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1. 发明申请

US20110105460A1 TRIAZOLE DERIVATIVE OR SALT THEREOF 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20110105460A1
公开(公告)日：2011-05-05
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A61K31/4196 , C07D401/12 , A61K31/4439 , C07D249/08 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/422 , A61K31/4245 , A61K31/5377 , C07D417/12 , A61K31/541 , C07D405/12 , A61K31/427 , C07D413/14 , C07D409/04 , C07D403/10 , C07D471/04 , A61K31/437 , A61P3/10 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

2. 发明申请

US20070243052A1 Loader work apparatus 有权
标题翻译：装载机工作装置
公开(公告)号：US20070243052A1
公开(公告)日：2007-10-18
申请号：US11726377
申请日：2007-03-21
申请人： Hiroki Fukudome , Masataka Takagi , Koji Saito , Eiji Miyazaki , Shuichi Takeshita
发明人： Hiroki Fukudome , Masataka Takagi , Koji Saito , Eiji Miyazaki , Shuichi Takeshita
IPC分类号： B66C23/00
CPC分类号： E02F3/382 , E02F3/627
摘要： A work apparatus to be mounted to a work vehicle includes: a pair of cylindrical masts 35 disposed erect on right and left sides of a vehicle body having a control valve; a boom 91 pivotally supported to the masts; an implement pivotally supported to the boom; a boom cylinder 60 for pivoting the boom; an implement cylinder 61 for operating the implement; a boom piping system communicating the control valve with the boom cylinder; and an implement piping system communicating the control valve with the implement cylinder; wherein a channel constituting member 84 constituting the boom piping system extends vertically within each mast; one end of the channel constituting member 84 extends to the outside at a lower portion of the mast to be connected with the control valve; and the other end of the channel constituting member 84 extends to the outside at an upper portion of the mast 35 to be connected with boom cylinder 60.
摘要翻译：要安装到作业车辆上的作业装置包括：一对直立在具有控制阀的车身的右侧和左侧的圆柱形桅杆35; 枢轴支撑在桅杆上的吊杆91; 可枢转地支撑在起重臂上的工具; 用于枢转吊杆的动臂缸60; 用于操作工具的工具缸61; 将控制阀与动臂缸连通的吊杆管道系统; 以及将控制阀与工具缸连通的工具管道系统; 其中构成动臂管道系统的通道构成构件84在每个桅杆内垂直延伸; 通道构成构件84的一端在与控制阀连接的桅杆的下部延伸到外部; 并且通道构成构件84的另一端在桅杆35的上部延伸到外部，以与动臂缸60连接。

3. 外观设计

USD533883S1 Boom assembly for a loader bucket 有权
标题翻译：装载机铲斗的起重机组装
公开(公告)号：USD533883S1
公开(公告)日：2006-12-19
申请号：US29233915
申请日：2005-07-11
申请人： Yoshitaka Higashikawa , Hiroki Fukudome
设计人： Yoshitaka Higashikawa , Hiroki Fukudome

4. 发明授权

US08377923B2 Triazole derivative or salt thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US08377923B2
公开(公告)日：2013-02-19
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A01N43/00 , A01N43/58 , A61K31/55 , C07D241/36 , C07D249/08 , C07D249/14
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

5. 发明授权

US08246286B2 Loader work apparatus 有权
标题翻译：装载机工作装置
公开(公告)号：US08246286B2
公开(公告)日：2012-08-21
申请号：US11726377
申请日：2007-03-21
申请人： Hiroki Fukudome , Masataka Takagi , Koji Saito , Eiji Miyazaki , Shuichi Takeshita
发明人： Hiroki Fukudome , Masataka Takagi , Koji Saito , Eiji Miyazaki , Shuichi Takeshita
IPC分类号： E02F3/36
CPC分类号： E02F3/382 , E02F3/627
摘要： A work apparatus to be mounted to a work vehicle includes: a pair of cylindrical masts 35 disposed erect on right and left sides of a vehicle body having a control valve; a boom 91 pivotally supported to the masts; an implement pivotally supported to the boom; a boom cylinder 60 for pivoting the boom; an implement cylinder 61 for operating the implement; a boom piping system communicating the control valve with the boom cylinder; and an implement piping system communicating the control valve with the implement cylinder; wherein a channel constituting member 84 constituting the boom piping system extends vertically within each mast; one end of the channel constituting member 84 extends to the outside at a lower portion of the mast to be connected with the control valve; and the other end of the channel constituting member 84 extends to the outside at an upper portion of the mast 35 to be connected with boom cylinder 60.
摘要翻译：要安装到作业车辆上的作业装置包括：一对直立在具有控制阀的车身的右侧和左侧的圆柱形桅杆35; 枢轴支撑在桅杆上的吊杆91; 可枢转地支撑在起重臂上的工具; 用于枢转吊杆的动臂缸60; 用于操作工具的工具缸61; 将控制阀与动臂缸连通的吊杆管道系统; 以及将控制阀与工具缸连通的工具管道系统; 其中构成动臂管道系统的通道构成构件84在每个桅杆内垂直延伸; 通道构成构件84的一端在与控制阀连接的桅杆的下部延伸到外部; 并且通道构成构件84的另一端在桅杆35的上部延伸到外部，以与动臂缸60连接。

