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1. 发明授权

US06427085B1 Cardiac sense amplifier for capture verification 有权
标题翻译：心脏放大器用于捕获验证
公开(公告)号：US06427085B1
公开(公告)日：2002-07-30
申请号：US09309951
申请日：1999-05-11
申请人： Scot C. Boon , Mark Gryzwa , Michael Lyden , Qingsheng Zhu , Paul Haefner
发明人： Scot C. Boon , Mark Gryzwa , Michael Lyden , Qingsheng Zhu , Paul Haefner
IPC分类号： A61N137
CPC分类号： A61N1/3712
摘要： A cardiac rhythm management device having a capture verification sensing circuit for use in either a normal beat to beat pacing mode or an autothreshold mode. The cardiac rhythm management device is coupled to one or more pacing leads having pacing/sensing electrodes coupled thereto, and includes a sensing circuit for sensing electrical activity of the patient's heart, wherein the sensing circuit includes a dedicated evoked response sense amplifier and at least one high pass coupling capacitor electrically connected as a portion of a high pass network and between a pacing/sensing electrode and a blanking switch. A plurality of high pass coupling capacitors are coupled in parallel each having a separate blanking switch, thereby creating a differential network to offset imbalance sensed from the electrode due to extraneous factors.
摘要翻译：一种具有捕获验证感测电路的心律管理装置，其用于正常搏动以节拍起搏模式或自阈值模式。心律管理装置耦合到具有与之相连的起搏/感测电极的一个或多个起搏引线，并且包括用于感测患者心脏的电活动的感测电路，其中感测电路包括专用的诱发响应读出放大器和至少一个高通耦合电容器作为高通网络的一部分并且在起搏/感测电极和消隐开关之间电连接。多个高通耦合电容器并联耦合，每个具有单独的消隐开关，由此产生差分网络以抵消由于外部因素而从电极感测的不平衡。

2. 发明授权

US06226551B1 Wide-band evoked response sensing for capture verification 有权
标题翻译：用于捕获验证的宽带诱发响应感测
公开(公告)号：US06226551B1
公开(公告)日：2001-05-01
申请号：US09309981
申请日：1999-05-11
申请人： Qingsheng Zhu , Michael Lyden , Scot C. Boon
发明人： Qingsheng Zhu , Michael Lyden , Scot C. Boon
IPC分类号： A61N137
CPC分类号： A61N1/3712
摘要： A cardiac rhythm management device having a capture verification sensing circuit for use in either a normal beat to beat pacing mode or an autothreshold mode. The cardiac rhythm management device is coupled to one or more pacing leads having pacing/sensing electrodes coupled thereto, and includes a sensing circuit for sensing electrical activity of the patient's heart. The sensing circuit includes a sense amplifier electrically connected in a manner, wherein a polarity of an amplitude of the sensed signal corresponding to an evoked response is opposite a polarity of an amplitude of the sensed signal corresponding to afterpotential. The sensing circuit further includes a band pass filter having a single high pass pole.
摘要翻译：一种具有捕获验证感测电路的心律管理装置，其用于正常搏动以节拍起搏模式或自阈值模式。心律管理装置耦合到具有与之相连的起搏/感测电极的一个或多个起搏引线，并且包括用于感测患者心脏的电活动的感测电路。感测电路包括以这种方式电连接的感测放大器，其中与诱发响应相对应的感测信号的振幅的极性与对应于后电位的感测信号的幅度的极性相反。感测电路还包括具有单个高通极的带通滤波器。

3. 发明授权

US5941903A Pacemaker for detection of evoked response 失效
标题翻译：起搏器检测诱发反应
公开(公告)号：US5941903A
公开(公告)日：1999-08-24
申请号：US70158
申请日：1998-04-30
申请人： Qingsheng Zhu , Michael Lyden , Scot Boon , Mark Gryzwa
发明人： Qingsheng Zhu , Michael Lyden , Scot Boon , Mark Gryzwa
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3716
摘要： A method and apparatus for attenuating polarization voltages or "afterpotentials" which develop at the heart tissue/electrode interface following the delivery of a pacing stimulus to the heart tissue such that the evoked response of the heart may be accurately detected to determine whether each pacing stimulus resulted in heart capture or contraction, thereby facilitating improved tracking of the capture threshold for minimizing power consumption while assuring therapeutic efficacy. The conventional large capacitance coupling capacitor used to suppress DC components of the pacing pulse is reduced to effectively lower the equivalent capacitance of the pacing and coupling capacitors following delivery of the pacing pulse, allowing shorter recharge and blanking intervals. As a result, the evoked response is more easily detected.
摘要翻译：一种在将起搏刺激递送到心脏组织之后，衰减极化电压或“后电位”的方法和装置，其在心脏组织/电极界面处发展，从而可以精确地检测心脏的诱发反应以确定每个起搏刺激导致心脏捕获或收缩，从而有助于改善捕获阈值的跟踪以最小化功率消耗，同时确保治疗功效。用于抑制起搏脉冲的DC分量的常规大电容耦合电容器被减少以有效地降低起搏脉冲递送后的起搏和耦合电容器的等效电容，从而允许较短的再充电和消隐间隔。结果，更容易检测到诱发反应。

