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1. 发明申请

US20130317057A1 ALDOSTERONE SYNTHASE INHIBITORS 有权
公开(公告)号：US20130317057A1
公开(公告)日：2013-11-28
申请号：US13811059
申请日：2011-07-20
申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jaiqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jaiqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
IPC分类号： C07D401/04 , C07D413/14 , A61K31/4375 , A61K31/4709 , A61K31/4439 , C07D471/04
CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04
摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要翻译：本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

2. 发明授权

US09382226B2 Aldosterone synthase inhibitors 有权
标题翻译：醛固酮合酶抑制剂
公开(公告)号：US09382226B2
公开(公告)日：2016-07-05
申请号：US13811059
申请日：2011-07-20
申请人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
发明人： Scott B. Hoyt , Min K. Park , Clare London , Yusheng Xiong , D. Jonathan Bennett , Jiaqiang Cai , Paul Ratcliffe , Andrew Cooke , Emma Carswell , John MacLean , Rohit Saxena , Bheemashankar A. Kulkarni , Archana Gupta
IPC分类号： C07D401/04 , C07D413/14 , C07D471/04 , A61K31/4375 , A61K31/4439 , A61K31/4184 , A61K31/4709
CPC分类号： C07D401/04 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4709 , C07D413/14 , C07D471/04
摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
摘要翻译：本发明涉及结构式（I）的化合物及其药学上可接受的盐。本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

3. 发明授权

US09351973B2 Pyrazolopyridyl compounds as aldosterone synthase inhibitors 有权
标题翻译：吡唑并吡啶基化合物作为醛固酮合酶抑制剂
公开(公告)号：US09351973B2
公开(公告)日：2016-05-31
申请号：US14346518
申请日：2012-09-17
申请人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61P9/12 , A61P13/12 , A61P9/00 , A61P9/10 , A61P1/16
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：本发明涉及以下结构式的吡唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

4. 发明授权

US09173873B2 Imidazopyridyl compounds as aldosterone synthase inhibitors 有权
公开(公告)号：US09173873B2
公开(公告)日：2015-11-03
申请号：US14346403
申请日：2012-09-17
申请人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
发明人： Amjad Ali , D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Michael Lo , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Jerry Andrew Taylor , Brent Whitehead , Yusheng Xiong
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04
摘要： This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

5. 发明授权

US08195723B2 Document management system for building maintenance and operational documents 失效
标题翻译：文件管理系统，用于建筑维护和运行文件
公开(公告)号：US08195723B2
公开(公告)日：2012-06-05
申请号：US12171706
申请日：2008-07-11
申请人： Michael Murdock , John MacLean , John Rexhausen
发明人： Michael Murdock , John MacLean , John Rexhausen
IPC分类号： G06F17/30
CPC分类号： G06Q10/00
摘要： A document management system separates building information into a variety of data sets. Each data set has at least one common attribute that links it to all other types of data sets for the building. The information for maintaining the building is stored in a manner allowing users to retrieve only selective information from a vast amount of stored information. Users can query and retrieve data sets in a vast number of combinations relating to a specific building, or floor, room, system or system component in the building.
摘要翻译：文件管理系统将建筑信息分成多种数据集。每个数据集具有至少一个通用属性，将其链接到建筑物的所有其他类型的数据集。用于维护建筑物的信息以允许用户从大量存储信息中仅检索选择性信息的方式存储。用户可以在与建筑物中的特定建筑物或楼层，房间，系统或系统组件相关的大量组合中查询和检索数据集。

6. 发明授权

US6042096A Workpiece locating device 失效
标题翻译：工件定位装置
公开(公告)号：US6042096A
公开(公告)日：2000-03-28
申请号：US822728
申请日：1997-03-24
申请人： John MacLean
发明人： John MacLean
IPC分类号： B27F7/15 , B23Q3/00
CPC分类号： B27F7/155 , Y10S269/91
摘要： There is provided a new and useful workpiece locating device for use on a machine table comprising at least two spaced elongated support members arranged in parallel so as to create at least one elongated slot, in a top surface of said table, between adjacent support members in which the locating device comprises a first member for insertion into the slot, which first member comprises a base having a width less the width of the slot and at least one locking means to releasably secure the base within the slot and a second member fastened to the first member in which the second member is upstanding relative to the top surface of the table when the device is positioned in the slot.
摘要翻译：提供了一种用于机台上的新的和有用的工件定位装置，其包括平行设置的至少两个间隔开的细长支撑构件，以便在所述工作台的顶表面中在相邻的支撑构件之间形成至少一个细长槽所述定位装置包括用于插入槽中的第一构件，该第一构件包括宽度小于所述狭槽的宽度的基座和至少一个锁定装置，以将所述基座可释放地固定在所述槽内，以及固定到所述槽的第二构件第一构件，其中当设备定位在槽中时，第二构件相对于工作台的顶表面直立。

