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1. 发明申请

US20100168430A1 MULTIKINASE INHIBITOR 有权
标题翻译：多金属酶抑制剂
公开(公告)号：US20100168430A1
公开(公告)日：2010-07-01
申请号：US11997967
申请日：2006-08-04
申请人： Sawako Ozawa , Nobuhiro Oikawa , Eisaku Mizuguchi , Hirosato Ebiike , Fumio Watanabe , Kenji Morikami , Nobuo Shimma , Nobuya Ishii , Toshiyuki Tsukaguchi , Yasuhiro Tamaki , Hidenori Takahashi
发明人： Sawako Ozawa , Nobuhiro Oikawa , Eisaku Mizuguchi , Hirosato Ebiike , Fumio Watanabe , Kenji Morikami , Nobuo Shimma , Nobuya Ishii , Toshiyuki Tsukaguchi , Yasuhiro Tamaki , Hidenori Takahashi
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents —(O)n—R; R represents a C1-C6 alkyl group or the like; n represents 0 or 1; X represents O or the like; R2, R3 and R4 are independently selected from a hydrogen atom or C1-C3 alkyl; or R2 and R3 may join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.
摘要翻译：旨在提供由式（1）表示的化合物：[其中Ar是选自下式（2）中的被连接的亚芳基：（其中*表示与氮原子的结合位点，**表示结合位点到T）; T表示 - （O）n -R; R表示C1-C6烷基等; n表示0或1; X表示O等; R2，R3和R4独立地选自氢原子或C1-C3烷基; 或者R 2和R 3可以与含有它们所结合的氮原子的脲结合物一起形成5-或6-元杂环; Y表示CH或N]，或其药学上可接受的盐或其前药，以及含有该化合物的药物组合物。

2. 发明申请

US20090175930A1 Composition Suppressing The Expression of Target Gene in Eyeball and Medicament For Treating of Disease in Eyeball 审中-公开
标题翻译：抑制眼球中靶基因表达和治疗眼球疾病药物的组合物
公开(公告)号：US20090175930A1
公开(公告)日：2009-07-09
申请号：US12087674
申请日：2007-01-10
申请人： Nobuhiro Yagi , Masahiro Yamauchi , Noboru Aoki , Yasuhiro Tamaki , Hidenori Takahashi , Aya Iriyama , Ryozo Nagai , Ichiro Manabe
发明人： Nobuhiro Yagi , Masahiro Yamauchi , Noboru Aoki , Yasuhiro Tamaki , Hidenori Takahashi , Aya Iriyama , Ryozo Nagai , Ichiro Manabe
IPC分类号： A61K9/127 , A61K31/7052 , A61P27/02
CPC分类号： A61K9/1272 , A61K9/0048 , A61K9/127 , A61K31/7105 , A61K48/0033 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： There is provided a composition comprising an RNA-encapsulated liposome, the RNA comprising a sequence being of 15 to 30 contiguous nucleotides of mRNA of a target gene associated with a disease in an eyeball, and a sequence complementary to the sequence, wherein the liposome is capable of reaching an eyeball, and the like. The liposome in which an RNA is encapsulated is, for example, a liposome composing a complex particle comprising a lead particle and the RNA as constituent components, the lead particle comprising a cationic lipid, and a bilayer lipid membrane for coating the complex particle. The bilayer lipid membrane is a bilayer lipid membrane comprising a neutral lipid, and a lipid derivative, a fatty acid derivative or an aliphatic hydrocarbon derivative of a water-soluble substance as constituent components.
摘要翻译：提供了包含RNA包封的脂质体的组合物，所述RNA包含与眼球中的疾病相关的靶基因的mRNA的15-30个连续核苷酸的序列和与该序列互补的序列，其中所述脂质体是能够达到眼球等。其中包封RNA的脂质体是例如构成包含铅颗粒和RNA作为组成成分的复合颗粒的脂质体，包含阳离子脂质的铅颗粒和用于涂覆复合颗粒的双层脂质膜。双层脂质膜是包含中性脂质和作为组成成分的水溶性物质的脂质衍生物，脂肪酸衍生物或脂肪族烃衍生物的双层脂质膜。

