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1. 发明申请

US20120071942A1 Subcutaneous Cardiac Sensing and Stimulation System 有权
标题翻译：皮下心脏感觉和刺激系统
公开(公告)号：US20120071942A1
公开(公告)日：2012-03-22
申请号：US13237221
申请日：2011-09-20
申请人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
IPC分类号： A61N1/365
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸腔内放置并且设置在壳体中或壳体上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

2. 发明授权

US08116868B2 Implantable device with cardiac event audio playback 失效
标题翻译：具有心脏事件音频播放的植入式设备
公开(公告)号：US08116868B2
公开(公告)日：2012-02-14
申请号：US10801139
申请日：2004-03-15
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61N1/365
CPC分类号： A61B5/0031 , A61B5/0006 , A61B5/02 , A61B5/11 , A61B7/023 , A61N1/05 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36578 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： Cardiac monitoring and stimulation methods and systems provide audio playback of cardiac events and transthoracic monitoring and therapy. A medical system includes a housing and electrodes configured for sensing cardiac electrical activity. Another sensor may be configured to sense heart movement and produce a signal in response, such as an audio signal. Memory stores the audio signal and the cardiac electrical signal. A controller and communications circuitry telemeter the cardiac electrical signal and the audio signal to a patient-external device. Energy delivery circuitry may deliver cardiac therapy. The device may further include a patient actuatable trigger configured to communicate to the controller via the communications circuitry. The controller may initiate storing of the cardiac electrical signal and the audio signal in response to the trigger. The patient-external device may further include a storage media.
摘要翻译：心脏监测和刺激方法和系统提供心脏事件和经胸监测和治疗的音频回放。医疗系统包括壳体和配置用于感测心脏电活动的电极。另一个传感器可以被配置为感测心脏运动并产生响应的信号，例如音频信号。存储器存储音频信号和心脏电信号。控制器和通信电路将心电信号和音频信号远程测量到病人 - 外部设备。能量输送电路可以提供心脏治疗。该设备还可以包括被配置为经由通信电路与控制器通信的患者致动触发器。响应于触发器，控制器可以开始存储心脏电信号和音频信号。患者外部设备还可以包括存储介质。

3. 发明申请

US20110098587A1 Subcutaneous Cardiac Signal Discrimination Employing Non-Electrophysiologic Signal 审中-公开
标题翻译：使用非电生理信号的皮下心脏信号鉴别
公开(公告)号：US20110098587A1
公开(公告)日：2011-04-28
申请号：US12983565
申请日：2011-01-03
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61B5/02
CPC分类号： A61B5/0464 , A61B5/0428 , A61B5/7203 , A61N1/36585 , A61N1/3956
摘要： A cardiac monitoring and/or stimulation system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals, and identifies the separated signal as a cardiac signal using information derived from a non-electrophysiologic sensor, such as an accelerometer or acoustic transducer. The signal processor may iteratively correlate separated signals from the plurality of composite signals with a non-electrophysiologic sensor signal until the cardiac signal is identified.
摘要翻译：心脏监测和/或刺激系统包括耦合到配置用于皮下非胸内感测的多个电极的壳体。信号处理器接收与多个源相关联的多个复合信号，从多个复合信号中分离信号，并使用从非电生理传感器（例如加速度计或者加速度计）得到的信息将分离的信号识别为心脏信号声换能器。信号处理器可以将来自多个复合信号的分离的信号与非电生理传感器信号迭代地相关，直到识别出心脏信号。

4. 发明授权

US07302294B2 Subcutaneous cardiac sensing and stimulation system employing blood sensor 失效
标题翻译：使用血液传感器的皮下心脏感知和刺激系统
公开(公告)号：US07302294B2
公开(公告)日：2007-11-27
申请号：US10817749
申请日：2004-04-02
申请人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
IPC分类号： A61N1/365
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸内放置并且设置在壳体中或外壳上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

