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1. 发明申请

US20110104768A1 METHOD FOR PRODUCTION OF POLYESTER COPOLYMER USING RECOMBINANT MICROORGANISM 有权
标题翻译：使用重组微生物生产聚酯共聚物的方法
公开(公告)号：US20110104768A1
公开(公告)日：2011-05-05
申请号：US12989333
申请日：2009-04-23
申请人： Seiichi Taguchi , Kenji Tajima , Yasuharu Satoh , Ken'ichiro Matsumoto , Miwa Yamada , Shusei Obata , Hiromi Kambe , Katsuhiro Kohda , Katsuhiro Ohno , Takashi Shimamura
发明人： Seiichi Taguchi , Kenji Tajima , Yasuharu Satoh , Ken'ichiro Matsumoto , Miwa Yamada , Shusei Obata , Hiromi Kambe , Katsuhiro Kohda , Katsuhiro Ohno , Takashi Shimamura
IPC分类号： C12P7/62 , C12N1/00 , C12N1/21
CPC分类号： C12P7/62
摘要： The object of the present invention is to provide a method for efficiently producing a polyester copolymer consisting of 3HB and LA via microbial fermentation with the use of a sugar as a starting material.The following is provided: a method for producing a polyester copolymer consisting of 3-hydroxybutyrate and lactate, which comprises the steps of: (1) culturing a recombinant microorganism having a protein capable of catalyzing a reaction of transferring CoA to propionic acid and/or lactate, a protein capable of catalyzing a reaction of forming acetoacetyl-CoA from two acetyl-CoA molecules, a protein capable of catalyzing a reaction of acetoacetyl-CoA reduction, and a protein capable of catalyzing a reaction of polyhydroxyalkanoate synthesis consisting of the following amino acid sequence (a) or (b) in a medium containing a carbon source: (a) an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution of at least one of the amino acids at positions 130, 325, 477, and 481 with different amino acid(s); or (b) an amino acid sequence derived from the protein specified in (a) by additional deletion or substitution of at least one amino acid other than the amino acids at positions 130, 325, 477, and 481 or by insertion of at least one amino acid residue; and (2) collecting the polyester copolymer from the culture product obtained in step (1). According to the production method of the present invention, a polyester copolymer consisting of 3HB and LA can be efficiently produced using an inexpensive carbon source as a starting material, and thus the production cost of a biodegradable plastic can be reduced.
摘要翻译：本发明的目的是提供一种利用糖作为原料，通过微生物发酵有效地制备由3HB和LA组成的聚酯共聚物的方法。提供以下：由3-羟基丁酸酯和乳酸酯组成的聚酯共聚物的制造方法，其特征在于，包括以下步骤：（1）培养具有能够催化将CoA转移到丙酸和/或乳酸盐，能够催化从两个乙酰辅酶A分子形成乙酰乙酰辅酶A的反应的蛋白质，能够催化乙酰乙酰辅酶A还原反应的蛋白质，以及能够催化由下列氨基组成的聚羟基链烷酸酯合成反应的蛋白质含有碳源的培养基中的酸序列（a）或（b）：（a）从SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列，通过将位置130的至少一个氨基酸置换，325,477和481具有不同的氨基酸; 或（b）衍生自（a）中规定的蛋白质的氨基酸序列，通过除了位置130,325,477和481之外的氨基酸以外的至少一个氨基酸的另外缺失或取代或通过插入至少一个氨基酸残基; 和（2）从步骤（1）获得的培养产物中收集聚酯共聚物。根据本发明的制造方法，可以使用廉价的碳源作为原料，有效地制造由3HB和LA组成的聚酯共聚物，从而可以降低生物降解性塑料的制造成本。

