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1. 发明授权

US08344022B2 Vaginal health products 有权
公开(公告)号：US08344022B2
公开(公告)日：2013-01-01
申请号：US12364673
申请日：2009-02-03
申请人： Julie M. Villanueva , Sohail Malik
发明人： Julie M. Villanueva , Sohail Malik
IPC分类号： A01N43/16 , A01N35/00 , A01N33/08 , A01N43/08 , A61K31/355 , A61K31/12 , A61K31/13 , A61K31/34
CPC分类号： A61K31/19 , A61K31/355 , A61K31/365 , Y10S514/967 , A61K2300/00
摘要： The invention provides compositions and methods for increasing cell growth, stimulating cell turnover and promoting the secretion of mucus within the reproductive tract of a female mammal.

2. 发明申请

US20110092522A1 Wound and Skin Care Procuts 失效
标题翻译：伤口和护肤品
公开(公告)号：US20110092522A1
公开(公告)日：2011-04-21
申请号：US12952633
申请日：2010-11-23
申请人： Sohail Malik
发明人： Sohail Malik
IPC分类号： A61K31/52 , A61K31/5575 , A61K31/343 , A61P17/02 , C12N5/071
CPC分类号： A61K31/52 , A61K31/19 , A61K31/194 , A61K31/365 , A61K31/519 , A61K31/60 , A61K31/70 , A61K2300/00
摘要： The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.
摘要翻译：本发明提供了使用可以刺激成纤维细胞或角质细胞增殖和/或刺激成纤维细胞产生胶原的化合物的组合物和方法。这些组合物和方法可用于治疗牙龈和皮肤相关的病症。

3. 发明授权

US07098189B2 Wound and skin care compositions 有权
公开(公告)号：US07098189B2
公开(公告)日：2006-08-29
申请号：US10320730
申请日：2002-12-16
申请人： Sohail Malik
发明人： Sohail Malik
IPC分类号： A61K31/19 , A61K31/60 , A61K31/70
CPC分类号： A61K31/52 , A61K31/19 , A61K31/194 , A61K31/365 , A61K31/519 , A61K31/60 , A61K31/70 , A61K2300/00
摘要： The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.

4. 发明申请

US20050239710A1 Anti-aging and wound healing compounds 有权
公开(公告)号：US20050239710A1
公开(公告)日：2005-10-27
申请号：US11031488
申请日：2005-01-07
申请人： Stephen Quirk , Sohail Malik
发明人： Stephen Quirk , Sohail Malik
IPC分类号： A61K38/00 , A61K38/55 , A61P17/00 , C07K14/00 , C07K14/50 , C07K14/81 , C12N9/99 , A61K38/10 , C07K7/08
CPC分类号： C07K14/8146 , A61K38/00 , Y02A50/401
摘要： The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.

5. 发明授权

US06396929B1 Apparatus, method, and computer program product for high-availability multi-agent cryptographic key recovery 有权
标题翻译：用于高可用性多代理加密密钥恢复的装置，方法和计算机程序产品
公开(公告)号：US06396929B1
公开(公告)日：2002-05-28
申请号：US09224892
申请日：1998-12-31
申请人： Sekar Chandersekaran , Sohail Malik , Michael Muresan , Narayanan Vasudevan
发明人： Sekar Chandersekaran , Sohail Malik , Michael Muresan , Narayanan Vasudevan
IPC分类号： H04L930
CPC分类号： H04L9/0894
摘要： An apparatus, method, and computer program product for high-availability multi-agent cryptographic key recovery. The present invention defines a key recovery block that specifies allowable subsets of the total set of key recovery agents that can participate in a key recovery. For each subset, key recovery information is computed and stored after the subset is specified. This key recovery information is only useable by that subset because it is computed using that subset of public keys of the agents. When key recovery is initiated, a trusted processor (a key recovery coordinator) validates the contents of the key recovery block and it uses and is allowed to use any of the subsets of the agents to process the key recovery request. Since many subsets could be specified, the likelihood of key recovery failure is greatly diminished.
摘要翻译：一种用于高可用性多代理加密密钥恢复的设备，方法和计算机程序产品。本发明定义了密钥恢复块，其指定可以参与密钥恢复的密钥恢复代理的总组的可允许子集。对于每个子集，在子集被指定之后，计算并存储密钥恢复信息。该密钥恢复信息只能由该子集使用，因为它是使用代理的公钥的该子集来计算的。当启动密钥恢复时，受信任的处理器（密钥恢复协调器）验证密钥恢复块的内容，并使用密钥恢复块，并允许其使用代理的任何子集来处理密钥恢复请求。由于可以指定许多子集，因此密钥恢复失败的可能性大大降低。

6. 发明授权

US5980902A Compositions for treating and preventing diabetes, impaired glucose tolerance and related symptoms, and methods for preparing and using such compositions 失效
标题翻译：用于治疗和预防糖尿病，葡萄糖耐量降低和相关症状的组合物，以及制备和使用该组合物的方法
公开(公告)号：US5980902A
公开(公告)日：1999-11-09
申请号：US48966
申请日：1998-03-26
申请人： Edayatimangalam Raja Bhavani Shanmugasundaram , Kalathinkal Radha Shanmugasundaram , Rolland Hebert , Sohail Malik , Michael Baker
发明人： Edayatimangalam Raja Bhavani Shanmugasundaram , Kalathinkal Radha Shanmugasundaram , Rolland Hebert , Sohail Malik , Michael Baker
IPC分类号： A01N65/00 , A61K36/27 , A61P3/10
CPC分类号： A61K36/27
摘要： Compositions derived from Gymnema sylvestre leaf materials are disclosed. Methods for isolating such compositions are also disclosed. The compositions may be administered orally, intravenously, subcutaneously or transdermally and are useful for treating patients having diabetes, impaired glucose tolerance, and various conditions associated with or symptoms of diabetes. Additionally, the compositions reduce polydipsia, polyuria and polyphagia, regenerate the pancreatic islets of Langerhans, including beta cells, increase endogenous insulin, lipase and amylase levels, increase production of proinsulin and c-peptide, and lower blood lipids and triglycerides and free fatty acids.
摘要翻译：公开了从Gymnema sylvestre叶材料得到的组合物。还公开了分离这些组合物的方法。组合物可以口服，静脉内，皮下或经皮施用，并且可用于治疗患有糖尿病，葡萄糖耐量降低以及与糖尿病相关或多种症状的各种病症。另外，组合物减少烦渴，多尿和多食，再生胰岛素胰岛，包括β细胞，增加内源性胰岛素，脂肪酶和淀粉酶水平，增加胰岛素原和c肽的产生，降低血脂和甘油三酯和游离脂肪酸。

