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1. 发明授权

US08957214B2 Pest control agent 有权
标题翻译：害虫控制剂
公开(公告)号：US08957214B2
公开(公告)日：2015-02-17
申请号：US13814753
申请日：2011-08-26
申请人： Shinzo Kagabu , Masaaki Mitomi , Shigeki Kitsuda , Ryo Horikoshi , Masahiro Nomura , Yasumichi Onozaki
发明人： Shinzo Kagabu , Masaaki Mitomi , Shigeki Kitsuda , Ryo Horikoshi , Masahiro Nomura , Yasumichi Onozaki
IPC分类号： C07D213/00 , A01N43/40 , C07D211/98 , A01N43/50 , A01N43/78 , A01N47/40 , C07C233/05 , C07C233/12 , C07C261/04 , C07C271/12 , C07C311/09 , C07F9/58 , C07D401/06
CPC分类号： A01N43/40 , A01N37/18 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/78 , A01N47/02 , A01N47/12 , A01N47/40 , A01N57/32 , C07C233/05 , C07C233/12 , C07C261/04 , C07C271/12 , C07C311/09 , C07D211/98 , C07D213/36 , C07D213/40 , C07D213/42 , C07D213/61 , C07D213/75 , C07D237/08 , C07D277/32 , C07D333/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D417/12 , C07F9/58
摘要： A compound of formula (Ie′): wherein Ar′, R1, R4e and Y are as defined herein and a method of controlling pests using the compound.
摘要翻译：式（Ie'）的化合物：其中Ar'，R 1，R 4e和Y如本文所定义，以及使用该化合物控制害虫的方法。

2. 发明申请

US20140039171A1 NOVEL MACROLIDE INTERMEDIATE AND NOVEL PRODUCTION PROCESS 审中-公开
标题翻译：新世界中间和新生产过程
公开(公告)号：US20140039171A1
公开(公告)日：2014-02-06
申请号：US14001014
申请日：2012-02-28
申请人： Kenichi Kurihara , Masaaki Mitomi , Nobuto Minoma
发明人： Kenichi Kurihara , Masaaki Mitomi , Nobuto Minoma
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , A61K31/7048 , Y02A50/402
摘要： Provided are: a novel monoalkylamino intermediate (I); and a production method for a compound represented by the formula (III), which is an animal antibacterial agent, via the novel monoalkylamino intermediate.
摘要翻译：提供：新型单烷基氨基中间体（I）; 和通过新型单烷基氨基中间体的作为动物抗菌剂的式（III）表示的化合物的制备方法。

3. 发明授权

US08557550B2 Pyripyropene a biosynthetic gene 有权
标题翻译：生物合成基因
公开(公告)号：US08557550B2
公开(公告)日：2013-10-15
申请号：US13055532
申请日：2009-07-24
申请人： Hiroyuki Anzai , Kentaro Yamamoto , Mariko Tsuchida , Kazuhiko Oyama , Masaaki Mitomi
发明人： Hiroyuki Anzai , Kentaro Yamamoto , Mariko Tsuchida , Kazuhiko Oyama , Masaaki Mitomi
IPC分类号： C12P17/18
CPC分类号： C12N9/1029 , C12N9/00 , C12N9/1085 , C12N15/52 , C12P17/181 , Y02P20/52
摘要： An isolated novel polynucleotide comprising a nucleotide sequence encoding at least one polypeptide involved in biosynthesis of pyripyropene A, a recombinant vector comprising the polynucleotide and a transformant comprising the polynucleotide are disclosed. By the present invention, a pyripyropene A biosynthetic gene useful for production of a novel pyripyropene analog, improvement of productivity of a pyripyropene A-producing bacterium, production of an insecticidal agent for microorganisms, creation of a plant resistant to insect pests or the like are provided.
摘要翻译：公开了一种分离的新型多核苷酸，其包含编码参与拟南芥的生物合成的至少一种多肽的核苷酸序列，包含该多核苷酸的重组载体和包含该多核苷酸的转化体。通过本发明，可用于生产新型拟线虫丙烯类似物的拟线虫丙烯生物合成基因，产生拟南芥生产菌的生产力的提高，微生物杀虫剂的生产，抗虫害害虫等的产生，提供。

4. 发明申请

US20130060042A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES 有权
标题翻译：生产吡啶衍生物的方法
公开(公告)号：US20130060042A1
公开(公告)日：2013-03-07
申请号：US13581857
申请日：2010-11-10
申请人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
发明人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.
摘要翻译：公开了一种有效生产在1-位和11位上具有酰氧基并在7-位具有羟基的吡啶并苯衍生物的方法。该方法包括在存在或不存在碱的情况下用酰化剂选择性地将式B1化合物的1位和11位羟基选择性酰化1-3步。