2. 发明授权

US08563281B2 Method for production of polyester copolymer using recombinant microorganism 有权
标题翻译：使用重组微生物生产聚酯共聚物的方法
公开(公告)号：US08563281B2
公开(公告)日：2013-10-22
申请号：US12989333
申请日：2009-04-23
申请人： Seiichi Taguchi , Kenji Tajima , Yasuharu Satoh , Ken'ichiro Matsumoto , Miwa Yamada , Shusei Obata , Hiromi Kambe , Katsunori Kohda , Katsuhiro Ohno , Takashi Shimamura
发明人： Seiichi Taguchi , Kenji Tajima , Yasuharu Satoh , Ken'ichiro Matsumoto , Miwa Yamada , Shusei Obata , Hiromi Kambe , Katsunori Kohda , Katsuhiro Ohno , Takashi Shimamura
IPC分类号： C12P7/62 , C12N1/20 , C12N1/00
CPC分类号： C12P7/62
摘要： The object of the present invention is to provide a method for efficiently producing a polyester copolymer consisting of 3-hydroxybutyrate and lactate via microbial fermentation with the use of a sugar as a starting material. The method may comprise culturing a recombinant microorganism expressing: a protein capable of catalyzing the transfer of CoA to propionic acid and/or lactate; a protein capable of catalyzing the formation of acetoacetyl-CoA from two acetyl-CoA molecules; a protein capable of catalyzing acetoacetyl-CoA reduction; and a protein capable of catalyzing polyhydroxyalkanoate synthesis. According to the production method, a polyester copolymer consisting of 3-hydroxybutyrate and lactate can be efficiently produced using an inexpensive carbon source as a starting material, and thus the production cost of a biodegradable plastic can be reduced.
摘要翻译：本发明的目的是提供一种通过使用糖作为原料通过微生物发酵有效地制备由3-羟基丁酸酯和乳酸酯组成的聚酯共聚物的方法。该方法可以包括培养表达：能够催化CoA转移到丙酸和/或乳酸盐的蛋白质的重组微生物; 能够催化从两个乙酰辅酶A分子形成乙酰乙酰辅酶A的蛋白质; 能够催化乙酰乙酰辅酶A还原的蛋白质; 和能够催化聚羟基链烷酸酯合成的蛋白质。根据该制造方法，可以使用廉价的碳源作为起始材料有效地制造由3-羟基丁酸酯和乳酸酯组成的聚酯共聚物，从而可以降低生物降解性塑料的制造成本。

3. 发明申请

US20080173828A1 Ion implantation device and method for implanting ions 审中-公开
标题翻译：离子注入装置和离子注入方法
公开(公告)号：US20080173828A1
公开(公告)日：2008-07-24
申请号：US12007392
申请日：2008-01-10
申请人： Katsuhiro Ohno , Koji Matsumoto
发明人： Katsuhiro Ohno , Koji Matsumoto
IPC分类号： H01J37/147 , H01J37/08
CPC分类号： H01J37/3171 , H01J37/18 , H01J37/304 , H01J2237/006 , H01J2237/31703
摘要： An ion implantation device includes: an ion source for retrieving an ion beam; a passage for passing the ion beam therethrough; a mass analysis magnet for selecting a predetermined ion species from the ion beam, the mass analysis magnet disposed in the passage; an implantation chamber for implanting the predetermined ion species in a target with the ion beam output from the mass analysis magnet; and an inner pressure controller for introducing an gas into the passage and for controlling an inner pressure of the passage. Since the above device includes the inner pressure controller, a concentration profile of the implanted ions in the target is appropriately controlled.
摘要翻译：离子注入装置包括：用于检索离子束的离子源; 用于使离子束通过的通道; 用于从所述离子束中选择预定离子种类的质量分析磁体，所述质量分析磁体设置在所述通道中; 植入室，用于将质量分析磁体输出的离子束注入目标物中的预定离子种类; 以及内部压力控制器，用于将气体引入通道并用于控制通道的内部压力。由于上述装置包括内压控制器，所以适当地控制靶中注入离子的浓度分布。