3. 发明申请

US20060010409A1 Semiconductor integrated circuit design method, design support system for the same, and delay library 审中-公开
标题翻译：半导体集成电路设计方法，设计支持系统相同，延时库
公开(公告)号：US20060010409A1
公开(公告)日：2006-01-12
申请号：US11101466
申请日：2005-04-08
申请人： Yasuhiro Tamaki , Kyoji Yamashita
发明人： Yasuhiro Tamaki , Kyoji Yamashita
IPC分类号： G06F17/50
CPC分类号： G06F17/5031
摘要： In a semiconductor integrated circuit design method for simulating a delay of a logic circuit based on delay values which are calculated for each kind of a plurality of cells composing the logic circuit or for each signal path of the logic circuit and which are stored in a delay library, the simulation is performed to a block including at least one cell, and a delay value varying dependent on a layout direction of the cell included in the block is used as the delay value in the delay library. By this method, timing verification can be performed according to the layout direction of each cell layouted on a wafer, attaining precise margin of the design and improving yield of the semiconductor integrated circuit.
摘要翻译：在一种半导体集成电路设计方法中，用于根据对构成逻辑电路的多种单元或逻辑电路的每个信号路径计算的延迟值进行模拟逻辑电路的延迟，并以延迟方式存储库，对包括至少一个单元的块执行模拟，并且使用根据块中包括的单元的布局方向而变化的延迟值作为延迟库中的延迟值。通过这种方法，可以根据布置在晶片上的每个单元的布局方向执行定时验证，从而获得设计的精确余量并提高半导体集成电路的产量。

4. 发明授权

US5984532A Optical fiber connector 失效
标题翻译：光纤连接器
公开(公告)号：US5984532A
公开(公告)日：1999-11-16
申请号：US29315
申请日：1998-02-12
申请人： Yasuhiro Tamaki , Toshiyuki Tanaka , Akito Nishimura , Yuichi Yoshida , Hiroshi Yokosuka
发明人： Yasuhiro Tamaki , Toshiyuki Tanaka , Akito Nishimura , Yuichi Yoshida , Hiroshi Yokosuka
IPC分类号： G02B6/38
CPC分类号： G02B6/3806 , G02B6/3837
摘要： An optical fiber connector comprising a base and a lid member constituting an element having a doubly split structure which forms a roughly rod-like shape when united, and a spring for housing the base and lid member and applying pressure for pressing them together, wherein centering grooves for positioning and centering optical fibers for adjoinment and connection are provided in at least one or between the opposing faces of the base and lid member which are put together. In a mode wherein the element is inserted into a C-shaped spring having a rod shape with a C-shaped cross section, the optical fibers which are inserted from both ends of the element are pushed to the centering groove and adjoined into connection. By inserting or withdrawing wedges into wedge insertion grooves formed between the base and the lid member, it is possible to open or close the element.
摘要翻译： PCT No.PCT / JP96 / 02357 Sec。 371日期1998年2月12日 102（e）1998年2月12日PCT PCT 1996年8月23日PCT公布。公开号WO97 / 08575 日期1997年3月6日一种光纤连接器，包括基座和盖构件，所述盖构件构成具有双组分结构的元件，所述双组分结构在组合时形成大致棒状形状;以及弹簧，用于容纳所述基座和盖构件并施加压力它们在一起，其中定位用于定位和定心用于邻接和连接的光纤的定心槽设置在放置在一起的基座和盖构件的至少一个或相对的面之间。在将元件插入具有C形横截面的棒状的C形弹簧的模式中，从元件的两端插入的光纤被推到定心槽并连接。通过将楔形物插入或取出成形在基部和盖部件之间的楔形插入槽，可以打开或关闭该元件。

5. 发明授权

US07195400B2 Optical connector and assembling method for the same 有权
标题翻译：光连接器及组装方法相同
公开(公告)号：US07195400B2
公开(公告)日：2007-03-27
申请号：US11132098
申请日：2005-05-17
申请人： Mariko Asano , Koki Narita , Yoshihiro Ouchi , Yasuhiro Tamaki , Yoshikazu Nomura , Hideyuki Hosoya
发明人： Mariko Asano , Koki Narita , Yoshihiro Ouchi , Yasuhiro Tamaki , Yoshikazu Nomura , Hideyuki Hosoya
IPC分类号： G02B6/28
CPC分类号： G02B6/3812 , G02B6/3843 , G02B6/3851 , G02B6/3861 , G02B6/3891
摘要： An optical connector ferrule has an optical fiber containing hole reaching from the rear end surface near the end surface and a fine pore extending from the optical fiber accommodating hole to the end surface to be connected. A bare fiber of a polarization-maintaining optical fiber is inserted into the fine pore. Since the length of the fine pore is short, the influence of the uniformness of the adhesive in the fine pore is smaller, and therefore the stress distribution is maintained, resulting in stabilizing the polarization characteristics. A flange unit is attached to the ferrule after an optical fiber is inserted to the ferrule and fixed. Therefore the optical fiber is easily adjusted with respect to the housing in the circumferential direction around the axis, and optical fibers are connected by but joining with high accuracy.
摘要翻译：光连接器套圈具有从靠近端面的后端面到达的光纤容纳孔和从光纤容纳孔延伸到要连接的端面的细孔。将偏光保持光纤的裸光纤插入细孔中。由于细孔的长度短，粘合剂在细孔中的均匀性的影响较小，因此保持应力分布，从而稳定极化特性。在将光纤插入套圈并固定之后，法兰单元附接到套圈。因此，光纤相对于壳体在周向上容易地绕轴线进行调节，并且光纤以高精度连接而是接合。

