专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09453066B2 FC binding protein and method for manufacturing same 有权
标题翻译： FC结合蛋白及其制造方法
公开(公告)号：US09453066B2
公开(公告)日：2016-09-27
申请号：US13583550
申请日：2011-03-10
申请人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
发明人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
IPC分类号： C07K1/00 , A23J1/00 , C07K14/735 , C07K1/22 , C07K17/08 , C07K16/00
CPC分类号： C07K14/70535 , C07K1/22 , C07K17/08 , C07K2319/21
摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.
摘要翻译：获得了与野生型人Fc受体相比，通过用野生型人细胞外结构域中的至少一个特定氨基酸残基取代的具有相对于热，酸和/或碱度的稳定性增加的Fc结合蛋白质 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主来表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

2. 发明申请

US20130079499A1 FC BINDING PROTEIN AND METHOD FOR MANUFACTURING SAME 有权
标题翻译： FC结合蛋白及其制造方法
公开(公告)号：US20130079499A1
公开(公告)日：2013-03-28
申请号：US13583550
申请日：2011-03-10
申请人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
发明人： Kouta Hatayama , Yoshiharu Asaoka , Toru Tanaka , Teruhiko Ide
IPC分类号： C07K14/735 , C07K17/08 , C07K1/22
CPC分类号： C07K14/70535 , C07K1/22 , C07K17/08 , C07K2319/21
摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.
摘要翻译：公开了：与野生型相比，相对于热，酸和/或碱度具有增加的稳定性的Fc结合蛋白; 其制造方法; 以及使用所述Fc结合蛋白作为亲和层析的配体来特异性分离含有Fc结合蛋白结合位点的蛋白质的方法。获得了与野生型人Fc受体相比，通过用野生型人细胞外结构域中的至少一个特定氨基酸残基取代的具有相对于热，酸和/或碱度的稳定性增加的Fc结合蛋白 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主来表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

3. 发明申请

US20190211077A2 IMPROVED FC-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHOD FOR SEPARATING ANTIBODY USING SAID ADSORBENT 审中-公开
公开(公告)号：US20190211077A2
公开(公告)日：2019-07-11
申请号：US15321916
申请日：2015-06-24
申请人： Yoshiharu ASAOKA , Toru TANAKA , Yosuke TERAO , Naoki YAMANAKA , Natsuko KIZU , Masaru AOKI , Teruhiko IDE
发明人： Yoshiharu ASAOKA , Toru TANAKA , Yosuke TERAO , Naoki YAMANAKA , Natsuko KIZU , Masaru AOKI , Teruhiko IDE
IPC分类号： C07K14/735 , C07K1/22 , C07K16/00 , B01J20/281 , G01N33/68 , B01D15/38
CPC分类号： C07K14/70535 , B01D15/3809 , C07K1/22 , C07K16/00 , C07K16/065 , C07K2317/10 , C07K2317/41 , C07K2317/732 , C12N15/09 , C12P21/02 , G01N30/482 , G01N33/6854 , G01N2030/486 , G01N2400/02
摘要： Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.

4. 发明授权

US5878340A Radio telecommunication apparatus for use in radio telecommunication system 失效
标题翻译：用于无线电通信系统的无线电通信设备
公开(公告)号：US5878340A
公开(公告)日：1999-03-02
申请号：US590879
申请日：1996-01-24
申请人： Yoshiharu Asaoka , Shinya Takahashi , Takashi Sakagawa
发明人： Yoshiharu Asaoka , Shinya Takahashi , Takashi Sakagawa
IPC分类号： H04W12/06 , H04B1/38
CPC分类号： H04W12/06
摘要： When a vehicle radio telephone has transmitted a call signal, a base-station/control-station suspends the communication channel. After the base-station/control-station transmits a PIN transmission request signal to the vehicle radio telephone via the communication channel, a liquid crystal display 452 incorporated in the telephone displays a PIN transmission request. Operating a key section 430 in the telephone generates a flash operation signal. When the base-station/control-station has received the flash operation signal, it transmits a telephone number transmission request signal. At this time, the PIN transmission request on the display 452 is erased, and a PIN is read from an ID/ROM and a PIN code signal is transmitted. Upon receiving the PIN code signal, the base-station/control-station examines whether or not the PIN indicated by the PIN code signal identical to a registered one. If they are identical to each other, the vehicle radio telephone is connected to a destination with an already received telephone number. Thus, the PIN can be easily and reliably transmitted from the vehicle radio telephone to the base-station/control-station.
摘要翻译：当车载无线电话已发送呼叫信号时，基站/控制站暂停通信信道。在基站/控制站经由通信信道向车载无线电话发送PIN发送请求信号之后，结合在电话中的液晶显示器452显示PIN发送请求。在电话中操作钥匙部分430产生闪光操作信号。当基站/控制站已经接收到闪光操作信号时，它发送电话号码发送请求信号。此时，显示器452上的PIN发送请求被擦除，并且从ID / ROM读取PIN并发送PIN码信号。在接收到PIN码信号时，基站/控制站检查由PIN码信号指示的PIN是否与已注册的PIN相同。如果它们彼此相同，则车载无线电话连接到具有已经接收到的电话号码的目的地。因此，可以容易且可靠地从车载无线电话向基站/控制站发送PIN。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式