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1. 发明授权

US07235255B2 Biological bioadhesive compositions and methods of preparation and use 有权
公开(公告)号：US07235255B2
公开(公告)日：2007-06-26
申请号：US11003556
申请日：2004-12-03
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61K13/00 , A61K33/14 , A61K31/56 , A01N59/08 , A01N45/00 , A61M5/00
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.

2. 发明授权

US07229633B2 Biological bioadhesive compositions and methods of preparation and use 有权
标题翻译：生物生物粘附剂组合物及其制备和使用方法
公开(公告)号：US07229633B2
公开(公告)日：2007-06-12
申请号：US11003106
申请日：2004-12-04
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61F13/00 , A61K33/14 , A61K31/56 , A01N59/08 , A01N45/00 , A61M5/00
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

3. 发明授权

US06468527B2 Biological bioadhesive composition and methods of preparation and use 有权
公开(公告)号：US06468527B2
公开(公告)日：2002-10-22
申请号：US09888310
申请日：2001-06-22
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61K3848
CPC分类号： A61L31/046 , A61L24/0015 , A61L24/106 , A61L27/225 , A61L2300/222 , A61L2300/258 , A61L2300/402 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/64
摘要： The present invention relates generally to the preparation and use of novel enhanced biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen component in the presence of various critical biological and non-biological agents. The invention further relates to a novel method of using said enhanced fibrin sealant whereby the sealant and accompanying agent are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant resulting in enhanced therapeutic value derived by the prolonged presence, and optionally time-released delivery, of said accompanying agent at the critical site.

4. 发明申请

US20110008316A1 Biological bioadhesive compositions and methods of preparation and use 审中-公开
标题翻译：生物生物粘附剂组合物及其制备和使用方法
公开(公告)号：US20110008316A1
公开(公告)日：2011-01-13
申请号：US12807366
申请日：2010-09-02
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61K38/48 , A61P41/00
CPC分类号： A61K38/363 , A61K31/573 , A61K38/4833 , C12Y304/21005 , A61K2300/00
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

5. 发明授权

US06921532B1 Biological Bioadhesive composition and methods of preparation and use 有权
标题翻译：生物生物粘合剂组合物及其制备和使用方法
公开(公告)号：US06921532B1
公开(公告)日：2005-07-26
申请号：US10280133
申请日：2002-10-22
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61L24/00 , A61L24/10 , A61L27/22 , A61L31/04 , A61K38/48
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

6. 发明申请

US20100268585A1 INJECTION ADVERTISING TECHNOLOGY 审中-公开
标题翻译：注射广告技术
公开(公告)号：US20100268585A1
公开(公告)日：2010-10-21
申请号：US12738048
申请日：2008-10-17
申请人： Stewart Padveen , Thomas E. Davis , Aaron John Cody , John Elery Danger Canty , Michael Richard Moore
发明人： Stewart Padveen , Thomas E. Davis , Aaron John Cody , John Elery Danger Canty , Michael Richard Moore
IPC分类号： G06Q30/00 , G06F15/16 , G06F9/445 , G06Q40/00
CPC分类号： G06Q40/12 , G06Q10/107 , G06Q20/10 , G06Q30/02 , G06Q30/0214 , G06Q30/0269 , H04L51/00
摘要： A method and information processing system for providing messaging through an electronic messaging system. At least one user is determined to have performed at least one of the following two acts, creating an electronic message and sending an electronic message. At least one message is selected from a data store in response to the user having performed at least one of the two acts. The message is embedded within the electronic message. An accounting record is updated that includes information for compensating the user based on sent electronic messages including the message, which has been embedded.
摘要翻译：一种用于通过电子消息系统提供消息传递的方法和信息处理系统。确定至少一个用户已经执行了以下两个动作中的至少一个，创建电子消息和发送电子消息。响应于用户执行了两个动作中的至少一个动作，从数据存储器中选择至少一个消息。消息嵌入在电子消息中。更新会计记录，其包括用于基于发送的电子消息补偿用户的信息，包括已经嵌入的消息。