5. 发明授权

US07218966B2 Multi-parameter arrhythmia discrimination 有权
标题翻译：多参数心律失常辨别
公开(公告)号：US07218966B2
公开(公告)日：2007-05-15
申请号：US10804471
申请日：2004-03-19
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61N1/365
CPC分类号： A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： An arrhythmia discrimination device and method involves receiving electrocardiogram signals and non-electrophysiologic signals at subcutaneous locations. Both the electrocardiogram-signals and non-electrophysiologic signals are used to discriminate between normal sinus rhythm and an arrhythmia. An arrhythmia may be detected using electrocardiogram signals, and verified using the non-electrophysiologic signals. A detection window may be initiated in response to receiving the electrocardiogram signal, and used to determine whether the non-electrophysiologic signal is received at a time falling within the detection window. Heart rates may be computed based on both the electrocardiogram signals and non-electrophysiologic signals. The rates may be used to discriminate between normal sinus rhythm and arrhythmia, and used to determining absence of an arrhythmia.
摘要翻译：心律失常鉴别装置和方法涉及在皮下位置接收心电图信号和非电生理信号。心电图信号和非电生理信号都用于区分正常窦性心律和心律失常。可以使用心电图信号检测心律不齐，并使用非电生理信号进行验证。可以响应于接收到心电图信号而启动检测窗口，并且用于确定在落在检测窗口内的时间是否接收到非电生理信号。可以基于心电图信号和非电生理信号计算心率。这些比率可用于区分正常窦性心律和心律不齐，并用于确定不存在心律失常。

6. 发明申请

US20060224188A1 Method and apparatus for synchronizing neural stimulation to cardiac cycles 有权
公开(公告)号：US20060224188A1
公开(公告)日：2006-10-05
申请号：US11099141
申请日：2005-04-05
申请人： Imad Libbus , Paul Haefner , Aaron McCabe , Yi Zhang
发明人： Imad Libbus , Paul Haefner , Aaron McCabe , Yi Zhang
IPC分类号： A61N1/32
CPC分类号： A61N1/36135 , A61N1/36114 , A61N1/365 , A61N1/36542 , A61N1/36564 , A61N1/36571
摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

7. 发明申请

US20050119708A1 Subcutaneous cardiac signal discrimination employing non-electrophysiologic signal 有权
标题翻译：使用非电生理信号的皮下心脏信号鉴别
公开(公告)号：US20050119708A1
公开(公告)日：2005-06-02
申请号：US10784478
申请日：2004-02-23
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61B5/0428 , A61B5/0464 , A61N1/05 , A61N1/365 , A61N1/39
CPC分类号： A61B5/0464 , A61B5/0428 , A61B5/7203 , A61N1/36585 , A61N1/3956
摘要： A cardiac monitoring and/or stimulation system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals, and identifies the separated signal as a cardiac signal using information derived from a non-electrophysiologic sensor, such as an accelerometer or acoustic transducer. The signal processor may iteratively correlate separated signals from the plurality of composite signals with a non-electrophysiologic sensor signal until the cardiac signal is identified.
摘要翻译：心脏监测和/或刺激系统包括耦合到配置用于皮下非胸内感测的多个电极的壳体。信号处理器接收与多个源相关联的多个复合信号，从多个复合信号中分离信号，并使用从非电生理传感器（例如加速度计或者加速度计）得到的信息将分离的信号识别为心脏信号声换能器。信号处理器可以将来自多个复合信号的分离的信号与非电生理传感器信号迭代地相关，直到识别出心脏信号。

