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1. 发明申请

US20060127481A1 Ophthalmic drug delivery system using polymer micell 审中-公开
标题翻译：使用聚合物胶束的眼药物递送系统
公开(公告)号：US20060127481A1
公开(公告)日：2006-06-15
申请号：US10551252
申请日：2004-03-29
申请人： Kazunori Kataoka , Yasuhiro Tamaki , Atsushi Harada , Fumitaka Tasaka
发明人： Kazunori Kataoka , Yasuhiro Tamaki , Atsushi Harada , Fumitaka Tasaka
IPC分类号： A61K31/555 , A61K9/14 , A61K31/409
CPC分类号： A61K41/0071 , A61K9/0048 , A61K9/1075 , A61K31/409 , A61K47/645 , A61K47/6907
摘要： The current situation is such that it is difficult for drugs to reach posterior tissues of eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to positerior tissues of eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.
摘要翻译：目前的情况是药物难以到达眼球的后部组织，如脉络膜和视网膜，结果是治疗这些区域的疾病是困难的。因此，如何有效地提供药物是非常重要的。已经发现，可以通过全身给药，特别是静脉内施用其中掺入药物的聚合物胶束来实现向眼球前组织（例如脉络膜和视网膜），特别是其中发生血管化的药物的有效递送。此外，已经发现，当使用感光性物质作为药物并进行PDT时，可以有效阻塞脉络膜新血管，以便用于治疗年龄相关性黄斑变性。

2. 发明申请

US20060110356A1 Ophthalmic drug delivery system using polymer micelle 审中-公开
标题翻译：使用聚合物胶束的眼药物递送系统
公开(公告)号：US20060110356A1
公开(公告)日：2006-05-25
申请号：US11251135
申请日：2005-10-14
申请人： Kazunori Kataoka , Yasuhiro Tamaki , Atsushi Harada , Fumitaka Tasaka
发明人： Kazunori Kataoka , Yasuhiro Tamaki , Atsushi Harada , Fumitaka Tasaka
IPC分类号： A61K31/77 , A61K9/127 , A61K31/409
CPC分类号： A61K41/0071 , A61K9/0048 , A61K9/1075 , A61K31/409 , A61K47/645 , A61K47/6907
摘要： The current situation is such that it is difficult for drugs to reach posterior tissues of an eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to positerior tissues of the eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.
摘要翻译：目前的情况是药物难以到达眼球的后部组织，例如脉络膜和视网膜，结果是治疗这些区域的疾病是困难的。因此，如何有效地提供药物是非常重要的。已经发现，可以通过全身给药，特别是静脉内施用其中掺入药物的聚合物胶束来实现药物到眼球的正面组织如脉络膜和视网膜的有效递送，特别是其中发生血管形成的那些。此外，已经发现，当使用感光性物质作为药物并进行PDT时，可以有效阻塞脉络膜新血管，以便用于治疗年龄相关性黄斑变性。

3. 发明授权

US07923034B2 Process for producing microparticles 有权
标题翻译：微粒生产方法
公开(公告)号：US07923034B2
公开(公告)日：2011-04-12
申请号：US10559173
申请日：2004-06-03
申请人： Kazuhito Yamada , Yasumasa Sasaki , Fumitaka Tasaka , Mitsuaki Kuwano
发明人： Kazuhito Yamada , Yasumasa Sasaki , Fumitaka Tasaka , Mitsuaki Kuwano
IPC分类号： A61K9/50
CPC分类号： A61K31/573 , A61K9/1647 , A61K31/58
摘要： An object of the present invention is to provide a solvent which is able to produce microparticles where content of the drug is still high and no initial burst takes place even when a drug having a low solubility in a halogenated hydrocarbon solvent is used. The present invention provides a process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising a first solvent: halogenated hydrocarbon, and a second solvent: a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.
摘要翻译：本发明的目的在于提供即使使用在卤代烃类溶剂中溶解性低的药物，也能够产生药物含量仍然很高而不发生初始爆发的微粒的溶剂。本发明提供了一种通过溶剂蒸发微胶囊化方法生产由生物可降解聚合物组成并含有在卤代烃中具有低溶解度的药物的微粒的方法，其特征在于药物和可生物降解聚合物溶解在包含第一溶剂：卤代烃和第二溶剂的混合溶剂中：上述药物的溶解度为0.3％（w / v）以上的与水不混溶的有机溶剂。

4. 发明申请

US20090036552A1 Noninvasive Drug Delivery System To Tissue of Posterior Segment of Eye Using Solid Composition 审中-公开
标题翻译：无创药物输送系统对使用固体组合物的眼后部组织
公开(公告)号：US20090036552A1
公开(公告)日：2009-02-05
申请号：US11989354
申请日：2006-07-28
申请人： Koumei Okabe , Fumitaka Tasaka
发明人： Koumei Okabe , Fumitaka Tasaka
IPC分类号： A61K47/32 , A61K47/38 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1652 , A61K31/573 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38
摘要： The present invention provides a drug delivery system by noninvasive administration, which is excellent in drug transfer to a tissue of the posterior segment of the eye via a local eye tissue. By administering a solid composition comprising a drug and a mucoadhesive substance having an adhesion strength of from 200 to 1000 g in the conjunctival sac, a drug delivery system excellent in drug transfer to a tissue of the posterior segment of the eye via a local eye tissue can be constructed.
摘要翻译：本发明提供了一种通过非侵入性给药的药物递送系统，其通过局部眼组织对眼后段的组织的药物转移性优异。通过在结膜囊中施用包含药物和粘附强度为200〜1000g的粘膜粘附物质的固体组合物，通过局部眼睛组织向药物转移到眼后段的组织而优异的药物递送系统可以建造。

5. 发明申请

US20130226111A1 DRUG SUPPORT BODY, AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：药物支持体及其生产方法
公开(公告)号：US20130226111A1
公开(公告)日：2013-08-29
申请号：US13812676
申请日：2011-07-28
申请人： Fumitaka Tasaka , Naohito Miyoshi , Yoshihide Horibe
发明人： Fumitaka Tasaka , Naohito Miyoshi , Yoshihide Horibe
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F15/002 , A61K9/0051 , A61K9/703 , B65C9/0006 , B65C2009/0087 , G09F2003/0222 , G09F2003/0225 , G09F2003/0226 , G09F2003/0227
摘要： A drug support body is provided that can be used to appropriately administer a drug to the anterior segment of the eye while the production cost is reduced. A drug layer containing a drug component to be administered to an anterior segment of the eye is provided at a halfway portion in a longitudinal direction of a base plate, wherein the base plate includes a bending portion that allows the base plate to bend in a direction opposite to a surface of the base plate on which the drug layer is provided, and by bending the base plate at the bending portion, at least a portion of a surface facing the base plate of the drug layer is exposed from the base plate.
摘要翻译：提供了一种药物支持体，其可以用于在眼睛的前部适当地施用药物，同时降低生产成本。在基板的长度方向的中途设置有含有要施用于眼前段的药物成分的药物层，其中，所述基板包括弯曲部，所述弯曲部允许所述基板沿着方向弯曲与设置有药物层的基板的表面相对，并且通过在弯曲部弯曲基板，与基板相对的面向药物层的基板的表面的至少一部分露出。

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