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1. 发明授权

US06834206B1 Method for the electrical stimulation of human tissue to encourage hair growth 失效
标题翻译：电刺激人体组织促进头发生长的方法
公开(公告)号：US06834206B1
公开(公告)日：2004-12-21
申请号：US10744187
申请日：2003-12-23
申请人： Sylvester A. Pitzen , Elizabeth Pitzen
发明人： Sylvester A. Pitzen , Elizabeth Pitzen
IPC分类号： A61N118
CPC分类号： A61N1/32
摘要： A method for applying a therapeutic signal (24) to a body portion (34) of a subject (20) to encourage hair growth utilizes an apparatus (22) that includes a first electrode (28) and a second electrode (32). The first electrode (28) is secured in contact with the skin surface of the subject (20) remote from the body portion (34), and the second electrode (32) is positioned at the body portion (34). The therapeutic signal (24) is provided at a conductive pod (114) of the second electrode (32). The second electrode (32) is manipulated by an operator to apply a circular motion (134) to the body portion (34) underlying the conductive pod (114). The circular motion (134) is repetitively applied as the conductive pod (114) is moved across the body portion (34) to loosen connective tissue at the body portion (34).
摘要翻译：将治疗信号（24）施加到受试者（20）的身体部分（34）以促进毛发生长的方法利用包括第一电极（28）和第二电极（32）的装置（22）。第一电极（28）固定成与远离主体部分（34）的被摄体（20）的皮肤表面接触，第二电极（32）位于主体部分（34）处。治疗信号（24）设置在第二电极（32）的导电容器（114）处。第二电极（32）由操作者操纵以向导电容器（114）下方的主体部分（34）施加圆周运动（134）。当导电荚（114）移动穿过主体部分（34）以松开身体部分（34）处的结缔组织时，循环运动（134）被重复施加。

2. 发明授权

US06813519B2 Ambulatory medical apparatus and method using a robust communication protocol 有权
公开(公告)号：US06813519B2
公开(公告)日：2004-11-02
申请号：US09768043
申请日：2001-01-22
申请人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Robert C. Dennard , John T. Armstrong , John D. Richert
发明人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Robert C. Dennard , John T. Armstrong , John D. Richert
IPC分类号： A61N118
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implanted medical device (e.g. infusion pump) and external device communicate with one another via telemetry wherein messages are transmitted under a robust communication protocol. The communication protocol gives enhanced assurance concerning the integrity of messages that impact medical operations of the implantable device. Messages are transmitted using a multipart format that includes a preamble, a frame sync, a telemetry ID, data, and a validation code. The data portion of the message includes an op-code that dictates various other elements that form part of the message. The data portion may also include additional elements such as sequence numbers, bolus numbers, and duplicate data elements. A telemetry ID for the transmitting device may be implicitly embedded in the message as part of the validation code that is sent with the message and that must be pre-known by the receiver to confirm the integrity of the received message.

3. 发明授权

US06760625B1 Battery monitoring system for an implantable medical device 有权
标题翻译：可植入医疗器械的电池监控系统
公开(公告)号：US06760625B1
公开(公告)日：2004-07-06
申请号：US09996310
申请日：2001-11-21
申请人： Mark W. Kroll
发明人： Mark W. Kroll
IPC分类号： A61N118
CPC分类号： A61N1/3708 , A61N1/08 , G01R31/3648
摘要： An implantable cardiac device, such as a pacemaker, provided with a carbon monofluoride (CFx) battery. The CFx battery enables replacement of the typical voltage tripler with a voltage doubler and eliminates the need for a bulky decoupling capacitor. The device includes a precision A/D and voltage monitor to enable more accurate prediction of impending battery end-of-life. Several methods of accurately determining a pending end-of-life of a battery with a flat voltage output throughout discharge, such as a CFx battery, are provided.
摘要翻译：一种植入式心脏装置，例如起搏器，其设置有一氟化碳（CFx）电池。 CFx电池可以使用倍压器替换典型的三电平电压，并且不需要大体积的去耦电容器。该器件包括一个精密的A / D和电压监视器，可以更准确地预测即将到来的电池的使用寿命。提供了几种准确地确定在整个放电期间具有平坦电压输出的电池的待命结束寿命的方法，例如CFx电池。