6. 发明授权

US06819855B2 Clip removing tool and clip removing method 失效
公开(公告)号：US06819855B2
公开(公告)日：2004-11-16
申请号：US10344304
申请日：2003-07-29
申请人： Kunihiko Fujiwara , Yukio Hayashi , Yasuhiro Tamaki , Yoshikazu Nomura
发明人： Kunihiko Fujiwara , Yukio Hayashi , Yasuhiro Tamaki , Yoshikazu Nomura
IPC分类号： G02B600
CPC分类号： G02B6/3893 , G02B6/385 , G02B6/3897 , G02B6/3898 , G02B6/43
摘要： The present invention is applied to a structure in which to attach a backplane connector to a backplane so that the backplane connector can be moved by a desired amount, a clip from which a pair of elastic pawls project is used to engage the backplane with the backplane connector through holes in the backplane. The present invention allows the clip of this structure to be removed efficiently. That is, the present invention provides a clip removing tool 50 comprising disengaging pieces 52a and 52b that push in a pair of elastic pawls 29b through an attaching slot 31 in a backplane 23, the elastic pawls 29b being engaged with locking portions 34 on opposite side portions of a BH housing 26 are pushed, to disengage the elastic pawls 29b from the locking portions 34, as well as a clip removing method using this clip removing tool.

7. 发明申请

US20060127481A1 Ophthalmic drug delivery system using polymer micell 审中-公开
标题翻译：使用聚合物胶束的眼药物递送系统
公开(公告)号：US20060127481A1
公开(公告)日：2006-06-15
申请号：US10551252
申请日：2004-03-29
申请人： Kazunori Kataoka , Yasuhiro Tamaki , Atsushi Harada , Fumitaka Tasaka
发明人： Kazunori Kataoka , Yasuhiro Tamaki , Atsushi Harada , Fumitaka Tasaka
IPC分类号： A61K31/555 , A61K9/14 , A61K31/409
CPC分类号： A61K41/0071 , A61K9/0048 , A61K9/1075 , A61K31/409 , A61K47/645 , A61K47/6907
摘要： The current situation is such that it is difficult for drugs to reach posterior tissues of eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to positerior tissues of eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.
摘要翻译：目前的情况是药物难以到达眼球的后部组织，如脉络膜和视网膜，结果是治疗这些区域的疾病是困难的。因此，如何有效地提供药物是非常重要的。已经发现，可以通过全身给药，特别是静脉内施用其中掺入药物的聚合物胶束来实现向眼球前组织（例如脉络膜和视网膜），特别是其中发生血管化的药物的有效递送。此外，已经发现，当使用感光性物质作为药物并进行PDT时，可以有效阻塞脉络膜新血管，以便用于治疗年龄相关性黄斑变性。

8. 发明申请

US20050129347A1 Optical fiber sheet and optical fiber sheet production method 有权
标题翻译：光纤片和光纤片生产方法
公开(公告)号：US20050129347A1
公开(公告)日：2005-06-16
申请号：US10489451
申请日：2002-05-29
申请人： Daigo Saito , Kazuhiro Takizawa , Tsuyoshi Shimomichi , Yasuhiro Tamaki , Yukio Hayashi , Kunihiko Fujiwara
发明人： Daigo Saito , Kazuhiro Takizawa , Tsuyoshi Shimomichi , Yasuhiro Tamaki , Yukio Hayashi , Kunihiko Fujiwara
IPC分类号： G02B6/38 , G02B6/44 , G02B6/12
CPC分类号： G02B6/4471 , G02B6/2558 , G02B6/3608 , G02B6/3887
摘要： The invention is an optical fiber sheet obtained by adhering together at least two sheets with an optical fiber placed therebetween, and placing a reinforcing tube over a portion of the optical fiber extending from an edge of the sheets, wherein the reinforcing tube is fixed to the sheets by bonding, with the reinforcing tube inserted between the sheets located up and below by an appropriate distance from an edge of the sheets.
摘要翻译：本发明是一种光纤片，其通过将光纤放置在其间的至少两片粘合在一起，并将加强管放置在从片材的边缘延伸的光纤的一部分上，其中将加强管固定到通过粘合将片材插入到位于上下的片材与片材的边缘适当距离之间的粘合。

