专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08569324B2 Potentiator for radiation therapy comprising pyridine derivative as active ingredient 有权
标题翻译：包括吡啶衍生物作为活性成分的放射治疗剂
公开(公告)号：US08569324B2
公开(公告)日：2013-10-29
申请号：US12978743
申请日：2010-12-27
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A61K31/435
CPC分类号： C07D213/69 , A61K41/0038
摘要： The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivative represented by general formula (1): wherein R1, R2, and R4 may be the same or different from one another and represent a hydrogen atom, hydroxy group, or protected hydroxy group, excluding the case where R1, R2, and R4 are all a hydrogen atom, and R3 represents a halogen atom, amino group, carboxyl group, carbamoyl group, cyano group, nitro group, alkyl group having 1 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, or carbonyl group containing an alkoxy group having 1 to 6 carbon atoms).
摘要翻译：本发明涉及一种放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少放射剂量和不良药物反应。提供一种放射治疗增强剂，其包含作为活性成分的通式（1）表示的吡啶衍生物：其中R 1，R 2和R 4可以相同或不同，表示氢原子，羟基或氨基，羧基，氨基甲酰基，氰基，硝基，碳原子数为1〜6的烷基，R 1，R 2，R 4全部为氢原子，R 3表示卤素原子，氨基，具有2〜6个碳原子的烯基或含有1〜6个碳原子的烷氧基的羰基）。

2. 发明授权

US06294535B1 Uracil derivatives and antitumor effect potentiator and antitumor agent containing the same 有权
标题翻译：尿嘧啶衍生物和抗肿瘤作用增强剂和抗肿瘤药含有相同的作用
公开(公告)号：US06294535B1
公开(公告)日：2001-09-25
申请号：US09457668
申请日：1999-12-09
申请人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
发明人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
IPC分类号： A61K31535
CPC分类号： C07D239/54 , C07D231/12 , C07D233/56 , C07D239/553 , C07D249/08 , C07D403/06 , C07D403/12
摘要： The invention relates to novel uracil derivatives having excellent inhibiting effects on human derived thymidine phosphorylates and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators and antitumor agents containing such novel compounds, and a process for their preparation and use are described. The novel uracil derivative compounds are represented by the general formula (1′):
摘要翻译：本发明涉及对人衍生的胸苷磷酸酯具有优异抑制作用的新型尿嘧啶衍生物和抗肿瘤活性。描述了含有这些新化合物的药物组合物，抗肿瘤增强剂和抗肿瘤剂及其制备和使用方法。新型尿嘧啶衍生物化合物由通式（1'）表示：

3. 发明授权

US5525603A Compositions, methods and kits for potentiating antitumor effect and for treating tumor 失效
标题翻译：用于增强抗肿瘤效果和治疗肿瘤的组合物，方法和试剂盒
公开(公告)号：US5525603A
公开(公告)日：1996-06-11
申请号：US414127
申请日：1995-03-30
申请人： Tetsuhiko Shirasaka , Masakazu Fukushima , Hideyuki Ohshimo , Yuji Shimamoto
发明人： Tetsuhiko Shirasaka , Masakazu Fukushima , Hideyuki Ohshimo , Yuji Shimamoto
IPC分类号： A61K31/44 , A61K31/53 , A61K31/505
CPC分类号： A61K31/53 , A61K31/44 , A61K31/70
摘要： This invention provides a composition, method and kit for potentiating the antitumor effect of tegafur and reducing the side effects of tegafur, comprising a compound of the formula ##STR1## wherein X is a halogen atom or a cyano group and oxonic acid or a pharmaceutically acceptable salt thereof, and also provides a composition, method and kit for treating a tumor, comprising tegafur, a compound of the formula (I) and oxonic acid or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种用于增强替加氟的抗肿瘤作用并降低替加氟的副作用的组合物，方法和试剂盒，其包含式（I）的化合物，其中X为卤素原子或氰基和奥钴酸，或还提供了用于治疗肿瘤的组合物，方法和试剂盒，其包含替加氟，式（I）的化合物和奥克辛酸或其药学上可接受的盐。

