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1. 发明申请

US20110105460A1 TRIAZOLE DERIVATIVE OR SALT THEREOF 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20110105460A1
公开(公告)日：2011-05-05
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A61K31/4196 , C07D401/12 , A61K31/4439 , C07D249/08 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/422 , A61K31/4245 , A61K31/5377 , C07D417/12 , A61K31/541 , C07D405/12 , A61K31/427 , C07D413/14 , C07D409/04 , C07D403/10 , C07D471/04 , A61K31/437 , A61P3/10 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

2. 发明授权

US08377923B2 Triazole derivative or salt thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US08377923B2
公开(公告)日：2013-02-19
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A01N43/00 , A01N43/58 , A61K31/55 , C07D241/36 , C07D249/08 , C07D249/14
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

3. 发明申请

US20090082367A1 TRIAZOLE DERIVATIVE OR A SALT THEREOF 审中-公开
标题翻译：三唑衍生物或其盐
公开(公告)号：US20090082367A1
公开(公告)日：2009-03-26
申请号：US12293214
申请日：2007-03-14
申请人： Seiji Yoshimura , Ryota Shiraki , Tomoaki Kawano , Daisuke Sasuga , Mitsuru Hosaka , Hiroki Fukudome , Kazuo Kurosawa , Hirofumi Ishii , Takanori Koike
发明人： Seiji Yoshimura , Ryota Shiraki , Tomoaki Kawano , Daisuke Sasuga , Mitsuru Hosaka , Hiroki Fukudome , Kazuo Kurosawa , Hirofumi Ishii , Takanori Koike
IPC分类号： A61K31/4196 , C07D401/06 , A61K31/4439 , A61K31/497 , A61P3/10 , A61K31/4709 , C07D403/06
CPC分类号： C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/08 , C07D409/06 , C07D409/08 , C07D409/12 , C07D413/06 , C07D417/06
摘要： [Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance.[Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.
摘要翻译： [问题]提供可用于治疗其中涉及11β-羟类固醇脱氢酶1型（11beta-HSD1）的疾病的化合物，特别是糖尿病和胰岛素抵抗。 [解决方法]发现三唑环的3-位被三取代甲基取代的三唑衍生物或其药学上可接受的盐，并且5位被低级烷基，环烷基或具有强的11beta-HSD1抑制活性。此外，由于本发明的三唑衍生物显示出优异的降血糖作用，因此可用于治疗糖尿病和胰岛素抵抗。

4. 发明申请

US20120277208A1 BENZAMIDE COMPOUND 审中-公开
标题翻译：苯甲酸化合物
公开(公告)号：US20120277208A1
公开(公告)日：2012-11-01
申请号：US13513667
申请日：2010-12-09
申请人： Masahiko Hayakawa , Seiji Yoshimura , Daisuke Sasuga , Takanori Koike , Takahiro Nigawara , Mitsuaki Okumura , Keisuke Maki
发明人： Masahiko Hayakawa , Seiji Yoshimura , Daisuke Sasuga , Takanori Koike , Takahiro Nigawara , Mitsuaki Okumura , Keisuke Maki
IPC分类号： A61K31/497 , A61P3/04 , A61P3/10 , C07D241/20 , A61K31/4965 , C07D413/14 , A61K31/4439 , C07D405/14 , A61K31/5377 , C07D405/12 , A61K31/4155 , C07D403/14 , A61K31/506 , C07D409/14 , C07D403/12
CPC分类号： C07D213/75 , C07D213/80 , C07D231/40 , C07D241/20 , C07D277/20 , C07D277/46 , C07D285/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14
摘要： [Problem]A compound which is useful as a GK activator is provided.[Means for Solution]The present inventors have conducted studies on compounds having a GK activating action, which are promising as active ingredients of pharmaceutical compositions for the treatment of diabetes, type 2 diabetes mellitus, obesity, metabolic syndrome and related diseases caused by the aforementioned diseases, and as a result, they have confirmed that a benzamide compound of the present invention has an excellent GK activating action, thereby completing the present invention. That is, the benzamide compound of the present invention has a GK activating action and can be used as an agent for preventing and/or treating diabetes, type 2 diabetes mellitus, obesity, metabolic syndrome, and related diseases caused by the aforementioned diseases.
摘要翻译： [问题]提供了可用作GK活化剂的化合物。 [解决方案]本发明人对具有GK活化作用的化合物进行研究，这些化合物作为用于治疗糖尿病，2型糖尿病，肥胖，代谢综合征和由上述引起的相关疾病的药物组合物的活性成分是有希望的疾病，结果证实本发明的苯甲酰胺化合物具有优异的GK活化作用，从而完成了本发明。也就是说，本发明的苯甲酰胺化合物具有GK活化作用，可用作预防和/或治疗由上述疾病引起的糖尿病，2型糖尿病，肥胖症，代谢综合征和相关疾病的药剂。

