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1. 发明授权

US08585678B2 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US08585678B2
公开(公告)日：2013-11-19
申请号：US12044230
申请日：2008-03-07
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M31/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

2. 发明申请

US20090318941A1 Self-Expandable Endovascular Device For Aneurysm Occlusion 审中-公开
标题翻译：用于动脉瘤闭塞的自扩张血管内装置
公开(公告)号：US20090318941A1
公开(公告)日：2009-12-24
申请号：US12294210
申请日：2007-03-23
申请人： Ivan Sepetka , Maria G. Aboytes , Hong Thu Doan , Ricardo Aboytes , Steven Hochberg , Peter Costantino , Craig F. Friedman , Arindam Datta
发明人： Ivan Sepetka , Maria G. Aboytes , Hong Thu Doan , Ricardo Aboytes , Steven Hochberg , Peter Costantino , Craig F. Friedman , Arindam Datta
IPC分类号： A61B17/08 , A61M25/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B17/12181 , A61B90/39 , A61B2017/00526 , A61B2017/00867 , A61B2017/00893 , A61B2017/12095
摘要： The self-expandable endovascular apparatus for aneurysm occlusion of the invention comprises a deformable shape memory frame with at least a partial segment covering comprised of a matrix implant material. The device can be folded and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expands in place as it adopts its original shape on release from the device into an aneurysm. A method of treating an aneurysm, comprises the steps of: (a) providing the self-expandable endovascular apparatus inserted into a lumen of a delivery device comprising a proximal end and a distal end, the distal end having a distal tip; (b) advancing the distal tip of the delivery device into an opening in an aneurysm having an interior sac; (c) advancing the apparatus through the lumen into the opening; and (d) withdrawing the delivery device, whereby the apparatus expands into the sac and covers the opening.
摘要翻译：本发明的用于动脉瘤闭塞的自扩张型血管内装置包括具有由基质植入材料构成的至少部分段覆盖物的可变形形状记忆框架。该装置可以被折叠和/或拉伸以采用窄的轮廓以装载到同轴输送装置中，并且在从装置释放到动脉瘤中时采用其原始形状而扩展就位。一种治疗动脉瘤的方法，包括以下步骤：（a）提供插入到包括近端和远端的输送装置的内腔中的自扩张型血管内装置，所述远端具有远端; （b）将输送装置的远端前进到具有内囊的动脉瘤的开口中; （c）使设备通过内腔进入开口; 和（d）取出输送装置，从而使装置膨胀成囊并覆盖开口。

3. 发明申请

US20060116714A1 Coupling and release devices and methods for their assembly and use 审中-公开
标题翻译：联轴器和释放装置及其组装和使用方法
公开(公告)号：US20060116714A1
公开(公告)日：2006-06-01
申请号：US11264402
申请日：2005-10-31
申请人： Ivan Sepetka , Maria Aboytes , Ricardo Aboytes
发明人： Ivan Sepetka , Maria Aboytes , Ricardo Aboytes
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12181 , A61B90/39 , A61B2017/00477 , A61B2017/00862 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12095
摘要： Devices and methods for coupling, delivery, detaching and controllably releasing a medical implant, and methods for the assembly and use of the devices, provide for mechanically simple and rapidly operated release of the implant without disturbing its precisely selected position. Embodiments of various aspects of the present invention employ, among other structures, a loop or other aperture-bearing engagement element releasably held by a mating retaining element, in some instances with the assistance of a member for constraining the engagement element relative to the retaining element. In another aspect, the loop or other aperture-bearing element may be at least temporarily placed in a tensile state to maintain coupling of the implant prior to release. Embodiments of the invention permit release through a practitioner actuation, such as causing one or more rotations that lead to the withdrawal of the retaining element from the loop or aperture-bearing element. Release may be immediate, or near-immediate, while the loop, which may in various embodiments be of a flexible material, is left behind with minimal or no disturbance of the implant.
摘要翻译：用于联接，输送，分离和可控地释放医用植入物的装置和方法以及用于组装和使用装置的方法提供植入物的机械简单且快速操作的释放，而不会干扰其精确选择的位置。除了其它结构之外，本发明的各个方面的实施例还使用可释放地由配合保持元件保持的环或其它孔隙接合元件，在一些情况下借助于用于约束接合元件相对于保持元件的构件。在另一方面，环或其它孔径承载元件可以至少暂时放置在拉伸状态以在释放之前保持植入物的联接。本发明的实施例允许从业者致动释放，例如引起一个或多个转动，导致保持元件从环或孔隙承载元件中退出。释放可以是立即的或接近即时的，而在各种实施例中可以是柔性材料的环被放置在植入物的最小或没有干扰之下。