4. 发明授权

US4540916A Electron gun for television camera tube 失效
标题翻译：电子枪电视摄像机管
公开(公告)号：US4540916A
公开(公告)日：1985-09-10
申请号：US437335
申请日：1982-10-28
申请人： Masanori Maruyama , Masakazu Fukushima , Shinichi Kato , Chihaya Ogusu
发明人： Masanori Maruyama , Masakazu Fukushima , Shinichi Kato , Chihaya Ogusu
IPC分类号： H01J29/48 , H01J29/46 , H01J29/56
CPC分类号： H01J29/488
摘要： An electron gun for a television camera tube comprises a cathode for emission of electrons, a first grid disposed subsequently to the cathode and having a first aperture supplied with a positive voltage relative to the cathode, a second grid disposed subsequently to the first grid and having a second aperture supplied with a higher positive voltage than that supplied to the first grid, and an intermediate grid interposed between the first and second grids and having a hole. The intermediate grid forms a divergent electron lens near the first aperture between the first and second grids. An electron beam having passed through the first aperture is once diverged by the divergent electron lens to form a crossover at an axial position of the gun which is remote from the first grid and at which the potential on the beam axis is high, whereby broadening of the width of the velocity distribution of extracted electrons can be suppressed to a minimum and the amount of beam current passing through the second aperture can be increased.
摘要翻译：一种用于电视摄像机管的电子枪包括用于发射电子的阴极，设置在阴极附近并具有相对于阴极提供正电压的第一孔径的第一栅极，以及随后设置在第一栅极上的第二栅极，提供具有比提供给第一格栅的正电压高的正电压的第二孔，以及插入在第一栅极和第二栅极之间并具有孔的中间栅格。中间栅格在第一和第二栅极之间的第一孔附近形成发散电子透镜。已经通过第一孔的电子束一旦被发散的电子透镜分开，在枪的轴向位置处形成一个与第一格栅远离的轴的交叉点，并且在该轴处的波束轴上的电位高，从而使提取的电子的速度分布的宽度可以被抑制到最小，并且可以增加通过第二孔径的束流的量。

5. 发明授权

US08440675B2 Potentiator of radiation therapy 有权
标题翻译：放射治疗药剂
公开(公告)号：US08440675B2
公开(公告)日：2013-05-14
申请号：US13242432
申请日：2011-09-23
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D403/06 , A61K31/513 , A61K31/7072
摘要： To provide a radiation therapy potentiator, which, when employed in combination with cancer radiation therapy, can reduce radiation dose and can mitigate adverse effects.The invention provides a radiation therapy potentiator containing, as an effective ingredient, a uracil derivative represented by formula (1) (wherein R1 represents a halogen atom or a cyano group; and R2 represents a 4- to 8-membered heterocyclic group having 1 to 3 nitrogen atoms and optionally having as a substituent a lower alkyl group, an imino group, a hydroxyl group, a hydroxymethyl group, a methanesulfonyloxy group, or an amino group; an amidinothio group in which a hydrogen atom attached to a nitrogen atom may be substituted by a lower alkyl group; a guanidino group in which a hydrogen atom attached to a nitrogen atom may be substituted by a lower alkyl group or a cyano group; a lower alkylamidino group; or a 1-pyrrolidinylmethyl group) or a pharmaceutically acceptable salt thereof.
摘要翻译：提供放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少辐射剂量并减轻不良反应。本发明提供一种放射治疗增效剂，其含有作为有效成分的式（1）表示的尿嘧啶衍生物（其中，R1表示卤素原子或氰基; R2表示具有1〜 3个氮原子，任选具有低级烷基，亚氨基，羟基，羟甲基，甲磺酰氧基或氨基作为取代基;其中与氮原子连接的氢原子可以是被低级烷基取代;其中与氮原子连接的氢原子可以被低级烷基或氰基取代的胍基，低级烷基脒基或1-吡咯烷基甲基）或其药学上可接受的盐其中。

6. 发明申请

US20130092616A1 SUBSTRATE FOR LIGAND IMMOBILIZATION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：用于配位固定的基板及其制造方法
公开(公告)号：US20130092616A1
公开(公告)日：2013-04-18
申请号：US13638007
申请日：2011-03-28
申请人： Shinichiro Nagasawa , Masakazu Fukushima
发明人： Shinichiro Nagasawa , Masakazu Fukushima
IPC分类号： C08F255/02 , A61M1/36 , C08F8/30
CPC分类号： C08F255/02 , A61M1/3679 , B01J20/321 , B01J20/3276 , B01J20/3278 , B01J20/328 , C08F8/30
摘要： The present invention provides a substrate for ligand support in which a copolymer represented by the following formula (1) is bonded to at least a surface of a water-insoluble carrier: [in the formula (1), n and m represent a positive integer, and a value of m/(n+m) is greater than or equal to 0.1 and less than or equal to 0.45, R1 represents H or CH3, R2 represents an organic group including an electrophilic functional group, and R3 represents
摘要翻译：本发明提供了一种用于配体载体的底物，其中由下式（1）表示的共聚物与至少一种水不溶性载体的表面键合：[式（1）中，n和m表示正整数，m /（n + m）的值大于或等于0.1且小于或等于0.45，R 1表示H或CH 3，R 2表示包含亲电子官能团的有机基团，R 3表示

7. 发明申请

US20120059009A1 ANTI-TUMOR AGENT CONTAINING TEGAFUR-GIMERACIL-OTERACIL POTASSIUM COMBINATION DRUG AND OXALIPLATIN 审中-公开
标题翻译：含TEGAFUR-GIMERACIL-OTERACIL钾组合药物和OXALIPLATIN的抗肿瘤剂
公开(公告)号：US20120059009A1
公开(公告)日：2012-03-08
申请号：US13319951
申请日：2010-05-11
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A61K31/53 , A61P35/00
CPC分类号： A61K31/4412 , A61K31/282 , A61K31/404 , A61K31/513 , A61K31/53 , A61K2300/00
摘要： To provide a novel combination therapy which exhibits remarkable anti-tumor effect.The invention provides an anti-tumor agent comprising a combination drug containing tegafur, gimeracil and oteracil potassium, oxaliplatin, and TSU-68 or a salt thereof, in combination.
摘要翻译：提供显示出显着的抗肿瘤效果的新型联合疗法。本发明组合提供包含组合药物的抗肿瘤剂，其包含替加氟，吉美脯氨酸和奥替卡尔钾，奥沙利铂和TSU-68或其盐。