7. 发明授权

US08688755B2 Document management system for buildings 失效
标题翻译：建筑文件管理系统
公开(公告)号：US08688755B2
公开(公告)日：2014-04-01
申请号：US13488408
申请日：2012-06-04
申请人： Michael Murdock , John MacLean , John Rexhausen
发明人： Michael Murdock , John MacLean , John Rexhausen
IPC分类号： G06F17/30
CPC分类号： G06Q10/00
摘要： A document management system separates building information into a variety of data sets. Each data set has at least one common attribute that links it to all other types of data sets for the building. The information for maintaining the building is stored in a manner allowing users to retrieve only selective information from a vast amount of stored information. Users can query and retrieve data sets in a vast number of combinations relating to a specific building, or floor, room, system or system component in the building.
摘要翻译：文件管理系统将建筑信息分成多种数据集。每个数据集具有至少一个通用属性，将其链接到建筑物的所有其他类型的数据集。用于维护建筑物的信息以允许用户从大量存储信息中仅检索选择性信息的方式存储。用户可以在与建筑物中的特定建筑物或楼层，房间，系统或系统组件相关的大量组合中查询和检索数据集。

8. 发明申请

US20120239635A1 Document Management System for Buildings 失效
标题翻译：建筑物文件管理系统
公开(公告)号：US20120239635A1
公开(公告)日：2012-09-20
申请号：US13488408
申请日：2012-06-04
申请人： Michael Murdock , John MacLean , John Rexhausen
发明人： Michael Murdock , John MacLean , John Rexhausen
IPC分类号： G06F17/30
CPC分类号： G06Q10/00
摘要： A document management system separates building information into a variety of data sets. Each data set has at least one common attribute that links it to all other types of data sets for the building. The information for maintaining the building is stored in a manner allowing users to retrieve only selective information from a vast amount of stored information. Users can query and retrieve data sets in a vast number of combinations relating to a specific building, or floor, room, system or system component in the building.
摘要翻译：文件管理系统将建筑信息分成多种数据集。每个数据集具有至少一个通用属性，将其链接到建筑物的所有其他类型的数据集。用于维护建筑物的信息以允许用户从大量存储信息中仅检索选择性信息的方式存储。用户可以在与建筑物中的特定建筑物或楼层，房间，系统或系统组件相关的大量组合中查询和检索数据集。

9. 发明申请

US20100010966A1 Document Management System For Building Maintenance And Operational Documents 失效
标题翻译：建筑维护和运行文件文件管理系统
公开(公告)号：US20100010966A1
公开(公告)日：2010-01-14
申请号：US12171706
申请日：2008-07-11
申请人： Michael Murdock , John MacLean , John Rexhausen
发明人： Michael Murdock , John MacLean , John Rexhausen
IPC分类号： G06F17/30
CPC分类号： G06Q10/00
摘要： A document management system separates building information into a variety of data sets. Each data set has at least one common attribute that links it to all other types of data sets for the building. The information for maintaining the building is stored in a manner allowing users to retrieve only selective information from a vast amount of stored information. Users can query and retrieve data sets in a vast number of combinations relating to a specific building, or floor, room, system or system component in the building.
摘要翻译：文档管理系统将建筑信息分为多种数据集。每个数据集具有至少一个通用属性，将其链接到建筑物的所有其他类型的数据集。用于维护建筑物的信息以允许用户从大量存储信息中仅检索选择性信息的方式存储。用户可以在与建筑物中的特定建筑物或楼层，房间，系统或系统组件相关的大量组合中查询和检索数据集。

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