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1. 发明申请

US20120226328A1 CARDIAC RESYNCHRONIZATION THERAPY PARAMETER OPTIMIZATION 审中-公开
标题翻译： CARDIAC RESYNCHRONIZATION治疗参数优化
公开(公告)号：US20120226328A1
公开(公告)日：2012-09-06
申请号：US13466431
申请日：2012-05-08
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

2. 发明授权

US08175703B2 Cardiac resynchronization therapy parameter optimization 有权
标题翻译：心脏再同步治疗参数优化
公开(公告)号：US08175703B2
公开(公告)日：2012-05-08
申请号：US11338935
申请日：2006-01-25
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

3. 发明申请

US20100023078A1 Cardiac resynchronization therapy parameter optimization 有权
标题翻译：心脏再同步治疗参数优化
公开(公告)号：US20100023078A1
公开(公告)日：2010-01-28
申请号：US11338935
申请日：2006-01-25
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

4. 发明授权

US07555340B2 Electrogram morphology-based CRT optimization 有权
标题翻译：基于电图形态的CRT优化
公开(公告)号：US07555340B2
公开(公告)日：2009-06-30
申请号：US11097460
申请日：2005-04-01
申请人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
发明人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/371
摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.
摘要翻译：一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

5. 发明授权

US08078276B2 Electrogram morphology-based CRT optimization 有权
标题翻译：基于电图形态的CRT优化
公开(公告)号：US08078276B2
公开(公告)日：2011-12-13
申请号：US12494628
申请日：2009-06-30
申请人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
发明人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/371
摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.
摘要翻译：一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

6. 发明申请

US20090264949A1 ELECTROGRAM MORPHOLOGY-BASED CRT OPTIMIZATION 有权
标题翻译：基于电化学形态的CRT优化
公开(公告)号：US20090264949A1
公开(公告)日：2009-10-22
申请号：US12494628
申请日：2009-06-30
申请人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
发明人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/371
摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.
摘要翻译：一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

7. 发明授权

US08565880B2 His-bundle capture verification and monitoring 有权
标题翻译： His-bundle捕获验证和监控
公开(公告)号：US08565880B2
公开(公告)日：2013-10-22
申请号：US13094416
申请日：2011-04-26
申请人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
发明人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
IPC分类号： A61N1/36
CPC分类号： A61N1/371 , A61B5/0031 , A61B5/04525 , A61B5/7264 , A61N1/3712 , A61N1/37247
摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.
摘要翻译：本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

8. 发明申请

US20110264158A1 HIS-BUNDLE CAPTURE VERIFICATION AND MONITORING 有权
标题翻译：验证和监控
公开(公告)号：US20110264158A1
公开(公告)日：2011-10-27
申请号：US13094416
申请日：2011-04-26
申请人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
发明人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/0031 , A61B5/04525 , A61B5/7264 , A61N1/3712 , A61N1/37247
摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.
摘要翻译：本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

9. 发明授权

US07917215B2 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US07917215B2
公开(公告)日：2011-03-29
申请号：US12276070
申请日：2008-11-21
申请人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos A. Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos A. Ricci , Scott A. Meyer
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

10. 发明授权

US07457664B2 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US07457664B2
公开(公告)日：2008-11-25
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋向闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

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