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1. 发明授权

US4812457A Prostaglandin derivatives 失效
标题翻译：前列腺素衍生物
公开(公告)号：US4812457A
公开(公告)日：1989-03-14
申请号：US149930
申请日：1988-01-29
申请人： Shuh Narumiya , Osamu Hayaishi , Yoshiharu Kimura , Masami Tsuboshima
发明人： Shuh Narumiya , Osamu Hayaishi , Yoshiharu Kimura , Masami Tsuboshima
IPC分类号： A61K31/557 , A61K31/5575 , A61K47/48 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00
CPC分类号： A61K31/557 , A61K47/48023 , A61K47/48038 , C07C405/00 , C07C405/0041
摘要： Permeability characterized in that the carboxy group at 1-position of the prostaglandin is combined with a cell membrane permeable substance having hydroxy group or amino group through the intermediation of an ester bond to the hydroxy group or an amide bond to the amino group are novel and have improved cell membrane permeability.
摘要翻译：渗透性特征在于前列腺素1位上的羧基与具有羟基或氨基的细胞膜可渗透物质通过酯键与羟基或与氨基的酰胺键相结合而新颖，具有改善的细胞膜通透性。

2. 发明申请

US20060128810A1 Remedies for allergic diseases 审中-公开
标题翻译：过敏性疾病的治疗方法
公开(公告)号：US20060128810A1
公开(公告)日：2006-06-15
申请号：US10530752
申请日：2003-10-09
申请人： Shuh Narumiya
发明人： Shuh Narumiya
IPC分类号： A61K31/557
CPC分类号： A61K31/5575 , A61K31/00 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a prophylactic and/or therapeutic agent for an allergic disease which contains a compound having an agonistic activity to EP3 receptor that is one of the prostaglandin E2 receptor subtypes. More specifically, a compound having an agonistic activity to EP3 receptor is effective in therapy of an allergic respiratory disease such as bronchial asthma, pediatric asthma, allergic asthma, or atopic asthma, and a selective agonistic compound can be expected to induce a more remarkable therapeutic effect.
摘要翻译：本发明涉及一种过敏性疾病的预防和/或治疗剂，其含有对作为前列腺素E2受体亚型之一的EP3受体具有激动作用的化合物。更具体地说，具有对EP3受体的激动作用的化合物在治疗过敏性呼吸系统疾病如支气管哮喘，儿科哮喘，过敏性哮喘或特应性哮喘中是有效的，并且选择性激动化合物可以预期诱导更显着的治疗影响。

3. 发明授权

US5084214A Phenolic thioethers, and their production and use 失效
标题翻译：酚醛树脂及其生产和使用
公开(公告)号：US5084214A
公开(公告)日：1992-01-28
申请号：US359718
申请日：1989-05-31
申请人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumihiko Watanabe , Saichi Matsumoto , Masami Doteuchi
发明人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumihiko Watanabe , Saichi Matsumoto , Masami Doteuchi
IPC分类号： A61K31/19 , A61K31/22 , A61K31/235 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P37/08 , C07C323/52 , C07C323/54 , C07C323/56
CPC分类号： C07C323/52 , Y02P20/55 , Y10S514/824
摘要： Phenolic thioethers of the formula: ##STR1## wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C.sub.4 -C.sub.15 alkylene group, a straight or branched C.sub.1 -C.sub.15 alkylene group having a phenylene group or a straight or branched C.sub.2 -C.sub.15 alkenylene group, and their salts, which inhibit the denaturation of low density lipoproteins (LDL) and the incorporation of LDL by macrophages and are useful as anti-arteriosclerosis agents.