5. 发明申请

US20070259854A1 Triazole Derivative or Salt Thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20070259854A1
公开(公告)日：2007-11-08
申请号：US11663089
申请日：2005-09-14
申请人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
发明人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
IPC分类号： A61K31/4196 , A61K31/55 , A61P7/12 , C07D223/00 , C07D249/08
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： [Problem] There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance. [Means for Solution] It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
摘要翻译： [问题]提供了可用于治疗其中参与了11β-羟类固醇脱氢酶1型（11beta-HSD1）的疾病的化合物，特别是糖尿病，胰岛素抵抗。 [解决方案]已经发现，其中三唑环被2-位上的三取代甲基或其药学上可接受的盐取代的三唑衍生物具有强的11beta-HSD1抑制活性。此外，本发明的三唑衍生物显示出优异的血糖降低作用，因此可用于治疗糖尿病，胰岛素抵抗。

6. 发明授权

US07776897B2 Triazole derivative or salt thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US07776897B2
公开(公告)日：2010-08-17
申请号：US11663089
申请日：2005-09-14
申请人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
发明人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance.It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
摘要翻译：提供了一种化合物，其可以用于治疗其中参与的11β-羟基类固醇脱氢酶（11＆bgr--HSD1）的疾病，特别是糖尿病，胰岛素抵抗。已经发现，其中三唑环被2-位上的三取代的甲基或其药学上可接受的盐取代的三唑衍生物具有强的11β-HSD1抑制活性。此外，本发明的三唑衍生物显示出优异的血糖降低作用，因此可用于治疗糖尿病，胰岛素抵抗。

7. 发明授权

US08354188B2 Polymer for lithium ion secondary battery and lithium ion secondary battery using same 有权
标题翻译：锂离子二次电池用聚合物及其使用的锂离子二次电池
公开(公告)号：US08354188B2
公开(公告)日：2013-01-15
申请号：US11887225
申请日：2006-03-10
申请人： Yasuo Takano , Naoki Imachi , Seiji Yoshimura , Shin Fujitani , Satoshi Nishikawa , Shinji Bessyo
发明人： Yasuo Takano , Naoki Imachi , Seiji Yoshimura , Shin Fujitani , Satoshi Nishikawa , Shinji Bessyo
IPC分类号： H01M2/16 , H01M2/08
CPC分类号： H01M10/0525 , H01M10/0565 , H01M10/058 , H01M10/0587 , H01M2300/0082 , Y02T10/7011 , Y10T29/49108
摘要： A polymer for bonding the positive electrode and negative electrode of a lithium secondary battery, which includes a positive electrode, a negative electrode and an electrolyte solution, with a separator arranged between the positive electrode and the negative electrode. The polymer contains a cationically polymerizable monomer unit (A), a monomer unit (B) providing affinity to the electrolyte solution, a monomer unit (C) providing poor solubility to the electrolyte solution, and a monomer unit (D) containing an anionic or nonionic hydrophilic group. This polymer can be obtained through radical polymerization such as emulsion polymerization or suspension polymerization, and is characterized by having a dissolution rate into a mixed solvent of ethylene carbonate (EC) and diethyl carbonate (DEC) [EC:DEC=5:5 (weight ratio)] of not more than 10% by weight.
摘要翻译：一种用于将正极，负极和电解液溶解在锂二次电池的正极和负极上的聚合物，其中隔板配置在正极和负极之间。聚合物含有阳离子聚合性单体单元（A），对电解质溶液提供亲和性的单体单元（B），对电解质溶液提供差的溶解度的单体单元（C）和含有阴离子或非离子亲水基团。该聚合物可以通过自由基聚合如乳液聚合或悬浮聚合获得，并且其特征在于具有在碳酸亚乙酯（EC）和碳酸二乙酯（DEC）的混合溶剂中的溶解速率[EC:DEC = 5:5（重量）比）]为10重量％以下。

