专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08551752B2 RNA polymerase mutant with improved functions 有权
标题翻译：具有改善功能的RNA聚合酶突变体
公开(公告)号：US08551752B2
公开(公告)日：2013-10-08
申请号：US13057418
申请日：2009-08-07
申请人： Seigo Oe , Hiroshi Sato , Teruhiko Ide
发明人： Seigo Oe , Hiroshi Sato , Teruhiko Ide
IPC分类号： C12N9/12
CPC分类号： C12N9/1247
摘要： Disclosed is a T7 RNA polymerase mutant having improved thermal stability and/or specific activity in comparison with wild-type T7-like bacteriophage RNA polymerase, wherein at least one amino acid residue corresponding to at least one of the amino acid residues selected from the group at least consisting of glutamine at position 768, lysine at position 179 and valine at position 685 of the amino acid sequence that composes wild-type T7 RNA polymerase shown in SEQ ID NO: 6, is substituted with another amino acid.
摘要翻译：公开了与野生型T7样噬菌体RNA聚合酶相比具有改进的热稳定性和/或比活性的T7RNA聚合酶突变体，其中至少一个氨基酸残基对应于选自下组的氨基酸残基由构成SEQ ID NO：6所示的野生型T7RNA聚合酶的氨基酸序列的768位的谷氨酰胺，179位的赖氨酸和685位的缬氨酸被另一个氨基酸取代。

2. 发明申请

US20110136181A1 RNA POLYMERASE MUTANT WITH IMPROVED FUNCTIONS 有权
标题翻译：具有改进功能的RNA聚合酶突变体
公开(公告)号：US20110136181A1
公开(公告)日：2011-06-09
申请号：US13057418
申请日：2009-08-07
申请人： Seigo Oe , Hiroshi Sato , Teruhiko Ide
发明人： Seigo Oe , Hiroshi Sato , Teruhiko Ide
IPC分类号： C12P19/34 , C12N9/12 , C07H21/04 , C12N1/21
CPC分类号： C12N9/1247
摘要： Disclosed is a T7 RNA polymerase mutant having improved thermal stability and/or specific activity in comparison with wild-type T7-like bacteriophage RNA polymerase, wherein at least one amino acid residue corresponding to at least one of the amino acid residues selected from the group at least consisting of glutamine at position 768, lysine at position 179 and valine at position 685 of the amino acid sequence that composes wild-type T7 RNA polymerase shown in SEQ ID NO: 6, is substituted with another amino acid.
摘要翻译：公开了与野生型T7样噬菌体RNA聚合酶相比具有改进的热稳定性和/或比活性的T7RNA聚合酶突变体，其中至少一个氨基酸残基对应于选自下组的氨基酸残基由构成SEQ ID NO：6所示的野生型T7RNA聚合酶的氨基酸序列的768位的谷氨酰胺，179位的赖氨酸和685位的缬氨酸被另一个氨基酸取代。

3. 发明授权

US08569014B2 Microorganism and method for producing canthaxanthin 失效
标题翻译：微生物和生产角黄素的方法
公开(公告)号：US08569014B2
公开(公告)日：2013-10-29
申请号：US13206999
申请日：2011-08-10
申请人： Toru Tanaka , Teruhiko Ide
发明人： Toru Tanaka , Teruhiko Ide
IPC分类号： C12P23/00
CPC分类号： C12R1/01 , C12P23/00
摘要： A carotenoid producing bacterium belonging to the genus Paracoccus that selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. A method for producing canthaxanthin by culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.
摘要翻译：属于副球菌属的产生类胡萝卜素的细菌选择性地生产角黄素，其量不小于包含β-胡萝卜素，β-隐黄质，海参酮，角黄素，3-羟基喹喔啉酮的生产类胡萝卜素总量的90重量％ 3'-羟基喹喔啉酮，玉米黄质，磷酸黄嘌呤，亚二黄素和虾青素。通过培养上述细菌生产角黄素的方法，然后在培养后从细菌细胞或培养液中收集类胡萝卜素。

