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1. 发明授权

US07258878B2 Anti-microbial composition and methods of use thereof 有权
标题翻译：抗微生物组合物及其使用方法
公开(公告)号：US07258878B2
公开(公告)日：2007-08-21
申请号：US11017226
申请日：2004-12-20
申请人： Sharon Linda Greene , Yanbin Huang , Lei Huang , Ilona F. Weart , Shu-Ping Yang , Sohail Malik , Robert B. Johnson
发明人： Sharon Linda Greene , Yanbin Huang , Lei Huang , Ilona F. Weart , Shu-Ping Yang , Sohail Malik , Robert B. Johnson
IPC分类号： A61K36/752
CPC分类号： A61K45/06 , A61K31/19 , A61K31/215 , A61K31/7048 , A61K36/61 , A61K2300/00
摘要： The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.
摘要翻译：本发明涉及用于治疗真菌和酵母菌感染的抗微生物组合物和方法。

2. 发明授权

US07786176B2 Vaginal treatment composition containing xylitol 有权
标题翻译：含有木糖醇的阴道治疗组合物
公开(公告)号：US07786176B2
公开(公告)日：2010-08-31
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

3. 发明申请

US20060134237A1 Anti-microbial composition and methods of use thereof 有权
标题翻译：抗微生物组合物及其使用方法
公开(公告)号：US20060134237A1
公开(公告)日：2006-06-22
申请号：US11017226
申请日：2004-12-20
申请人： Sharon Greene , Yanbin Huang , Lei Huang , Ilona Weart , Shu-Ping Yang , Sohail Malik , Robert Johnson
发明人： Sharon Greene , Yanbin Huang , Lei Huang , Ilona Weart , Shu-Ping Yang , Sohail Malik , Robert Johnson
IPC分类号： A61K31/7048 , A61K31/192 , A61K36/61
CPC分类号： A61K45/06 , A61K31/19 , A61K31/215 , A61K31/7048 , A61K36/61 , A61K2300/00
摘要： The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.
摘要翻译：本发明涉及用于治疗真菌和酵母菌感染的抗微生物组合物和方法。

4. 发明授权

US07238677B2 Prevention of urogenital infections 有权
标题翻译：预防泌尿生殖器感染
公开(公告)号：US07238677B2
公开(公告)日：2007-07-03
申请号：US10401522
申请日：2003-03-28
申请人： Shu-Ping Yang , Yanbin Huang , Ilona F. Weart
发明人： Shu-Ping Yang , Yanbin Huang , Ilona F. Weart
IPC分类号： A61K31/70
CPC分类号： A61F13/8405 , A61F13/2051 , A61K31/728 , Y02A50/473
摘要： The invention provides hyaluronic acid compounds and derivatives thereof for preventing urogenital infections by a variety of pathogens, as well as compositions, articles and methods for treating and preventing urogenital infections.
摘要翻译：本发明提供了用于预防各种病原体的泌尿生殖感染的透明质酸化合物及其衍生物，以及用于治疗和预防泌尿生殖器感染的组合物，制品和方法。

5. 发明授权

US07658947B2 Thermo-gelling composition 有权
标题翻译：热凝胶组合物
公开(公告)号：US07658947B2
公开(公告)日：2010-02-09
申请号：US10877855
申请日：2004-06-25
申请人： Yanbin Huang , Shu-Ping Yang , Sharon Linda Greene
发明人： Yanbin Huang , Shu-Ping Yang , Sharon Linda Greene
IPC分类号： A61K9/14
CPC分类号： A61K9/0024 , A61K8/042 , A61K8/365 , A61K8/731 , A61K47/12 , A61K47/38 , A61K2800/5422 , A61Q19/00
摘要： There is provided a new thermo-gelling composition made with methylcellulose and citric acid. This composition may also have an effective amount of a treating agent, which may be a medicinal agent, cosmetic agent, moisturizer, adjuvant, nutritional agent, other ingredients and combinations thereof. The composition is useful in delivering moisturizers or pharmaceutically active agents to the user in a controlled release manner through the mucosal tissues in a body cavity, or on body surfaces, or as a subcutaneously injected medicament. The composition may also be used as a replacement for the soft tissues of the body as in, for example, the foot cushion and cartilage repair.
摘要翻译：提供了由甲基纤维素和柠檬酸制成的新的热凝胶组合物。该组合物还可以具有有效量的处理剂，其可以是药剂，化妆品，保湿剂，佐剂，营养剂，其它成分及其组合。该组合物可用于通过体腔或身体表面的粘膜组织或皮下注射的药物以控制释放的方式向使用者输送保湿剂或药物活性剂。该组合物还可以用作身体的软组织的替代物，例如在脚垫和软骨修复中。