9. 发明授权

US5963699A Optical fiber mechanical splice 失效
标题翻译：光纤机械接头
公开(公告)号：US5963699A
公开(公告)日：1999-10-05
申请号：US862395
申请日：1997-05-23
申请人： Toshiyuki Tanaka , Yasuhiro Tamaki , Hiroshi Yokosuka , Shinji Nagasawa , Mitsuru Kihara
发明人： Toshiyuki Tanaka , Yasuhiro Tamaki , Hiroshi Yokosuka , Shinji Nagasawa , Mitsuru Kihara
IPC分类号： G02B6/24 , G02B6/38 , G02B6/40 , G02B6/255
CPC分类号： G02B6/3806
摘要： Productivity of switching optical connections is improved significantly with the mechanical splice presented. A single fiber cable or a fiber tape, with the bare fiber exposed at the tip, is inserted from the terminal ends of an aligner element, and are clamped between a lid and a base member of the aligner element, A U-shaped spring clamp is coupled to the aligner element to secure the cables clamped in the aligner element. After the aligner element is closed and coupled into the spring clamp, wedge insertion openings provided in the front face of the aligner element enable to lift the lid member from the base member sufficiently to enable removal of one or both of the cables. The mechanical splice is constructed simply and ruggedly so that cables can be connected or disconnected manually by coupling the aligner element into or decoupling from the spring clamp. The external shape of the aligner is angular, and permits stable handling on workbench or with tools, thus leading to improved productivity in field installation as well as in assembly operations.
摘要翻译：使用机械接头提高了切换光连接的生产率。一根光纤电缆或一条光纤带，裸露的光纤在尖端处被从定位器元件的末端插入，并被夹在盖子和定位器元件的底座部件之间。U型弹簧夹联接到对准器元件以固定夹在对准元件中的电缆。在对准器元件闭合并联接到弹簧夹中之后，设置在对准器元件的前表面中的楔形插入孔使得能够将盖构件从基座部件提升到能够移除一个或两个电缆。机械接头简单而坚固地构造，使得可以通过将对准器元件连接到弹簧夹或从弹簧夹脱离来手动连接或断开电缆。对准器的外部形状是有角度的，并且允许在工作台或工具上的稳定操作，从而在现场安装以及组装操作中提高生产率。

10. 发明申请

US20100297157A1 VACCINE THERAPY FOR CHOROIDAL NEOVASCULARIZATION 审中-公开
标题翻译： VOCCINE治疗用于短暂的新生血管
公开(公告)号：US20100297157A1
公开(公告)日：2010-11-25
申请号：US12526626
申请日：2008-02-15
申请人： Yasuhiro Tamaki , Hideaki Tahara
发明人： Yasuhiro Tamaki , Hideaki Tahara
IPC分类号： A61K39/00 , A61K38/00 , A61P35/00 , C07K7/06
CPC分类号： A61K39/0008 , A61K38/00 , A61K2039/55566 , C07K14/71
摘要： The present inventors administered a peptide derived from VEGFR-2, which is known as one of the proteins involved in neovascularization, to model mice (A2/Kb transgenic mice) expressing human HLA-A*0201, and tested whether or not the peptide has vaccine effect. As a result, the present inventors successfully discovered that vaccination using this peptide as an antigen is effective for inhibition of choroid neovascularization, and thereby completed the present invention. More specifically, the present invention provides vaccines for treatment and/or prevention of diseases caused by choroid neovascularization (neovascular maculopathy), which contain a VEGFR-2-derived peptide as an active ingredient.
摘要翻译：本发明人施用源自VEGFR-2的肽，其被称为参与新生血管形成的蛋白质之一，以模拟表达人HLA-A * 0201的小鼠（A2 / Kb转基因小鼠），并测试肽是否具有疫苗效果。结果，本发明人成功地发现使用该肽作为抗原的疫苗接种对于抑制脉络膜新血管形成有效，从而完成了本发明。更具体地，本发明提供了用于治疗和/或预防由脉络膜新生血管形成（新生血管性黄斑病变）引起的疾病的疫苗，其含有VEGFR-2衍生的肽作为活性成分。

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