4. 发明授权

US5948916A Arylthiadiazole derivative and antiviral agent containing the same 失效
标题翻译：芳基噻二唑衍生物和含有它们的抗病毒剂
公开(公告)号：US5948916A
公开(公告)日：1999-09-07
申请号：US809836
申请日：1997-06-09
申请人： Katsushi Ijichi , Shiro Shigeta , Masanori Baba , Masatoshi Fujiwara , Tomoyuki Yokota , Hiromitsu Takayama , Shin-ichiro Sakai , Yasuaki Hanasaki , Teruhiko Ide , Hiroyuki Watanabe , Kimio Katsuura
发明人： Katsushi Ijichi , Shiro Shigeta , Masanori Baba , Masatoshi Fujiwara , Tomoyuki Yokota , Hiromitsu Takayama , Shin-ichiro Sakai , Yasuaki Hanasaki , Teruhiko Ide , Hiroyuki Watanabe , Kimio Katsuura
IPC分类号： C07D285/10 , C07D417/12 , C07D285/125
CPC分类号： C07D285/10 , C07D417/12
摘要： Novel arylthiadiazole derivatives and salts thereof useful for preventing and treating human viral infection and a novel virucide which contains the arylthiadiazole derivative or a salt thereof are provided. N,N-dimethyl �3-(3-(amino-2,6-dichlorophenyl)-1,2,5-thiadiazol-4-yl! carbamate or its salt, and virucide containing the same as an effective component.
摘要翻译： PCT No.PCT / JP95 / 01898 Sec。 371日期：1997年6月9日 102（e）日期1997年6月9日PCT 1995年9月21日PCT PCT。出版物WO96 / 09296 日期：1996年3月28日提供了用于预防和治疗人类病毒感染的新型芳基噻二唑衍生物及其盐，以及含有芳基噻二唑衍生物或其盐的新型杀病毒剂。 N，N-二甲基[3-（3-（氨基-2,6-二氯苯基）-1,2,5-噻二唑-4-基]氨基甲酸酯或其盐，以及含有与有效成分相同的病毒核苷酸。

5. 发明申请

US20100196962A1 IL-6 RECEPTOR IL-6 DIRECT FUSION PROTEIN 有权
标题翻译： IL-6受体IL-6直接融合蛋白
公开(公告)号：US20100196962A1
公开(公告)日：2010-08-05
申请号：US12407170
申请日：2009-03-19
申请人： Teiji EKIDA , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
发明人： Teiji EKIDA , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
IPC分类号： C12P21/00 , C07H21/04 , C12N1/19
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C12N2501/125
摘要： The present invention intends to provide an IL-6R.IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker.The IL-6 receptor.IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.
摘要翻译：本发明意图提供IL-6R.IL-6融合蛋白等，其中IL-6R和IL-6直接连接而不连接。本发明的IL-6受体-IL-6融合蛋白具有构成IL-6受体的一个氨基酸残基和构成IL-6的一个氨基酸残基直接结合的结构。