4. 发明授权

US6013499A Rho target protein kinase p160 失效
标题翻译： Rho靶蛋白激酶p160
公开(公告)号：US6013499A
公开(公告)日：2000-01-11
申请号：US685871
申请日：1996-07-24
申请人： Shuh Narumiya , Akihiro Iwamatsu
发明人： Shuh Narumiya , Akihiro Iwamatsu
IPC分类号： G01N33/53 , A61K38/45 , C07H21/04 , C07K14/47 , C12N1/21 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/09 , C12Q1/48 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/566 , C07K14/00
CPC分类号： C12N9/1205
摘要： The object of the present invention is to provide a target protein for the activated Rho protein. The present invention is a protein having the activated Rho protein binding activity and protein kinase activity, or derivatives thereof. The molecular weight of the protein is about 160 kDa as measured by SDS-PAGE. The protein kinase activity of the protein is enhanced when it binds to the activated Rho protein.
摘要翻译：本发明的目的是提供活化的Rho蛋白的靶蛋白。本发明是具有活化的Rho蛋白结合活性和蛋白激酶活性的蛋白质或其衍生物。通过SDS-PAGE测量，蛋白质的分子量为约160kDa。当蛋白质与活化的Rho蛋白质结合时，蛋白质的蛋白激酶活性得到增强。

5. 发明授权

US6111072A Rho target protein human mDia and gene encoding same 失效
标题翻译： Rho靶蛋白人类mDia和基因编码相同
公开(公告)号：US6111072A
公开(公告)日：2000-08-29
申请号：US899595
申请日：1997-07-24
申请人： Shuh Narumiya , Nobuaki Takahashi
发明人： Shuh Narumiya , Nobuaki Takahashi
IPC分类号： C07K14/47 , C07K1/00
CPC分类号： C07K14/47
摘要： An objective of the present invention is to provide an activated Rho protein target protein derived from a human and a gene coding for the same. The present invention provides a protein derived from a human and a derivative thereof which has the following characteristics: (1) having activated Rho protein binding activity, (2) having profilin binding activity, (3) the gene coding for the protein being located at q31.2 of chromosome 5, and (4) having a molecular weight of about 150 kDa as measured by SDS-PAGE. Respiratory tract hypersensitivity, bronchial asthma, acute myelocytic leukemia (AML) and myelodysplasia syndrome (MDS) can be diagnosed using the nucleotide sequence coding for this protein.
摘要翻译：本发明的目的是提供一种来源于人的活化的Rho蛋白质靶蛋白及其编码基因。本发明提供衍生自人及其衍生物的蛋白质，其具有以下特征：（1）具有活化的Rho蛋白结合活性，（2）具有丝氨酸结合活性，（3）编码蛋白质的基因位于染色体5的q31.2和（4）通过SDS-PAGE测量分子量为约150kDa。呼吸道超敏反应，支气管哮喘，急性骨髓性白血病（AML）和骨髓增生异常综合征（MDS）可以使用编码该蛋白的核苷酸序列进行诊断。

6. 发明申请

US20060058394A1 Medicine of post-traumatic stress disorder 审中-公开
标题翻译：创伤后应激障碍医学
公开(公告)号：US20060058394A1
公开(公告)日：2006-03-16
申请号：US11249484
申请日：2005-10-14
申请人： Shuh Narumiya , Takayuki Maruyama
发明人： Shuh Narumiya , Takayuki Maruyama
IPC分类号： A61K31/557
CPC分类号： A61K31/5575 , A61K31/00
摘要： The treatment and/or prophylactic drugs of post-traumatic stress disorder (PTSD) containing compounds (EP1 agonists), which activate EP1 receptor that is subtype of prostaglandin E2 receptor, as an active ingredient. EP1 agonists such as (13E)-(11α,15S,17S)-2,5-ethano-6,9-dioxo-11,15-dihydro-17,20-dimethylprosta-13-enoic acid, PGE1, or PGE2, etc. are useful for the treatment of post-traumatic stress disorder (PTSD).
摘要翻译：包含化合物（EP 1激动剂）的创伤后应激障碍（PTSD）的治疗和/或预防药物，其激活作为前列腺素E2受体亚型的EP 1受体，作为活性成分。 EP 1激动剂如（13E） - （11α，15S，17S）-2,5-乙基-6,9-二氧代-11,15-二氢-17,20-二甲基丙基-13- 辛酸，PGE 1或PGE 2等可用于治疗创伤后应激障碍（PTSD）。

