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1. 发明申请

US20070213686A1 System and method for prevention of radiocontrast induced nephropathy 审中-公开
标题翻译：用于预防放射性对照诱导的肾病的系统和方法
公开(公告)号：US20070213686A1
公开(公告)日：2007-09-13
申请号：US11347008
申请日：2006-02-03
申请人： Vandana Mathur , Craig Ball , Jeffrey Elkins , Harry Goodson , Samir Patel
发明人： Vandana Mathur , Craig Ball , Jeffrey Elkins , Harry Goodson , Samir Patel
IPC分类号： A61B19/00
CPC分类号： A61M5/1723 , A61B90/00 , A61B2017/22082 , A61M5/007 , A61M25/0068 , A61M2005/1403 , A61M2025/0037 , A61M2025/1045
摘要： An apparatus and method particularly useful in treatments and therapies directed at the kidneys such as the prevention of radiocontrast nephropathy (RCN) arising from diagnostic procedures using iodinated contrast materials. A series of treatment schemes are provided based upon local therapeutic agent delivery to the kidneys that can be used as a prophylactic treatment for patients undergoing interventional procedures that have been identified as being at an elevated risk for developing RCN as well as for low risk patients. The methods may include pre-exposure and post contrast exposure treatments alone or in combination with the local delivery of therapeutic agents to the kidneys. Among the agents identified for such treatments are normal saline and the vasodilators papaverine and fenoldopam mesylate and appropriate dosing is provided.
摘要翻译：特别适用于针对肾脏的治疗和疗法的装置和方法，例如使用碘化造影剂的诊断程序引起的放射性对比肾病（RCN）的预防。提供了一系列基于局部治疗剂递送到肾脏的治疗方案，其可用作对已经被鉴定为发展RCN和低风险患者的高风险的介入手术的患者的预防性治疗。所述方法可以包括单独的暴露前曝光和造影后处理，或与治疗剂局部递送到肾脏的方法。鉴定用于这种治疗的药剂是生理盐水，并且提供了血管扩张剂罂粟碱和甲磺酸芬诺多胺，并提供适当的给药。

2. 发明申请

US20060149350A1 Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens 失效
标题翻译：在分支体内进行双侧干预或诊断的系统和方法
公开(公告)号：US20060149350A1
公开(公告)日：2006-07-06
申请号：US11295735
申请日：2005-12-05
申请人： Samir Patel , Harry Goodson , Jeffrey Elkins , Craig Ball , Vandana Mathur
发明人： Samir Patel , Harry Goodson , Jeffrey Elkins , Craig Ball , Vandana Mathur
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61B2017/00331 , A61B2017/22068 , A61B2017/22071 , A61F2/013 , A61F2/958 , A61F2002/065 , A61F2002/821 , A61F2002/9517 , A61F2002/9528 , A61M25/1002
摘要： Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination delivery/interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.
摘要翻译：分叉输送组件提供从患者的主体空间或内腔延伸的第一和第二分支腔的双向通路。将一个或多个介入装置与输送组件组合以用于输送到分支腔中的一个或两个。使用组合递送/介入装置组件进行双侧肾支架置入或栓塞保护程序。流体也可以从组件注入或吸出。分叉导管具有位于一个分叉分支上的第一流体端口，位于分叉的第二分支上的第二流体端口和位于第一和第二端口定位的位于腔静脉内的第三流体端口在第一和第二肾静脉内双侧。

3. 发明申请

US20050267010A1 Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy 失效
标题翻译：用于治疗充血性心力衰竭和BNP治疗的双侧局部肾移植
公开(公告)号：US20050267010A1
公开(公告)日：2005-12-01
申请号：US11129101
申请日：2005-05-13
申请人： Harry Goodson , Samir Patel , Craig Ball , Jeffrey Elkins
发明人： Harry Goodson , Samir Patel , Craig Ball , Jeffrey Elkins
IPC分类号： A61K38/17 , A61K38/22 , A61M25/00 , A61M25/04
CPC分类号： A61M25/0041 , A61K38/2242 , A61M25/0054 , A61M25/04 , A61M2025/0681 , A61M2210/1085
摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.
摘要翻译：本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。本发明包括用于肾药物递送的装置和使用方法。

4. 发明申请

US20050245882A1 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US20050245882A1
公开(公告)日：2005-11-03
申请号：US11084434
申请日：2005-03-18
申请人： Jeffrey Elkins , Aurelio Valencia , Samir Patel , Ricardo Aboytes , Harry Goodson , Craig Ball
发明人： Jeffrey Elkins , Aurelio Valencia , Samir Patel , Ricardo Aboytes , Harry Goodson , Craig Ball
IPC分类号： A61M20060101 , A61M5/31 , A61M25/00 , A61M37/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

