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1. 发明申请

US20130138174A1 AUTOTHRESHOLD WITH SENSING FROM PACING CATHODE 有权
标题翻译：自动检测从PACING CATHODE
公开(公告)号：US20130138174A1
公开(公告)日：2013-05-30
申请号：US13684814
申请日：2012-11-26
申请人： David W. Yost , Deepa Mahajan , Clayton S. Foster , Aaron R. McCabe , Shibaji Shome , Amy Jean Brisben
发明人： David W. Yost , Deepa Mahajan , Clayton S. Foster , Aaron R. McCabe , Shibaji Shome , Amy Jean Brisben
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： Cardiac electrostimulation energy is delivered to a heart chamber of a subject according to a normal pacing mode using a set of implantable pacing electrodes. When a threshold test for the heart chamber is initiated and a sensing electrode independent from the set of pacing electrodes is unavailable for the heart chamber, cardiac electrostimulation energy is delivered to the subject according to a threshold test mode. The threshold test mode includes sensing a cardiac activity signal from a subject using a set of sensing electrodes that includes an electrode common to the set of pacing electrodes, and changing the electrostimulation energy and sensing a resulting cardiac activity signal using the set of sensing electrodes to determine the optimum electrostimulation energy for capture of the heart chamber.
摘要翻译：心脏电刺激能量使用一组可植入起搏电极根据正常起搏模式递送到受试者的心室。当启动心脏室的阈值测试并且独立于该组起搏电极的感测电极不能用于心脏室时，根据阈值测试模式将心脏电刺激能量递送给受试者。阈值测试模式包括使用包括一组起搏电极的电极的一组感测电极来感测来自对象的心脏活动信号，并且使用该组感测电极改变电刺激能量并感测所得到的心脏活动信号，确定用于捕获心室的最佳电刺激能量。

2. 发明授权

US08352029B2 Flexible neural stimulation engine 有权
标题翻译：灵活的神经刺激引擎
公开(公告)号：US08352029B2
公开(公告)日：2013-01-08
申请号：US12785954
申请日：2010-05-24
申请人： David J. Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
发明人： David J. Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for implementing a neural stimulation therapy mode in an implantable medical device (IMD) comprising the acts of mapping respective device states, defined by one or more timer states that include at least one neural event timer or one or more indications of one or more sensed physiologic events, to associated device actions in a stored neural table, storing an event represented as a device status word and a time stamp in a queue in response to an action input, and comparing one or more current timer states or one or more indications of one or more sensed physiologic events to a device state contained in the neural table and, if found to match, causing performance of one or more associated device actions, wherein the device actions include one or more of a neural stimulation energy delivery or a change in one or more timer states.
摘要翻译：一种用于在可植入医疗装置（IMD）中实现神经刺激治疗模式的方法，包括映射由包括至少一个神经事件计时器或一个或多个指示的一个或多个定时器状态定义的各个装置状态的动作检测到的生理事件，到存储的神经表中的相关设备动作，响应于动作输入将表示为设备状态字的事件和时间戳存储在队列中，以及比较一个或多个当前定时器状态或一个或多个指示一个或多个感测到的生理事件到包含在神经表中的设备状态，并且如果发现匹配，导致一个或多个相关联的设备动作的性能，其中设备动作包括神经刺激能量递送或改变中的一个或多个在一个或多个定时器状态。

3. 发明申请

US20110098773A1 ESTIMATION OF DEDICATED BIPOLAR PACING VECTOR THRESHOLD 有权
标题翻译：专用双极板矢量阈值的估计
公开(公告)号：US20110098773A1
公开(公告)日：2011-04-28
申请号：US12906849
申请日：2010-10-18
申请人： Amy Jean Brisben , Aaron R. McCabe , Kevin John Stalsberg , Jacob I. Laughner , Clayton S. Foster , David W. Yost
发明人： Amy Jean Brisben , Aaron R. McCabe , Kevin John Stalsberg , Jacob I. Laughner , Clayton S. Foster , David W. Yost
IPC分类号： A61N1/36
CPC分类号： A61N1/371 , A61N1/3712 , A61N1/37282
摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.
摘要翻译：描述了允许估计电刺激捕获阈值（例如专用双极起搏矢量阈值）的方法和装置。在一个示例中，可以使用第一和第二起搏向量之间的等能量假设从第一起搏向量的测量的电刺激捕获阈值和第一和第二起搏向量的阻抗来估计第二起搏向量的电刺激捕获阈值。在一个示例中，可以从测量数据确定第一和第二起搏向量之间的关系，并且可以使用关系的参数与第一起搏向量的电刺激捕获阈值的测量来估计第二起搏向量的电刺激捕获阈值起搏向量

