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1. 发明授权

US06605595B1 Avermectin derivatives 有权
标题翻译：阿维菌素衍生物
公开(公告)号：US06605595B1
公开(公告)日：2003-08-12
申请号：US09890824
申请日：2002-02-11
申请人： Satoshi Omura , Toshiaki Sunazuka , Andreas Turberg , Georg von Samson-Himmelstjerna , Olaf Hansen , Achim Harder
发明人： Satoshi Omura , Toshiaki Sunazuka , Andreas Turberg , Georg von Samson-Himmelstjerna , Olaf Hansen , Achim Harder
IPC分类号： A01N4304
CPC分类号： C07H17/08 , A61K31/7048
摘要： Avermectin derivatives represented by the general formula (I) or salts thereof: wherein —X----Y— represents —CH═CH—, —CH2—C(═O)—, —CH2—CH2—, or —CH2—CH(R13)—; for example, 1) when —X----Y— represents —CH═CH—, R1 represents (R11)(R12)C [wherein R11 represents a substituted or unsubstituted lower alkyl group; a formyl group; a lower alkoxylcarbonyl group etc.; and R12 represents a hydrogen atom or a lower alkyl group]; when the bond between R2 and a carbon atom at the 5-position is a single bond, R2 represents a hydroxyl group or a tri(lower alkyl)silyloxy group; or R2 forms a carbonyl group or a hydroxime group together with the carbon atom at the 5-position; 2) when —X----Y— represents —CH2—C(═O)—, R1 represents (R11a)(R12a)C [wherein R11a represents a lower alkoxycarbonyl group, or —COOCH2CH═CH2; and R12a represents a hydrogen atom]; and R2 represents a hydroxyl group or a tri(lower alkyl)silyloxy group.
摘要翻译：由通式（I）表示的阿维菌素衍生物或其盐：其中-X-Y-表示-CH = CH-，-CH 2 -C（= O） - ， - CH 2 -CH 2 - 或-CH 2 - CH（R 13） - ; 例如，1）当-X ----Y-表示-CH = CH-时，R1表示（R11）（R12）C [其中R11表示取代或未取代的低级烷基; 甲酰基; 低级烷氧基羰基等; R12表示氢原子或低级烷基]。当R 2与5位的碳原子之间的键是单键时，R 2表示羟基或三（低级烷基）甲硅烷氧基; 或R 2与5-位上的碳原子一起形成羰基或羟基基团; 2）当-X ----Y-表示-CH2-C（= O） - 时，R1表示（R11a）（R12a）C [其中R11a表示低级烷氧基羰基或-COOCH2CH = CH2; R12a表示氢原子]; 并且R 2表示羟基或三（低级烷基）甲硅烷氧基。

2. 发明申请

US20090131341A1 Novel Dihydropseudoerythromycin Derivatives 有权
标题翻译：新型二氢假红霉素衍生物
公开(公告)号：US20090131341A1
公开(公告)日：2009-05-21
申请号：US12083484
申请日：2006-10-13
申请人： Satoshi Omura , Toshiaki Sunazuka , Kenichiro Nagai , Hideaki Shima , Haruko Yamabe
发明人： Satoshi Omura , Toshiaki Sunazuka , Kenichiro Nagai , Hideaki Shima , Haruko Yamabe
IPC分类号： A61K31/7048 , C07H17/08 , A61P1/00 , A61P29/00
CPC分类号： C07H17/08
摘要： A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the compound as an active ingredient.
摘要翻译：由式[I]表示的化合物，其中每个符号如说明书或其药理学上可接受的盐中所定义，以及含有该化合物作为活性成分的药物组合物。

3. 发明申请

US20060281780A1 Pest control agents 有权
标题翻译：害虫控制剂
公开(公告)号：US20060281780A1
公开(公告)日：2006-12-14
申请号：US11443299
申请日：2006-05-31
申请人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
发明人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
IPC分类号： A01N43/42 , A01N43/40
CPC分类号： A01N43/90
摘要： There is provided a pest control agent comprising a compound represented by formula (I) as active ingredient.
摘要翻译：提供了包含由式（I）表示的化合物作为活性成分的害虫防治剂。