8. 发明授权

US08058261B2 3′-ethynylcytidine derivative 失效
标题翻译： 3'-乙炔基胞苷衍生物
公开(公告)号：US08058261B2
公开(公告)日：2011-11-15
申请号：US12375077
申请日：2007-07-23
申请人： Motoaki Tanaka , Masakazu Fukushima
发明人： Motoaki Tanaka , Masakazu Fukushima
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/06
摘要： To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug.The invention provides a 3′-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.
摘要翻译：提供表现出优异的抗肿瘤活性和优异的口服吸收并且是有用的抗肿瘤药物的化合物。本发明提供由式（1）表示的3'-乙炔基胞苷衍生物：其中X表示（取代）烷基羰基，（取代）烷氧基羰基或氢原子; Y和Z之一表示氢原子或（R 1）（R 2）（R 3）Si表示的基团，另一个表示由（R 4）（R 5）（R 6）Si - 表示的基团，R 1，R 2，R 3，R 4，R 5和R 6各自表示（取代的）烷基，（取代的）环烷基或（取代的）芳基）或其盐。

9. 发明申请

US20090306008A1 3'-ETHYNYLCYTIDINE DERIVATIVE 失效
标题翻译： 3'-乙酰基衍生物
公开(公告)号：US20090306008A1
公开(公告)日：2009-12-10
申请号：US12375077
申请日：2007-07-23
申请人： Motoaki Tanaka , Masakazu Fukushima
发明人： Motoaki Tanaka , Masakazu Fukushima
IPC分类号： A61K31/7068 , C07H19/067 , A61P35/00
CPC分类号： C07H19/06
摘要： To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug.The invention provides a 3′-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.
摘要翻译：提供表现出优异的抗肿瘤活性和优异的口服吸收并且是有用的抗肿瘤药物的化合物。本发明提供由式（1）表示的3'-乙炔基胞苷衍生物：其中X表示（取代）烷基羰基，（取代）烷氧基羰基或氢原子; Y和Z之一表示氢原子或（R 1）（R 2）（R 3）Si表示的基团，另一个表示由（R 4）（R 5）（R 6）Si - 表示的基团，R 1，R 2，R 3，R 4，R 5和R 6各自表示（取代的）烷基，（取代的）环烷基或（取代的）芳基）或其盐。

10. 发明授权

US06479500B1 Agents for alleviating side effects 有权
标题翻译：减轻副作用的药剂
公开(公告)号：US06479500B1
公开(公告)日：2002-11-12
申请号：US09701041
申请日：2000-11-22
申请人： Masakazu Fukushima , Noriyuki Yamamoto , Norihiko Suzuki
发明人： Masakazu Fukushima , Noriyuki Yamamoto , Norihiko Suzuki
IPC分类号： A61P3900
CPC分类号： C07D403/06 , A61K9/0019 , A61K9/0031 , A61K9/02 , A61K9/1652 , A61K9/2018 , A61K9/4858 , A61K31/4745 , A61K31/513 , A61K31/7072 , A61K33/24 , A61K45/06 , Y10S514/867 , A61K2300/00
摘要： The present invention provides an agent for alleviating side effects caused by use of an anti-tumor agent, which contains 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidi nedione (1) represented by formula (1): or a pharmaceutically acceptable salt thereof. The 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione or a pharmaceutically acceptable salt thereof exhibit an inflammatory-suppressing action in the digestive tract and advantageously alleviate diarrhea and loss of body weight concomitant with administration of a chemical for treating cancer without suppressing the anti-tumor effect. Thus, the compounds of the present invention are of great value as agents for alleviating side effects caused by use of an anti-tumor agent, which enable not only the chemotherapy to be continuedly carried out, but also the body exhaustion to be effectively prevented.
摘要翻译：本发明提供了减轻由使用抗5-氯-6-（2-亚氨基吡咯烷-1-基）甲基-2,4（1H，3H） - 嘧啶二酮的抗肿瘤剂引起的副作用的药剂（1）表示的化合物或其药学上可接受的盐。 5-氯-6-（2-亚氨基吡咯烷-1-基）甲基-2,4（1H，3H） - 嘧啶二酮或其药学上可接受的盐在消化道中表现出炎症抑制作用，有利地减轻腹泻和损失的体重，同时施用用于治疗癌症的化学物质而不抑制抗肿瘤作用。因此，本发明的化合物作为减轻使用抗肿瘤剂引起的副作用的药剂，作为不仅能够持续进行化学疗法而且能够有效防止身体排气的药剂，具有重要价值。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式