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1. 发明申请

US20130092616A1 SUBSTRATE FOR LIGAND IMMOBILIZATION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：用于配位固定的基板及其制造方法
公开(公告)号：US20130092616A1
公开(公告)日：2013-04-18
申请号：US13638007
申请日：2011-03-28
申请人： Shinichiro Nagasawa , Masakazu Fukushima
发明人： Shinichiro Nagasawa , Masakazu Fukushima
IPC分类号： C08F255/02 , A61M1/36 , C08F8/30
CPC分类号： C08F255/02 , A61M1/3679 , B01J20/321 , B01J20/3276 , B01J20/3278 , B01J20/328 , C08F8/30
摘要： The present invention provides a substrate for ligand support in which a copolymer represented by the following formula (1) is bonded to at least a surface of a water-insoluble carrier: [in the formula (1), n and m represent a positive integer, and a value of m/(n+m) is greater than or equal to 0.1 and less than or equal to 0.45, R1 represents H or CH3, R2 represents an organic group including an electrophilic functional group, and R3 represents
摘要翻译：本发明提供了一种用于配体载体的底物，其中由下式（1）表示的共聚物与至少一种水不溶性载体的表面键合：[式（1）中，n和m表示正整数，m /（n + m）的值大于或等于0.1且小于或等于0.45，R 1表示H或CH 3，R 2表示包含亲电子官能团的有机基团，R 3表示

2. 发明授权

US08569324B2 Potentiator for radiation therapy comprising pyridine derivative as active ingredient 有权
标题翻译：包括吡啶衍生物作为活性成分的放射治疗剂
公开(公告)号：US08569324B2
公开(公告)日：2013-10-29
申请号：US12978743
申请日：2010-12-27
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A61K31/435
CPC分类号： C07D213/69 , A61K41/0038
摘要： The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivative represented by general formula (1): wherein R1, R2, and R4 may be the same or different from one another and represent a hydrogen atom, hydroxy group, or protected hydroxy group, excluding the case where R1, R2, and R4 are all a hydrogen atom, and R3 represents a halogen atom, amino group, carboxyl group, carbamoyl group, cyano group, nitro group, alkyl group having 1 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, or carbonyl group containing an alkoxy group having 1 to 6 carbon atoms).
摘要翻译：本发明涉及一种放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少放射剂量和不良药物反应。提供一种放射治疗增强剂，其包含作为活性成分的通式（1）表示的吡啶衍生物：其中R 1，R 2和R 4可以相同或不同，表示氢原子，羟基或氨基，羧基，氨基甲酰基，氰基，硝基，碳原子数为1〜6的烷基，R 1，R 2，R 4全部为氢原子，R 3表示卤素原子，氨基，具有2〜6个碳原子的烯基或含有1〜6个碳原子的烷氧基的羰基）。

3. 发明授权

US06294535B1 Uracil derivatives and antitumor effect potentiator and antitumor agent containing the same 有权
标题翻译：尿嘧啶衍生物和抗肿瘤作用增强剂和抗肿瘤药含有相同的作用
公开(公告)号：US06294535B1
公开(公告)日：2001-09-25
申请号：US09457668
申请日：1999-12-09
申请人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
发明人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
IPC分类号： A61K31535
CPC分类号： C07D239/54 , C07D231/12 , C07D233/56 , C07D239/553 , C07D249/08 , C07D403/06 , C07D403/12
摘要： The invention relates to novel uracil derivatives having excellent inhibiting effects on human derived thymidine phosphorylates and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators and antitumor agents containing such novel compounds, and a process for their preparation and use are described. The novel uracil derivative compounds are represented by the general formula (1′):
摘要翻译：本发明涉及对人衍生的胸苷磷酸酯具有优异抑制作用的新型尿嘧啶衍生物和抗肿瘤活性。描述了含有这些新化合物的药物组合物，抗肿瘤增强剂和抗肿瘤剂及其制备和使用方法。新型尿嘧啶衍生物化合物由通式（1'）表示：

4. 发明授权

US5525603A Compositions, methods and kits for potentiating antitumor effect and for treating tumor 失效
标题翻译：用于增强抗肿瘤效果和治疗肿瘤的组合物，方法和试剂盒
公开(公告)号：US5525603A
公开(公告)日：1996-06-11
申请号：US414127
申请日：1995-03-30
申请人： Tetsuhiko Shirasaka , Masakazu Fukushima , Hideyuki Ohshimo , Yuji Shimamoto
发明人： Tetsuhiko Shirasaka , Masakazu Fukushima , Hideyuki Ohshimo , Yuji Shimamoto
IPC分类号： A61K31/44 , A61K31/53 , A61K31/505
CPC分类号： A61K31/53 , A61K31/44 , A61K31/70
摘要： This invention provides a composition, method and kit for potentiating the antitumor effect of tegafur and reducing the side effects of tegafur, comprising a compound of the formula ##STR1## wherein X is a halogen atom or a cyano group and oxonic acid or a pharmaceutically acceptable salt thereof, and also provides a composition, method and kit for treating a tumor, comprising tegafur, a compound of the formula (I) and oxonic acid or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种用于增强替加氟的抗肿瘤作用并降低替加氟的副作用的组合物，方法和试剂盒，其包含式（I）的化合物，其中X为卤素原子或氰基和奥钴酸，或还提供了用于治疗肿瘤的组合物，方法和试剂盒，其包含替加氟，式（I）的化合物和奥克辛酸或其药学上可接受的盐。

