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1. 发明授权

US08364264B2 Pacing interval adjustment for cardiac pacing response determination 有权
标题翻译：心脏起搏反应确定的起搏间隔调整
公开(公告)号：US08364264B2
公开(公告)日：2013-01-29
申请号：US11242240
申请日：2005-10-03
申请人： Scott A. Meyer , Yanting Dong , Kevin J. Stalsberg , Alok Sathaye
发明人： Scott A. Meyer , Yanting Dong , Kevin J. Stalsberg , Alok Sathaye
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61N1/3682 , A61N1/3684 , A61N1/3712
摘要： The waveform morphology of a propagated pacing response signal may be adjusted to achieve a waveform morphology that enhances cardiac pacing response determination. One or more pacing intervals may be adjusted to achieve at least one cardiac pacing response waveform morphology that enhances determination of the cardiac pacing response. The heart is paced using the one or more adjusted pacing intervals and the cardiac response to the pacing is determined. The one or more adjusted pacing intervals may include an atrioventricular pacing delay, an interatrial pacing delay, an interventricular pacing delay, or other inter-chamber or inter-site pacing delays. Adjusting the one or more pacing intervals may be used to increase a difference between a first waveform morphology associated with multi-chamber capture and a second waveform morphology associated with single chamber capture.
摘要翻译：可以调节传播的起搏响应信号的波形形态，以实现增强心脏起搏响应确定的波形形态。可以调整一个或多个起搏间隔以实现至少一个心脏起搏响应波形形态，其增强心脏起搏响应的确定。心脏使用一个或多个调整的起搏间隔进行起搏，并且确定对起搏的心脏反应。一个或多个调整的起搏间隔可以包括房室起搏延迟，房间起搏延迟，室间起搏延迟或其他间室间或间部间起搏延迟。可以使用调整一个或多个起搏间隔来增加与多室捕获相关联的第一波形形态与与单室捕获相关联的第二波形形态之间的差异。

2. 发明授权

US08145296B2 Adaptive windowing for cardiac waveform discrimination 有权
标题翻译：心脏波形鉴别的自适应窗口
公开(公告)号：US08145296B2
公开(公告)日：2012-03-27
申请号：US12538297
申请日：2009-08-10
申请人： Kevin J. Stalsberg , Yanting Dong , Scott Meyer , Eric K. Enrooth , Derek D. Bohn
发明人： Kevin J. Stalsberg , Yanting Dong , Scott Meyer , Eric K. Enrooth , Derek D. Bohn
IPC分类号： A61B5/042
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/0472 , A61B5/7217
摘要： Cardiac devices and methods provide adaptation of detection windows used to determine a cardiac response to pacing. Adapting a detection window involves sensing a cardiac signal indicative of a particular type of cardiac pacing response, and detecting a feature of the sensed cardiac signal. The cardiac response detection window associated with the type of cardiac pacing response is preferentially adjusted based on the location of the detected cardiac feature. Preferential adjustment of the detection window may involve determining a direction of change between the detection window and the detected feature. The detection window may be adapted more aggressively in a more preferred direction and less aggressively in a less preferred direction.
摘要翻译：心脏装置和方法提供用于确定对起搏的心脏反应的检测窗口的适应。适应检测窗口包括感测指示特定类型的心脏起搏反应的心脏信号，以及检测感测到的心脏信号的特征。基于检测到的心脏特征的位置优先调整与心脏起搏响应类型相关联的心脏响应检测窗口。检测窗口的优先调整可以包括确定检测窗口和检测到的特征之间的变化方向。检测窗口可以在更优选的方向上更积极地改变，并且在较不优选的方向上较不积极地适配。

3. 发明授权

US08271086B2 Pacing output determination based on selected capture threshold values 有权
标题翻译：基于所选捕获阈值的起搏输出确定
公开(公告)号：US08271086B2
公开(公告)日：2012-09-18
申请号：US12341617
申请日：2008-12-22
申请人： John Voegele , Clayton Foster , David W. Yost , Scott Meyer , Yanting Dong , Kevin J. Stalsberg , Derek D. Bohn , Eric K. Enrooth
发明人： John Voegele , Clayton Foster , David W. Yost , Scott Meyer , Yanting Dong , Kevin J. Stalsberg , Derek D. Bohn , Eric K. Enrooth
IPC分类号： A61N1/365 , A61N1/08
CPC分类号： A61N1/3712
摘要： Approaches for adjusting the pacing energy delivered by a pacemaker are provided. Adjusting the pacing energy involves performing a plurality of capture threshold tests, each capture threshold test measuring a capture threshold of the heart. One or more measured captured thresholds are selected, including at least one capture threshold that is higher relative to other measured capture thresholds acquired by the plurality of capture threshold tests. The pacing energy is adjusted based on the one or more selected capture thresholds.
摘要翻译：提供了调节由起搏器提供的起搏能量的方法。调整起搏能量包括执行多个捕获阈值测试，每个捕获阈值测试测量心脏的捕获阈值。选择一个或多个测量的捕获阈值，包括相对于通过多个捕获阈值测试获取的其他测量的捕获阈值更高的捕获阈值。基于一个或多个选择的捕获阈值来调整起搏能量。