6. 发明申请

US20090152781A1 Vibration-Isolating Device for Steering Wheel of Traveling Working Vehicle with Wheel Steering Mechanism 有权
标题翻译：具有车轮转向机构的行走车辆方向盘的隔振装置
公开(公告)号：US20090152781A1
公开(公告)日：2009-06-18
申请号：US12212232
申请日：2008-09-17
申请人： Nobuyuki Yoshii , Kiyoshige Maezawa , Tadashi Nakamura , Hiroki Fukudome
发明人： Nobuyuki Yoshii , Kiyoshige Maezawa , Tadashi Nakamura , Hiroki Fukudome
IPC分类号： F16F7/00 , B62D1/16
CPC分类号： F16D3/68 , B62D7/224 , F16D3/70 , F16F15/124
摘要： A vibration-isolating device for a steering wheel of a travelling working vehicle equipped with a wheel steering mechanism includes a first steering shaft (32) that transmits rotational displacement, the first steering shaft being operatively connected to the steering wheel (7); a second steering shaft (33) that transmits rotational displacement, the second steering shaft being operatively connected to the wheel steering mechanism (P, 23); and a vibration-isolating connecting mechanism (31) that operatively connects the first steering shaft (32) and the second steering shaft (33) to each other so that rotational displacement can be transmitted. When the angles of rotational displacement of the first steering shaft (32) and the second steering shaft (33) are within ranges of rotation angles for linearly driving the vehicle, rotational displacement cannot be transmitted between the first steering shaft (32) and the second steering shaft (33).
摘要翻译：一种配备有车轮转向机构的行驶工作车辆的方向盘的防振装置，包括：第一转向轴（32），其传递旋转位移，所述第一转向轴与所述方向盘（7）可操作地连接; 第二转向轴（33），其传递旋转位移，所述第二转向轴可操作地连接到所述车轮转向机构（P，23）; 以及将第一转向轴（32）和第二转向轴（33）可操作地连接的振动隔离连接机构（31），从而能够传递旋转位移。当第一转向轴（32）和第二转向轴（33）的旋转位移角度在用于线性驱动车辆的旋转角度的范围内时，旋转位移不能在第一转向轴（32）和第二转向轴转向轴（33）。

7. 发明授权

US07442001B2 Boom assembly 有权
标题翻译：起重机组装
公开(公告)号：US07442001B2
公开(公告)日：2008-10-28
申请号：US11225850
申请日：2005-09-13
申请人： Yoshitaka Higashikawa , Naoki Onishi , Ryoichi Nishi , Hiroki Fukudome
发明人： Yoshitaka Higashikawa , Naoki Onishi , Ryoichi Nishi , Hiroki Fukudome
IPC分类号： E02F9/00
CPC分类号： E02F3/34 , Y10T29/49448
摘要： A boom assembly is bent at a longitudinal center portion thereof to present an upwardly convex shape. The assembly includes a front boom body and a rear boom body. The front boom body and the rear main body each includes a main body consisting essentially of a pair of right and left lateral plates and a top plate interconnecting upper edges of the respective lateral plates. The main body is formed with an upper face and a lower edge thereof being bent in a longitudinal direction thereof into an arc face having a predetermined radius of curvature. The front or rear main body further includes a bottom plate disposed downwardly of the top plate and between the right and left lateral plates. Each main body is formed by bending a plate member into a reverse U-shaped cross section and each bottom plate is comprised of a plate member provided separately from the plate member forming the main body.
摘要翻译：吊杆组件在其纵向中心部分处弯曲以呈现向上凸起的形状。组件包括前悬臂本体和后悬臂本体。前悬臂主体和后主体各自包括主体，主体由一对左右侧板和与各侧板的上边缘相互连接的顶板组成。该主体形成有一个上表面和一个下边缘沿其纵向方向弯曲成具有预定曲率半径的圆弧面。前后主体还包括设置在顶板下方以及左右侧板之间的底板。每个主体通过将板构件弯曲成相反的U形横截面而形成，并且每个底板由与构成主体的板构件分开设置的板构件构成。