5. 发明授权

US4540916A Electron gun for television camera tube 失效
标题翻译：电子枪电视摄像机管
公开(公告)号：US4540916A
公开(公告)日：1985-09-10
申请号：US437335
申请日：1982-10-28
申请人： Masanori Maruyama , Masakazu Fukushima , Shinichi Kato , Chihaya Ogusu
发明人： Masanori Maruyama , Masakazu Fukushima , Shinichi Kato , Chihaya Ogusu
IPC分类号： H01J29/48 , H01J29/46 , H01J29/56
CPC分类号： H01J29/488
摘要： An electron gun for a television camera tube comprises a cathode for emission of electrons, a first grid disposed subsequently to the cathode and having a first aperture supplied with a positive voltage relative to the cathode, a second grid disposed subsequently to the first grid and having a second aperture supplied with a higher positive voltage than that supplied to the first grid, and an intermediate grid interposed between the first and second grids and having a hole. The intermediate grid forms a divergent electron lens near the first aperture between the first and second grids. An electron beam having passed through the first aperture is once diverged by the divergent electron lens to form a crossover at an axial position of the gun which is remote from the first grid and at which the potential on the beam axis is high, whereby broadening of the width of the velocity distribution of extracted electrons can be suppressed to a minimum and the amount of beam current passing through the second aperture can be increased.
摘要翻译：一种用于电视摄像机管的电子枪包括用于发射电子的阴极，设置在阴极附近并具有相对于阴极提供正电压的第一孔径的第一栅极，以及随后设置在第一栅极上的第二栅极，提供具有比提供给第一格栅的正电压高的正电压的第二孔，以及插入在第一栅极和第二栅极之间并具有孔的中间栅格。中间栅格在第一和第二栅极之间的第一孔附近形成发散电子透镜。已经通过第一孔的电子束一旦被发散的电子透镜分开，在枪的轴向位置处形成一个与第一格栅远离的轴的交叉点，并且在该轴处的波束轴上的电位高，从而使提取的电子的速度分布的宽度可以被抑制到最小，并且可以增加通过第二孔径的束流的量。

6. 发明申请

US20090137640A1 POTENTIATOR FOR RADIATION THERAPY COMPRISING PYRIDINE DERIVATIVE AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于将吡啶衍生物作为活性成分包含的放射治疗的潜在剂
公开(公告)号：US20090137640A1
公开(公告)日：2009-05-28
申请号：US11910150
申请日：2006-03-31
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A61K31/44 , C07D213/69 , A61P35/00
CPC分类号： C07D213/69 , A61K41/0038
摘要： The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivative represented by general formula (1): wherein R1, R2, and R4 may be the same or different from one another and represent a hydrogen atom, hydroxy group, or protected hydroxy group, excluding the case where R1, R2, and R4 are all a hydrogen atom, and R3 represents a halogen atom, amino group, carboxyl group, carbamoyl group, cyano group, nitro group, alkyl group having 1 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, or carbonyl group containing an alkoxy group having 1 to 6 carbon atoms).
摘要翻译：本发明涉及一种放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少放射剂量和不良药物反应。提供一种放射治疗增强剂，其包含作为活性成分的通式（1）表示的吡啶衍生物：其中R 1，R 2和R 4可以相同或不同，表示氢原子，羟基或氨基，羧基，氨基甲酰基，氰基，硝基，碳原子数为1〜6的烷基，R 1，R 2，R 4全部为氢原子，R 3表示卤素原子，氨基，具有2〜6个碳原子的烯基或含有1〜6个碳原子的烷氧基的羰基）。