6. 发明授权

US08399012B2 Degradable therapeutic delivery device 有权
标题翻译：可降解治疗输送装置
公开(公告)号：US08399012B2
公开(公告)日：2013-03-19
申请号：US11405262
申请日：2006-04-17
申请人： Molly K. Smith , Kelly D. Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
发明人： Molly K. Smith , Kelly D. Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
IPC分类号： A61F6/06 , A61F2/00 , A61F6/14 , A61F13/00 , C08L67/02
CPC分类号： A61K47/34 , A61F6/08 , A61K9/0036 , A61K31/00 , A61K31/19 , A61M31/002 , C08G63/12 , C08G63/16 , C08G63/914
摘要： A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
摘要翻译：公开了一种可生物降解的生物输送装置。生物输送装置由包含多元醇和多元酸的反应产物的聚合物形成。当暴露于水时，聚合物通过水解降解。特别有利的是，聚合物可以形成为具有弹性和柔性。在一个实施方案中，聚合物形成阴道插入物。当聚合物降解时，聚合物将酸释放到阴道环境中以降低环境的pH。

7. 发明申请

US20070026074A1 Vaginal treatment composition 有权
标题翻译：阴道治疗组合物
公开(公告)号：US20070026074A1
公开(公告)日：2007-02-01
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K9/14 , A61K31/70 , A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物，例如天然存在的钠（Na +）+和钙（Ca 2+）+阳离子提供阴道粘膜。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

8. 发明申请

US20070243229A1 Degradable therapeutic delivery device 有权
标题翻译：可降解治疗输送装置
公开(公告)号：US20070243229A1
公开(公告)日：2007-10-18
申请号：US11405262
申请日：2006-04-17
申请人： Molly Smith , Kelly Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
发明人： Molly Smith , Kelly Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
IPC分类号： A61F2/02 , C08G63/91
CPC分类号： A61K47/34 , A61F6/08 , A61K9/0036 , A61K31/00 , A61K31/19 , A61M31/002 , C08G63/12 , C08G63/16 , C08G63/914
摘要： A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
摘要翻译：公开了一种可生物降解的生物输送装置。生物输送装置由包含多元醇和多元酸的反应产物的聚合物形成。当暴露于水时，聚合物通过水解降解。特别有利的是，聚合物可以形成为具有弹性和柔性。在一个实施方案中，聚合物形成阴道插入物。当聚合物降解时，聚合物将酸释放到阴道环境中以降低环境的pH。