4. 发明申请

US20100023082A1 INDIVIDUALIZED MORPHOLOGY FEATURE EVALUATION AND SELECTION FOR DISCRIMINATION IN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可移植医疗设备中的个体化形态学特征评估与选择
公开(公告)号：US20100023082A1
公开(公告)日：2010-01-28
申请号：US12507436
申请日：2009-07-22
申请人： Yanting Dong , M. Jason Brooke , Dan Li , Kevin J. Stalsberg
发明人： Yanting Dong , M. Jason Brooke , Dan Li , Kevin J. Stalsberg
IPC分类号： A61N1/365 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/0002 , A61B5/04525 , A61N1/365 , A61N1/3702
摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.
摘要翻译：一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。处理器包括特征模块和检测模块。特征模块被配置为识别传感器信号中的特征并且确定传感器信号中的特征的质量的度量。所述检测模块被配置为当所述特征的质量度量满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

5. 发明申请

US20070078489A1 Pacing interval adjustment for cardiac pacing response determination 有权
标题翻译：心脏起搏反应确定的起搏间隔调整
公开(公告)号：US20070078489A1
公开(公告)日：2007-04-05
申请号：US11242240
申请日：2005-10-03
申请人： Scott Meyer , Yanting Dong , Kevin Stalsberg , Alok Sathaye
发明人： Scott Meyer , Yanting Dong , Kevin Stalsberg , Alok Sathaye
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61N1/3682 , A61N1/3684 , A61N1/3712
摘要： The waveform morphology of a propagated pacing response signal may be adjusted to achieve a waveform morphology that enhances cardiac pacing response determination. One or more pacing intervals may be adjusted to achieve at least one cardiac pacing response waveform morphology that enhances determination of the cardiac pacing response. The heart is paced using the one or more adjusted pacing intervals and the cardiac response to the pacing is determined. The one or more adjusted pacing intervals may include an atrioventricular pacing delay, an interatrial pacing delay, an interventricular pacing delay, or other inter-chamber or inter-site pacing delays. Adjusting the one or more pacing intervals may be used to increase a difference between a first waveform morphology associated with multi-chamber capture and a second waveform morphology associated with single chamber capture.
摘要翻译：可以调节传播的起搏响应信号的波形形态，以实现增强心脏起搏响应确定的波形形态。可以调整一个或多个起搏间隔以实现至少一个心脏起搏响应波形形态，其增强心脏起搏响应的确定。心脏使用一个或多个调整的起搏间隔进行起搏，并且确定对起搏的心脏反应。一个或多个经调整的起搏间隔可以包括房室起搏延迟，房间起搏延迟，室间起搏延迟或其他间室间或间部间起搏延迟。可以使用调整一个或多个起搏间隔来增加与多室捕获相关联的第一波形形态与与单室捕获相关联的第二波形形态之间的差异。

6. 发明授权

US09993205B2 Cardiac response classification using retriggerable classification windows 有权
公开(公告)号：US09993205B2
公开(公告)日：2018-06-12
申请号：US12818066
申请日：2010-06-17
申请人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61N1/08 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

7. 发明申请

US20130013020A1 Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification 有权
标题翻译：心脏起搏反应分类融合与噪声管理方法与系统
公开(公告)号：US20130013020A1
公开(公告)日：2013-01-10
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

8. 发明申请

US20120226328A1 CARDIAC RESYNCHRONIZATION THERAPY PARAMETER OPTIMIZATION 审中-公开
标题翻译： CARDIAC RESYNCHRONIZATION治疗参数优化
公开(公告)号：US20120226328A1
公开(公告)日：2012-09-06
申请号：US13466431
申请日：2012-05-08
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

9. 发明申请

US20120165895A1 Non-Captured Intrinsic Discrimination in Cardiac Pacing Response Classification 审中-公开
标题翻译：心脏起搏反应分类中不被捕获的内在歧视
公开(公告)号：US20120165895A1
公开(公告)日：2012-06-28
申请号：US13411852
申请日：2012-03-05
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/371 , A61B5/04525
摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.
摘要翻译：心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

10. 发明授权

US08116870B2 Capture detection for multi-chamber pacing 有权
标题翻译：捕获检测多腔起搏
公开(公告)号：US08116870B2
公开(公告)日：2012-02-14
申请号：US12214852
申请日：2008-06-23
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stahlsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stahlsberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61N1/3684
摘要： Multi-chamber pacing may result in capture of one chamber, capture of multiple chambers, fusion, or non-capture. Approaches for detecting various capture conditions during multi-chamber pacing are described. Pacing pulses are delivered to left and right heart chambers during a cardiac cycle. A cardiac electrogram signal is sensed following the delivery of the pacing pulses. Left chamber capture only, right chamber capture only, and bi-chamber capture may be distinguished based on characteristics of the cardiac electrogram signal. Multi-chamber capture detection may be implemented using detection windows having dimensions of time and amplitude. The detection windows are associated with expected features, such as expected signal peaks, under a particular capture condition. The cardiac electrogram signal features are compared to detection windows to determine the capture condition.
摘要翻译：多腔起搏可能导致一个腔室的捕获，多个腔室的捕获，融合或非捕获。描述了在多室起搏期间检测各种捕获条件的方法。在心动周期期间，起搏脉冲被传送到左心室和右心室。在起搏脉冲输送之后感测心电图信号。仅左室捕获，右室捕获，双室捕获可以基于心电图信号的特征来区分。可以使用具有时间和幅度尺寸的检测窗来实现多室捕获检测。检测窗口与特定捕获条件下的预期特征（例如期望的信号峰值）相关联。将心电图信号特征与检测窗口进行比较以确定捕获条件。

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