8. 发明申请

US20070259854A1 Triazole Derivative or Salt Thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20070259854A1
公开(公告)日：2007-11-08
申请号：US11663089
申请日：2005-09-14
申请人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
发明人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
IPC分类号： A61K31/4196 , A61K31/55 , A61P7/12 , C07D223/00 , C07D249/08
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： [Problem] There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance. [Means for Solution] It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
摘要翻译： [问题]提供了可用于治疗其中参与了11β-羟类固醇脱氢酶1型（11beta-HSD1）的疾病的化合物，特别是糖尿病，胰岛素抵抗。 [解决方案]已经发现，其中三唑环被2-位上的三取代甲基或其药学上可接受的盐取代的三唑衍生物具有强的11beta-HSD1抑制活性。此外，本发明的三唑衍生物显示出优异的血糖降低作用，因此可用于治疗糖尿病，胰岛素抵抗。

9. 发明授权

US08579364B2 Work vehicle 有权
标题翻译：工作车辆
公开(公告)号：US08579364B2
公开(公告)日：2013-11-12
申请号：US12054747
申请日：2008-03-25
申请人： Hiroki Fukudome , Naoya Tsuda , Kenzo Ushiro
发明人： Hiroki Fukudome , Naoya Tsuda , Kenzo Ushiro
IPC分类号： B62D25/06 , B62D25/07
CPC分类号： B62D33/0625 , B62D25/06 , E02F3/964 , E02F9/08 , E02F9/163
摘要： A work vehicle includes a front loader mounted at a front portion of the work vehicle to be vertically pivotable, a driving control device, and a canopy device for covering the driving control device from above, the canopy device including a roof disposed upwardly of the driving control device and a support body for supporting the roof. The roof includes a front visor portion which projects, in a plan view thereof, to a position same as or more forwardly of a front end portion of the driving control device. To a lower face of said front visor portion, there are attached a pair of right and left front illumination lamps, and there is provided an upper concave portion at the right/left center thereof. A lower face of the upper concave portion is formed as an inclined face which is inclined upward from a rear portion to a front edge of the front visor portion so as to be located at a higher position than the attaching position of the front illumination lamps.
摘要翻译：工作车辆包括安装在作业车辆的前部以便可竖直枢转的前装载机，驱动控制装置和用于从上方覆盖驱动控制装置的顶盖装置，所述顶盖装置包括设置在驾驶控制装置和用于支撑屋顶的支撑体。屋顶包括前遮阳板部分，其在平面图中突出到与驱动控制装置的前端部分相同或更向前的位置。在所述前遮阳板部分的下表面上安装有一对右前照明灯和左前照明灯，并且在其左右中心设置有上凹部。上凹部的下表面形成为从前遮光板部的后部向前方倾斜的倾斜面，位于比前照明灯的安装位置更高的位置。

10. 发明授权

US07776897B2 Triazole derivative or salt thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US07776897B2
公开(公告)日：2010-08-17
申请号：US11663089
申请日：2005-09-14
申请人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
发明人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance.It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
摘要翻译：提供了一种化合物，其可以用于治疗其中参与的11β-羟基类固醇脱氢酶（11＆bgr--HSD1）的疾病，特别是糖尿病，胰岛素抵抗。已经发现，其中三唑环被2-位上的三取代的甲基或其药学上可接受的盐取代的三唑衍生物具有强的11β-HSD1抑制活性。此外，本发明的三唑衍生物显示出优异的血糖降低作用，因此可用于治疗糖尿病，胰岛素抵抗。

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