7. 发明授权

US06596720B1 Anti-HIV compositions 失效
标题翻译：抗HIV组合物
公开(公告)号：US06596720B1
公开(公告)日：2003-07-22
申请号：US10111396
申请日：2002-05-03
申请人： Hiroo Hoshino , Kenji Kitazato , Masakazu Fukushima
发明人： Hiroo Hoshino , Kenji Kitazato , Masakazu Fukushima
IPC分类号： A61K31535
CPC分类号： A61K31/7072 , A61K31/506 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention provides: an anti-HIV composition comprising at least one member selected from the group consisting of trifluridine and derivatives thereof, and a pharmaceutically acceptable carrier; an anti-HIV composition comprising (a) at least one member selected from the group consisting of trifluridine and derivatives thereof, (b) a thymidine phosphorylase inhibitor, and a pharmaceutically acceptable carrier; and a composition for potentiating the anti-HIV activity of trifluridine and derivatives thereof, comprising a thymidine phosphorylase inhibitor and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供：抗HIV组合物，其包含选自三氟尿苷及其衍生物中的至少一种和药学上可接受的载体;抗HIV组合物，其包含（a）至少一种选自以下的成员：的三氟尿苷及其衍生物，（b）胸苷磷酸化酶抑制剂和药学上可接受的载体; 以及用于增强三氟尿苷及其衍生物的抗HIV活性的组合物，其包含胸苷磷酸化酶抑制剂和药学上可接受的载体。

8. 发明授权

US4866337A Image pick-up tube with electrostatic deflecting electrode structure 失效
标题翻译：具有静电偏转电极结构的摄像管
公开(公告)号：US4866337A
公开(公告)日：1989-09-12
申请号：US15378
申请日：1987-02-17
申请人： Masanori Maruyama , Kentaro Oku , Masakazu Fukushima , Shinichi Kato , Mitsuhiro Kurashige
发明人： Masanori Maruyama , Kentaro Oku , Masakazu Fukushima , Shinichi Kato , Mitsuhiro Kurashige
IPC分类号： H01J29/76 , H01J29/74
CPC分类号： H01J29/74
摘要： In an electromagnetic focusing electrostatic type image pick-up tube the electrostatic deflecting electrodes formed on the inner surface of the tube consist of 2 pairs of electrodes. Each of these electrostatic deflecting electrodes has a zig-zag shape from the electron gun towards the target. This zig-zag shape is twisted in the circumferential direction around the axis of the tube and variation rates of this twist amount are different, depending on the position in the axial direction.
摘要翻译：在电磁聚焦静电型图像拾取管中，形成在管的内表面上的静电偏转电极由2对电极组成。这些静电偏转电极中的每一个具有从电子枪朝向目标的之字形。这种锯齿形状围绕管的轴线在圆周方向上扭曲，并且该扭转量的变化率根据轴向方向上的位置而不同。

9. 发明授权

US4701668A Cylindrical image pickup tube having electrostatic deflection electrodes formed of straight line pattern yokes 失效
标题翻译：具有由直线图案轭形成的静电偏转电极的圆柱形图像拾取管
公开(公告)号：US4701668A
公开(公告)日：1987-10-20
申请号：US867155
申请日：1986-05-27
申请人： Kentaro Oku , Masakazu Fukushima , Hitomi Suzuki , Masanori Maruyama
发明人： Kentaro Oku , Masakazu Fukushima , Hitomi Suzuki , Masanori Maruyama
IPC分类号： H01J29/64 , H01J29/74 , H01J29/70
CPC分类号： H01J29/74
摘要： A magnetic focusing and electrostatic deflecting image pickup tube comprises electrostatic deflection electrodes each constituted by a straight arrow pattern yoke composed of straight line segments arrayed in a linear zigzag pattern. The pattern yoke has a twist angle set at a value not greater than 105.degree.. An average value of angles formed by each upper apex and two lower apices adjacent to the upper apex of the zigzag pattern yoke with reference to the axis of the tube lies within a range of 116.degree. to 127.degree..
摘要翻译：磁聚焦和静电偏转图像拾取管包括静电偏转电极，每个静电偏转电极由以直线形之字形图案排列的直线段组成的直箭头图案磁轭构成。图案磁轭的扭转角设定在105度以下。相对于管的轴线，每个上顶点和相邻于之字形图形磁轭的上顶点的两个下顶点形成的角度的平均值在116°至127°的范围内。

10. 发明授权

US4663560A Magnetic focus and electrostatic deflection type image pick-up tube 失效
标题翻译：磁焦和静电偏转型摄像管
公开(公告)号：US4663560A
公开(公告)日：1987-05-05
申请号：US668844
申请日：1984-11-06
申请人： Kentaro Oku , Masakazu Fukushima
发明人： Kentaro Oku , Masakazu Fukushima
IPC分类号： H01J29/74 , H01J31/38 , H01J29/78 , H01J31/36
CPC分类号： H01J31/38 , H01J29/74
摘要： A magnetic focus and electrostatic deflection type image pick-up tube in which electrostatic deflection electrodes assuming a cylindrical shape as a whole are twisted about the axis of the cylinder at an angle selected so as to range from 21.degree. to 60.degree.. The spot of the electron beam is less enlarged in an oval shape at the corners of target in the imaging tube.
摘要翻译：一种磁焦点和静电偏转型图像拾取管，其中呈圆柱形状的静电偏转电极整体以围绕气缸轴线的角度以21°至60°的角度被选定。电子束的斑点在成像管中的靶的角落处以椭圆形较小的扩大。

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