5. 发明申请

US20130023017A1 METHOD FOR PRODUCING PYRIPYROPENE 有权
标题翻译：生产吡啶的方法
公开(公告)号：US20130023017A1
公开(公告)日：2013-01-24
申请号：US13575159
申请日：2011-01-19
申请人： Hiroyuki Anzai , Kentaro Yamamoto , Kazuhiko Oyama , Mariko Tsuchida , Kimihiko Goto , Masaaki Mitomi
发明人： Hiroyuki Anzai , Kentaro Yamamoto , Kazuhiko Oyama , Mariko Tsuchida , Kimihiko Goto , Masaaki Mitomi
IPC分类号： C12P17/18 , C12N15/53 , C12N1/19 , C12N15/63 , C12N1/21 , C12N1/15 , C12P17/16 , C12N15/54
CPC分类号： C12P17/181 , C12N9/0071 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/52 , C12Y114/13008 , C12Y114/14001 , C12Y203/00 , C12Y203/01 , C12Y205/01 , C12Y406/01 , C12Y602/01
摘要： There is provided a method for culturing a microorganism in which a particular polynucleotide or a recombinant vector comprising it/them is introduced with an intermediate compound necessary for biosynthesis of pyripyropene. A. The method of the present invention allows for the production of pyripyropene.
摘要翻译：提供了一种培养微生物的方法，其中将特定的多核苷酸或其包含的重组载体与生物合成吡啶并苯所必需的中间体化合物引入。 A.本发明的方法允许生产吡啶并苯。

6. 发明申请

US20120330022A1 METHOD FOR PRODUCING PYRIPYROPENE DERIVATIVES BY THE ENZYMATIC METHOD 审中-公开
标题翻译：通过酶法制备吡啶衍生物的方法
公开(公告)号：US20120330022A1
公开(公告)日：2012-12-27
申请号：US13575171
申请日：2011-01-19
申请人： Kentaro Yamamoto , Mariko Tsuchida , Kazuhiko Oyama , Kimihiko Goto , Masaaki Mitomi
发明人： Kentaro Yamamoto , Mariko Tsuchida , Kazuhiko Oyama , Kimihiko Goto , Masaaki Mitomi
IPC分类号： C12P17/18 , C07D493/04
CPC分类号： C07D403/04 , C07D403/08 , C12P17/181
摘要： There is provided a method for producing a pyripyropene derivative represented by the following formula A by an enzyme method. The production method of the present invention allows for production of a pyripyropene derivative under simpler conditions and in shorter steps. [wherein R represents a linear, branched or cyclic C2-6 alkylcarbonyl group (when the alkyl moiety of this group is branched or cyclic, C3-6 alkyl carbonyl group)].
摘要翻译：提供了通过酶法制备由下式A表示的嘧啶衍生物的方法。本发明的制备方法允许在更简单的条件下和较短的步骤中生产吡啶并苯衍生物。 [其中R表示直链，支链或环状C 2-6烷基羰基（当该基团的烷基部分为支链或环状时，为C 3-6烷基羰基）]。

7. 发明申请

US20120330021A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES AND INTERMEDIATES FOR THE PRODUCTION THEREOF 有权
标题翻译：生产吡啶衍生物的方法及其生产中间体
公开(公告)号：US20120330021A1
公开(公告)日：2012-12-27
申请号：US13572971
申请日：2012-08-13
申请人： Kimihiko Goto , Kazumi Yamamoto , Masayo Sakai , Masaaki Mitomi , Takashi Ando
发明人： Kimihiko Goto , Kazumi Yamamoto , Masayo Sakai , Masaaki Mitomi , Takashi Ando
IPC分类号： C07D493/04
CPC分类号： C07D493/04 , Y02P20/55
摘要： A process for producing compound C represented by formula C is disclosed: wherein R′ represents substituent groups as described herein. The process can produce pyripyropene derivatives that have acyloxy groups at the 1- and 11-positions and a hydroxyl group at the 7-position and are useful as insect pest control agents at a high yield.
摘要翻译：公开了制备由式C表示的化合物C的方法：其中R'表示如本文所述的取代基。该方法可以产生在1-位和11位上具有酰氧基并且在7-位上具有羟基并且以高产率用作害虫控制剂的吡哆烯衍生物。