7. 发明授权

US5736025A Control of temperature gradients during gel electrophoresis using turbulent gas flow 失效
标题翻译：使用湍流气流控制凝胶电泳过程中的温度梯度
公开(公告)号：US5736025A
公开(公告)日：1998-04-07
申请号：US744689
申请日：1996-11-07
申请人： Douglas H. Smith , Brian J. Mifsud , Dean S. Burgi , Thomas E. Davis , Steven M. VanHuystee
发明人： Douglas H. Smith , Brian J. Mifsud , Dean S. Burgi , Thomas E. Davis , Steven M. VanHuystee
IPC分类号： G01N27/447 , C25B9/00
CPC分类号： G01N27/44708
摘要： A gel electrophoresis separation apparatus comprising, in combination, a gaseous heat-exchange medium, a gaseous heat-exchange medium driving means, and an impingement means, whereby the gaseous heat-exchange medium is driven by the gaseous heat-exchange medium driving means across the impingement means to provide a flow of the gaseous heat-exchange medium on the surface of the gel plates, whereby the flow induced by passage of the gaseous heat-exchange medium through the impingement means thereby minimizes temperature gradients within the gel by forced convection.
摘要翻译：一种凝胶电泳分离装置，其组合包括气体热交换介质，气体热交换介质驱动装置和冲击装置，由此气态热交换介质由气体热交换介质驱动装置驱动冲击意味着在凝胶板的表面上提供气态热交换介质的流动，由此通过气体热交换介质通过冲击装置引起的流动从而通过强制对流使凝胶内的温度梯度最小化。

8. 发明授权

US5660984A DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof 失效
标题翻译： DNA分离装置，其包含无孔DNA结合，阴离子交换树脂及其使用方法
公开(公告)号：US5660984A
公开(公告)日：1997-08-26
申请号：US353074
申请日：1994-12-09
申请人： Thomas E. Davis , Alison M. Grothe , Henry L. Schwartz , John Gripp , Danny G. Morrow , Steven Van Huystee
发明人： Thomas E. Davis , Alison M. Grothe , Henry L. Schwartz , John Gripp , Danny G. Morrow , Steven Van Huystee
IPC分类号： B01J41/20 , C12N15/10 , C12Q1/68 , B01D15/04 , B01D24/00
CPC分类号： C12N15/1017 , B01J41/20 , C12Q1/6806
摘要： This invention relates to isolating a DNA sample from a heterogeneous mixture of the DNA and other compounds. The invention relates in particular to isolating a plasmid DNA sample from a cleared bacterial lysate. The invention provides an apparatus and method for using the apparatus to rapidly and economically isolate a DNA sample from such a mixture without the use of hazardous chemicals.
摘要翻译：本发明涉及从DNA和其它化合物的非均相混合物中分离DNA样品。本发明特别涉及从澄清的细菌裂解液中分离质粒DNA样品。本发明提供了一种使用该装置的装置和方法，用于在不使用危险化学品的情况下快速且经济地分离DNA样品与这种混合物。

9. 发明授权

US4120265A Aquarium divider 失效
标题翻译：水族箱分隔线
公开(公告)号：US4120265A
公开(公告)日：1978-10-17
申请号：US742868
申请日：1976-11-18
申请人： Thomas E. Davis
发明人： Thomas E. Davis
IPC分类号： A01K63/00 , A01K64/00
CPC分类号： A01K63/006
摘要： An aquarium tank having a bottom and four side walls is characterized by a transparent divider diagonally dividing the tank into two physically separate compartments, while maintaining the visual impression of a single compartment aquarium. The divider is vertical, rests on the bottom of the aquarium, and is of a height slightly greater than the level of water in the aquarium. The divider is clear and transparent throughout the major portion of the area thereof, and includes perforate areas adjacent its two ends for passage of water between the two compartments. Resilient mounting members at the two vertical ends of the divider provide a snug fit thereof into diagonally opposite corners of the aquarium. As a consequence of the physical separation of the compartments, newly born fry may be confined in one of the compartments safe from larger predatory fish in the other compartment.
摘要翻译：具有底部和四个侧壁的水族箱具有透明分隔器，将罐体对角地分成两个物理分离的隔室，同时保持单个隔室水族箱的视觉印象。分隔线是垂直的，位于水族箱的底部，高度略高于水族箱的水位。分隔件在其整个区域的主要部分是透明和透明的，并且包括邻近其两端的穿孔区域，用于在两个室之间通过水。在分隔器的两个垂直端部处的弹性安装构件提供与水族箱的对角相对的角部的紧贴配合。由于隔间的物理分离，新出生的鱼苗可能被限制在另一个隔间中较大的掠食性鱼类的一个隔间中。

10. 发明授权

US4054194A Discharge chute for concrete mix 失效
标题翻译：混凝土混合料排料槽
公开(公告)号：US4054194A
公开(公告)日：1977-10-18
申请号：US644717
申请日：1975-12-29
申请人： Thomas E. Davis
发明人： Thomas E. Davis
IPC分类号： B28C5/42 , B65G11/16 , B65G11/10
CPC分类号： B65G11/166 , B28C5/4248
摘要： A conveying chute for freshly mixed concrete is made from a metal frame having a replaceable polyurethane liner. The liner is formed flat about a porous metal reinforcement and is held in a curved trough defining shape by the frame.
摘要翻译：用于新拌混凝土的输送滑槽由具有可更换聚氨酯衬垫的金属框架制成。衬套围绕多孔金属加强件平坦地形成并且被保持在通过框架限定形状的弯曲槽中。

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