4. 发明授权

US06760622B2 Implantable multi-chamber cardiac stimulation device with sensing vectors 有权
标题翻译：植入式多室心脏刺激装置与传感向量
公开(公告)号：US06760622B2
公开(公告)日：2004-07-06
申请号：US09897300
申请日：2001-07-03
申请人： John R. Helland , Eric Falkenberg
发明人： John R. Helland , Eric Falkenberg
IPC分类号： A61N118
CPC分类号： A61N1/368 , A61N1/3684
摘要： An implantable multi-chamber cardiac stimulation device and method are provided for accurately sensing cardiac activity from three or four heart chambers using passive sensing electrodes placed in each heart chamber. Multiple intra-chamber or inter-chamber sensing vectors are established between passive sensing electrodes. Sampled sensing vector signals are processed such that a cardiac depolarization may be accurately detected, as well as its origin and direction of propagation. Time intervals between detected depolarization signals may be used to determine conduction time or heart rate. Diagnostic indicators of heart failure condition normally obtained from a 12-lead surface ECG study, such as P-wave or R-wave duration, may also be determined from the sensing vectors. Based on precise and detailed evaluation of sensing vector signals, stimulation therapy may be provided immediately upon a detected change in heart rhythm or heart failure condition.
摘要翻译：提供可植入的多室心脏刺激装置和方法，用于使用放置在每个心室中的无源感测电极来精确地感测来自三个或四个心室的心脏活动。在无源感测电极之间建立多个室内或室间感应向量。对采样的感测向量信号进行处理，使得可以精确地检测心脏去极化，以及其起始点和传播方向。可以使用检测到的去极化信号之间的时间间隔来确定传导时间或心率。通常从12导联表面ECG研究获得的心力衰竭病例的诊断指标，例如P波或R波持续时间，也可以从感测向量确定。基于感测矢量信号的精确和详细的评估，可以在检测到的心律或心力衰竭状况的变化时立即提供刺激治疗。

5. 发明授权

US06721598B1 Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system 失效
标题翻译：冠状窦心脏引导用于左右心脏和系统的刺激和感测
公开(公告)号：US06721598B1
公开(公告)日：2004-04-13
申请号：US09945415
申请日：2001-08-31
申请人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
发明人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N118
CPC分类号： A61N1/056 , A61N1/0563 , A61N2001/0585
摘要： An implantable cardiac stimulation system and lead is capable of sensing electrical activity of the right and left heart and delivering stimulation pulses to the right and left heart. The system includes a single cardiac lead including a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, a left atrial defibrillation electrode, and a right atrial pacing electrode. The system further includes a cardiac stimulation device including a pulse generator for delivering pacing pulses to any combination of the pacing electrodes, delivering defibrillation pulses to any combination of the defibrillation electrodes, and sensing electrical activity with any combination of the pacing electrodes. The lead is implantable in the coronary sinus of the heart and may further include a right atrial defibrillation coil electrode.
摘要翻译：植入式心脏刺激系统和引线能够感测右心和左心的电活动，并将刺激脉冲输送到右心和左心。该系统包括单心心脏导联，其包括左心室起搏电极，左心室除颤电极，左心房起搏电极，左心房除颤电极和右心房起搏电极。该系统还包括心脏刺激装置，其包括用于将起搏脉冲发送到起搏电极的任何组合的脉冲发生器，将除颤脉冲输送到除颤电极的任何组合，以及用起搏电极的任何组合感测电活动。铅可植入心脏的冠状窦，并可进一步包括右心房除颤线圈电极。

6. 发明授权

US06684107B1 Wrinkle-reducing system 失效
标题翻译：防皱系统
公开(公告)号：US06684107B1
公开(公告)日：2004-01-27
申请号：US09920550
申请日：2001-08-01
申请人： Gary Binder
发明人： Gary Binder
IPC分类号： A61N118
CPC分类号： A61N1/32
摘要： A system for reducing wrinkles on human skin utilizes an electrode to conduct a microcurrent through the surface of the wrinkle into the underlying dermal layer. The electrode is moved in multiple passes along the length of the wrinkle with the electrode in contact with the surface of the wrinkle while generating a periodically repeating microcurrent having a peak amplitude in the range of 10-40 microamps, a peak current density in the range of 10-50 microamps/cm2, and a frequency in the range of 5-15 Hz. The electrode device is self-contained in a battery-containing, cordless case from which a contact electrode protrudes. A hand-engaging second electrode on the surface of the case completes a conductive path through the user's body.
摘要翻译：用于减少人体皮肤皱纹的系统利用电极将皱纹表面的微电流传导到下面的真皮层中。电极沿着皱纹的长度在多个通道中移动，电极与皱纹的表面接触，同时产生具有在10-40微安范围内的峰值振幅的周期性重复的微电流，峰值电流密度在该范围内为10-50微安/厘米2，频率范围为5-15赫兹。电极装置独立于包含接触电极的电池的无绳外壳中。壳体表面上的手工接合的第二电极完成穿过使用者身体的导电路径。