4. 发明申请

US20100298900A1 CARDIAC PACEMAKER WITH TABLE-BASED PACING MODE IMPLEMENTATION 审中-公开
标题翻译：具有基于表的PACING模式实现的CARDIAC PACEMAKER
公开(公告)号：US20100298900A1
公开(公告)日：2010-11-25
申请号：US12848894
申请日：2010-08-02
申请人： David W. Yost , Doug M. Birkholz , James A. Esler
发明人： David W. Yost , Doug M. Birkholz , James A. Esler
IPC分类号： A61N1/362
CPC分类号： A61N1/362
摘要： A device and method for implementing a bradycardia pacing mode are disclosed which is mostly hardware-based but still allows the flexibility for making major changes in brady behavior normally found only in firmware-based implementations. The brady behavior of the device is encapsulated by a table in an area of RAM referred to as brady RAM, and the brady behavior can be changed by re-loading the brady RAM with a different table.
摘要翻译：公开了一种用于实现心动过缓起搏模式的装置和方法，其基本上是基于硬件的，但是仍然允许在通常仅在基于固件的实现中通常发现的轻度行为的主要变化的灵活性。设备的缓冲行为由RAM中称为brady RAM的RAM中的表封装，并且可以通过用不同的表重新加载brady RAM来改变brady行为。

5. 发明授权

US08457741B2 Estimation of dedicated bipolar pacing vector threshold 有权
公开(公告)号：US08457741B2
公开(公告)日：2013-06-04
申请号：US12906849
申请日：2010-10-18
申请人： Amy Jean Brisben , Aaron R. McCabe , Kevin John Stalsberg , Jacob I. Laughner , Clayton S. Foster , David W. Yost
发明人： Amy Jean Brisben , Aaron R. McCabe , Kevin John Stalsberg , Jacob I. Laughner , Clayton S. Foster , David W. Yost
IPC分类号： A61N1/368
CPC分类号： A61N1/371 , A61N1/3712 , A61N1/37282
摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.

6. 发明申请

US20100234912A1 FLEXIBLE NEURAL STIMULATION ENGINE 有权
标题翻译：柔性神经刺激引擎
公开(公告)号：US20100234912A1
公开(公告)日：2010-09-16
申请号：US12785954
申请日：2010-05-24
申请人： David J. Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
发明人： David J. Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
IPC分类号： A61N1/08 , A61N1/365
CPC分类号： A61N1/362
摘要： A method for implementing a neural stimulation therapy mode in an implantable medical device (IMD) comprising the acts of mapping respective device states, defined by one or more timer states that include at least one neural event timer or one or more indications of one or more sensed physiologic events, to associated device actions in a stored neural table, storing an event represented as a device status word and a time stamp in a queue in response to an action input, and comparing one or more current timer states or one or more indications of one or more sensed physiologic events to a device state contained in the neural table and, if found to match, causing performance of one or more associated device actions, wherein the device actions include one or more of a neural stimulation energy delivery or a change in one or more timer states.
摘要翻译：一种用于在可植入医疗装置（IMD）中实现神经刺激治疗模式的方法，包括映射由包括至少一个神经事件计时器或一个或多个指示的一个或多个定时器状态定义的各个装置状态的动作检测到的生理事件，到存储的神经表中的相关设备动作，响应于动作输入将表示为设备状态字的事件和时间戳存储在队列中，以及比较一个或多个当前定时器状态或一个或多个指示一个或多个感测到的生理事件到包含在神经表中的设备状态，并且如果发现匹配，导致一个或多个相关联的设备动作的性能，其中设备动作包括神经刺激能量递送或改变中的一个或多个在一个或多个定时器状态。

7. 发明授权

US07751884B2 Flexible neural stimulation engine 有权
标题翻译：灵活的神经刺激引擎
公开(公告)号：US07751884B2
公开(公告)日：2010-07-06
申请号：US11550912
申请日：2006-10-19
申请人： David Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
发明人： David Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
IPC分类号： A61N1/08
CPC分类号： A61N1/362
摘要： An implantable medical device comprising stimulation circuitry adapted to provide neural stimulation energy to a neural stimulation electrode, one or more timers, including at least one neural event timer, a device behavior memory including a neural table, and a comparison circuit. The neural table maps a particular device state defined at least in part by a neural event timer to one or more associated device actions that include at least one of a neural stimulation energy delivery, a change in state of at least one neural event timer, and both a neural stimulation energy delivery and a change in state of one or more timers. The comparison circuit is adapted to compare a current state of one or more timers to a device state in the neural table and, if found to match, causing performance of one or more associated device actions.
摘要翻译：一种可植入医疗装置，包括适于向神经刺激电极提供神经刺激能量的刺激电路，包括至少一个神经事件定时器的一个或多个定时器，包括神经表的装置行为存储器和比较电路。所述神经表将至少部分由神经事件计时器定义的特定装置状态映射到一个或多个相关联的装置动作，其包括神经刺激能量递送，至少一个神经事件定时器的状态改变和神经刺激能量传递和一个或多个定时器的状态变化。比较电路适于将一个或多个定时器的当前状态与神经表中的设备状态进行比较，并且如果发现匹配，则导致执行一个或多个相关联的设备动作。

