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1. 发明申请

US20060030814A1 Method and apparatus for selective drug infusion via an intra-aortic flow diverter delivery catheter 审中-公开
标题翻译：通过主动脉内分流器输送导管选择性药物输注的方法和装置
公开(公告)号：US20060030814A1
公开(公告)日：2006-02-09
申请号：US11083802
申请日：2005-03-18
申请人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M25/00 , A61M25/0074 , A61M25/0082 , A61M25/04 , A61M29/02 , A61M39/06 , A61M2025/0073 , A61M2025/1052
摘要： A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要翻译：局部肾递送系统包括流动隔离组件和局部注射组件。在一种模式中的流动隔离组件适于仅沿着沿着主动脉壁的外周隔离部分流动区域，使得在其中注入的流体被维持以基本上流入肾动脉。描述了各种类型的流动隔离组件和局部注射组件。

2. 发明申请

US20060036218A1 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US20060036218A1
公开(公告)日：2006-02-16
申请号：US11084738
申请日：2005-03-16
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自插管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

3. 发明申请

US20070249997A1 METHOD AND APPARATUS FOR SELECTIVE MATERIAL DELIVERY VIA AN INTRA-RENAL CATHETER 有权
标题翻译：通过内镜导管选择性材料输送的方法和装置
公开(公告)号：US20070249997A1
公开(公告)日：2007-10-25
申请号：US11768390
申请日：2007-06-26
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

4. 发明申请

US20080103442A1 INTRA-AORTIC RENAL DRUG DELIVERY CATHETER 审中-公开
标题翻译： INTRA-AORTIC肾脏药物输送管
公开(公告)号：US20080103442A1
公开(公告)日：2008-05-01
申请号：US11968237
申请日：2008-01-02
申请人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
发明人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
IPC分类号： A61M31/00 , A61M29/02
CPC分类号： A61M25/1002 , A61M2025/0034 , A61M2025/0035 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/1004 , A61M2025/105 , A61M2025/1059 , A61M2025/1084
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要翻译：用于将治疗剂或诊断剂递送到主要血管的分支金黄色血管的导管包括细长轴，其具有至少一个内腔，其与所述轴的远侧部分中的药剂输送端口流体连通，所述可扩张管状构件所述轴的远端部分和所述管状部件上的径向可扩张部件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。

5. 发明申请

US20060189960A1 Intra-aortic renal drug delivery catheter 有权
标题翻译：主动脉内肾脏药物输送导管
公开(公告)号：US20060189960A1
公开(公告)日：2006-08-24
申请号：US11221679
申请日：2005-09-07
申请人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
发明人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M2025/0034 , A61M2025/0035 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/1004 , A61M2025/105 , A61M2025/1059 , A61M2025/1084
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要翻译：用于将治疗剂或诊断剂递送到主要血管的分支金黄色血管的导管包括细长轴，其具有至少一个内腔，其与所述轴的远侧部分中的药剂输送端口流体连通，所述可扩张管状构件所述轴的远端部分和所述管状部件上的径向可扩张部件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。

6. 发明申请

US20060067972A1 Devices for renal-based heart failure treatment 审中-公开
标题翻译：肾脏心力衰竭治疗装置
公开(公告)号：US20060067972A1
公开(公告)日：2006-03-30
申请号：US11167056
申请日：2005-06-23
申请人： Randy Kesten , Sophia Pesotchinsky
发明人： Randy Kesten , Sophia Pesotchinsky
IPC分类号： A61K38/18 , A61K31/7076 , A61K31/522 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/522 , A61K31/7076 , A61K38/2242 , A61M5/14276 , A61M5/1723 , A61M39/0208
摘要： Methods and devices are provided to preferentially deliver biologically active substances to a patient's renal artery, particularly for the treatment of congestive heart failure. The apparatus will comprise an implantable depot which may be in the form of a biodegradable vascular implant, a replenishable reservoir, a drug pump, or combinations thereof. The reservoirs will preferentially be refillable using needles or other transcutaneous techniques.
摘要翻译：提供的方法和装置优先将生物活性物质递送到患者的肾动脉，特别是用于治疗充血性心力衰竭。该装置将包括可植入的贮库，其可以是可生物降解的血管植入物，可补充储存器，药物泵或其组合的形式。储存器将优先使用针头或其他经皮技术来重新填充。