4. 再颁专利

USRE35333E Infrared detector 失效
标题翻译：红外探测器
公开(公告)号：USRE35333E
公开(公告)日：1996-09-24
申请号：US261815
申请日：1994-06-17
申请人： Naoko Iwasaki , Katsuhiro Ohno
发明人： Naoko Iwasaki , Katsuhiro Ohno
IPC分类号： G01J5/06
CPC分类号： G01J5/061
摘要： An infrared detector wherein an infrared detecting device can be cooled efficiently without increasing thermal stresses generated in the device body owing to cooling during the operation of the detector, and intrusion of ambient light can be prevented. A container for the infrared detecting device, which includes a bottom plate having a projection formed in the center thereof, is provided on an inner end portion of an inner cylinder constituting a dewar, and the infrared detecting device is placed on and secured to the projection of the bottom plate. The container bottom plate is made of an Invar, while the end portion of the inner cylinder is made of a Kovar or an Invar.
摘要翻译：一种红外检测器，其中可以有效地冷却红外线检测装置，而不会由于在检测器的操作期间的冷却而增加在装置主体中产生的热应力，并且可以防止环境光的侵入。一种用于红外线检测装置的容器，其包括在其中心形成有突起的底板，设置在构成杜瓦瓶的内筒的内端部，并且红外线检测装置被放置并固定到突起的底板。容器底板由殷钢制成，而内筒的端部由科瓦或殷钢制成。

5. 发明授权

US4837922A Process for manufacturing a composite magnetic head structure 失效
标题翻译：复合磁头结构的制造方法
公开(公告)号：US4837922A
公开(公告)日：1989-06-13
申请号：US213465
申请日：1988-06-27
申请人： Jirou Toriu , Katsuhiro Ohno , Jun Miyajima
发明人： Jirou Toriu , Katsuhiro Ohno , Jun Miyajima
IPC分类号： G11B5/265
CPC分类号： G11B5/2651 , Y10T29/49057
摘要： A composite magnetic head tip has a pair of head cores (2,3) facing each other and each having a center core (5,7) and a side core (4,6) which are separated by a magnetic gap (8,9) and are glass welded together at an apex portion (32). Each head core has a set of notches (14,14') which define a track width in the magnetic gap. Each notch is formed so that it begins at a confronting surface (29) where the center cores face each other, crosses through the magnetic gap, and ends on a sliding surface (28) for slidably contacting a magnetic medium. The notches end at a point which is directly above the welded position (19) provided at the apex portion of each head core. A process for manufacturing the composite magnetic head tip includes the steps of first forming a head core and then forming a set of notches therein, then forming another head core and forming another set of notches therein, aligning track widths and then glass molding each of the head cores together while at the same time filling the track notches with the same glass molding. An alternative process involves forming the notches in the head core blocks such that the lower surface (31) of the notches passes below the apex portion of the head core blocks, and applying glass molding to the notches and between the two head cores using a glass material that has a melting point substantially as low as the melting point of the glass material used for glass welding the side and center cores.
摘要翻译：复合磁头尖端具有彼此面对的一对磁头磁芯（2,3），每个具有中心磁芯（5,7）和侧磁芯（4,6），它们被磁隙（8,9 ），并且在顶部（32）处被玻璃焊接在一起。每个磁芯芯具有限定磁隙中的磁道宽度的一组凹口（14,14'）。每个凹口形成为使得其开始于中心芯彼此面对的相对表面（29），穿过磁隙，并且在滑动表面（28）上终止以滑动地接触磁性介质。切口在直接位于设置在每个头部芯部的顶点处的焊接位置（19）的上方终止。制造复合磁头头的方法包括以下步骤：首先形成头芯，然后在其中形成一组凹口，然后形成另一个头芯，并在其中形成另一组凹口，对准轨道宽度，然后玻璃成型头芯在一起，同时用相同的玻璃成型填充轨道凹口。替代方法包括在头芯块中形成凹口，使得凹口的下表面（31）穿过头芯块的顶部部分的下方，并且使用玻璃将玻璃模制件施加到凹口和两个头部芯部之间材料的熔点基本上低于用于玻璃焊接侧面和中心芯的玻璃材料的熔点。