8. 发明授权

US08521285B2 Estimation of dedicated bipolar pacing vector threshold 有权
标题翻译：专用双极起搏矢量阈值的估计
公开(公告)号：US08521285B2
公开(公告)日：2013-08-27
申请号：US12906855
申请日：2010-10-18
申请人： Amy Jean Brisben , Aaron R. McCabe , Clayton S. Foster , David W. Yost , Kevin John Stalsberg , Jacob I. Laughner
发明人： Amy Jean Brisben , Aaron R. McCabe , Clayton S. Foster , David W. Yost , Kevin John Stalsberg , Jacob I. Laughner
IPC分类号： A61N1/36
CPC分类号： A61N1/3712 , A61N1/3627
摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.
摘要翻译：描述了允许估计电刺激捕获阈值（例如专用双极起搏矢量阈值）的方法和装置。在一个示例中，可以使用第一和第二起搏向量之间的等能量假设从第一起搏向量的测量的电刺激捕获阈值和第一和第二起搏向量的阻抗来估计第二起搏向量的电刺激捕获阈值。在一个示例中，可以从测量数据确定第一和第二起搏向量之间的关系，并且可以使用关系的参数与第一起搏向量的电刺激捕获阈值的测量来估计第二起搏向量的电刺激捕获阈值起搏向量

9. 发明申请

US20120303082A1 Adjusting Cardiac Pacing Response Sensing Intervals 审中-公开
标题翻译：调整心脏起搏反应感测间隔
公开(公告)号：US20120303082A1
公开(公告)日：2012-11-29
申请号：US13306611
申请日：2011-11-29
申请人： Yanting Dong , Shibaji Shome , Aaron McCabe , Amy J. Brisben , Clayton Foster , David W. Yost , Kenneth N. Hayes
发明人： Yanting Dong , Shibaji Shome , Aaron McCabe , Amy J. Brisben , Clayton Foster , David W. Yost , Kenneth N. Hayes
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/371 , A61B5/0422 , A61B5/04525 , A61B5/0456 , A61B5/4836 , A61B5/7217 , A61B5/7267 , A61N1/3712
摘要： Discrimination between different types of possible cardiac pacing responses may depend on the timing of expected features that are sensed within a temporal framework. The temporal framework may include classification intervals, blanking periods and appropriately timed back up paces. The classification intervals and blanking periods of the temporal framework are intervals of time that have time parameters that include start time, end time, and length. The relationships and timing parameters of the elements of the temporal framework, e.g., blanking periods, classification intervals, delay periods, and backup pacing, should support detection of features used to discriminate between different types of pacing responses. As the system learns the morphology of the particular patient by analyzing the waveform of the pacing response signal, the temporal framework for pacing response determination may be adjusted to accommodate the individual patient.
摘要翻译：不同类型的可能心脏起搏反应之间的歧视可能取决于在时间框架内感测到的预期特征的时间。时间框架可以包括分类间隔，消隐期和适当定时的后台步数。时间框架的分类间隔和消隐期是具有包括开始时间，结束时间和长度的时间参数的时间间隔。时间框架的元素的关系和定时参数，例如消隐期，分类间隔，延迟周期和备份起搏应该支持用于区分不同类型的起搏响应的特征的检测。当系统通过分析起搏响应信号的波形来学习特定患者的形态时，可调整起搏响应确定的时间框架以适应个体患者。

10. 发明申请

US20110098774A1 ESTIMATION OF DEDICATED BIPOLAR PACING VECTOR THRESHOLD 有权
公开(公告)号：US20110098774A1
公开(公告)日：2011-04-28
申请号：US12906855
申请日：2010-10-18
申请人： Amy Jean Brisben , Aaron R. McCabe , Clayton S. Foster , David W. Yost , Kevin John Stalsberg , Jacob I. Laughner
发明人： Amy Jean Brisben , Aaron R. McCabe , Clayton S. Foster , David W. Yost , Kevin John Stalsberg , Jacob I. Laughner
IPC分类号： A61N1/08
CPC分类号： A61N1/3712 , A61N1/3627
摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.

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