4. 发明申请

US20050137640A1 Adaptive safety pacing 有权
标题翻译：适应性安全起搏
公开(公告)号：US20050137640A1
公开(公告)日：2005-06-23
申请号：US10952345
申请日：2004-09-28
申请人： Scott Freeberg , Michael Lyden , Qingsheng Zhu
发明人： Scott Freeberg , Michael Lyden , Qingsheng Zhu
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3712
摘要： Methods and systems involve adjusting an energy used for safety pacing based on the capture threshold. The safety pacing energy may be adjusted prior to a capture threshold test. During the capture threshold test, backup safety paces are delivered using the adjusted pacing energy. Following suspension of automatic capture verification, the device may enter a suspension mode. During the suspension mode, safety pacing pulses are delivered using a pacing energy adjusted based on capture threshold.
摘要翻译：方法和系统包括根据捕获阈值调整用于安全起搏的能量。可以在捕获阈值测试之前调整安全起搏能量。在捕获阈值测试期间，使用调整的起搏能量传送备用安全步伐。在停止自动捕获验证之后，设备可能进入暂停模式。在悬架模式下，使用基于捕获阈值调整的起搏能量来传送安全起搏脉冲。

5. 发明授权

US06505071B1 Cardiac management device with capability of noise detection in automatic capture verification 有权
标题翻译：具有自动捕获验证中噪声检测能力的心脏管理装置
公开(公告)号：US06505071B1
公开(公告)日：2003-01-07
申请号：US09461976
申请日：1999-12-15
申请人： Qingsheng Zhu , Michael Lyden , Scott Freeberg , Laura Mepham
发明人： Qingsheng Zhu , Michael Lyden , Scott Freeberg , Laura Mepham
IPC分类号： A61N118
CPC分类号： A61N1/3704 , A61N1/3712
摘要： An implantable cardiac rhythm management device operable in an autothreshold or autocapture verification mode, wherein the rhythm management device is capable of detecting noise that affects signal characteristics of a sensed intracardial evoked response electrogram signal. The device includes a noise detection circuit that determines whether a minimum peak timing occurs during a predetermined time following delivery of a stimulation pulse. If a minimum peak timing occurs during the predetermined time following delivery of the stimulation pulse, then significant amounts of noise affecting the signal characteristics of the electrocardiogram signal is assumed.
摘要翻译：一种可在自动阈值或自动捕获验证模式中操作的可植入心律管理装置，其中所述节律管理装置能够检测影响感测到的心内诱发反应电描记信号的信号特性的噪声。该装置包括噪声检测电路，其确定在递送刺激脉冲之后的预定时间期间是否发生最小峰值定时。如果在递送刺激脉冲之后的预定时间期间发生最小峰值定时，则假定影响心电图信号的信号特性的大量噪声。

6. 发明申请

US20070265672A1 METHOD FOR MONITORING END OF LIFE FOR BATTERY 有权
标题翻译：电池寿命监测方法
公开(公告)号：US20070265672A1
公开(公告)日：2007-11-15
申请号：US11779779
申请日：2007-07-18
申请人： Michael Lyden
发明人： Michael Lyden
IPC分类号： A61N1/00
CPC分类号： A61N1/378 , A61N1/3708 , G01R31/3651 , G01R31/3693 , H02J2007/005
摘要： A system is described. The system includes a lithium battery, a charge storage capacitor electrically connected to the lithium battery, a first device, and at least one second device. The first device is electrically connected to the lithium battery and is powered by the lithium battery. The at least one second device is attached to the charge storage capacitor and adapted to read a rate of charge storage in the charge storage capacitor or to calculate the rate of charge storage by measuring both a time of charging and a charge stored or added to the charge storage capacitor during the time of charging.
摘要翻译：描述系统。该系统包括锂电池，电连接到锂电池的电荷存储电容器，第一装置和至少一个第二装置。第一器件电连接到锂电池并由锂电池供电。所述至少一个第二装置附接到所述电荷存储电容器，并且适于读取所述电荷存储电容器中的电荷存储速率，或通过测量充电时间和存储或添加到所述电荷存储电容器中的电荷来计算电荷存储速率充电时电池存储电容器。

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