7. 发明授权

US5804415A Prostaglandin E receptors, their DNA and production 失效
公开(公告)号：US5804415A
公开(公告)日：1998-09-08
申请号：US685945
申请日：1996-07-22
申请人： Atsushi Ichikawa , Shuh Narumiya
发明人： Atsushi Ichikawa , Shuh Narumiya
IPC分类号： C07K14/705 , C07K14/435 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： C07K14/72
摘要： Disclosed are (1) a protein capable of receiving PGE, (2) a recombinant DNA coding for said protein, (3) a vector having said DNA, (4) a transformant carrying said vector, and (5) a method for producing said protein wherein said transformant is cultured in a culture medium, the protein being useful not only in cloning other PGE receptor genes, clarifying the structure of PGE receptors and elucidating the function of PGE, but also in searching for PGE antagonists and agonists and so on.

8. 发明授权

US5576192A Prostaglandin E receptors, their DNA and production 失效
标题翻译：前列腺素E受体，其DNA和产生
公开(公告)号：US5576192A
公开(公告)日：1996-11-19
申请号：US390162
申请日：1995-02-17
申请人： Atsushi Ichikawa , Shuh Narumiya
发明人： Atsushi Ichikawa , Shuh Narumiya
IPC分类号： C07K14/705 , C07K14/435 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： C07K14/72
摘要： Disclosed are (1) a protein capable of receiving PGE, (2) a recombinant DNA coding for said protein, (3) a vector having said DNA, (4) a transformant carrying said vector, and (5) a method for producing said protein wherein said transformant is cultured in a culture medium, the protein being useful not only in cloning other PGE receptor genes, clarifying the structure of PGE receptors and elucidating the function of PGE, but also in searching for PGE antagonists and agonists and so on.
摘要翻译：公开了（1）能够接受PGE的蛋白质，（2）编码所述蛋白质的重组DNA，（3）具有所述DNA的载体，（4）携带所述载体的转化体，和（5）蛋白质，其中所述转化体在培养基中培养，该蛋白质不仅用于克隆其他PGE受体基因，澄清PGE受体的结构和阐明PGE的功能，而且用于寻找PGE拮抗剂和激动剂等。

9. 发明授权

US4954514A (Di-tert-butylhydroxyphenyl)thio derivatives and antiarterioschlerosis compositions thereof 失效
标题翻译：（二叔丁基羟基苯基）硫代衍生物及其抗动脉硬化组合物
公开(公告)号：US4954514A
公开(公告)日：1990-09-04
申请号：US451743
申请日：1989-12-18
申请人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumrhio Watanabe , Masami Doteuchi , Takuji Mizui
发明人： Toru Kita , Shuh Narumiya , Masayuki Narisada , Fumrhio Watanabe , Masami Doteuchi , Takuji Mizui
IPC分类号： A61K31/165 , A61K31/16 , A61K31/275 , A61K31/41 , A61P1/04 , A61P3/06 , A61P9/10 , A61P29/00 , A61P37/08 , A61P43/00 , C07C323/32 , C07C323/41 , C07C323/60 , C07C323/62 , C07D257/04
CPC分类号： C07D257/04 , C07C323/60
摘要： (Di-tert-butylhydroxyphenyl)thio derivatives of the formula: ##STR1## wherein R is cyano, carbamoyl, or 5-tetrazolyl; n is an integer of 2 to 6; provided that when R is cyano, n is not 2; or a pharmaceutically acceptable salt thereof; useful in treating arterioschlerosis, ulcer, inflammation, allergy, or the like.

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