8. 发明申请

US20120277440A1 IMINO DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND INSECTICIDES CONTAINING SAME 审中-公开
标题翻译： IMINO衍生物，其制备方法和含有其的杀虫剂
公开(公告)号：US20120277440A1
公开(公告)日：2012-11-01
申请号：US13520668
申请日：2011-01-06
申请人： Shinzo Kagabu , Satoru Kumazawa , Tsumoru Watanabe , Taiji Miyake , Masahiro Nomura , Satoshi Nakamura , Masaaki Mitomi
发明人： Shinzo Kagabu , Satoru Kumazawa , Tsumoru Watanabe , Taiji Miyake , Masahiro Nomura , Satoshi Nakamura , Masaaki Mitomi
IPC分类号： C07D417/06
CPC分类号： C07D417/06 , A01N43/78 , C07D417/14
摘要： To provide a novel imino derivative capable of being an insecticide compound which is excellent in characteristics such as sustained effects and a broad spectrum.An imino derivative represented by Formula (A) shown below: wherein “Ar” represents a heterocyclic group which may have a substituent on the ring, “X” represents a sulfur atom or CH2, NR; “R” represents a hydrogen atom or an alkyl group; “Ya” is selected from “C(═S)NR1R2”, “C(═S)SR3”, “C(═O)SR4”, “C(═S)OR4”, “SO2Zα”, and “OZβ”; and, each of “R1” to “R4”, “Zα”, and “Zβ” represents a hydrogen atom or a certain substituent; is provided.
摘要翻译：提供能够成为持续效果和广谱特性优异的杀虫剂化合物的新型亚氨基衍生物。由下式（A）表示的亚氨基衍生物：其中Ar表示可在环上具有取代基的杂环基，X表示硫原子或CH2，NR; R表示氢原子或烷基; Ya选自C（= S）NR1R2，C（= S）SR3，C（= O）SR4，C（= ORS）OR4，SO2Zα和OZ。并且R 1至R 4，Z a和Z bb中的每一个; 表示氢原子或某一取代基; 被提供。

9. 发明申请

US20110009662A1 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID 有权
标题翻译：生产含磷酸脱氢山梨醇酸的方法
公开(公告)号：US20110009662A1
公开(公告)日：2011-01-13
申请号：US12529953
申请日：2008-03-19
申请人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07C227/14
CPC分类号： C07F9/4006 , C07F9/3217
摘要： A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2′, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.
摘要翻译：通过少量步骤有效地制备作为除草剂L-AMPB的中间体的N-取代的2-氨基-4-（取代的 - 氧甲基氧膦基）-2-丁烯酸酯的方法。该方法包括使由下式（1）表示的化合物（其中R 1表示C 1-4烷基）与下式（2）表示的化合物反应：（其中R2，R2'和R3各自表示C1- 4烷基，R 4表示苄氧基羰基）。

10. 发明申请

US20100160640A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES AND INTERMEDIATES FOR THE PRODUCTION THEREOF 有权
标题翻译：生产吡啶衍生物的方法及其生产中间体
公开(公告)号：US20100160640A1
公开(公告)日：2010-06-24
申请号：US12733113
申请日：2008-08-13
申请人： Kimihiko Goto , Kazumi Yamamoto , Masayo Sakai , Masaaki Mitomi , Takashi Ando
发明人： Kimihiko Goto , Kazumi Yamamoto , Masayo Sakai , Masaaki Mitomi , Takashi Ando
IPC分类号： C07D493/04
CPC分类号： C07D493/04 , Y02P20/55
摘要： Disclosed is a process for producing compound C represented by formula C: wherein R′ represents straight chain, branched chain, or cyclic C2-6 alkylcarbonyl, wherein R1b is used as a protective group for hydroxyl at the 7-position of compound C. R1b represents formyl; optionally substituted straight chain C1-4 alkylcarbonyl; optionally substituted benzyl; group —SiR3R4R5 optionally substituted by halogen atom wherein R3, R4, and R5 each independently represent straight chain or branched chain C1-6 alkyl or phenyl; C1-6 alkyloxy-C1-6 alkyl optionally substituted by halogen atom; C1-6 alkylthio-C1-6 alkyl optionally substituted by halogen atom; straight chain, branched chain, or cyclic C1-4 alkyl optionally substituted by halogen atom, provided that, when alkyl in the C1-4 alkyl group is of a branched chain or cyclic type, the alkyl group is C3-4 alkyl; C2-6 alkenyl optionally substituted by halogen atom; C2-6 alkynyl optionally substituted by halogen atom; or an optionally substituted saturated or unsaturated five- or six-membered heterocyclic group. The process can produce pyripyropene derivatives that have acyloxy groups at the 1- and 11-positions and a hydroxyl group at the 7-position and are useful as insect pest control agents at a high yield.
摘要翻译：公开了一种制备由式C表示的化合物C的方法：其中R'表示直链，支链或环状C 2-6烷基羰基，其中R 1b用作化合物C的7-位羟基保护基。R1b 代表甲酰基; 任选取代的直链C 1-4烷基羰基; 任选取代的苄基; 基团-SiR 3 R 4 R 5任选被卤素原子取代，其中R 3，R 4和R 5各自独立地表示直链或支链C 1-6烷基或苯基; 任选被卤素原子取代的C 1-6烷氧基-C 1-6烷基; 任选被卤素原子取代的C 1-6烷硫基-C 1-6烷基; 直链，支链或任选被卤素原子取代的环状C 1-4烷基，条件是当C 1-4烷基中的烷基为支链或环状时，该烷基为C 3-4烷基; 任选被卤素原子取代的C 2-6烯基; 任选被卤素原子取代的C 2-6炔基; 或任选取代的饱和或不饱和的五元或六元杂环基。该方法可以产生在1-位和11位上具有酰氧基并且在7-位上具有羟基并且以高产率用作害虫防治剂的吡哆烯衍生物。

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