7. 发明授权

US08091556B2 Methods and apparatus for reducing localized circulatory system pressure 有权
标题翻译：减少局部循环系统压力的方法和装置
公开(公告)号：US08091556B2
公开(公告)日：2012-01-10
申请号：US09839643
申请日：2001-04-20
申请人： Gad Keren , Randy Kesten
发明人： Gad Keren , Randy Kesten
IPC分类号： A61B19/00
CPC分类号： A61M27/006 , A61B17/00234 , A61B2017/00243 , A61B2017/00252 , A61F2/2412 , A61F2/2493 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/125 , A61M27/002
摘要： Methods and apparatus for decreasing cardiac pressure in a patient by implanting a shunt communicating with an area outside a first portion, whereby a volume of blood sufficient to reduce pressure in a first portion is released. Preferably, the end diastolic pressure in the left ventricle is reduced, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle. Most preferably, the shunt selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart above a threshold pressure, so that shunting is prevented during left ventricular systole, or, alternatively, selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart is between a lower threshold and a higher threshold. In certain embodiments a semi-passive check-valve is controlled and actuated by an external signal.
摘要翻译：通过植入与第一部分之外的区域连通的分流器来降低患者心脏压力的方法和装置，由此释放足以减少第一部分中的压力的体积的血液。优选地，左心室的舒张末期压力降低，这是通过使分流器与左心室连通而实现的，因此从左心室释放少量的血液。最优选地，当左心室和心脏另一腔室之间的压差高于阈值压力时，分流器选择性地允许流动，使得在左心室收缩期间防止分流，或者当选择性地允许左心室和心脏的另一个腔室处于较低阈值和较高阈值之间。在某些实施例中，半被动止回阀由外部信号控制和致动。

8. 发明授权

US08235933B2 Methods and apparatus for reducing localized circulatory system pressure 有权
标题翻译：减少局部循环系统压力的方法和装置
公开(公告)号：US08235933B2
公开(公告)日：2012-08-07
申请号：US13107832
申请日：2011-05-13
申请人： Gad Keren , Randy Kesten
发明人： Gad Keren , Randy Kesten
IPC分类号： A61M5/00
CPC分类号： A61M27/006 , A61B17/00234 , A61B2017/00243 , A61B2017/00252 , A61F2/2412 , A61F2/2493 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/125 , A61M27/002
摘要： The present invention is directed to methods and apparatus for decreasing pressure in the left atrium of a patient by implanting a valved shunt through the atrial septum, whereby a volume of blood sufficient to reduce pressure in said left atrium is released to the right atrium.
摘要翻译：本发明涉及通过植入瓣膜分流穿过心房隔膜来减轻患者左心房压力的方法和装置，由此将足以减少所述左心房压力的一定体积的血液释放到右心房。

9. 发明申请

US20110218478A1 METHODS AND APPARATUS FOR REDUCING LOCALIZED CIRCULATORY SYSTEM PRESSURE 有权
公开(公告)号：US20110218478A1
公开(公告)日：2011-09-08
申请号：US13107843
申请日：2011-05-13
申请人： Gad Keren , Randy Kesten
发明人： Gad Keren , Randy Kesten
IPC分类号： A61M1/00
CPC分类号： A61M27/006 , A61B17/00234 , A61B2017/00243 , A61B2017/00252 , A61F2/2412 , A61F2/2493 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/125 , A61M27/002
摘要： The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released. Preferably, the first portion comprises the left ventricle and the pressure reduced is the end diastolic pressure, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle to reduce the end diastolic pressure. Most preferably, the shunt selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart above a threshold pressure, whereby shunting is prevented during left ventricular systole, or, alternatively, selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart is between a lower threshold and a higher threshold, whereby shunting is again prevented during left ventricular systole. In certain embodiments a semi-passive check-valve is controlled and actuated by an external signal, either using a signal generated by an intra-corporeal electrical battery or an externally coupled energy source. In certain embodiments, the shunt has a pump with an input connected to the left ventricle, or other portion with excessive pressure, and an output connected to a volume of lower pressure. The preferred method of implanting the shunt to effect the present invention is by deploying a tubular element having two ends and a tissue affixation element disposed at each of said ends via a catheter, preferably, the fixation element is a shape retaining metallic material that returns to its original shape as part of the retention aspect of its function. In preferred embodiments of the apparatus, the tubular element is comprised of a biologically inert non-metallic material.

10. 发明授权

US08328751B2 Methods and apparatus for reducing localized circulatory system pressure 有权
公开(公告)号：US08328751B2
公开(公告)日：2012-12-11
申请号：US13107843
申请日：2011-05-13
申请人： Gad Keren , Randy Kesten
发明人： Gad Keren , Randy Kesten
IPC分类号： A61B19/00
CPC分类号： A61M27/006 , A61B17/00234 , A61B2017/00243 , A61B2017/00252 , A61F2/2412 , A61F2/2493 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/125 , A61M27/002
摘要： The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released. Preferably, the first portion comprises the left ventricle and the pressure reduced is the end diastolic pressure, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle to reduce the end diastolic pressure. Most preferably, the shunt selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart above a threshold pressure, whereby shunting is prevented during left ventricular systole, or, alternatively, selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart is between a lower threshold and a higher threshold, whereby shunting is again prevented during left ventricular systole. In certain embodiments a semi-passive check-valve is controlled and actuated by an external signal, either using a signal generated by an intra-corporeal electrical battery or an externally coupled energy source. In certain embodiments, the shunt has a pump with an input connected to the left ventricle, or other portion with excessive pressure, and an output connected to a volume of lower pressure. The preferred method of implanting the shunt to effect the present invention is by deploying a tubular element having two ends and a tissue affixation element disposed at each of said ends via a catheter, preferably, the fixation element is a shape retaining metallic material that returns to its original shape as part of the retention aspect of its function. In preferred embodiments of the apparatus, the tubular element is comprised of a biologically inert non-metallic material.

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