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1. 发明授权

US09382226B2 Aldosterone synthase inhibitors 有权
标题翻译：醛固酮合酶抑制剂
公开(公告)号：US09382226B2
公开(公告)日：2016-07-05
申请号：US13811059
申请日：2011-07-20
申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
IPC分类号： C07D401/04 , C07D413/14 , C07D471/04 , A61K31/4375 , A61K31/4439 , A61K31/4184 , A61K31/4709
CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04
摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要翻译：本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

2. 发明申请

US20130317057A1 ALDOSTERONE SYNTHASE INHIBITORS 有权
公开(公告)号：US20130317057A1
公开(公告)日：2013-11-28
申请号：US13811059
申请日：2011-07-20
申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jaiqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jaiqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
IPC分类号： C07D401/04 , C07D413/14 , A61K31/4375 , A61K31/4709 , A61K31/4439 , C07D471/04
CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04
摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要翻译：本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

3. 发明授权

US09351973B2 Pyrazolopyridyl compounds as aldosterone synthase inhibitors 有权
标题翻译：吡唑并吡啶基化合物作为醛固酮合酶抑制剂
公开(公告)号：US09351973B2
公开(公告)日：2016-05-31
申请号：US14346518
申请日：2012-09-17
申请人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61P9/12 , A61P13/12 , A61P9/00 , A61P9/10 , A61P1/16
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：本发明涉及以下结构式的吡唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

4. 发明授权

US09173873B2 Imidazopyridyl compounds as aldosterone synthase inhibitors 有权
公开(公告)号：US09173873B2
公开(公告)日：2015-11-03
申请号：US14346403
申请日：2012-09-17
申请人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
发明人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04
摘要： This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

5. 发明申请

US20080005103A1 Intellectual property search, marketing and licensing connection system and method 审中-公开
标题翻译：知识产权搜索，营销和许可连接系统和方法
公开(公告)号：US20080005103A1
公开(公告)日：2008-01-03
申请号：US11808357
申请日：2007-06-08
申请人： Paul Ratcliffe , Cory Sorice , Steven Walk
发明人： Paul Ratcliffe , Cory Sorice , Steven Walk
IPC分类号： G06F17/30 , G06F15/00
CPC分类号： G06Q10/10 , G06F2216/11
摘要： An intellectual property information search and technology marketing and licensing connection platform is provided. The present invention provides new and valuable information and connections for technology marketing and connections in a web accessible format for registered and non-registered users. Marketing is based on keywords, user actions, search results and other factors. Dynamic patent status determination is integrated into the system and is displayed and used for search result filtering and relevancy. User actions and input are also factors for document relevancy and ranking. The system also provides an improved user interface for reviewing intellectual property information with optimized image size, selectable text, and improved navigation.
摘要翻译：提供知识产权信息搜索和技术营销和许可连接平台。本发明为注册用户和非注册用户提供用于技术营销和网络可访问格式的连接的新的和有价值的信息和连接。营销是基于关键字，用户操作，搜索结果等因素。将动态专利状态确定集成到系统中，并显示并用于搜索结果过滤和相关性。用户操作和输入也是文档相关性和排名的因素。该系统还提供了改进的用户界面，用于通过优化的图像大小，可选择的文本和改进的导航来检查知识产权信息。

6. 发明申请

US20070082931A1 Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US20070082931A1
公开(公告)日：2007-04-12
申请号：US11506579
申请日：2006-08-18
申请人： Paul Ratcliffe , Julia Adam-Worrall , Angus Morrison , Stuart Francis , Takao Kiyoi
发明人： Paul Ratcliffe , Julia Adam-Worrall , Angus Morrison , Stuart Francis , Takao Kiyoi
IPC分类号： A61K31/433 , A61K31/4245 , A61K31/427 , A61K31/422 , C07D417/14 , C07D413/14
CPC分类号： C07D413/14 , C07D417/14
摘要： Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the indole derivatives and use of the derivatives for the treatment of pain.
摘要翻译：本文公开的是式（I）的吲哚衍生物，其中每个取代基被给出如说明书和权利要求书中阐述的定义。还公开了含有吲哚衍生物的药物组合物和用于治疗疼痛的衍生物的用途。

7. 发明申请

US20140379589A1 SYSTEM AND METHOD FOR DISPUTE RESOLUTION 审中-公开
标题翻译：用于争议解决的系统和方法
公开(公告)号：US20140379589A1
公开(公告)日：2014-12-25
申请号：US14314860
申请日：2014-06-25
申请人： Paul Ratcliffe
发明人： Paul Ratcliffe
IPC分类号： G06Q50/18 , G06F3/0484 , G06F3/0481
CPC分类号： G06Q50/182
摘要： The invention provides a dispute resolution platform comprising servers, software, data, and communication capabilities providing a user interface and systems enabling live settlement, live decisions, and live feedback from a group of users who are not a party to the dispute. The present invention provides an online dispute resolution platform enabling parties to describe their dispute, upload evidence, comments, testimony, affidavits and comments from witnesses through a system which identifies opportunities for settlement and prompts users. The system allows the parties to settle their dispute prior to a live hearing, during a live hearing, or after a live hearing,
摘要翻译：本发明提供了一种争议解决平台，其包括服务器，软件，数据和通信能力，提供用户界面和系统，以支持实时结算，实时决策和来自不是争议方的用户组的实时反馈。本发明提供了一个在线争议解决平台，使各方能够通过识别结算机制和提示用户的系统来描述他们的争议，上传证据，评论，证词，誓言和评论。该制度允许各方在现场听证会，现场听证会或实况听证会之前解决争议，