7. 发明授权

US06681136B2 Device and method to modulate blood pressure by electrical waveforms 失效
标题翻译：用电波形调节血压的装置和方法
公开(公告)号：US06681136B2
公开(公告)日：2004-01-20
申请号：US10006471
申请日：2001-12-04
申请人： Eleanor L. Schuler , Claude K. Lee
发明人： Eleanor L. Schuler , Claude K. Lee
IPC分类号： A61N118
CPC分类号： A61N1/40 , A61N1/32 , A61N1/36114 , A61N1/36117
摘要： A method and device for modulating blood pressure. The method comprises selecting waveforms from a storage area that are representative of body organ function. The selected waveforms are then transmitted to a treatment member, which is in direct contact with the body, and which then broadcasts the waveforms to a target zone to modulate blood pressure. A control module is provided for transmission to the treatment member. The control module contains the waveforms which are selected and transmitted to the treatment member, and computer storage can be provided for greater storage capacity and manipulation of the waveforms.
摘要翻译：用于调节血压的方法和装置。该方法包括从代表身体器官功能的存储区域中选择波形。然后将所选择的波形传送到与身体直接接触的处理部件，然后将波形广播到目标区域以调节血压。提供控制模块用于传送到处理构件。控制模块包含被选择并传送到处理构件的波形，并且可以提供计算机存储器以获得更大的存储容量和波形的操纵。

8. 发明授权

US06681135B1 System and method for employing temperature measurements to control the operation of an implantable medical device 有权
标题翻译：用于采用温度测量来控制可植入医疗装置的操作的系统和方法
公开(公告)号：US06681135B1
公开(公告)日：2004-01-20
申请号：US09725329
申请日：2000-11-22
申请人： Timothy J. Davis , James D. Reinke , David W. Graden , John D. Wahlstrand
发明人： Timothy J. Davis , James D. Reinke , David W. Graden , John D. Wahlstrand
IPC分类号： A61N118
CPC分类号： A61N1/08 , A61N1/3655
摘要： A medical implantable device that includes a temperature sensor circuit and a control circuit coupled to the temperature sensor circuit to control non-therapy operation of the medical implantable device in response to temperature measurements obtained by the temperature sensor circuit.
摘要翻译：一种医疗可植入装置，其包括温度传感器电路和耦合到所述温度传感器电路的控制电路，以响应于所述温度传感器电路获得的温度测量来控制所述医学可植入装置的非治疗操作。

9. 发明授权

US06658297B2 Method and apparatus for control of bowel function 有权
公开(公告)号：US06658297B2
公开(公告)日：2003-12-02
申请号：US09949424
申请日：2001-09-07
申请人： Gerald E. Loeb
发明人： Gerald E. Loeb
IPC分类号： A61N118
CPC分类号： A61N1/36007 , A61N1/37205 , A61N1/3756
摘要： Spinal cord injury and other injuries and diseases of the nervous system often result in the inability to sense the need to empty the rectum or to control the timing of bowel movements. This invention includes microminiature electronic devices implanted on or around the large bowel to sense the volume and nature of rectal contents and to stimulate peristaltic contractions to empty the large bowel when it is convenient for the patient to do so.

10. 发明授权

US06658292B2 Detection of patient's position and activity status using 3D accelerometer-based position sensor 有权
公开(公告)号：US06658292B2
公开(公告)日：2003-12-02
申请号：US09939051
申请日：2001-08-24
申请人： Mark W. Kroll , Chris Sorensen , Gene A. Bornzin
发明人： Mark W. Kroll , Chris Sorensen , Gene A. Bornzin
IPC分类号： A61N118
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36542
摘要： An implantable cardiac stimulation device is equipped with an accelerometer-based sensor to sense a patient's movement and produce a vertical acceleration component indicative of a patient's acceleration in a vertical direction. A vertical velocity component is computed from the vertical acceleration component. The device further includes a minute ventilation sensor to sense minute ventilation of the patient. Coupled to the various sensors is a processor that is programmed to determine a patient's position and activity status, such as whether the patient is ascending/descending stairs or is sitting up from a lying position, based on the vertical velocity and minute ventilation data. The patient's status dictates whether to administer cardiac pacing therapy to the patient and the kind of therapy to be applied.

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