8. 发明授权

US08033271B2 Diagnostic device and diagnostic method for fuel vapor treatment system of vehicle 有权
标题翻译：汽车燃油蒸气处理系统诊断装置及诊断方法
公开(公告)号：US08033271B2
公开(公告)日：2011-10-11
申请号：US12433963
申请日：2009-05-01
申请人： Seiji Yoshimura
发明人： Seiji Yoshimura
IPC分类号： F02M33/02 , F02M25/08
CPC分类号： F02M25/0809 , F02D41/0032 , F02D41/22 , F02D41/2422 , Y02T10/40
摘要： A diagnostic device for a fuel vapor treatment system having: a canister that captures fuel vapor generated in a fuel tank; a purge passage for purging fuel vapor from the canister to an intake passage of an internal combustion engine; a purge valve provided in the purge passage to adjust a flow rate of fuel vapor; a processing device that depressurize an fuel vapor path extending from the fuel tank to the purge valve via the canister by a pump and performs a diagnostic processing for diagnosing a leak of fuel vapor from the fuel vapor path based on a change in pressure in the fuel vapor path during depressurization; and an angle detection device that detects an angle of inclination of the vehicle. The processing device determines, based on an inclination angle of the vehicle detected by the angle detection device, whether the diagnostic processing can be performed.
摘要翻译：一种用于燃料蒸汽处理系统的诊断装置，具有：罐，其捕获在燃料箱中产生的燃料蒸气; 吹扫通道，用于将燃料蒸气从罐排出到内燃机的进气通道; 设置在净化通道中以调节燃料蒸气的流量的净化阀; 一种处理装置，其通过泵将经由所述罐从所述燃料箱延伸到所述排放阀的燃料蒸气路径减压，并且执行用于基于所述燃料中的压力变化来诊断来自所述燃料蒸气路径的燃料蒸气泄漏的诊断处理减压过程中的蒸气路径; 以及检测车辆的倾斜角度的角度检测装置。处理装置基于角度检测装置检测到的车辆的倾斜角度来判定是否能够进行诊断处理。

9. 发明申请

US20090246635A1 Polymer for Lithium Ion Secondary Battery and Lithium Ion Secondary Battery Using Same 有权
标题翻译：锂离子二次电池和锂离子二次电池使用相同的聚合物
公开(公告)号：US20090246635A1
公开(公告)日：2009-10-01
申请号：US11887225
申请日：2006-03-10
申请人： Yasuo Takano , Naoki Imachi , Seiji Yoshimura , Shin Fujitani , Satoshi Nishikawa , Shinji Bessyo
发明人： Yasuo Takano , Naoki Imachi , Seiji Yoshimura , Shin Fujitani , Satoshi Nishikawa , Shinji Bessyo
IPC分类号： H01M4/58 , H01M4/82
CPC分类号： H01M10/0525 , H01M10/0565 , H01M10/058 , H01M10/0587 , H01M2300/0082 , Y02T10/7011 , Y10T29/49108
摘要： A polymer for bonding the positive electrode and negative electrode of a lithium secondary battery, which includes a positive electrode, a negative electrode and an electrolyte solution, with a separator arranged between the positive electrode and the negative electrode. The polymer contains a cationically polymerizable monomer unit (A), a monomer unit (B) providing affinity to the electrolyte solution, a monomer unit (C) providing poor solubility to the electrolyte solution, and a monomer unit (D) containing an anionic or nonionic hydrophilic group. This polymer can be obtained through radical polymerization such as emulsion polymerization or suspension polymerization, and is characterized by having a dissolution rate into a mixed solvent of ethylene carbonate (EC) and diethyl carbonate (DEC)[EC:DEC=5:5 (weight ratio)] of not more than 10% by weight.
摘要翻译：一种用于将正极，负极和电解液溶解在锂二次电池的正极和负极上的聚合物，其中隔板配置在正极和负极之间。聚合物含有阳离子聚合性单体单元（A），对电解质溶液提供亲和性的单体单元（B），对电解质溶液提供差的溶解度的单体单元（C）和含有阴离子或非离子亲水基团。该聚合物可以通过自由基聚合如乳液聚合或悬浮聚合获得，并且其特征在于具有在碳酸亚乙酯（EC）和碳酸二乙酯（DEC）的混合溶剂中的溶解速率[EC:DEC = 5:5（重量）比）]为10重量％以下。

10. 发明授权

US07371842B2 Polynucleotide encoding a 35 KDA protein thats binds to WF00144 失效
标题翻译：编码与WF00144结合的35KDa蛋白的多核苷酸
公开(公告)号：US07371842B2
公开(公告)日：2008-05-13
申请号：US10511270
申请日：2003-04-28
申请人： Hidenori Nakajima , Mitsuru Ohkubo , Seiji Yoshimura , Nobuya Nishio , Kaori Nishio
发明人： Hidenori Nakajima , Mitsuru Ohkubo , Seiji Yoshimura , Nobuya Nishio , Kaori Nishio
IPC分类号： C07H21/04 , C12P21/06 , C12N15/00 , C07K14/00
CPC分类号： C12N9/88 , C07K14/4702 , G01N2500/00
摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.
摘要翻译：目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物的糖生产。从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产生调节的蛋白质和编码该多核苷酸的多核苷酸。此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。

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