6. 发明授权

US5478849A Thiadiazole derivative, process for producing it and agricultural and horticultural fungicide using it as an active ingredient 失效
标题翻译：噻二唑衍生物，其生产方法和农业和园艺用杀真菌剂作为活性成分
公开(公告)号：US5478849A
公开(公告)日：1995-12-26
申请号：US230789
申请日：1994-04-21
申请人： Yasuaki Hanasaki , Hiroyuki Watanabe , Kimio Katsuura , Masatoshi Fujiwara , Teruhiko Ide
发明人： Yasuaki Hanasaki , Hiroyuki Watanabe , Kimio Katsuura , Masatoshi Fujiwara , Teruhiko Ide
IPC分类号： A01N43/82 , A01N43/832 , A01N47/06 , A01N47/18 , C07D285/10
CPC分类号： C07D285/10 , A01N43/82 , A01N47/06 , A01N47/18
摘要： Disclosed is (a) 1,2,5-thiadiazole derivatives represented by the following formulae [I] or [III]: ##STR1## wherein X and Y are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, a nitro group, a trifluoromethyl group, a carboxyl group, an alkoxycarbonyl group having from 2 to 5 carbon atoms, a naphthyl group or a tetrahydronaphthyl group; and A represents an alkyl group having from 1 to 6 carbon atoms, --C(.dbd.O)OR.sup.1, --C(.dbd.O)NR.sup.2 R.sup.3, a phenyl group which may be substituted by at least one of an alkyl group having from 1 to 6 carbon atoms and an alkoxy group having from 1 to 4 carbon atoms, --CHR.sup.4 C(.dbd.O)R.sup.5 or --C(.dbd.O)R.sup.6, in which R.sup.1 represents an alkyl group having from 1 to 6 carbon atoms, R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, R.sup.4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R.sup.5 represents an alkoxy group having from 1 to 4 carbon atoms or an amino group which may be substituted by at least one of an alkyl group having from 1 to 4 carbon atoms and a phenyl group which may be substituted by at least one halogen atom, and R.sup.6 represents an alkyl group having from 1 to 6 carbon atoms, (b) a process for producing the compound represented by formula [I] and (c) an agricultural and horticultural fungicide comprising the compound represented by formula [III].
摘要翻译：公开了（a）由下式[I]或[III]表示的1,2,5-噻二唑衍生物：相同或不同，表示氢原子，卤素原子，1〜6的烷基碳原子，具有1至4个碳原子的烷氧基，硝基，三氟甲基，羧基，具有2至5个碳原子的烷氧基羰基，萘基或四氢萘基; 并且A表示具有1至6个碳原子的烷基，-C（= O）OR 1，-C（= O）NR 2 R 3，可被至少一个具有1-6个碳原子的烷基取代的苯基碳原子和具有1至4个碳原子的烷氧基，-CHR 4 C（= O）R 5或-C（= O）R 6，其中R 1表示具有1至6个碳原子的烷基，R 2和R 3为相同或不同，各自表示氢原子或具有1至6个碳原子的烷基，R 4表示氢原子或具有1至4个碳原子的烷基，R 5表示具有1至4个碳原子的烷氧基或可被至少一个具有1至4个碳原子的烷基和可被至少一个卤素原子取代的苯基取代的氨基，R 6表示具有1至6个碳原子的烷基原子，（b）由式[I]和（c）代表的化合物的制备方法，包括该组合物的农业和园艺杀真菌剂并由式[III]表示。

7. 发明授权

US5330991A Tetrahydroisoquinoline compounds and fungicides containing the same 失效
标题翻译：四氢异喹啉化合物和含有它们的杀真菌剂
公开(公告)号：US5330991A
公开(公告)日：1994-07-19
申请号：US917289
申请日：1992-07-23
申请人： Takumi Tokunaga , Teruhiko Ide , Hiroyuki Watanabe , Kenji Tsuzuki
发明人： Takumi Tokunaga , Teruhiko Ide , Hiroyuki Watanabe , Kenji Tsuzuki
IPC分类号： A01N43/42 , C07D217/04 , C07D217/24 , C07D217/26 , A61K31/47 , C07D215/12
CPC分类号： A01N43/42 , C07D217/04 , C07D217/24 , C07D217/26
摘要： Tetrahydroisoquinoline derivatives of the following formula [I] and acid addition salts thereof, and ##STR1## (wherein in all of these formulae, R.sup.1 represents C.sub.1 -C.sub.5 straight or branched alkyl, C.sub.2 -C.sub.5 straight or branched alkenyl or C.sub.2 -C.sub.5 straight or branched alkynyl; R.sup.2 represents hydrogen atom, C.sub.1 -C.sub.10 straight or branched alkyl, C.sub.2 -C.sub.10 straight or branched alkenyl, C.sub.2 -C.sub.10 straight or branched alkynyl, C.sub.1 -C.sub.10 straight or branched alkoxy, C.sub.2 -C.sub.10 straight or branched alkenyloxy, C.sub.2 -C.sub.10 straight or branched alkynyloxy, or C.sub.1 -C.sub.10 straight or branched halogenated alkyl; R.sup.3, R.sup.4 R.sup.5 and R.sup.6, the same or different represent hydrogen atom, C.sub.1 -C.sub.10 straight or branched alkyl, C.sub.2 -C.sub.10 straight or branched alkenyl, C.sub.2 -C.sub.10 straight or branched alkynyl, C.sub.1 -C.sub.10 straight or branched alkoxy, C.sub.2 -C.sub.10 straight or branched alkenyloxy, C.sub.2 -C.sub.10 straight or branched alkynyloxy or halogen atom, with the proviso that R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are not hydrogen atoms simultaneously).
摘要翻译：下式[I]的四氢异喹啉衍生物及其酸加成盐，和，R1表示C1-C5直链或支链烷基，C2-C5直链或支链烯基或C2-C5直链或支链炔基; R2表示氢原子，C1-C10直链或支链烷基，C2-C10直链或支链烯基，C2-C10直链或支链炔基，C1-C10直链或支链烷氧基，C2-C10直链或支链烯氧基，C2-C10直链或支链炔氧基或C1-C10直链或支链卤代烷基; R3，R4R5和R6相同或不同，表示氢原子，C1-C10直链或支链烷基，C2-C10直链或支链烯基，C2-C10直链或支链炔基，C1-C10直链或支链烷氧基，C2-C10直链或支链烯氧基，C2-C10直链或支链炔氧基或卤素原子，条件是R3，R4，R5和R6同时不是氢原子）。