5. 发明申请

US20070167913A1 VASCULAR SHEATH WITH VARIABLE LUMEN CONSTRUCTION 审中-公开
标题翻译：具有可变的建筑结构的血管
公开(公告)号：US20070167913A1
公开(公告)日：2007-07-19
申请号：US11548565
申请日：2006-10-11
申请人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
发明人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
IPC分类号： A61M5/178 , A61F2/06 , A61M31/00
CPC分类号： A61M25/0662 , A61F2/07 , A61F2002/065 , A61M25/0668 , A61M2025/0024 , A61M2025/0183 , A61M2025/0188 , A61M2025/0681
摘要： A system for delivering a renal treatment and a peripheral treatment includes a renal catheter, a peripheral catheter, and an introducer sheath having first and second lumens. The first lumen is configured to receive the renal catheter and is sized to extend from a patient insertion site to a femoral or iliac artery location near or distal to a patient aortic branch. The second lumen is configured to receive the peripheral catheter and is sized to extend from the patient insertion site to an opposite femoral or iliac artery location near or distal to the patient aortic branch. A method of delivering a renal treatment and a peripheral treatment includes positioning an introducer sheath in an iliac artery, advancing a renal catheter and a peripheral catheter through the introducer sheath, where the renal catheter is separated from the peripheral catheter within the introducer sheath by a flap.
摘要翻译：用于递送肾脏治疗和外周治疗的系统包括肾导管，外周导管和具有第一和第二腔的导引鞘。第一管腔被配置为接纳肾导管，其尺寸设计成从患者插入位置延伸到患者主动脉分支附近或远侧的股骨或髂动脉位置。第二管腔构造成接收外周导管，其尺寸设计成从患者插入位置延伸到患者主动脉分支附近或远侧的相对的股骨或髂动脉位置。递送肾脏治疗和周边治疗的方法包括将引导器鞘定位在髂动脉中，使肾导管和外周导管穿过导引鞘，其中肾导管与导引鞘内的周围导管分开一个皮瓣

6. 发明申请

US20060036218A1 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US20060036218A1
公开(公告)日：2006-02-16
申请号：US11084738
申请日：2005-03-16
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自插管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

7. 发明申请

US20070249997A1 METHOD AND APPARATUS FOR SELECTIVE MATERIAL DELIVERY VIA AN INTRA-RENAL CATHETER 有权
标题翻译：通过内镜导管选择性材料输送的方法和装置
公开(公告)号：US20070249997A1
公开(公告)日：2007-10-25
申请号：US11768390
申请日：2007-06-26
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

8. 发明申请

US20060079859A1 Renal infusion systems and methods 有权
标题翻译：肾输液系统及方法
公开(公告)号：US20060079859A1
公开(公告)日：2006-04-13
申请号：US11241749
申请日：2005-09-29
申请人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
发明人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
IPC分类号： A61M31/00
CPC分类号： A61M25/00 , A61M25/0068 , A61M25/0074 , A61M25/008 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0057 , A61M2025/0183 , A61M2025/0681 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2025/1095 , A61M2029/025 , A61M2210/127
摘要： Systems, devices, and methods for delivering treatment to the renal arteries are provided. Exemplary systems include a delivery catheter having a distal bifurcation, an introducer assembly comprising an introducer sheath in operative association with a Y-hub, wherein Y-hub includes a first port for receiving the delivery catheter and a second port for receiving a second catheter, and a constraint assembly for holding the distal bifurcation of the delivery catheter in a low-profile configuration when it is advanced distally beyond the introducer sheath.
摘要翻译：提供了用于将治疗递送到肾动脉的系统，装置和方法。示例性系统包括具有远端分叉的输送导管，导引器组件，其包括与Y型轮毂可操作地相关联的引导器护套，其中Y型毂包括用于接收输送导管的第一端口和用于接收第二导管的第二端口，以及约束组件，当约束组件向远侧远离导引鞘时，用于将输送导管的远端分叉保持在低轮廓构型。

9. 发明申请

US20060030814A1 Method and apparatus for selective drug infusion via an intra-aortic flow diverter delivery catheter 审中-公开
标题翻译：通过主动脉内分流器输送导管选择性药物输注的方法和装置
公开(公告)号：US20060030814A1
公开(公告)日：2006-02-09
申请号：US11083802
申请日：2005-03-18
申请人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M25/00 , A61M25/0074 , A61M25/0082 , A61M25/04 , A61M29/02 , A61M39/06 , A61M2025/0073 , A61M2025/1052
摘要： A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要翻译：局部肾递送系统包括流动隔离组件和局部注射组件。在一种模式中的流动隔离组件适于仅沿着沿着主动脉壁的外周隔离部分流动区域，使得在其中注入的流体被维持以基本上流入肾动脉。描述了各种类型的流动隔离组件和局部注射组件。

10. 发明申请

US20050197624A1 Sheath for use in peripheral interventions 审中-公开
标题翻译：护套用于外围干预
公开(公告)号：US20050197624A1
公开(公告)日：2005-09-08
申请号：US11073421
申请日：2005-03-04
申请人： Harry Goodson , Craig Ball , Jeffrey Elkins
发明人： Harry Goodson , Craig Ball , Jeffrey Elkins
IPC分类号： A61M25/00 , A61M25/06 , A61M29/00
CPC分类号： A61M25/0662 , A61M25/0032 , A61M25/007
摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.
摘要翻译：双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且构造成允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉导引鞘的插入点进入患者。

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