4. 发明申请

US20130131091A1 HARMFUL ORGANISM CONTROL AGENT 审中-公开
标题翻译：有害有机体控制剂
公开(公告)号：US20130131091A1
公开(公告)日：2013-05-23
申请号：US13699367
申请日：2011-05-23
申请人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Yoshimasa Fukuda , Nozomu Nakanishi , Masato Tani , Nobuto Minowa , Masaaki Mitomi , Satoshi Omura , Toshiaki Sunazuka , Hiroshi Tomoda
发明人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Yoshimasa Fukuda , Nozomu Nakanishi , Masato Tani , Nobuto Minowa , Masaaki Mitomi , Satoshi Omura , Toshiaki Sunazuka , Hiroshi Tomoda
IPC分类号： A01N43/90 , C07D498/04 , C07D493/04
CPC分类号： A01N43/90 , C07D491/04 , C07D493/04 , C07D498/04
摘要： The present invention provides a composition for use as a harmful organism control agent comprising as an active ingredient one or more of compounds represented by formula (I) or salts thereof and an agriculturally or zootechnically acceptable carrier. wherein Het represents pyridyl; X represents an oxygen atom; R1, R2, R3, R7, R10a, R10b, R11, and R12 represent a hydrogen atom; R4, R5, and R6 represent a hydrogen atom, hydroxyl, optionally substituted C1-18 alkylcarbonyloxy, optionally substituted C1-18 alkylsulfonyloxy, optionally substituted arylcarbonyloxy, C1-6 alkyloxy-C1-6 alkyloxy, C1-6 alkyloxy-C1-6 alkyloxy-C1-6 alkyloxy; R8 represents a hydrogen atom; and R13a, R13b, and R13c represent methyl.
摘要翻译：本发明提供一种用作有害生物体控制剂的组合物，其包含作为活性成分的一种或多种式（I）表示的化合物或其盐以及农业或动物技术上可接受的载体。其中Het表示吡啶基; X表示氧原子; R1，R2，R3，R7，R10a，R10b，R11和R12表示氢原子; R4，R5和R6表示氢原子，羟基，任选取代的C 1-18烷基羰基氧基，任选取代的C 1-18烷基磺酰氧基，任选取代的芳基羰氧基，C 1-6烷氧基-C 1-6烷氧基，C 1-6烷氧基-C 1-6烷氧基 -C 1-6烷氧基; R8表示氢原子; R13a，R13b和R13c表示甲基。

5. 发明授权

US5869675A Lactacystin derivatives 失效
标题翻译：乳酸衍生物
公开(公告)号：US5869675A
公开(公告)日：1999-02-09
申请号：US979637
申请日：1997-11-28
申请人： Satoshi Omura , Toshiaki Sunazuka , Haruo Tanaka
发明人： Satoshi Omura , Toshiaki Sunazuka , Haruo Tanaka
IPC分类号： C07D207/12 , C07D207/28 , C07D401/12
CPC分类号： C07D401/12 , C07D207/28
摘要： Novel lactacystin derivatives other than lactacystin per se, with superior activity for the genesis of neurites and highly selective toxicity and low cytotoxicity as compared with known lactacystin have been prepared, of the formula ##STR1## wherein R is lower alkoxy, --S--(CH.sub.2).sub.n R.sup.1 or --S--(CH.sub.2) .sub.n --CH(R.sup.2)-(R.sup.3), in which R.sup.1 is branched or straight-chain lower alkyl, hydroxy, carboxyl, lower alkoxycarbonyl, optionally substituted phenyl, substituted or unsubstituted amino or pyridyl, R.sup.2 is substituted or unsubstituted amino, lower alkyl or amino acid residue, R.sup.3 is carboxyl, lower alkoxycarbonyl, lower alkenyloxycarbonyl or amino acid residue, and n is 0-4, or a pharmacologically acceptable salt thereof.
摘要翻译：与已知的乳胞蛋白相比，已经制备了除了乳糖蛋白本身以外的新型乳胞素衍生物，具有优异的神经突发生活性和高选择性毒性和低细胞毒性，其中R为低级烷氧基，-S - （CH2）nR1或-S-（CH2）n-CH（R2） - （R3），其中R1是支链或直链低级烷基，羟基，羧基，低级烷氧基羰基，任选取代的苯基，取代或未取代的氨基或吡啶基，R2为取代或未取代的氨基，低级烷基或氨基酸残基，R3为羧基，低级烷氧基羰基，低级链烯氧基羰基或氨基酸残基，n为0-4，或其药理学上可接受的盐。

