及用于细胞再生,生长或分化的调节剂的方法; 细胞再生,生长或分化的调节剂; 等等。 更具体地,本发明提供筛选与细胞再生,生长和分化相关的基因的方法,其包括在具有再生,分化或生长能力的细胞中统一地定量分析多个基因的表达水平从而鉴定相关基因的步骤 与细胞的再生,生长或分化; 筛选与细胞再生,生长和分化相关基因的方法,其包括在具有再生,分化或生长能力的细胞中统计分析多个基因的表达水平的步骤,从而鉴定一种或多种在 与其他细胞相比,细胞或表达特异性; 以及将能够调节所识别的基因或其基因产物的功能的至少一种候选物质与细胞接触并比较接触前后的变化的步骤; 等等。