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1. 发明授权

US06468527B2 Biological bioadhesive composition and methods of preparation and use 有权
公开(公告)号：US06468527B2
公开(公告)日：2002-10-22
申请号：US09888310
申请日：2001-06-22
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61K3848
CPC分类号： A61L31/046 , A61L24/0015 , A61L24/106 , A61L27/225 , A61L2300/222 , A61L2300/258 , A61L2300/402 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/64
摘要： The present invention relates generally to the preparation and use of novel enhanced biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen component in the presence of various critical biological and non-biological agents. The invention further relates to a novel method of using said enhanced fibrin sealant whereby the sealant and accompanying agent are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant resulting in enhanced therapeutic value derived by the prolonged presence, and optionally time-released delivery, of said accompanying agent at the critical site.

2. 发明申请

US20110008316A1 Biological bioadhesive compositions and methods of preparation and use 审中-公开
标题翻译：生物生物粘附剂组合物及其制备和使用方法
公开(公告)号：US20110008316A1
公开(公告)日：2011-01-13
申请号：US12807366
申请日：2010-09-02
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61K38/48 , A61P41/00
CPC分类号： A61K38/363 , A61K31/573 , A61K38/4833 , C12Y304/21005 , A61K2300/00
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

3. 发明授权

US06921532B1 Biological Bioadhesive composition and methods of preparation and use 有权
标题翻译：生物生物粘合剂组合物及其制备和使用方法
公开(公告)号：US06921532B1
公开(公告)日：2005-07-26
申请号：US10280133
申请日：2002-10-22
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61L24/00 , A61L24/10 , A61L27/22 , A61L31/04 , A61K38/48
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

4. 发明授权

US07235255B2 Biological bioadhesive compositions and methods of preparation and use 有权
公开(公告)号：US07235255B2
公开(公告)日：2007-06-26
申请号：US11003556
申请日：2004-12-03
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61K13/00 , A61K33/14 , A61K31/56 , A01N59/08 , A01N45/00 , A61M5/00
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.

5. 发明授权

US07229633B2 Biological bioadhesive compositions and methods of preparation and use 有权
标题翻译：生物生物粘附剂组合物及其制备和使用方法
公开(公告)号：US07229633B2
公开(公告)日：2007-06-12
申请号：US11003106
申请日：2004-12-04
申请人： Sam L. Austin , Thomas E. Davis
发明人： Sam L. Austin , Thomas E. Davis
IPC分类号： A61F13/00 , A61K33/14 , A61K31/56 , A01N59/08 , A01N45/00 , A61M5/00
CPC分类号： A61L24/106 , A61L24/0015 , A61L27/225 , A61L31/046 , A61L2300/222 , A61L2300/418 , A61L2300/43 , A61L2300/45
摘要： The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.
摘要翻译：本发明一般涉及依赖于组合纤维蛋白原和凝血酶的生物组织粘合剂的制备和应用。更具体地说，本发明涉及一种制备纤维蛋白密封剂的方法，其中所述密封剂通过在生物和/或非生物制剂如药物，化学品和蛋白质的存在下重构纤维蛋白原或凝血酶组分来形成。优选将这些试剂引入溶液中，例如含有皮质类固醇的溶液，如含有醋酸倍他米松或倍他米松磷酸钠的倍他米松溶液; 曲马松醇溶液; 或甲基强的松龙溶液。这些溶液可以代替通常用于制备纤维蛋白密封剂例如氯化钙的其它溶液的补充，或作为其补充。本发明还涉及使用改进的纤维蛋白密封剂的新方法，其中密封剂和伴随剂直接输送到体内的关键部位并由于密封剂的生物静态质量而被密封就位。这通过在关键部位的特定药剂的长期存在和任选的时间释放的递送来为患者提供治疗价值。

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