4. 发明申请

US20050245882A1 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US20050245882A1
公开(公告)日：2005-11-03
申请号：US11084434
申请日：2005-03-18
申请人： Jeffrey Elkins , Aurelio Valencia , Samir Patel , Ricardo Aboytes , Harry Goodson , Craig Ball
发明人： Jeffrey Elkins , Aurelio Valencia , Samir Patel , Ricardo Aboytes , Harry Goodson , Craig Ball
IPC分类号： A61M20060101 , A61M5/31 , A61M25/00 , A61M37/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

5. 发明授权

US08012121B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
公开(公告)号：US08012121B2
公开(公告)日：2011-09-06
申请号：US11768390
申请日：2007-06-26
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.

6. 发明申请

US20060036218A1 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US20060036218A1
公开(公告)日：2006-02-16
申请号：US11084738
申请日：2005-03-16
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自插管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

7. 发明申请

US20080281350A1 Aneurysm Occlusion Devices 审中-公开
标题翻译：动脉瘤闭塞装置
公开(公告)号：US20080281350A1
公开(公告)日：2008-11-13
申请号：US11956323
申请日：2007-12-13
申请人： Ivan Sepetka , Greg Mirigian , Arindam Datta , Steven Hochberg , Ricardo Aboytes , Trang Ngo
发明人： Ivan Sepetka , Greg Mirigian , Arindam Datta , Steven Hochberg , Ricardo Aboytes , Trang Ngo
IPC分类号： A61M29/02
CPC分类号： A61B17/12022 , A61B17/0057 , A61B17/12113 , A61B17/12145 , A61B17/12172 , A61B17/12181 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/00619 , A61B2017/12054 , A61B2017/12095 , A61M2025/0042
摘要： An implantable occlusion device for bridging the neck of an aneurysm comprises a biocompatible matrix. The device is movable between a compressed position prior to implantation and a generally concave or cup-shaped position following implantation. The device may comprise a frame having a plurality of elements. The frame elements have a first pre-deployment position generally parallel to a major axis of the delivery lumen, and a second post-deployment position spread radially from the major axis of the delivery lumen. The biocompatible matrix and/or the frame elements may also form or be manipulated to form a generally concave or cupped shape. The matrix can be porous or semiporous, such as a foam or a reticulated matrix. The occlusion device can be folded, twisted and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expand in place as it adopts its original shape on release. The device may be released or manipulated to a desired shape to occlude an aneurysm. Methods of using the implantable device are also provided.
摘要翻译：用于桥接动脉瘤颈部的可植入闭塞装置包括生物相容性基质。该装置可在植入之前的压缩位置和植入后的大致凹形或杯状位置之间移动。该装置可以包括具有多个元件的框架。框架元件具有大致平行于输送腔的长轴的第一预部署位置和从输送腔的长轴径向扩展的第二后部署位置。生物相容性基质和/或框架元件也可以形成或被操作以形成大体上凹形或杯状的形状。基质可以是多孔的或半孔的，例如泡沫或网状基质。闭塞装置可以被折叠，扭曲和/或拉伸以采用狭窄的轮廓以装载到同轴输送装置中，并且在释放时采用其原始形状而扩展就位。该装置可以被释放或操纵到期望的形状以阻塞动脉瘤。还提供了使用可植入装置的方法。

8. 发明申请

US20080154236A1 METHOD AND APPARATUS FOR INTRA-AORTIC SUBSTANCE DELIVERY TO A BRANCH VESSEL 有权
标题翻译：用于运输物流输送到分支机构的方法和装置
公开(公告)号：US20080154236A1
公开(公告)日：2008-06-26
申请号：US12044230
申请日：2008-03-07
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M31/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

9. 发明授权

US07914503B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US07914503B2
公开(公告)日：2011-03-29
申请号：US11084738
申请日：2005-03-16
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

10. 发明授权

US07364566B2 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US07364566B2
公开(公告)日：2008-04-29
申请号：US11084434
申请日：2005-03-18
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M29/00 , A61M25/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

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