8. 发明授权

US09453066B2 FC binding protein and method for manufacturing same 有权
标题翻译： FC结合蛋白及其制造方法
公开(公告)号：US09453066B2
公开(公告)日：2016-09-27
申请号：US13583550
申请日：2011-03-10
申请人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
发明人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
IPC分类号： C07K1/00 , A23J1/00 , C07K14/735 , C07K1/22 , C07K17/08 , C07K16/00
CPC分类号： C07K14/70535 , C07K1/22 , C07K17/08 , C07K2319/21
摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.
摘要翻译：获得了与野生型人Fc受体相比，通过用野生型人细胞外结构域中的至少一个特定氨基酸残基取代的具有相对于热，酸和/或碱度的稳定性增加的Fc结合蛋白质 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主来表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

9. 发明授权

US08883969B2 Method for production of carotenoid-synthesizing microorganism and method for production of carotenoid 有权
标题翻译：类胡萝卜素合成微生物的生产方法及类胡萝卜素生产方法
公开(公告)号：US08883969B2
公开(公告)日：2014-11-11
申请号：US12089486
申请日：2006-09-25
申请人： Teruhiko Ide , Toru Tanaka
发明人： Teruhiko Ide , Toru Tanaka
IPC分类号： C07K14/00 , A23L1/275 , C12P23/00 , A23K1/16 , C12N15/74
CPC分类号： C12P23/00 , A23K20/179 , A23L5/44 , C12N15/743
摘要： A method for producing a carotenoid comprising the steps of cultivating a cell transformed with a DNA sequence comprising a DNA sequence depicted in anyone of SEQ ID NOs: 2-7 or a cell transformed with a vector having a DNA sequence depicted in anyone of SEQ ID NOs: 2-7 under proper culture conditions and isolating the carotenoid from the cell or the culture.
摘要翻译：一种制备类胡萝卜素的方法，包括以下步骤：培养用包含SEQ ID NO：2-7中任一个所示的DNA序列的DNA序列转化的细胞，或用SEQ ID NO：2-7中任一个所示DNA片段的载体转化的细胞 NOS：2-7在适当的培养条件下，从细胞或培养物中分离类胡萝卜素。

10. 发明申请

US20130079499A1 FC BINDING PROTEIN AND METHOD FOR MANUFACTURING SAME 有权
标题翻译： FC结合蛋白及其制造方法
公开(公告)号：US20130079499A1
公开(公告)日：2013-03-28
申请号：US13583550
申请日：2011-03-10
申请人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
发明人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
IPC分类号： C07K14/735 , C07K17/08 , C07K1/22
CPC分类号： C07K14/70535 , C07K1/22 , C07K17/08 , C07K2319/21
摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.
摘要翻译：公开了：与野生型相比，相对于热，酸和/或碱度具有增加的稳定性的Fc结合蛋白; 其制造方法; 以及使用所述Fc结合蛋白作为亲和层析的配体来特异性分离含有Fc结合蛋白结合位点的蛋白质的方法。获得了与野生型人Fc受体相比，通过用野生型人细胞外结构域中的至少一个特定氨基酸残基取代的具有相对于热，酸和/或碱度的稳定性增加的Fc结合蛋白 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主来表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式