7. 发明授权

US07645583B2 Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin 失效
标题翻译：鉴定用于抑制C-反应蛋白与纤连蛋白复合的化合物
公开(公告)号：US07645583B2
公开(公告)日：2010-01-12
申请号：US11302994
申请日：2005-12-14
申请人： RameshBabu Boga , Sohail Malik , Stephen Quirk
发明人： RameshBabu Boga , Sohail Malik , Stephen Quirk
IPC分类号： G01N33/53 , G01N33/533 , G01N21/76
CPC分类号： G01N33/558 , G01N33/68 , G01N2333/4737 , G01N2333/78 , G01N2500/02 , Y10S436/815
摘要： Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly, inhibitory compounds identified by the disclosed methods may be utilized to prevent and treat damaged tissue, inflammatory conditions, cardiovascular conditions, renal conditions, periodontal conditions and obesity, among other conditions. For example, the compounds identified by the disclosed methods may be utilized to treat tissue that has suffered trauma, e.g., burns or wounds, as well as tissue that is inflamed due to any of several causes. The disclosed compounds may also be utilized to improve the accuracy of assays designed to assess CRP or Fn levels in a sample, for instance in a plasma sample, as a risk assessment tool in certain medical conditions and to discover new treatments.
摘要翻译：公开了用于鉴定可能抑制C-反应蛋白和纤连蛋白之间的复合物形成的化合物的筛选方法。通过公开的方法鉴定的化合物可以用于抑制已知在皮肤老化期间以及在几种疾病过程中发生的目标分析物。因此，通过所公开的方法鉴定的抑制性化合物可以用于预防和治疗受损组织，炎性病症，心血管病，肾病，牙周病和肥胖等疾病。例如，通过所公开的方法鉴定的化合物可以用于治疗已经遭受创伤的组织，例如烧伤或伤口，以及由于几种原因中的任何一种而发炎的组织。所公开的化合物还可以用于提高设计用于评估样品中的CRP或Fn水平的测定的准确度，例如在血浆样品中，作为某些医疗条件下的风险评估工具并发现新的治疗。

8. 发明授权

US07196162B2 Anti-aging and wound healing compounds 有权
标题翻译：抗衰老和伤口愈合化合物
公开(公告)号：US07196162B2
公开(公告)日：2007-03-27
申请号：US11031488
申请日：2005-01-07
申请人： Stephen Quirk , Sohail Malik
发明人： Stephen Quirk , Sohail Malik
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/8146 , A61K38/00 , Y02A50/401
摘要： The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.
摘要翻译：本发明提供了可用于促进健康皮肤发育和治疗伤口的基质金属蛋白酶抑制剂。抑制剂是具有与基质金属蛋白酶的酶原形式的切割区相关的序列的肽。本发明的肽抑制剂可以配制成促进愈合和健康皮肤发育的治疗组合物，乳液，霜剂，皮肤覆盖物和伤口敷料，阻止瘢痕形成和起皱并改善愈合的效果。

9. 发明授权

US07096505B2 System and method to support varying maximum cryptographic strength for common data security architecture (CDSA) applications 有权
标题翻译：支持普通数据安全架构（CDSA）应用程序的最大加密强度的系统和方法
公开(公告)号：US07096505B2
公开(公告)日：2006-08-22
申请号：US10788855
申请日：2004-02-27
申请人： Narayanan Vasudevan , Sohail Malik
发明人： Narayanan Vasudevan , Sohail Malik
IPC分类号： G06F11/00 , G06F17/60
CPC分类号： H04L63/0428
摘要： A technique for cryptographic strength selection for at least one application is provided, in accordance with a framework for providing cryptographic support of the at least one application. Data encryption is performed at a first cryptographic strength when the at least one application is privileged to perform encryption at a first cryptographic strength. Data encryption is performed at a second cryptographic strength when the at least one application is not privileged to perform encryption at the first cryptographic strength. The first cryptographic strength is stronger than the second cryptographic strength.
摘要翻译：根据用于提供至少一个应用的加密支持的框架，提供了至少一个应用的加密强度选择技术。当至少一个应用被授权以第一加密强度执行加密时，以第一加密强度执行数据加密。当至少一个应用程序不具有以第一加密强度进行加密的特权时，以第二加密强度执行数据加密。第一密码强度比第二密码强度更强。

10. 发明授权

US07094754B2 Anti-aging and wound healing compounds 有权
公开(公告)号：US07094754B2
公开(公告)日：2006-08-22
申请号：US10219561
申请日：2002-08-15
申请人： Stephen Quirk , Sohail Malik , Julie M. Villanueva
发明人： Stephen Quirk , Sohail Malik , Julie M. Villanueva
IPC分类号： A61K38/00
CPC分类号： C07K14/8146 , A61K38/00
摘要： The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.

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