8. 发明申请

US20150100479A1 SYSTEM FOR MONITORING THE COMPLIANCE RELATIONSHIPS OF BANKING ENTITIES WITH VALIDATION, REROUTING, AND FEE DETERMINATION OF FINANCIAL TRANSACTIONS 审中-公开
标题翻译：监管实体与财务交易确认，转让和费用确认合规关系的制度
公开(公告)号：US20150100479A1
公开(公告)日：2015-04-09
申请号：US14511082
申请日：2014-10-09
申请人： Avi Jorisch , Paul Ratcliffe
发明人： Avi Jorisch , Paul Ratcliffe
IPC分类号： G06Q30/00 , G06Q20/38
CPC分类号： G06Q30/018 , G06Q20/027 , G06Q20/10 , G06Q20/4016 , G06Q20/405
摘要： A system and method for validating a given wire or financial transaction to determine if the destination bank or any connecting or correspondent banks have a direct or indirect relationship with an illicit entity and, if an illicit relationship is identified, the system attempts to reroute the transaction along a compliant path. Such indirect illicit relationship may be set to require at least two degrees of separation and may be user or bank defined depending on their risk tolerance. The rerouted compliance path may identify multiple paths and rank and prioritize that paths based on risk tolerance, associated fees of the banking touch points, and can automatically approve reroutes or display paths to the user for selection. Further, the system allows banks to set and can then determine any compliance fee splits amongst all entities that may receive a portion of the fee and any adjustments from any rerouted paths.
摘要翻译：用于验证给定的电汇或金融交易以确定目的地银行或任何连接或代理银行是否与非法实体具有直接或间接关系的系统和方法，并且如果识别出非法关系，则系统尝试重新路由交易沿着合规的路径。这种间接非法关系可以被设置为要求至少两个分离度，并且可以根据其风险承受力来定义用户或银行。重新路由的合规路径可以基于风险承受力，银行接触点的相关费用来识别多个路径并对该路径进行排序和优先级排序，并且可以自动批准重新路由或显示路径以供用户选择。此外，该系统允许银行设置并且然后可以确定可能接收费用的一部分的所有实体中的任何合规费用分段以及从任何重新路由的路径的任何调整。

9. 发明申请

US20080090802A1 QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES 有权
标题翻译：喹唑啉酮和异喹啉酮酰胺衍生物
公开(公告)号：US20080090802A1
公开(公告)日：2008-04-17
申请号：US11852762
申请日：2007-09-10
申请人： Jeffrey Letourneau , Patrick Jokiel , Susan Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan McArthur , Fiona Jeremiah , Paul Ratcliffe , Jurgen Schulz
发明人： Jeffrey Letourneau , Patrick Jokiel , Susan Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan McArthur , Fiona Jeremiah , Paul Ratcliffe , Jurgen Schulz
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/551 , A61P25/00 , C07D401/02 , C07D403/02 , C07D413/14
CPC分类号： C07D403/04 , C07D217/24 , C07D239/91 , C07D401/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/08 , C07D487/04
摘要： Disclosed herein are quinazolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
摘要翻译：本文公开的式I的喹唑啉酮衍生物或其药学上可接受的盐或溶剂化物，其中每个取代基都给出如说明书和权利要求书中所阐述的定义。还公开了包含根据本发明的喹唑啉酮或异喹啉酮及其在治疗中的用途的药物组合物。

10. 发明申请

US20050149401A1 System and method for an intellectual property collaboration network 审中-公开
标题翻译：知识产权协作网络的系统和方法
公开(公告)号：US20050149401A1
公开(公告)日：2005-07-07
申请号：US11029374
申请日：2005-01-06
申请人： Paul Ratcliffe , Cory Sorice
发明人： Paul Ratcliffe , Cory Sorice
IPC分类号： G06Q10/00 , G06F17/60
CPC分类号： G06Q10/10 , G06Q30/0207 , G06Q50/184
摘要： The present invention provides a system and method for providing an intellectual property collaboration network for the development and improvement of inventions and technology with inventors being granted equity or an ownership interest in patent arrays or companies which patent, market, license and generate revenue from the developed technology. The present invention provides a unique way of distributing equity to contributing inventors of ideas and owners of patents within the network for those technologies which are grouped and related. The system of the present invention enables inventors to submit ideas, collaborate on projects, advance technology and protect inventions through an intellectual property network which provides inventors equity in companies or patent arrays in exchange for the developments which are then patented, marketed, and licensed with revenue flowing through the companies and patent arrays back to the inventors and other contributors of the system. The system may also be used for existing and donated patents which can be marketed and licensed through the system including granting equity or ownership interest in the patent arrays or companies to owners of the existing or donated patents.
摘要翻译：本发明提供了一种提供用于发明和改进发明和技术的知识产权协作网络的系统和方法，其中发明人被授予权利或所有者权益，专利数量或公司的专利，市场，许可和从发达国家获得收入技术。本发明提供了一种独特的方法，用于为分组和相关的那些技术在网络内向发明人的思想和专利所有者分配权益。本发明的系统使得发明家能够通过知识产权网络提交想法，合作项目，推进技术和保护发明，这些知识产权网络为发明人在公司或专利阵列中的权益提供交换，以便随后获得专利，销售和许可的开发通过公司和专利阵列的收入回到发明家和系统的其他贡献者。该系统还可以用于可以通过该系统销售和许可的现有和捐赠的专利，包括授予专利阵列的权益或所有者权益或对现有或捐赠的专利的所有者的公司。

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