6. 发明申请

US20090035811A1 Artificial scaffolding material for protein retention and use of the same 有权
标题翻译：用于蛋白质保留和使用的人造脚手架材料
公开(公告)号：US20090035811A1
公开(公告)日：2009-02-05
申请号：US12219911
申请日：2008-07-30
申请人： Katsunori Kohda , Katsuhiro Ohno , Takao Imaeda , Kazuo Sakka
发明人： Katsunori Kohda , Katsuhiro Ohno , Takao Imaeda , Kazuo Sakka
IPC分类号： C12P1/02 , C12N11/16
CPC分类号： C12N11/16 , C07K14/33 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P7/40 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides an artificial scaffolding material for retaining proteins suitable for placing contiguously one species or two or more species of proteins such as enzymes. To this end, the artificial scaffolding material for retaining proteins is provided with a cell and scaffolding proteins heterologous to the cell and placed on the surface layer side of the cell at an extent that allows aggregation properties to be conferred to the cell, and provided with a plurality of non-covalently binding protein-binding domains arranged in tandem.
摘要翻译：本发明提供了一种人造脚手架材料，其用于保留适于邻近地放置一种或两种或更多种蛋白质（例如酶）的蛋白质。为此，用于保留蛋白质的人造脚手架材料具有与细胞异源的细胞和支架蛋白，并以允许聚集性质赋予细胞的程度放置在细胞的表面层侧，并且具有多个非共价结合的蛋白质结合域串联布置。

7. 发明授权

US5260575A Infrared detector 失效
标题翻译：红外探测器
公开(公告)号：US5260575A
公开(公告)日：1993-11-09
申请号：US29033
申请日：1993-03-10
申请人： Naoko Iwasaki , Katsuhiro Ohno
发明人： Naoko Iwasaki , Katsuhiro Ohno
IPC分类号： G01J5/06
CPC分类号： G01J5/061 , F25D19/006
摘要： An infrared detector wherein an infrared detecting device can be cooled efficiently without increasing thermal stresses generated in the device body owing to cooling during the operation of the detector, and intrusion of ambient light can be prevented. A container for the infrared detecting device, which includes a bottom plate having a projection formed in the center thereof, is provided on an inner end portion of an inner cylinder constituting a dewar, and the infrared detecting device is placed on and secured to the projection of the bottom plate. The container bottom plate is made of an Invar, while the end portion of the inner cylinder is made of a Kovar or an Invar.
摘要翻译：一种红外检测器，其中可以有效地冷却红外线检测装置，而不会由于在检测器的操作期间的冷却而增加在装置主体中产生的热应力，并且可以防止环境光的侵入。一种用于红外线检测装置的容器，其包括在其中心形成有突起的底板，设置在构成杜瓦瓶的内筒的内端部，并且红外线检测装置被放置并固定到突起的底板。容器底板由殷钢制成，而内筒的端部由科瓦或殷钢制成。

8. 发明授权

US08361752B2 Artificial scaffolding material for protein retention and use of the same 有权
公开(公告)号：US08361752B2
公开(公告)日：2013-01-29
申请号：US12219911
申请日：2008-07-30
申请人： Katsunori Kohda , Katsuhiro Ohno , Takao Imaeda , Kazuo Sakka
发明人： Katsunori Kohda , Katsuhiro Ohno , Takao Imaeda , Kazuo Sakka
IPC分类号： C12P1/00 , C12P21/04 , C12N15/00
CPC分类号： C12N11/16 , C07K14/33 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P7/40 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides an artificial scaffolding material for retaining proteins suitable for placing contiguously one species or two or more species of proteins such as enzymes. To this end, the artificial scaffolding material for retaining proteins is provided with a cell and scaffolding proteins heterologous to the cell and placed on the surface layer side of the cell at an extent that allows aggregation properties to be conferred to the cell, and provided with a plurality of non-covalently binding protein-binding domains arranged in tandem.