9. 发明申请

US20060127459A1 Urogenital infection inhibition 审中-公开
标题翻译：泌尿生殖器感染抑制
公开(公告)号：US20060127459A1
公开(公告)日：2006-06-15
申请号：US11012758
申请日：2004-12-15
申请人： Lei Huang , Shu-Ping Yang , Yanbin Huang
发明人： Lei Huang , Shu-Ping Yang , Yanbin Huang
IPC分类号： A61K31/765 , A61K9/70
CPC分类号： A61K9/0034 , A61K9/0036 , A61K31/75 , A61K31/765
摘要： There is provided compositions and methods to inhibit the adherence of pathogenic microorganisms to cells. The composition includes water soluble PEO/PEG polymers which may be hydrophilic or amphiphilic block copolymers. One example of a suitable composition is polyethylene glycol or polyethylene oxide with a chemical formula of H—(OCH2CH2)n-OH. Another example of a suitable composition is amphiphilic block copolymer with a chemical formula PEOm-Xp-PEOn, where PEO is —(OCH2CH2)n-O and X is PPO(—(OCH2CH2CH2)m-), or PLGA (poly(lactic-co-glycolic acid), or PMMA (polymethyl methacrylate), or PBO (polybutylene oxide). The pathogenic microorganism may be a bacterial, fungal, viral or trichomonial pathogen and the composition prevents adherence of the pathogenic microorganism in, for example, a urogenital tract of a mammal and aids in reducing malodor generation. The composition may be applied to vaginal health products like, for example, moisturizer, gel, jelly, cream, insert (tablet), ointment, foam. The composition may also be applied to a feminine hygiene product, like, for example, a tampon, feminine pad, feminine wipe or panty liners.
摘要翻译：提供了抑制致病微生物对细胞的粘附的组合物和方法。该组合物包括可以是亲水性或两亲性嵌段共聚物的水溶性PEO / PEG聚合物。合适组合物的一个实例是具有化学式为H-（OCH 2 CH 2）n -OH的聚乙二醇或聚环氧乙烷。合适的组合物的另一个实例是具有化学式PEOm-Xp-PEOn的两亲嵌段共聚物，其中PEO是 - （OCH2CH2）nO，X是PPO（ - （OCH2CH2CH2）m-）或PLGA（聚（乳酸 - 乙醇酸）或PMMA（聚甲基丙烯酸甲酯）或PBO（聚环氧丁烷），病原微生物可以是细菌，真菌，病毒或毛滴虫病原体，并且该组合物可防止病原微生物在例如泌尿生殖道哺乳动物，有助于减少恶臭的产生，该组合物可用于例如保湿剂，凝胶，果冻，霜剂，插入物（片剂），软膏，泡沫等阴道保健品，该组合物也可用于女性卫生产品，例如，棉塞，女性衬垫，女性擦拭物或内裤衬里。

10. 发明申请

US20100275915A1 METHOD FOR REDUCING ODOR USING COORDINATED POLYDENTATE COMPOUNDS 失效
标题翻译：使用协调的聚氨酯化合物减少气味的方法
公开(公告)号：US20100275915A1
公开(公告)日：2010-11-04
申请号：US12835418
申请日：2010-07-13
申请人： Bin Wu , Kevin P. McGrath , Jaeho Kim , Bao Trong Do , Sharon Linda Greene , Yanbin Huang , Kaiyuan Yang
发明人： Bin Wu , Kevin P. McGrath , Jaeho Kim , Bao Trong Do , Sharon Linda Greene , Yanbin Huang , Kaiyuan Yang
IPC分类号： A61L15/46 , A61L9/01 , A61L9/012 , C08F8/42 , A61M16/06
CPC分类号： D21H21/14 , A61L9/014 , A61L15/46 , A61L2300/102 , A61L2300/802
摘要： A method for reducing odor is provided. The method comprises forming a coordination complex between a transition metal and a polydentate compound, and contacting the coordinated complex with an odorous compound. The transition metal provides one or more active sites for capturing the odorous compound. In some embodiments, the polydentate compound may be a polyalkylimine, such as polyethyleneimine, polypropyleneimine, or a dendrimer thereof.
摘要翻译：提供了减少气味的方法。该方法包括在过渡金属和多齿化合物之间形成配位络合物，并使配位络合物与有气味化合物接触。过渡金属提供了一个或多个用于捕获有气味化合物的活性位点。在一些实施方案中，多齿化合物可以是聚烷基亚胺，例如聚乙烯亚胺，聚丙烯亚胺或其树枝状大分子。

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