6. 发明授权

US08367707B2 Pest control agents 有权
公开(公告)号：US08367707B2
公开(公告)日：2013-02-05
申请号：US12903624
申请日：2010-10-13
申请人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
发明人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
IPC分类号： A01N43/40 , A61K31/44 , C07D211/34
CPC分类号： A01N43/90
摘要： Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:

7. 发明授权

US08133871B2 Dihydropseudoerythromycin derivatives 有权
标题翻译：二氢假红霉素衍生物
公开(公告)号：US08133871B2
公开(公告)日：2012-03-13
申请号：US12083484
申请日：2006-10-13
申请人： Satoshi Omura , Toshiaki Sunazuka , Kenichiro Nagai , Hideaki Shima , Haruko Yamabe
发明人： Satoshi Omura , Toshiaki Sunazuka , Kenichiro Nagai , Hideaki Shima , Haruko Yamabe
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the compound as an active ingredient.
摘要翻译：由式[I]表示的化合物，其中每个符号如说明书或其药理学上可接受的盐中所定义，以及含有该化合物作为活性成分的药物组合物。

8. 发明授权

US07838538B2 Pest control agents 有权
标题翻译：害虫控制剂
公开(公告)号：US07838538B2
公开(公告)日：2010-11-23
申请号：US12318232
申请日：2008-12-23
申请人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
发明人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
IPC分类号： A61K31/44 , A01N43/40 , C07D405/00
CPC分类号： A01N43/90
摘要： Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:
摘要翻译：公开了一种用作害虫控制剂的组合物，其包含式（I）表示的化合物或其农业和园艺可接受的盐作为活性成分和农业和园艺可接受的载体：

9. 发明授权

US07034005B2 Use of agent for suppressing infection and proliferation of human immunodeficiency syndrome virus 失效
公开(公告)号：US07034005B2
公开(公告)日：2006-04-25
申请号：US10294587
申请日：2002-11-15
申请人： Satoshi Omura , Kiyoko Akagawa , Toshiaki Sunazuka
发明人： Satoshi Omura , Kiyoko Akagawa , Toshiaki Sunazuka
IPC分类号： A61K31/70
CPC分类号： C07H17/08 , A61K31/436
摘要： The present invention relates to agent for suppressing infection and proliferation of human immunodeficiency syndrome virus (HIV-1), which infects immunocompetent cells such as macrophage or dendritic cell and causes destruction of immune system, and use of known compounds, macrolide derivatives for suppression of infection and proliferation of human immunodeficiency syndrome virus in M type macrophage derived from human monocytes. The present invention is useful for treatment of patients with HIV-1 infection by low cost chemotherapeutic agents, and in addition, is clinically used as supplement agent in HAART.

10. 发明申请

US20110034404A1 PEST CONTROL AGENTS 有权
标题翻译：虫控制剂
公开(公告)号：US20110034404A1
公开(公告)日：2011-02-10
申请号：US12903624
申请日：2010-10-13
申请人： Kimihiko GOTO , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
发明人： Kimihiko GOTO , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
IPC分类号： A01N43/90 , A01P7/04 , C07D493/04 , C07H17/04 , C07D495/04
CPC分类号： A01N43/90
摘要： Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:
摘要翻译：公开了用作害虫控制剂的组合物，其包含式（I）表示的化合物或其农业和园艺可接受的盐作为活性成分和农业和园艺可接受的载体：

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