9. 发明授权

US06540805B2 High-performance filter for intake air for gas turbine, and filter unit using such filter for intake air for gas turbine 有权
公开(公告)号：US06540805B2
公开(公告)日：2003-04-01
申请号：US09836859
申请日：2001-04-18
申请人： Katsuhiro Ohno , Fumio Nakajima , Hitoshi Niinuma
发明人： Katsuhiro Ohno , Fumio Nakajima , Hitoshi Niinuma
IPC分类号： B01D4610
CPC分类号： B01D46/523 , B01D46/0023 , B01D46/10 , B01D46/18 , B01D2275/10 , B01D2279/60
摘要： A high-performance filter for an intake air for a gas turbine according to the present invention includes a low-efficiency filter media and a high-efficiency filter media superposed closely on each other in the named order from an upstream side in a direction of an air flow. Each of the filter media is formed with a filtering area of 20 to 35 m2. The filter media having a filtration efficiency of 40 to 70% for particles having a particle size of 0.3 &mgr;m is disposed as a layer upstream in the air flow direction, and the filter media having a filtration efficiency of 90 to 99.99% for particles having a particle size of 0.3 &mgr;m is disposed as a downstream layer. In addition, a filter unit according to the present invention is made using the above filter, Thus, even when the filter unit is used for atmospheric dusts including a high concentration of dusts having a particle size of 0.3 to 0.5 &mgr;m, a life of 8,000 hours or more, and the deposition of the atmospheric dusts in an air compressor or the like in a conventional gas turbine plant can be alleviated, thereby preventing a reduction in power-generating output and ensuring that it is unnecessary over a long period of time to carry out the washing or cleaning of the air compressor and the like and the replacement of the filter. In addition, the filter unit can be placed in a reduced space.

10. 发明授权

US5296710A Infrared radiation detector 失效
标题翻译：红外辐射探测器
公开(公告)号：US5296710A
公开(公告)日：1994-03-22
申请号：US868836
申请日：1992-04-15
申请人： Katsuhiro Ohno , Akifumi Wada , Yousuke Sugiura , Masatoshi Yasunaga
发明人： Katsuhiro Ohno , Akifumi Wada , Yousuke Sugiura , Masatoshi Yasunaga
IPC分类号： G01J1/02 , G01J5/02 , G01J5/06 , G01J5/28 , G01J5/30 , H01L23/44 , H01L27/14 , H01L31/00 , H01L31/024 , G01J5/04
CPC分类号： G01J5/061 , H01L23/445 , H01L31/024 , H01L2224/48091 , H01L2924/12032 , H01L2924/19107
摘要： An infrared radiation detector so adapted as to prevent the image signals from deteriorating due to the short length of leads extending within the cryogenic container with the infrared radiation sensing element accommodated within and to correspond to the increasing number of the leads and terminals, associated with a high density of elements. The infrared radiation detector is composed of an inner cylinder and an outer cylinder. The outer cylinder is disposed so as to lie in the same plane as the sub-package on which the multi-layered ceramic lead plate composed of a plurality of bonding pads for wire bonding, internally embedded lead layers, and plug-in terminals for fetching signals is mounted. The bonding pad of the sub-package is bonded to the bonding pad of the ceramic lead plate through a wire bonding.
摘要翻译：一种红外辐射检测器，其适于防止图像信号由于在低温容器内延伸的引线的短长度而变差，其中红外辐射感测元件容纳在其内并且对应于越来越多的引线和端子，与元素密度高。红外线辐射检测器由内筒和外筒构成。外筒设置成与其上由用于引线接合的多个接合焊盘，内部引入层和用于取出的插入式端子组成的多层陶瓷引线板的子封装体在同一平面中信号被安装。子封装的焊盘通过引线接合结合到陶瓷引线板的焊盘。

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