8. 发明授权

US07865233B2 Subcutaneous cardiac signal discrimination employing non-electrophysiologic signal 有权
标题翻译：使用非电生理信号的皮下心脏信号鉴别
公开(公告)号：US07865233B2
公开(公告)日：2011-01-04
申请号：US10784478
申请日：2004-02-23
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61B5/0452
CPC分类号： A61B5/0464 , A61B5/0428 , A61B5/7203 , A61N1/36585 , A61N1/3956
摘要： A cardiac monitoring and/or stimulation system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals, and identifies the separated signal as a cardiac signal using information derived from a non-electrophysiologic sensor, such as an accelerometer or acoustic transducer. The signal processor may iteratively correlate separated signals from the plurality of composite signals with a non-electrophysiologic sensor signal until the cardiac signal is identified.
摘要翻译：心脏监测和/或刺激系统包括耦合到配置用于皮下非胸内感测的多个电极的壳体。信号处理器接收与多个源相关联的多个复合信号，从多个复合信号中分离信号，并使用从非电生理传感器（例如加速度计或者加速度计）得到的信息将分离的信号识别为心脏信号声换能器。信号处理器可以将来自多个复合信号的分离的信号与非电生理传感器信号迭代地相关，直到识别出心脏信号。

9. 发明申请

US20090118626A1 Calculating Respiration Parameters Using Impedance Plethysmography 审中-公开
标题翻译：使用阻抗体积描记法计算呼吸参数
公开(公告)号：US20090118626A1
公开(公告)日：2009-05-07
申请号：US11933872
申请日：2007-11-01
申请人： Loell Boyce Moon , Paul Haefner , Andres Belalcazar
发明人： Loell Boyce Moon , Paul Haefner , Andres Belalcazar
IPC分类号： A61B5/0205
CPC分类号： A61B5/0535 , A61B5/0809
摘要： A method of determining a value for a respiration parameter in a test subject can include capturing—using a fully implanted system that includes a wireless transmitter and at least a first lead wire having a first electrode disposed thereon and a second lead wire having a second electrode disposed thereon—information indicative of an impedance measure between the first and second electrodes and across a thoracic region of the test subject; wirelessly transmitting, from the implanted system and to external equipment, the captured information; and determining a respiration parameter of the test subject based on the captured information. The at least first and second lead wires can be positioned in the test subject subcutaneously and external of any cranial, thoracic, abdominal and pelvic cavities of the test subject
摘要翻译：确定测试对象中的呼吸参数的值的方法可以包括捕获 - 使用完全植入的系统，其包括无线发射器和至少第一引线，其具有设置在其上的第一电极和具有第二电极的第二引线布置在其上的信息 - 指示所述第一和第二电极之间以及穿过所述测试对象的胸部区域的阻抗测量值的信息; 从植入系统和外部设备无线传输所捕获的信息; 以及基于所捕获的信息确定所述测试对象的呼吸参数。至少第一和第二引线可以被测试对象的皮下和外部位于测试对象的任何颅脑，胸部，腹部和盆腔内

10. 发明申请

US20070123923A1 Implantable medical device minimizing rotation and dislocation 审中-公开
标题翻译：植入式医疗器械减少旋转和脱位
公开(公告)号：US20070123923A1
公开(公告)日：2007-05-31
申请号：US11290355
申请日：2005-11-30
申请人： Curtis Lindstrom , Ronald Heil , Jason Shiroff , Paul Haefner , Adam Cates , Darrell Wagner
发明人： Curtis Lindstrom , Ronald Heil , Jason Shiroff , Paul Haefner , Adam Cates , Darrell Wagner
IPC分类号： A61N1/375 , A61F2/04
CPC分类号： A61F2/0095 , A61N1/375
摘要： Housings for implantable medical devices are configured so as to engage with surrounding tissues inside of a body and resist both rotation in place and movement through the body. Device housings include shapes, surface features, and/or standard surfaces and may include attached implements that engage the surrounding tissue. Shapes include elongated members, flared ends, and so forth. Surface features include pores, grooves, through-holes, and so forth. Attached implements include needles, barbs, tension springs, and so forth. Also provided are methods for engaging an implantable medical device with surrounding tissues.
摘要翻译：用于可植入医疗装置的壳体构造成与身体内的周围组织接合并抵抗适当位置的旋转和穿过身体的运动。设备外壳包括形状，表面特征和/或标准表面，并且可以包括接合周围组织的附接工具。形状包括细长构件，扩口端等。表面特征包括孔，槽，通孔等。附件包括针，倒钩，拉伸弹簧等。还提供了用于使可植入医疗装置与周围组织接合的方法。

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